the minimally conscious state clinical features pathophysiology and therapeutic implications

... improved by the development of effective chemotherapy in the 1970s and subsequently improved by the development of hematopoietic stem cell transplantation therapy in the 1980s However, the clinical ... associated with the plasma membrane [10,12] After the cloning of the Flt3 gene, soluble mouse Flt3 was used to clone the gene encoding the mouse Flt3 ligand (FL) [13] The mouse FL cDNA was then used ... blood and bone marrow) and the prostate, ovary, kidney, lung, colon, small intestine, testis, heart and placenta, with the highest level of expression in peripheral blood mononuclear cells [11] The...

Ngày tải lên: 10/08/2014, 21:23

... http://www.implementationscience.com/content/6/1/69 candidate theories (i.e., middle-range or ‘educated guess’ theories) These candidate theories will be continuously tested and appended as they evolve (or new theories emerge) and will ... RTA and LOA synthesis methods will thus enable the organisation of guideline attributes and their trade-offs and interpret them according to how their relationships can be mapped to reveal the implications ... two events (X and Y), one needs to understand the underlying mechanism (M) that connects them and the context (C) in which the relationship occurs’ [25] Its primary focus is to test the causal mechanisms...

Ngày tải lên: 10/08/2014, 11:20

... invasion and address its therapeutic implications Early events in oncogenesis Mutations In the last 20 years somatic mutations have been identified and associated with the development of cancer These ... are seen in the transition from normal to intraepithelial cancer to invasive disease The understanding of the timing of instability during progression, the rate of instability and the mechanisms ... reagents and data interpretation need to be developed and standardized A comprehensive and integrated approach linking laboratory findings of IEN of the lung with clinical features holds the potential...

Ngày tải lên: 12/08/2014, 18:21

... epiregulin ADAM10, on the other hand, appears to be the major sheddase for the release of EGF and betacellulin [35,36] In certain situations however, other ADAMs including ADAM8, 9, 12, 17 and 19 can activate ... Conversion of these ligands to their active state is primarily mediated by either ADAM10 or ADAM17 Thus, ADAM17 appears to be the physiological sheddase for TGF-alpha, amphiregulin, HB-EGF, and epiregulin ... Shedding of other adhesion proteins such as L-selectin, ICAM-1 or VCAM, on the other hand, might be expected to modulate binding of tumour cells to the vasculature wall and thus play a role in the intravasation...

Ngày tải lên: 13/08/2014, 13:20

... overview of the study This part is devoted to presenting the methodology of the research, including the data collection instruments and procedure and data analysis The subjects of the study The six ... particular, the author search for every lexical item related to the examined device in all the texts, then calculate them and sum up Step 2: the absolute count of each category is then converted to the ... create coherence and thus comprehensibility of the text In other words, the more related lexical items are used the more cohesiveness of the text they create Pedagogical implications The above concluding...

Ngày tải lên: 10/08/2015, 19:47

... cytokines and adhesion molecules are involved During the early phase, specific adhesion molecules are expressed ex novo or upregulated on the surface of the endothelium (selectins) and the epithelium ... the quality of life, and certain therapeutic approaches The strength of the considerations mentioned prompted the World Health Organization to publish an extensive position paper devoted to the ... relationship between rhinitis and asthma and its therapeutic implications [27], highlighting the concept of ‘one airway one disease’ The link between upper respiratory disease and asthma is also evident...

Ngày tải lên: 12/08/2014, 18:20

... 2003 and April 2004 were enrolled into the study All patients were admitted to the study only once over the enrolment period The subjects were evaluated at admission, and then daily for the first ... admission patients and their aggressive behaviour, which have recently been the object of a specific publication [4] The present paper focuses mainly on the management of SPDC patients and their attitudes ... at assessing the sociodemographic and clinical characteristics of patients, their pathways to psychiatric admission, and describing their behaviour, subjective wellbeing, management and attitude...

Ngày tải lên: 08/08/2014, 23:20

... drug chemotherapy Among them, 28 patients received post-operative combined chemotherapy and thoracic radiotherapy and 22 patients had chemotherapy alone Immunohistochemistry (IHC) The paraffin ... to radiotherapy, which agreed with the finding from head and neck study that EGFR expression was correlated with Table COX-2 expression and correlation with clinical features Clinical features ... activation and subsequent COX-2 upregulation EGFR activation could induce COX-2 expression via the ras/raf MAPK pathway [3] On the other hand, COX-2 could induce the activation and expression of EGFR The...

Ngày tải lên: 10/08/2014, 10:21

... Table (corrected table six) COX-2 expression and correlation with clinical features EGFR Positive expression rate P value Clinical features 0.448 Clinical features Ages negative positive < 60 18 14 ... Shen Yali, Xu Feng, Wang Jin: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features Journal of Experimental & Clinical Cancer Research 2011, 30:27 ... as: Li et al.: Correction: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features Journal of Experimental & Clinical Cancer Research 2011 30:32...

Ngày tải lên: 10/08/2014, 10:21

... cerebral veins and sinous The veins of the brain have no muscular tissue in their thin walls and possess no valves as compared to other types of veins They emerge from the brain and lie in the subarachnoid ... space They pierce the arachnoid mater and the meningeal layer of the dura and drain into the cranial venous sinuses Blood from both brain is drained by cerebral veins into dural sinuses and then ... of stroke However, there are few studies on CVT, therefore we decided to study CVT with the following objectives: OBJECTIVES OF THE STUDY To describe some clinical features and brain images of...

