the development of breast cancer

... the distance from the balloon to the skin surface. The greater the volume of the balloon, with the attendant compression of adjacent breast tissue, the more fully the target breast tissue will ... acteristics of both groups are shown in Table 2. The majority of patients were post-menopausal Caucasian women with no prior history of cancer and no family history of breast cancer. The study ... R, Taylor C, Wang Y, Early Breast Cancer Trialists’ Collaborative Group (EBCTCG): Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence

Ngày tải lên: 09/08/2014, 01:24

... standardise breast cancer treatment in the UK [56] The treatment of breast cancer varies depending on the characteristics of the tumour such as size and the presence of certain ... factors 27 1.1.7 Breast cancer subtypes 28 1.1.8 Tests for molecular profile of breast cancer 29 1.2 Treatment of breast cancer 31 1.2.1 Surgery 31 1.2.2 Chemotherapy 32 1.2.3 Radiotherapy 32 ... outcomes and molecular profiles. Over the past decade, through the use of molecular profiling, the number of different subtypes of breast cancer has grown and understanding the pathways driving

Ngày tải lên: 22/12/2014, 21:49

... were due to breast cancer With the increase in age, the risk for breast cancer and death rates due to it generally increases [1] The highest incidence of breast cancer was in Northern America ... position of furan for the breast cancer therapy The synthesized furan deriva-tives were determined for their anticancer potential antago-Fig 7 Docking model of compound 8 Trang 8against MCF-7/2a breast ... expressed in breast cancer sub-progression Therefore, selective ER α antagonists may be helpful for the breast cancer treatment [10] Rationale of study Currently, a number of breast cancer drugs

Ngày tải lên: 29/05/2020, 13:21

... out the pos-sibility of off-targets and indirect effects These findings Fig 7 Effect of miR-154 on susceptibility of breast cancer cells to doxorubicin The effect of doxorubicin (DOX) either ... Tehran, Iran Full list of author information is available at the end of the article Trang 2Breast cancer is known as the most frequently diagnosed and the leading cause of cancer mortality in women ... regulators of the expression of numerous genes by their deacetylase activity [7] On the other hand, NAMPT increases the activity of estrogen receptor and thus facilitates breast cancer propagation

Ngày tải lên: 17/06/2020, 18:43

... of MDSCs We first examined the L-Arg medi-ated regulation of the subsets and maturation of DCs late in breast cancer development As shown in Fig 4, there were higher percentages and numbers of ... effects in the breast cancer [38, 45, 46] Therefore, we further evaluated the role of NO in breast cancer by supplementation of an NOS inhibi-tor, aminoguanidine (AG) into the 4 T1 TB mice with ... apoptosis of cancer cells [64] In breast cancers, the percentage of Tregs, as assessed by Foxp3 positivity, increases in parallel with the disease stage [65, 66], indicating that the presence of Tregs

Ngày tải lên: 21/09/2020, 01:29

... cancer is the leading type of new cancer cases and the second leading cause of cancer related deaths in fe-males worldwide [1] During the past 30 years, the inci-dence and mortality of breast cancer ... Sensitivity of BSGI in different characteristics of breast cancer b TNR of BSGI distribution for different breast cancer molecular subtypes Table 4 Analysis of BSGI false positive in diagnosis of breast ... denser breasts, and recent re-search also indicated that women with higher breast density are at an increased risk of breast cancer, and this is one of the highest risk factors for the prediction of

Ngày tải lên: 21/09/2020, 01:57

... one of the leading causes of cancer mor-bidity and mortality among women worldwide [1] The majority of breast cancer patients have tumors that ex-press hormone receptors [2, 3] and can thus be offered ... through breast cancer surgery and approximately 58 % of these patients were included [33] A lack of research nurses explains most of the patients who were missed and approximately 5 % of the patients ... analyses of the Table 1 Patient characteristics of the AI-treated patients with ER+ tumors included in the DMET™ chip analysis and the extended cohort Patients included in the analysis of the DMET

Ngày tải lên: 21/09/2020, 09:43

... factor for breast cancer, besides the family history of breast cancer [4–9] However, whether the modulation of p53 activation may contribute to the gen-etic basis underlying the effect of reproductive ... processes The relevance of deficient FATSexpression to the onset of breast cancer and the role of p53 as a guardian of maternal reproduction support our findings that the promotion of p53 activation ... However, whether the non-proteolytic ubiquitination of p53 by FATS may have some physiologic significance and whether the genetic variants of FATS may modulate the risk of breast cancer remain

Ngày tải lên: 28/09/2020, 01:25

... C L E Open AccessIntegrity of the LXXLL motif in Stat6 is required for the inhibition of breast cancer cell growth and enhancement of differentiation in the context of progesterone Min Wei1,2*, ... Taken together, these data identify Stat6 as a coactivator of PR mediating the growth-inhibitory and differentiation effects of progesterone on breast cancer cells Keywords: Breast cancer, Stat6, ... Trang 2The steroid hormones estrogen and progesterone play key roles in the growth of the mammary gland [1] Estrogens appear to be the main drivers of proliferation of the mammary gland epithelium,

Ngày tải lên: 05/11/2020, 01:56

... inhib-ition of BMP4 signaling decreased metastasis of MDA-MB-231 breast cancer cells [11] Yet there is one study where BMP4 reduced migration of MDA-MB-231 cells [12] Nevertheless, the majority of the ... dissimilar morphology for the breast cancer cells In PEG gel, BMP4 inhibited the growth of MCF-10A and the three breast cancer cell lines examined, thus closely resembling the 2D culture conditions, ... that the effects of BMP4 cannot be simply explained by the molecular subtype of the cell line Neither could we link the BMP4-induced phenotypes to other known cell line characteristics, such as the

