submissions from successful phase i applicants

... protective immunity in the context of larger Phase IIb studies, and ultimately the prioritization of novel vaccine candidates Collective evidence reinforces the fundamental biologic capacity of ... polyfunctional cytokine response (Supplementary Fig S2) consistent with prior immunogenicity studies of AERAS-40221,23,24 We note that BCG vaccination resulted in minimal induction of antigen-specific ... antigen-specific T cell clones for their ability to recognize either peptide-pulsed or Mtb-infected dendritic cells (DC) Surprisingly, the T cell clones from the initial five participants revealed

Ngày tải lên: 08/11/2022, 15:02

... exclusion criteria included liver enzyme levels outside the normal range, chronic HIV or HCV infection, or evidence of any other clinically significant acute or chronic disease Subjects receiving immune ... II mAbs [3], and is dependent upon the specific binding of sLAG-3 to MHC class II molecules located in membrane lipid raft microdomains [8] Finally, the immunostimulatory activity of sLAG-3 in ... distribution, and reproduction in any medium, provided the original work is properly cited. Trang 2A clinically effective therapeutic vaccine to fight viruses or tumour requires the generation

Ngày tải lên: 11/08/2014, 10:23

... antibodies in IS to serum IgG is consistent with this dual origin of bronchial IgG antibod-ies IgA antibody levels in IS showed no correlation to sys-temic and BALF antibody levels of this isotype ... at 37 Binding was visualized with peroxidase-con-jugated IgG- or IgA-specific binding rabbit antihuman sec-ondary antibodies (Dako, Hamburg, Germany, the Binding Site, Birmingham, UK), diluted ... applied in the process of optimization of the vaccination strategy The use of IS for detection of vaccine induced antibodies has limitations A major drawback of the IS technique is its age restriction

Ngày tải lên: 12/08/2014, 15:21

... diagnostic category-specific survival derived from breed-specific Cox re-gressions Estimated ratios are given in brackets when they were not significant (p≥0.05) The data are from dogs life-insured ... category)*100 3 - SP = specific diagnosis proportional mortality = number dead with the specific diagnosis / number dead in this diagnostic category)*100 Trang 10tions In previous studies, it has been shownthat ... (male as baseline) was significant with respect to total or diagnos-tic mortality as well as for diagnosdiagnos-tic categories within breeds The direction and magnitude of the associations are presented

Ngày tải lên: 12/08/2014, 15:21

... of using RFID for dealing with data capturing in the initial stage After the data collection, further applicable dimension is explored like visibility and traceability A manufacturing services ... This index indicates the involvement of a logistics Quantity Time 1 Operator 1 Location 1 EPC OperatorID JobID Material Product BufferID MachineID Time_In Time_Out Duration Tuple Dimension Information ... activity monitoring using data mining techniques (Liu et al., 2012) This framework is verified by the empirical study using real RFID datasets Integrating techniques for clustering, pattern mining

Ngày tải lên: 26/04/2016, 14:52

... more speciically linked: job applications to banks might beneit from anything linking to inance or economics and those to international organisations might similarly list any overseas involvements ... direction it is taking you in Here a range of suggestions are made and one particular area is investigated in more detail to illustrate the possibilities Nothing here is complicated or likely to ... opportunities and assess each possibility in this way – asking how it can help your immediate studies and how it might help beyond that You cannot do everything and need to it in good choices in this

Ngày tải lên: 17/11/2016, 13:43

... seismic loads acting on the stem portion of cantilever retaining walls A typical Corps cantilever retaining wall is shown in Figure 1-1 It is envisioned that this information will be used in the ... to walls retaining nonyielding backfill Examples of Corps retaining walls that typically exhibit these two conditions in seismic evaluations are shown in Fig-ure 1-2 In this figFig-ure F V and ... leading to refinement of the Ebeling and Morrison (1992) simplified seismic engineering procedure for Corps retaining structures Specific items addressed in this Phase 1 report deal with the seismic

Ngày tải lên: 30/04/2018, 09:14

... deterioration (ACI 2002) In general, the durability of a concrete can be summarized as the capability of a concrete to continue performing its designed functions while maintaining its dimensional ... permeability, the polycarboxylate superplasticizer also contributes to improving workability and durability Finally, the addition of steel fibers aids in preventing the propagation of microcracks ... observed improved durability characteristics including increased resistance to chloride penetration and abrasion These findings indicate that the full promises of UHPC’s benefits are not only realized

Ngày tải lên: 28/03/2019, 08:24

... setting a timer or alarm to use for limited durations, using applications with reminders to discourage unlocking devices, ignoring messages or notifications that were unimportant, and avoiding ... use: “Sometimes [when] I finish halfway I [will] want to continue, but the time limit is running out, so I have to [switch] off Sometimes I will ask my parents [I want to] play a little bit more ... possible They used them from morning until night time, often interspersed with their daily activities and with frequent “checking” of the device Upon waking up in the morn-ing, they started using

Ngày tải lên: 01/02/2020, 05:07

... vaccine Here, we evaluated the safety and efficacy of a novel modified-DC vaccine in patients with stage I to IIIA NSCLC Trang 3Eligibility criteria Patients with histologically confirmed stage I ... Flagellin, a specific ligand for TLR5, plays an important role in activating immune re-sponse via triggering TLR signaling [44, 45] A bacterial filament protein, flagellin incombination with siRNA-SOCS1 ... Our findings on the safety and efficacy of the vaccine in this phase I trial warrant future phase II/III clinical trial Keywords: Modified-DCvaccine, Non-small cell lung cancer (NSCLC), Phase I

