the role of civil society organizations in regulating business

... results in the activation of the TBK1/IRF3 pathway Trang 8CHAPTER 1: INTRODUCTION Trang 91.1 The role of IRFs in type 1 interferon induction The innate immune system is coordinated by an intricate ... result in development of combinatorial therapies with genotoxic agents that further increase the expression of NKG2D ligands on tumour cells Interestingly, the effector functions of the ATM/ATR kinases ... Thus, the loss of p53 function results in the loss of the DDR and the apoptotic machinery, which is major step in which the cell can overcome its intrinsic safeguard mechanism to stop proliferating

Ngày tải lên: 13/10/2015, 15:54

... at the provincial and district level is limited resulting in a lack of monitoring and correction of the ac-curacy of the assessment results, and affecting the CSO's goal of “enhancing community ... Klein, 2006) 2 Methodology The research was conducted on the basis of reviewing and evaluating the results of the im-plementation of studies and projects of more than 20 representative CSOs in ... central role in climate vulnerability assessment and then chair or coordinate implementation of climate change adaptation models in the priority sectors of the NAP CSOs’ capacity and roles in CVA

Ngày tải lên: 15/05/2020, 03:24

... Reporting and commenting help create and maintain public awareness Professional investigative reporting goes a step further, in producing in-depth analysis of cases The exposure of cases, in many occasions, ... interest, not being a part of governmental institutions, without the purpose of economic profit nor the purpose of reaching political office Civil society organizations are a particular way in which ... on the original perceptions and opinions of the awareness raising phase, testing whether the original concerns where satisfies or not Although in each of the three phases access to information

Ngày tải lên: 18/10/2022, 00:15

... helps define an individual’s sense of being in a particular location Other research has focused on the attitude of “being at home” in a community; in other words, the feeling of a good fit or the ... compelling finding is that while many of the variable clusters tell different stories – that is they do not appear to contain the same information, since the clustering is generally made within a ... focus on the standardized coefficients in the analysis, since certain scaling variations exist among the variables Since the inclusion of the control variables reduces our sample, we also run the

Ngày tải lên: 30/03/2014, 16:20

... observe the factors that influence the perception and the purchasing attitude towards such products and the role of logos on the label in influencing their choices In particular, to investigate ... factors that influence the perception and the pur-chasing attitude towards PDO/PGI products, to analyse the role of labelling in influenc-ing consumers’ choices and ascertain the existence of market ... During the interviews 46% of the total sample selected the Mortadella with the PGI mark, 43% the one without the PGI mark and the remaining 11% stated no preference The Mortadella with the

Ngày tải lên: 08/04/2014, 18:33

... KOS-GFP spread in the eyes or periocular skin of scid mice during the first 6 days p.i (Fig 6A) In contrast, CyP treatment enhanced the spread of KOS-GFP into the periocular skin of scid mice on ... and/or professional APCs confer innate resistance to HSV-1 infection via the secretion of IFN-γ at early times p.i The following study was initiated to determine if NK cells provide innate resistance ... shed infectious KOS continuously dur-ing the 14-day sampldur-ing period (Fig 4A) Treatment with rabbit anti-asialo GM1 had no effect on the titers of infec-tious KOS recovered from the eyes of

Ngày tải lên: 19/06/2014, 08:20

... each pair of individuals, divided by the number of individuals in the group The clusters consisted of those individuals who, when combined together,generated the lowest squared deviation (the least ... one-half of thesubjects completed the between-subjects material first, and one-half of the subjects completedthe within-subjects material first Due to the length of the within-subjects part of the ... 40% of the labor force consists of members of dual-income households(Zedeck, 1992) Therefore, since the work/family issue is becoming increasingly importantand potentially offers recruiting advantages

Ngày tải lên: 07/07/2014, 10:38

... arthritis, another major advantage of the AIA model is that the time point of induction of arthritis is known, allowing manipulation of CD4+CD25+ Treg cell number in vivo at defined stages in the disease ... rest of the body was determined using a γ-counter Thereafter, the total radioactivity recovered per animal was calculated by adding the counts of the organs and the rest of the body (a) The proportion ... 14 days after intra-articular antigen challenge in the absence of Treg cells Compatible with these findings is that the production of cytokines in response to mBSA was greater in CD25depleted

Ngày tải lên: 09/08/2014, 06:22

... dis-tinct role in the adaptive immune response to influenza through regulation of B-cell isotype switching [95,96]. The role of TLR3 in the immune response to influ-enza has been debated in the ... including the cytoplasmic NLRs and RLRs play important roles in the induction of lung inflammation For example, the cyto-plasmic NALP3 protein, a member of the NLR family that triggers assembly of ... expres-sion in the airway lining fluid [92,93] Mice that survived beyond the acute phase of infection had large regions of lung interstitial and intra-alveolar fibrosis and ALI [93]. The role of TLRs

