the interplay between signaling pathways and transcription regulation

... coupled with the extrusion of H+from the mitochondrial matrix to the inner-membrane space, thus generating the proton motive force, which is used to drive the synthesis of ATP and other energy-requiring ... Proton motive force and the mitochondrial membrane potential (ΔΨm) are then tightly related, so that ΔΨmrepresents a good indicator of the energy status of the mitochondrion and of the cellular homeostasis ... of the recognition of itsanchor protein Fis1 There, SNO-Drp1 multimerizes and acts to tighten the target organelle in order to share the depolarized portion fromthe healthy part Although there

Ngày tải lên: 02/11/2022, 09:25

... that the first display contains 12 of these stimuli, and the second display another 12 One position in the grid is thereby left empty, for the observer to find Trying to mentally compare the two ... on each of the two successive stimulus displays, 12 squares appeared in the one color, with the squares in the other display having the second color The order of these colors was randomly drawn, ... bottom plot): The activity peaks are closer together, the interval in-between during which nei-ther stimulus is above threshold is shorter, and nei-there is more overlap between the activity distributions

Ngày tải lên: 24/11/2022, 17:47

... mathematical models for the Notch signalling pathway alone, the Wnt signalling pathway alone, and the interactions between them These models can simulate the dynamics of the Notch and Wnt pathways in somitogenesis, ... of the Notch and Wnt path-ways and their crosstalk in somitogenesis In this study, we have proposed three more complicated mathematical models for the Notch and Wnt signaling pathways and their ... for the Notch signaling model and their biological explanations are given in Additional file 1 Here we assumed the Dll1 ligand and the Notch receptor are synthesized at a constant rate and the

Ngày tải lên: 02/11/2022, 14:31

... detected in the gel prote-of theheart, liver, adipose tissue, kidney, and brain All spots weredistributed in the region of pI 4–9 and had relative molecularweights (MW) between 15 and 200 KDa The protein ... camel and control gels were then excised from the gel andincubated with trypsin to digest the proteins in the gel, whichwere then analyzed by MALDI-time of flight (TOF) MS/MS Camel heart proteomeThe ... between different organs in the ca-mel and the rat are examined by two-dimensional (2D) mass spectrometry (MS/MS)-enabled 2D electrophoresis This study affords a better understanding of the interplay

Ngày tải lên: 14/01/2020, 14:31

... mind that the opinions expressed and any recommendations made are those of the individual speakers themselves and do not represent the position of the Academies Indeed, the purpose of the Roundtable ... showing various pathways inside and outside the body related to obesity At the center of the illustration were the critical interactions between energy intake and energy expenditure, the Trang 238 ... increased weight in the subjects because the focus was on the decreases in weight and the general toxicity caused by high doses of the substances Then, over the next few years there were several

Ngày tải lên: 14/09/2020, 17:11

... LD and AV conceived and performed the experiments, analysed the data and wrote the paper AG and HV designed the experiments, analysed the data and wrote/edited the paper AV and LL carried out the ... revealed that the UPR, in turn, regulates the expression of PlGF in HCC cells Thus, our study sheds light on the reciprocal interac-tions between PlGF, hypoxia and the UPR and suggests that the antitumour ... attenuates the carcinogen-induced up-regulation of chaperones, such as Grp78 and Grp94, and Trang 6the activation of the Perk pathway without affecting Ire1activation These chaperones and Perk

Ngày tải lên: 21/09/2020, 10:13

... The mediating roles of CSR and ORC in the relationship between GHRM and CSPThis study highlights the importance of examining the relationship between Green Human Resource Management (GHRM) and ... both their internal community—employees—and their external stakeholders, including suppliers and customers (Samad et al., 2021) Thus, the hypothesis is established based on these insights. Hypothese ... relationship between GHRM and CSP, leading to the acceptance of hypothesis H1 Furthermore, CSP is positively associated with CSP ENP, CSP ECP, and CSP SCP, validating hypotheses H5a, H5b, and H5c

Ngày tải lên: 08/03/2025, 06:14

... dimension represents the extension of the built-up areas i.e the land covered by buildings and other man-made structures and activities”, Factor scores mapping The maps are provided in the Appendix ... on the “non-farm income” component On the other hand, the fact that these inhabitants are temporary living away from their village could explain the above average waste quantity generated in the ... perceiving the relationship (if any) between each extracted component and the waste production in the Duy Tien district The maps are presented in the Appendix A “Non-farming income” There are

Ngày tải lên: 13/02/2014, 12:20

... countries at the time of the Asian crisis (1997), the Russiandefault (1998) and a couple of periods of …nancial turmoil in Brazil (1999 and about the link between exchange rates and interest ... and knowl-edge of the structure of the model, they are in a position to deduce the sources of the shocks that hit the economy A state-contingent reaction function isthen feasible Using (1), the ... rateappreciation The interest rate hike puts a limit to the increase in aggregatedemand, while also being instrumental to the strengthening of the exchangerate via the UIP schedule The latter strengthening

Ngày tải lên: 22/03/2014, 23:20

... four of the questions were the same for guests and employees If employees believe they care about the guest’s stay, then the guest feels the same The interrelationship of service quality and customer ... could enhance the ‘organization’s ability to assess the individual and the potential employee's ability to determine whether the job fit their expectations The use of a RJPE would put the applicant ... that further study of land based hospitality organizations was needed to gain a better understanding of the relationship between the employee and the customer In 1985, Parasuraman, Zeithaml, and

