the obvious and the novel

... search continues for novel therapeutic strategies and drugs to treat and to overall improve the quality of life of CRC patients Recently novel targeted therapy against angiogenesis and epidermal growth ... THE NOVEL CANDIDATE TUMOR SUPPRESOR GENE DLEC1 IN THE HCT116 COLORECTAL CANCER CELL LINE YUN TONG (B.Sc (Hons), NUS) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE Trang 2First and ... progression and cell proliferation, and identify the relevant mechanisms involved Trang 274 MATERIALS AND METHODS 4.1 Cells lines and cell culture The HCT116 (human colorectal tumor) and HT29...

Ngày tải lên: 16/10/2015, 15:37

... dialogues of the novel Gone with the wind (English version) and the translation Cuon theo chieu gio (Vietnamese version), and the similarities and differences in the use of personal pronoun and nouns ... understanding of the functions, semantics, pragmatics and culture of each terms (whether to use personal pronoun or noun to address) Therefore, “Address terms in the novel Gone with the wind and their ... results 5 Contribution of the thesis This is the first study about the number of address terms and their translation from English and Vietnamese and the differences in the use of address terms...

Ngày tải lên: 23/05/2016, 09:01

... sentences percentage and classified them into the standard of the levels 3.3 Summary of the chapter The research was qualitative and quantitative research The source of the data was the novel Jane Eyre ... IV: FINDINGS AND DISCUSSIONS 36 4.1 The forms of conditional sentences in the novel and its Vietnamese equivalents 37 4.1.1 The basic types of conditional sentences in the novel and its Vietnamese ... descriptive and contrastive methods through the novel “Jane Eyre” and then to provide Vietnamese learners with the deeper understanding of English conditional sentences and some ways to help them overcome...

Ngày tải lên: 24/06/2016, 21:21

... to the notion of modality and translation and some other notions related to these Modality in language is the speaker’s attitude to the proposition of the utterance, of the utterance context and ... (morphological, syntactic, textual and Trang 8stylistic) On the other hand, if something is added from translator’s own language to the original text because of the transference rather the replace, gain will ... to phrases and their meanings Therefore, to do well their good jobs, translators should be equipped with full knowledge of translation-related tasks They are the problems of loss and gain or...

Ngày tải lên: 06/12/2018, 11:23

... significance, the scope and the research questions Trang 8Chapter 2: The literature review, presents the previous study related to the thesis and the theoretical background of the study which ... and Their Functions in the Novel “Sense and Sensibility” By Jane Austen and Its Vietnamese Version” as the topic of my M.A thesis It should be studied in extensive depth with the hope that the ... importance to the study 2.1 LITERATURE REVIEW The theories are obtained from the linguists of functional grammar There are numerous theories used, as the grand theories are from Halliday and Matthiessen...

Ngày tải lên: 24/12/2018, 13:16

... to the notion of modality and translation and some other notions related to these Modality in language is the speaker’s attitude to the proposition of the utterance, of the utterance context and ... (morphological, syntactic, textual and Trang 8stylistic) On the other hand, if something is added from translator’s own language to the original text because of the transference rather the replace, gain will ... to phrases and their meanings Therefore, to do well their good jobs, translators should be equipped with full knowledge of translation-related tasks They are the problems of loss and gain or...

Ngày tải lên: 24/12/2018, 13:17

... novel “Vanity Fair” by W.M Thackeray, and above 70 examples from other books, novels and dictionaries… and just briefs the similarities and differences between them To serve the purpose of the ... interpret and express the idea with the verb get and also, the confusion in the choice of words and their meaning is difficult task for Vietnamese learners of English Awareness of the meanings of these ... English have a better understanding of the verb get and then use them in daily communication effective 1.5 Significance of the Study Theoretical significance Theoretically, the study will provide...

Ngày tải lên: 17/09/2019, 23:22

... novel “Vanity Fair” by W.M Thackeray, and above 70 examples from other books, novels and dictionaries… and just briefs the similarities and differences between them To serve the purpose of the ... interpret and express the idea with the verb get and also, the confusion in the choice of words and their meaning is difficult task for Vietnamese learners of English Awareness of the meanings of these ... English have a better understanding of the verb get and then use them in daily communication effective 1.5 Significance of the Study Theoretical significance Theoretically, the study will provide...

Ngày tải lên: 27/10/2019, 20:45

... clause to create the message together Theme is put at first in the clause The theme is an element which functions as the departure point of the message The rest of clause, in which the theme is developed, ... Rheme Therefore, the structure of clause as message consists of two parts: theme, which is always put at first in the clause, and Rheme – the remainder which together with the theme produce the ... James The novel reached No 2 on the USA Today best seller list and is considered by The Guardian to be No 11 on the Top 100 Bestselling Books of All Time in the United Kingdom 1.2 AIMS AND OBJECTIVES...

Ngày tải lên: 14/02/2020, 09:27

... trying to understand the cultural terms The translator needs to apply the rule of the target language, and then the target readers will understand the translation result, while the translator is ... translator to another Kelly (2005) states translation as the skill of understanding the source text and rendering it in the target language by using the register, the background knowledge, and other language ... the lexicon, grammatical structure and communication situation are studied during the translation and their meaning is defined, and then reconstructing the same meaning by using the lexicon and...

Ngày tải lên: 16/02/2020, 14:47

...   An artist and a bachelor: Henry James, mastery, and the Gender, genre, and the airplane of first-person narration  ‘‘The Lesson of the Master’’ and other vicissitudes of the literary life ... melancholy of bachelors: melancholy,The bachelor narrator and the ‘‘good uncle’’: Chance and Lord Jim  The pendulum of the other man: The Good Soldier and The Great Gatsby  Trang 9This book, ... Roland Barthes – both an imaginary subject or character and a narrative device or trope⁴ – butthis peculiar bridging of the thematic and the formal has virtually  Bachelors, manhood, and the novel...