Ngày tải lên: 21/10/2014, 21:52

... transaction to the acquire and is reimbursed the amount of the sales ticket by the acquirer (4) - The acquirer then summits the ticket to the issuer for payment, via the ICO interchange and settlement ... maintaining the flow of funds and information between issuing and acquiring members The exchange of financial information is called clearing The exchange of the actual funds for the transaction and the ... meets the qualification standards of an ICO and an acquirer 7 The ICO usually require that the merchant be financially responsible and good repute The merchant has a written agreement with the...

Ngày tải lên: 03/04/2013, 12:13

... laundering and corruption threaten the credibility and effectiveness of international financial institution (IFI) programs and the integrity of the IFIs themselves Thus, we urge the IMF and the World ... system If there is obscurity about their ownership, banks and other financial institutions may not be able to discover the identity of the beneficiary of the account and will be unable to meet their ... their financial procedures and controls and those of recipients, and to improve ways to strengthen safeguards on the use of their funds as well as governance and anti-corruption measures in their...

Ngày tải lên: 17/02/2014, 21:20

... both the acetylation state of the promoter region of the active b-globin gene [19] and the DNase I general sensitivity in the b-globin locus are the same as the wild type control [17] Thus, there ... regions, and each of these regions was deleted in DT40 cells The roles of the DHSs on Ig-b gene expression and the maintenance of active chromatin state in the Ig-b locus were examined in the deletion ... Size of the bands observed in each autoradiogram is indicated at the right side The 6.6 kb band detected in lanes b, c, and d in autoradiogram (B), and lanes c and d in (C) is derived from the extra...

Ngày tải lên: 19/02/2014, 16:20

... standing Task Force/Committees and approved by Executive and/ or Council These evidence-based guidelines reflect emerging clinical and scientific advances in the specific clinical discipline and ... annually among the Caucasians in the United States Among African Americans, the incidence appears to be similar or higher, but among the Asian and native-Americans, the incidence is lower In the Far ... helps the practicing oncologists and hematologists in handling those effective agents to minimize the risk of the VTE associated with the use of those agents Dr Agutter and Dr Malone from Theoretical...

Ngày tải lên: 19/02/2014, 23:20

... events in the coming years The present report is expected to increase the awareness amongst the practitioners regarding the clinical presentation and benign and self-limiting nature of the presented ... children [7,9] during the outbreak, there were two adults affected with the disease during the outbreak The disease in these two adults was similar to the affected children There was no statistically ... KAR, et al HAND, FOOT AND MOUTH DISEASE ABSTRACT Objective: To describe the epidemiology and clinical features of cases in a outbreak of Hand, Foot and Mouth Disease (HFMD) Design:...

Ngày tải lên: 05/03/2014, 12:20

... was restated in the Queen’s Speech and the Budget The Budget also set out the first steps in trying to achieve these aims However, the Government wants to go further to improve incentives and reduce ... and then to remain in work and increase their earnings Getting the balance between these two elements will be crucially important We also want to remove the fear that the system will punish them ... outweigh the risks; •  urther incentivise and encourage households and families to move into f work and to increase the amount of work they do, by improving the rewards from work at low earnings, and...

Ngày tải lên: 06/03/2014, 08:20

... compared to 22 700 in 2000 The respective numbers for the MRR scenario and the TSAP are approximately 15 300 and 16 900 (IIASA, 2010) The objectives of the TSAP states that the number of years of ... quality regulations and establishing ambient air quality standards Thematic assessment | Air pollution Box 1.1 The main air pollutants and their effects on human health and the environment Nitrogen ... Northern Europe: Denmark, Estonia, Finland, Iceland, Latvia, Lithuania, Norway, Sweden; North-western Europe: Belgium, France (north of 45 ° latitude), Ireland, Luxembourg, the Netherlands, the...

Ngày tải lên: 06/03/2014, 16:20

... air quality in downwind states and helps them attain and maintain the 24-hour PM2.5 air quality standards established in 2006 and the 1997 annual PM2.5 standards  Twenty states are required to ... states and helps them attain and maintain the 1997 8-hour ozone standard Additionally, EPA is issuing a proposed rule requesting comment on inclusion of the following six states in the Cross -State ... the end of this fact sheet identifies the states covered by the final rule and the emissions they will need to control, including the six states proposed in the supplemental notice of proposed...

Ngày tải lên: 06/03/2014, 19:20

... catalase T and catalase A, did not alter the growth, either after the single treatments or after the associations of both treatments (Fig 1) On the other hand, the deficiency of sulfiredoxin, a low ... suggest that other enzymes whose genes are regulated by these factors could also be involved in the antioxidant defense of respiratory-incompetent cells On the other hand, Msn2 and Msn4 appear ... Perhaps the decreased levels of these enzymes, and other yet not detected, could be responsible for the reduced viability of tsa1D cells grown in the presence of H2O2 plus antimycin A (Fig 1) The...

Ngày tải lên: 16/03/2014, 14:20