Ngày tải lên: 23/03/2014, 05:23

... involves the study of the interactions between the components of a biological system, and how these interactions give rise to the function and behaviour of that system (for example, the enzymes and ... good estimate to the real fluxes through the system as predicted by Teusink et al The discrepancy between the real and FBA solu-tion is due to FBA disregarding the branches of the pathway not involved ... concentration, the two versions of linlog approximation are indistinguishable For many of the remaining metabolites, there is a good agreement between the real and estimated model steady states, despite the

Ngày tải lên: 23/03/2014, 07:20

... (TGF)-b, Hedgehog, and Janus-acti-vated kinase (JAK)⁄ signal transducer and activator of transcription (STAT) signaling pathways Moreover, these signaling pathways play a central role in the embryonic ... Taken together, these data demonstrate the pres-ence and function of the PtdIns3K⁄ Akt pathway in mammalian preimplantation embryos These results further our knowledge of the PtdIns3K⁄ Akt signaling ... than on the ventral side, during the early cleavage stages By the 16- and 32-cell stages, b-catenin accumulates in the dorsal but not the ventral nuclei when zygotic transcription begins The pattern

Ngày tải lên: 30/03/2014, 03:20

... fur-ther the specificity of the interaction, native cardosin B was used in the binding assays Despite the high simi-larity between the two pistil aspartic proteinases, nei-ther the RGD nor the ... the RGD-mediated interaction between integrins and their ligands for the activation of essential signalling pathways in cell proliferation and growth has been well studied [11] In contrast, the ... between the C2 domain and the double mutated (AGD⁄ AGE) cardosin A The docking model shown in Fig 9 further highlights the role of RGD and KGE in complex formation Moreover, it appears that the

Ngày tải lên: 30/03/2014, 11:20

... burnout, and workplace aggression Trang 5O Besides, Saari and Judge (2004) cited the results of some studies from Hackett and Guion (1985), Hulin, Roznowski, and Hachiya (1985) and Kohler and Mathieu ... outcomes of the work and Knowledge of the Actual Results of the Work Activities (cited in Thakor and Joshi, 2005; Rungtusanatham and Anderson, 1996) O Furthermore, the three critical psychological ... Rungtusanatham and Anderson, Trang 162.Literature ReviewsResearch Framework Trang 172.Literature Reviews2.5 Job Satisfaction and Job Performance The study of the relationship between job satisfaction and

Ngày tải lên: 18/04/2014, 16:24

... levels and sources for elderly people(aged 60 and over) and for the non-elderly and compares these to the Vietnamese average The officialincome definition developed by GSO is used.On average, the ... rise to their entitlement to a pension However, both these and other elders continueto work Figures 3 and 4 show economic activity rates for men age 60 and over and for women aged 55 andover, ... abandon work altogether Figures, 5 and 6 show theweekly hours of work for men and women and additionally shows the hours of housework undertakenalongside economic activity ("work") The

Ngày tải lên: 27/05/2014, 07:47

... controlled by signaling pathways, some of the pathways are inside-out signals that might occur through regulation of the interaction of the cell with the extracellular matrix and through the response ... throughout the body of the cell, and the substrate at the basal surface of the ECs Interestingly, forces acting at one surface may be propagated internally or even to other surfaces of the cell, or they ... blood flow and effects from other neighboring cells and matrix The biophysical aspects of the endothelium through which the leukocytes transmigrate, in addition to the biophysical aspects of the leukocytes...

Ngày tải lên: 22/03/2014, 21:20

... binding GST-IjBa in the presence and absence of ATP, and the value of a indicates whether the binding of one substrate (ATP) affects the afnity of the enzyme for the other substrate (GST-IjBa) [59] ... cells in terms of the peak periods and frequency This clearly demonstrated that these cells have the ability to synchronize their oscillations with each other The study of signaling pathway dynamics ... monolaurate)] was dispensed into the wells and the plates left to incubate for 15 The plates were inverted to remove the detergent after the 15 incubation period and the wells were washed twice with...

Ngày tải lên: 16/03/2014, 11:20

... regulates Pn(σ) The length of the common border between σ and ρ is lρ, σ, which is the count of all 8-connected lattice sites between and ρ, and σ, g(x) = , f (x) = x and n(σ) returns the set of cells ... point (the centroid of the cell's lattice sites) of each primary cell Let D be the set of distances between the center of each Voronoi cell and its vertices, then the VRI is the ratio of the mean ... acquire new signaling properties and in so doing influence the final form the pattern will take The process is both iterative and dynamic In this work, we explore how the interplay between three...

Ngày tải lên: 13/08/2014, 16:21

... some other receptor proteins have been involved in the signaling pathways mediated by semaphorins, like c-Met and Ron, 11 ErbB2, integrins, and L1 The characteristics and functions of these receptors ... domain and three PSI domains at the N-terminus of their extracellular domain At the C-terminus of PSI domains, there are three IPT (Ig-like, plexins and transcription factors) domains in their ... activates receptor signaling (Takahashi and Strittmatter, 2001) The Sema domain prevents plexin-A1 activation in the basal state Both the Sema portion and the remainder of the extracellular domain...

Ngày tải lên: 11/09/2015, 09:11

... slow the economy Therefore, we may conjecture that the relationship between default risk and interest rates is sensitive to some measure of where the economy is in the business cycle and/ or other ... over the change in the 10-year Treasury bond yield, the change in slope (defined as the difference between 10-year and 2-year Treasury bond yields), the convexity, the change in leverage, the ... BBB and maturities ranging from intermediate to long-term They find the relation between credit spreads and interest rates (level and slope) differ based on the maturity, credit ratings, and the...

Ngày tải lên: 26/10/2012, 11:21