Ngày tải lên: 05/11/2020, 06:12

... risk of breast cancer (OR 1.15, 95% CI 1.01–1.30) Although the associations with breast cancer were of similar magnitude and direction for most SNPs when comparing the two datasets, the risk of breast ... most SNPs, the magnitude of risk associated with each subtype was the same as with the overall risk of breast cancer Fur-ther, onlyTLR9 was not significant at the gene level for either ductal ... CI 0.73–0.95) The four other intronic SNPs did not show evidence of af-fecting breast cancer risk and were not in LD with any other SNPs in this region (all pairwise r2≤ 0.50) Of the two SNPs

Ngày tải lên: 05/11/2020, 06:22

... suppresses the invasiveness of breast cancer cells Using an vitro assay, we assessed if Sox2 regulates the in-vasiveness of two ER + breast cancer cell lines (i.e., MCF7 and ZR751), both of which ... up-regulation of the Twist1 mRNA as well as an upregulation of the Twist1 protein, although these changes were confined to the RU cells Correlating with these findings, the expres-sion level of E-cadherin, ... Sox2 does not bind to the promoter region of Twist1 and the expression of Twist1 is regulated by other factors The mechanism underlying the decision as to whether Sox2 binds to the Twist1 gene promoter

Ngày tải lên: 05/11/2020, 06:49

... chemotherapy and radiotherapy However, with the high invasion and migration of breast cancer cells, it is necessary to explore the effects of anesthesia strategies during treatment of breast cancer Previous ... detected the function of OPRK1 in migration of breast cancer, as MDA-MB-231 cells with high expression of OPRK1 while the expression of OPRK1 in MCF-7 was low In addition, the normal cell of MCF-10A ... inhib-ited the invasion and migration of breast cancer cells in vitro The effects of OPRK1 knockdown on the expression of migration‑associated factors in breast cancer Epithelial-mesenchymal transition

Ngày tải lên: 12/01/2022, 22:17

... of Cur14–16 Therefore, the natural herbal Cur is less toxic than other chemotherapeutic agents in the treatment of cancer Despite of the safety and the broad pharmacological effects of Cur, the ... colorectal cancer is the world most common cancer and the third leading cause of cancer death in both male and female1,2 In spite of the development of novel powerful treatment, chemotherapy still plays ... colon cancer in the future. Cancer is one of the most severe diseases with increasing morbidity and mortality every year around the world According to statistics in the United States, colorectal cancer

Ngày tải lên: 01/11/2022, 09:55

... are some of the new drugs developed to target the breast cancer cell [79] The discovery of HER 2 targeted therapy has revolutionized the management of breast cancer How-ever, the cost of these ... within Africa and the rest of the world was difficult in the absence of rich data Chemotherapy Cost and access to drugs The cost of newer and more effective systemic therapies for cancer continues ... from the perspective of oncologists with local experience Keywords: Breast cancer, Radiotherapy, Chemotherapy, Targeted therapies, Survival, Hormonal therapy Background Publications on breast cancer

Ngày tải lên: 19/11/2022, 11:41

... (in the ovaries) and is essential for the development of the breast, paradoxically oestrogen is also involved in the development of breast cancer via the stimulation and proliferation of breast ... doubled the risk of breast cancer for the daughters of the women who took it 55 . This shows how a hormone, when present at the wrong time (in this case during the development of baby girls in the ... breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer. Cancer Causes Control, 8, pp49-56. 18 Collaborative Group on Hormonal Factors in Breast Cancer...

Ngày tải lên: 15/03/2014, 01:20

... Sometimes the cancer cells spread outside the breast to other parts of the body. This means they metastasize (meh-TASS-ta-size). Ducts in the breast carry milk to the nipple. Most breast cancers ... If all 100 of these women take medicine to reduce the risk of breast cancer, about half as many (1 woman) will get breast cancer. = the number of women who will get invasive breast cancer without ... out of 100). = the number of women who will get invasive breast cancer when all the women take medicine (1 out of 100). 7 Most women will never get breast cancer. A woman’s risk of breast cancer...

Ngày tải lên: 29/03/2014, 01:20

... incidence [risk] of invasive breast cancer over the period of the study. Although tamoxifen prevented the appearance of a substantial number of breast cancers over the duration of this study, the term ... function of the number of tumors that are ER positive rather than a function of the total number of breast cancer events. Thus, if the expected proportion of ER-negative tumors is high, then the ability ... preventing breast cancer without increasing the risk of endometrial cancer (65). The uncertainty of the clinical application of the current find- ings is analogous to uncertainties related to the use of...

Ngày tải lên: 15/02/2014, 04:20

... be devoted to the development and refining of technologies for the early detection of breast cancer. The purpose of the study de- scribed in this report was to review the breast cancer detection ... physical examination of the breast are now the mainstays for early detection of breast cancer. Screening for early cancer detection has been credited for part of the recent reduction in breast cancer mortality, ... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the...

Ngày tải lên: 05/03/2014, 12:20

... services. The continuing education of professionals focuses on the role of the professional as the initial point of contact between potential cancer patients and the health care system. These professionals ... screening of breast cancer, and has given special attention to supporting the development of national programmes for the early detection of breast cancer. The participation of regional experts in the ... developing breast cancer. Worldwide, 75% of new cases and 84% of breast cancer deaths occur in women aged 50 and older, with the number of breast cancers diagnosed in women in their fourth decade of...

Ngày tải lên: 28/03/2014, 23:20