Ngày tải lên: 30/03/2020, 19:22

... 120 h, 168 h and 216 h The results revealed that the activities of the cells treated with NaCl decreased significantly at 24 h and 120 h, and the activities reached to 30 % and 5 % of the control, ... identified on the basis of their UV and MS data, and 13 of them were unambiguously identi-fied by comparing their retention time (Rt) on HPLC chromatogram, UV and MS data with those of authentic compounds ... and suspension cells would be useful for further research on the biological functions of 2-(2-phenylethyl)chromones in stress responses and the mechanism of agarwood formation On the other hand,...

Ngày tải lên: 22/05/2020, 04:28

... Table 3, all the synthesized compounds were tested for their cytotoxicity on three tumor cell lines (HepG2, HT-29, and Hela) and three non-tumor cell lines (MDCK HY926 and H9C2) using the standard ... the first hour, intermittently observed in the next 4 h, and thereafter over a period of 24 h Observations of the signs for toxicity and deaths were last for 14  days The mortality response and ... and YZ analysed data; PW, WG and MY wrote the paper HL was the principle investigator of the project and provided the research funding All authors read and approved the final manuscript. Author...

Ngày tải lên: 29/05/2020, 14:37

... Travel in Egypt, Arabia Petraea, and the Holy Land, on the other hand, was published Clearly, the Harpers placed great hope in Stephens.12 The ®rm's decision to publish and to promote Stephens's work ... a source, Poe revised and adapted the passage to make it a microcosm of the American journey to the West Coming from the East, the The novel 71 buffalo attempt to cross the river, but, unable ... compares the sound of the maelstro m with that of the buffalo moaning, and the story ends with the setting moon, an analogue for the setting sun The old Norwegian guide who survives his brothers...

Ngày tải lên: 01/11/2013, 09:20

... allusions with her political theme The most obvious of these is the dynamic of the thriller, which leaves Grace’s fate unclear until the The State and the Novel 35 final page The other is an extended allusion ... anglophobe’, The State and the Novel 15 who feels the British, lacking ‘literature, culture, language and manners’, flatter themselves as the liberators of the French (it is the French and the Americans ... of the novel, and the uncertainty about character and motivation that accompanies it But since that sense of limitation and uncertainty stems from the state of the nation the novel discovers, then...

Ngày tải lên: 01/11/2013, 10:20

... further evidence that the functions of Vrp1p in endocytosis, cytokinesis, and growth at elevated temperature, on the one hand, and in cortical actin-patch polarization, on the other hand, are at least ... in G buffer The beads were washed extensively and the bound proteins were eluted The eluted proteins were resolved by SDS ⁄ PAGE and the proteins were transferred to a PVDF membrane and immunoblotted ... coli, the encoded proteins were expressed and affinity purified, and beads bearing the purified proteins were incubated with crude yeast cell lysate The beads were washed extensively and the bound...

Ngày tải lên: 18/02/2014, 16:20

... removal of the CUB domains and thereby activation of the growth factor domains PDGF-C and -D contain both the CUB and growth factor domains when they are secreted and proteolytic cleavage is therefore ... of the proposed PDGF-C model [57] displaying the twisted b-sheets and the N-terminal a-helix of the PDGF-C monomer (A) and the PDGF-CC dimer (B) The N-terminal (N) and C-terminal (C) ends for the ... the cytoplasm and nucleus, a feature also described for PDGF-B [31,32] The function of these two PDGFs in the nucleus is unclear The region N-terminal of the CUB domain in PDGF-C and PDGF-D The...

Ngày tải lên: 19/02/2014, 07:20

... corresponding to the immunoreactivity of ERK1/2 and phospho ERK1/2 (A,B), and MEK1/2 and phospho MEK1/2 (C,D) The lower part of each panel reports the quantitative analysis of phospho ERK1/2 (A,B), and phospho ... to be elucidated and are the subject for future investigations Nevertheless, the cellular targets and signaling mechanisms uncovered in the present study are associated with the modulation of ... GPCR- and receptor tyrosine kinase (RTK)-mediated signaling and that the activation of ERK by GPCRs closely parallels that employed by RTK [33] On the whole, these observations suggest that the...

Ngày tải lên: 21/02/2014, 01:21

... individual diagnosis and therapy, and an understanding of the structure of these allergens is essential to the improvement of diagnosis and the design of adequate therapeutic treatment We previously ... to the N-terminal portion of the allergen Based on this partial sequence, two specific primers were designed and used together with the anchor primer AP2 to obtain the 5¢ and 3¢ portions of the ... sequence and sequence alignment of Cyn d 24 (A) Nucleotide and deduced amino acid sequences of Cyn d 24 The numbers on the right of the figure indicate the positions of the nucleotide sequence The...

Ngày tải lên: 07/03/2014, 12:20

... unique features such as the organization of disulfide bonds at their N- and C-termini, with the cysteine residues following a class-specific topology, and on the basis of their genomic organization, ... cells [50] The interplay between decorin and the EGFR is further underscored by osteosarcoma cells which escape the decorin-suppressing activity via protracted expression and activation of their endogenous ... tubular epithelial cells [57] In addition, decorin binds to and sequesters the IGF-I (KD  18 nm), the natural ligand of this RTK [55] By binding to the IGF-IR, decorin triggers phosphorylation and...

Ngày tải lên: 15/03/2014, 23:20