Ngày tải lên: 11/08/2014, 03:20

... [66] The binding of PTN with syndecan-3 induces neurite outgrowth of embryonic neurons [67] Heparitinase, which cleaves the heparin sulfate chain and disrupts the binding of PTN, inhibits PTN-induced ... through β-catenin The binding of Wnt to frizzleds inhibits the activity of glycogen synthase kinase 3β (GSK-3β) and thus stabilizes β-catenin in the cytoplasm β-catenin accumu-lates in the cytoplasm ... action inactivates RPTP β/ζ, which results in an increase of the phosphorylation of β-catenin on its tyrosine residues (Tyr-Pi) and the release of β-catenin from cadherins (B) In the absence of Wnt

Ngày tải lên: 12/08/2014, 11:22

... protein D plays an important role in delaying the appearance of pneumococci in the blood and in limiting their numbers in the bloodstream SP-D binds and agglutinates S pneumoniae in the presence of ... protein D (SP-D) as the first line of defence in natural innate immunity to microbial invasion of the respiratory tract, involved in the binding, aggrega-tion, and phagocytic uptake of invading ... pneumoniae in vitro In this study, the role of SP-D in innate immunity against S pneumoniae was investigated in vivo, by comparing the outcome of intranasal infection in surfactant protein D deficient

Ngày tải lên: 12/08/2014, 18:20

... Diagram of silastic H-shaped prosthesis inserted into the portal vein and the inferior vena cava of the in vivo rabbit modelFigure 1 Diagram of silastic H-shaped prosthesis inserted into the portal ... by relat- ing the readings to the wet weight of the liver, determined at the end of each experiment. The "buffering capacity" of the HA was expressed in % as: [Increase in HA flow ... occlusion in the dog: the effect of hepatic denervation. Pflugers Arch 1980, 386:77-83. 22. R Burton-Opitz: The vascularity of the liver:the influence of the portal blood flow upon the fllow in the

Ngày tải lên: 13/08/2014, 13:20

... [5] Insulin binds to the insulin receptor (IR) tyrosine kinase on the surface of muscle and adipose cells (Figure1) GLUT4 GLUT4 Trang 16This binding induces a conformational change in the receptor ... with cataplerosis to sustain the supply of oxaloacetate for glucose production in the liver 1.5 Role of PDC in maintaining blood glucose levels The mechanisms regulating hepatic glucose production ... off the insulin signaling cascade and prevent insulin stimulated glucose uptake, resulting in less glucose disposal and greater insulin resistance Although the current knowledge of insulin signaling

Ngày tải lên: 24/08/2014, 09:57

... by the inclusion of profilin and α-actinin The role of these proteins in promoting actin nucleation and maintaining actin treadmilling is summarised in figure 1.1c How these factors and many others ... 1986) The nucleotide status of depolymerised ADP-bound G-actin is regulated by actin monomer binding proteins Profilins are actin monomer binding proteins that bind G-actin and promote the release ... N-terminal GTPase binding domain (GBD), which interacts with a Dia-autoregulatory domain (DAD) in the C-terminus and acts to hold the DRF in an inactive conformation (Alberts, 2001) The binding of

Ngày tải lên: 22/12/2014, 18:48

... surveying the employees The target population of the study included the employees in Ho Chi Minh City currently working in the industry of retailing and financial ... in the industry of retail and financial services in Ho Chi Minh City, Vietnam Of course, the data for the study is delimited to the surveyed employees of the ... companies (44.7%); in financial services (53.4%) and in retail industry (46.6%) respectively. The findings of the study indicated that transformational leadership behaviors including intellectual

Ngày tải lên: 01/06/2015, 20:09

... University Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... and Initiatives Business accelerators and/or entrepreneurial initiatives Linking teaching and research to business opportunities Collaboration with local business and industry Small Business ... opportunities Shippensburg University Small Business Initiative in the Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Indirect Contributions...

Ngày tải lên: 21/02/2014, 01:20

... antigen in itself [7,20]. At least for these antibodies, the role of the V L domain might be to increase the affinity by supporting the V H domain. The phenomenon may also be observed in the chain ... Although the Fv was designed based on HyHEL-10, it is not clear whether or not H39 is dominantly tuning the V H ⁄ V L interaction of other Fvs, including HyHEL-10. In addition, the effect of the H39 ... clarify the effect of the interface mutations on the antigen- binding affinity. To investigate systematically this unsought relationship between the antigen-binding affinity of Fv and the V H ⁄ V L interaction...

Ngày tải lên: 07/03/2014, 12:20

... their brand attitude, may suggest an interesting implication for the new brand advertising strategy. Instead of focusing on the content of the message which only emphasizes the benefits of ... gift giving is instrumental in maintaining social ties and serves as a mean of symbolic communication in social relationship. Most of the researches before and after the appearance of Sherry’s ... described in details the stages of the whole gift- exchange processes, researchers have examined the influence of many variables within these stages. This model divides gifting activities into...

Ngày tải lên: 14/03/2014, 14:20

... school. Conley (2001) finds that a doubling of net worth results in an 8.3% increase in the probability of attending college. Further, when net worth is included in the model, Black youth are ... youth. Youth savings. Youth were asked in 2002 whether they had a savings or bank account in their name. If they had an account, they were also asked whether they were saving some of this money ... ―very concerned‖ about the cost of college, compared to 19% of high-income parents. Further, they find that 71% of low-income youth say they are very concerned about the cost of college (ACSFA,...

Ngày tải lên: 15/03/2014, 10:20