... Please refer to the chart at the end of the lab to correctly identify the interface identifiers to be used based on the equipment in the lab The configuration output used in this lab is produced ... order to reduce the cost of the dialup connection To configure a static route, the network address of the network that is going to be reached must be known The IP address of the next router on the ... ‘interesting’ to cause the DDR interface to dialup the remote router For the moment, declare that all IP traffic is interesting using the dialer-list command Moscow(config)#dialer-list protocol ip...
Ngày tải lên: 21/12/2013, 19:15
... signal to move into the nucleus either on its own or with the help of an adaptor protein that facilitates entry into or retention in the nucleus – it is possible that the adaptor protein is more ... form a complex with the nuclear adaptor Fe65 and the histone acetyltransferase Tip60 in order to target to the nucleus [61,62] Other ICDs function exclusively in the cytoplasm The adhesion protein ... staining in the nucleus: (a) the PEST domain adjacent to the RING domain is likely to ensure that the cytoplasmic tail, and thus the RNF13 E3 activity, has a short half-life that is tightly regulated...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension pdf
... embedded into the lipid bilayer via GPI, which helps anchor TNSALP to the plasma membrane, but is secreted out of the cell To investigate whether this mutant protein is secreted, we labeled the transfected ... (1559delT) is synthesized as a secretory form lacking glycosylphosphatidylinositol (GPI), most of newly synthesized molecules form the aggregate and fail to exit from the ER Furthermore, the accumulated ... in the medium (Fig 4B, lane 4), suggesting that the 80 kDa form was processed to the 90 kDa form in the Golgi apparatus before being released into the medium In support of this, this secretory...
Ngày tải lên: 19/02/2014, 17:20
The nobel prize in physiology or medicine 2010 is awarded to
... điều này, ông hợp tác với bác sĩ Patrick Steptoe bệnh viện Oldham Steptoe người tiên phong lĩnh vực nội soi, ý tưởng cho mục đích R.E Patrick Steptoe bác sĩ hợp tác với R.E để phát triển thí ... Steptoe Giám đốc Y khoa Bourn trường Clinic ông qua đời vào năm 1988, Robert Edwards giám đốc nghiên cứu ông nghỉ hưu IVF cải thiện lan rộng to n giới Các kỹ thuật thụ tinh ống nghiệm thành lập to n ... K Hansson, Medicine, Secretary of the Nobel Assembly; Outi Hovatta, Obstetrics and Gynaecology; Christer Höög, Genetics; Klas Kärre, Immunology, Chairman of the Nobel Committee; Hugo Lagercrantz,...
Ngày tải lên: 23/02/2014, 20:45
Báo cáo khoa học: Structure of Streptococcus agalactiae serine⁄threonine phosphatase The subdomain conformation is coupled to the binding of a third metal ion pptx
... structure The phosphate is bound indirectly to the metal ions via water molecules and the Wn–P–O angle (146°) is reasonably close to optimal when the roughness of the analysis is taken into account ... stalled at R-factors of 26 and 30% This may be due to real disorder in the crystal as the mean B-factor from the refinement was rather high ˚ ˚ (78.5 A2) – as was the Wilson B-factor (77 A2) It ... to the mechanism of the enzyme (see Discussion) 3132 Discussion Overall structure The structure of SaSTP is very similar to that of ˚ MtSTP, with an rmsd ⁄ Ca of 1.8 A overall (Table 1) All the...
Ngày tải lên: 07/03/2014, 09:20
Báo cáo khoa học: A region within the C-terminal domain of Ure2p is shown to interact with the molecular chaperone Ssa1p by the use of cross-linkers and mass spectrometry doc
... peptides The list of light and heavy precursor masses was further used either to analyze the MS ⁄ MS spectra acquired in the data-dependent acquisition analysis or to build an inclusion list with the ... within the same area in the 3D structure of Ure2p Thus, the binding of Ssa1p to the region centered on lysine 339 could abolish the acquisition by Ure2p of an assembly competent state The results ... in the interaction with Ssa1p is shown in (D) Lysine 339 is shown in orange; the region of Ure2p whereby exposure to the solvent was shown to change upon assembly into fibrils by HXMS [33] is...
Ngày tải lên: 15/03/2014, 00:20
Economic Effects of Reducing the Fiscal Restraint That Is Scheduled to Occur in 2013 docx
... at the That estimate is smaller than the change in the automatic stabilizers from 2012 to 2013 that is presented in Table C-2 of The Budget and Economic Outlook: Fiscal Years 2012 to 2022 The ... reducing the fiscal restraint scheduled to occur next year would boost the economy in the short run, doing so would reduce output and income in the longer run relative to what would otherwise occur The ... REDUCING THE FISCAL RESTRAINT THAT IS SCHEDULED TO OCCUR IN 2013 Growing debt would increase the likelihood of a sudden fiscal crisis, during which investors would lose confidence in the government’s...
Ngày tải lên: 15/03/2014, 20:20
Báo cáo khoa học: MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane ppt
... retinal pigment epithelium faces the subretinal space The inner and outer segments adjacent to the OLM are the most apical side of photoreceptors and extend into the subretinal space The OLM contains ... opening up the structure of the molecules and allowing their intermolecular binding This mediator might be missing in the retina or is competed out by another protein that does not facilitate the binding ... functional complexes at the photoreceptor synapse It remains to be shown MPP3 is recruited to the MPP5 protein scaffold whether these complexes are redundant or have unique functions In the OPL, MPP3 partially...
Ngày tải lên: 16/03/2014, 13:20
how the use of the diary form narrative is beneficial to the
... one person was telling the whole story, the reader would see and hear what the person telling the story heard and wrote down So using, the diary, Bram Stoker could make the reader "see" exactly ... when the diary form of narrative is used For instance, after Lucy had written what was happening to her when her mother passed away, the story went back in time for another important matter to ... as a whole and the reader can feel as if they are part of the group and read, and think along with the characters Another thing dealing with the diary form is quick referencing The reader, if...
Ngày tải lên: 21/03/2014, 22:04
Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx
... in the presence of mM EGTA to increase pH to a value of 6.25 (A) Log of fluorescence intensities corresponding to tryptophan emission (j) or Oregon green emission (h) is plotted vs pH (B) The ... or by the presence of protons We have shown that the helix latch and the G2 to G4–6 interaction in general is not reduced by low pH It is possible therefore that in pH-activated gelsolin, the helical ... wavelength of tryptophan fluorescence emission is plotted vs pH Kd is less for the last condition (Kd ¼ 0.025 M)1) than for the other two (Kd ¼ 0.042 M)1) or for a small tryptophan peptide (21...
Ngày tải lên: 23/03/2014, 21:20
She is going to go on business at the end of June potx
... at the end of the street (cuối đường), at the end of the book (cuối sách) Mạo từ the đứng trước từ bắt đầu nguyên âm “a, e, i, o, u”, the phát âm /ði/ - Trái nghĩa với “at the end” “at the ... chia dựa theo chủ ngữ “going to viết tắt “gonna” văn nói Nếu muốn chia dạng phủ định, ta thêm “not” vào sau động từ to be” - “She is going to – cô Trong câu chủ ngữ “she” nên động từ to be” ... biết thêm chi tiết từ đó) She is going to go on business at the end of June 2 Các bạn di chuột vào cụm từ để biết chức cụm câu: She is going to go on business at the end of June 3 Tại câu lại...
Ngày tải lên: 02/04/2014, 21:21
Báo cáo sinh học: "Bisphosphonate-associated osteonecrosis of the jaw is linked to suppressed TGFb1-signaling and increased Galectin-3 expression: A histological study on biopsies" pot
... of the manuscript, particularly the discussion section EN interpreted the data and harvested the samples KA established the immunohistochemistry, analyzed the tissue samples, interpreted the ... osteoradionecrosis-adjacent tissues (p < 0.038) compared to the periosteal fibrous tissue of the normal jaw Discussion This was the first study to address the influence of BP on key regulators of oral ... and immunohistochemical methods The observers were blinded to the tissue origin of the visual fields The qualifaction of the observers were dentist (1) and physician (2) engaged in their dental/medical...
Ngày tải lên: 18/06/2014, 19:20
Báo cáo sinh học: " Recombinant Tula hantavirus shows reduced fitness but is able to survive in the presence of a parental virus: analysis of consecutive passages in a cell culture" pot
... rodent to another If transmission is performed in a samplinglike fashion – and this seems to be the case for hantaviruses [13] – the recombinant would have fair chances to survive The existence ... [25,24] The hairpin in TULV plus-sense S RNA (Fig 3) is formed by the almost perfect inverted repeat that includes nt 344 to 374 In the minus-sense RNA, the structure is slightly weaker due to the ... reason for the observed lower fitness of the recTULV might be that it was generated in the presence of the wt variant, with which it has to compete, and thus not given enough time to to establish a...
Ngày tải lên: 18/06/2014, 22:20
Báo cáo hóa học: " Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug " pot
... contributed to the conception of the studies and the critical review of the manuscript DCQ contributed to the design of the experiments and analysis of the data KAK contributed to the acquisition ... contributed to the conception of the studies and the critical review of the manuscript PCT contributed to the design of experiments, the acquisition and analysis of data and the critical review of the ... (N)-MCT The mechanism of action of this compound is incompletely understood, although it appears to require phosphorylation by the viral TK to the monophosphate (N-MCT-MP) [12] This is significant...
Ngày tải lên: 20/06/2014, 01:20
Báo cáo hóa học: " Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection" pdf
... viral vector); (ii) whether the impairment is antigen-specific, (iii) whether a similar impairment is observed following primary versus secondary infection; (iv) whether the impairment is observed ... non-respiratory infection, and (v) whether there is a difference in the percentage of virus-specific IFNγ + CD8+ T cells in the lungs versus the spleen after respiratory and non-respiratory infections ... PCR [9] The VV-M2 virus used in the present study contains a disrupted thymidine kinase gene due to the M2 insert [10] This disruption has been shown to result in attenuation compared to its strain...
Ngày tải lên: 20/06/2014, 01:20
báo cáo hóa học:" An HIV epidemic is ready to emerge in the Philippines Review" ppt
... "knowing" their client was reason enough to not use a condom [8] Filipino women also tend to believe that the decision to use a condom is up to the man [8] Men tend to feel the need to maintain their ... 1992 to act as an advisory body to the President for the development of policy for the control of AIDS The PNAC consists of members from the government, public, civil society, private sector and ... at diagnosis is decreasing The underlying cause of these symptoms needs to be addressed in order to prevent an emergent epidemic The promotion of HIV prevention and education messages is underfunded...
Ngày tải lên: 20/06/2014, 08:20