Ngày tải lên: 23/07/2020, 02:59

... therapies in that it binds a conformational epitope that traps HER3 in the inactive conformation preventing its receptor activation, and pos-sesses the unique ability to inhibit both ligand-induced ... (U3–1287) which provided some evidence of disease stabilization in patients with solid tumors [21], and which subsequently demonstrated encour-aging efficacy in combination with erlotinib [22] Simi-larly, ... National University Hospital Clinical Research Institute, National Taiwan University Hospital Research Ethics Committee, Vall d ’Hebron University Hospital (CEIC Hospital Vall Hebron), University

Ngày tải lên: 06/08/2020, 04:06

... K, Mita A, et al Phase II study evaluating the efficacy, safety, and pharmacodynamic correlative study of dual antiangiogenic inhibition using bevacizumab in combination with sorafenib in patients ... suniti-nib [39] The combination of pazopasuniti-nib and bevacizu-mab appeared feasible and a promising efficacy was expected This trial is the first to report this combination in patients with ... Day 15, with 37% of inter-individual variability in apparent clearance These values were sig-nificantly higher than those previously described in the initial phase 1 trial with pazopanib as monotherapy

Ngày tải lên: 06/08/2020, 06:43

... change from baseline (n = 26) in target lesion size is presented in Fig 2 Selumetinib in combination with dacarbazine Dose-limiting toxicities Seven patients received selumetinib 50 mg BID plus ... selumetinib plus dacarbazine in patients with BRAF-mutant metastatic melanoma [13], have more re-cently been assessed in phase II trials Additional phase II and phase III trials of selumetinib plus ... compared with single agent administration [1, 11] Combinations with docetaxel and dacarbazine have since shown clinical activ-ity in phase II trials [12, 13] This phase I study was the basis for

Ngày tải lên: 20/09/2020, 01:33

... lo Studio dei Carcinomi dell ’Apparato Digerente (GISCAD), Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC) Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent ... Androulakis N, Kotsakis A, Samonis G, Georgoulias V A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally ... Harmonisation E6 requirements for Good Clinical Practice and with the ethical principles outlined in the Declaration of Helsinki Please see Additional file 1 for a complete list of Institutional

Ngày tải lên: 20/09/2020, 18:08

... Writing (Original Draft), Writing (Review and Editing), Visualization, Supervision, Project Administration, and Funding Acquisition JT: Methodology, Software, Validation, Formal Analysis, Investigation, ... Investigation, Data Curation, Writing (Original Draft), Writing (Review and Editing), and Visualization AC: Methodology, Software, Validation, Formal Analysis, Investigation, Data Curation, Writing ... (Original Draft), Writing (Review and Editing), and Visualization LOL: Methodology, Software, Validation, Formal Analysis, Investigation, Data Curation, Writing (Original Draft), Writing (Review

Ngày tải lên: 20/09/2020, 18:48

... tissue from testosterone suppression This may lead to false-positive results with ASTRO definition and a recalculation with nadir + definition was performed With this definition no biochemical failure ... multicenter phase III trial could be started comparing conventional fractionation of 74 Gy in Gy fraction with hypofractionation giving 66 Gy in 25 fractions of 2.64 Gy in patients with localized prostate ... the highest probability of toxicity which, if true, implies that the irradiation schedule does not warrant further investigation, in this trial P0 has been taken as 50% incidence of grade II or...

Ngày tải lên: 09/08/2014, 10:21

... proportion of Illiterate women using family planning CPR(illiterate) = ∑w i i CPR i (illiterate) ∑w i i Where, w i = Proportion(illiterate) * Pi (1991) ∑ Proportion(illiterate) * P i (district population) ... corresponding district level indicators For example, I= ∑ I (i, j ) * W (i, j ) i, j I indicator at the national level I (i, j ) is the same indicator for ith district in jth state W (i, j ) is weight ... population) (1991) (district population) i i.e the proportion of population illiterate in ith district to the sum of illiterate population of all districts within the state The estimates at the national...

Ngày tải lên: 05/03/2014, 10:20

... fame difiance from the Priiin as before, moving the Paper either towards the Prifm or from ir, LInti I found the jufi difiancc where the Reailinear Sides of the Image became mofi d&n& For in this ... intermediate $aces; Which agrees with, tkxcfir& ProprAit~oq that: pi: ht$ which differ in CSolour &o di%x in Refi~q.$~ B iry, The length of the kmge iiti &e $&qpitig Ex,pegi.metits 1ne3hred from ... Reflexions fixffcrs nk Alecration in its Modifications and Properties, I IICE here take notice of any R&a&ions made in the Sides af the firT1; Prifm, becaufe the Light enters it perycndiculnrly...

Ngày tải lên: 17/03/2014, 14:57

... We are moving from this whole idea of ownership—It is mine If I own it, I can maintain it, I can control it— to an Internet world where everything is shared That is a relationship issue rather ... Purchasing supplies and materials from a specific vendor; Accessing facilities manuals (e.g., maintenance or training); Publishing static project information; Taking interactive training courses; ... developed by Facility Information Systems, Inc (FIS), a venture-capital-backed firm with offices in Camarillo, California (www.fisinc.com) FIS was unique in that it uses Oracle 8i for its backend...

Ngày tải lên: 29/03/2014, 11:20

... their individual efforts in gathering information and writing sections of the report vii viii ACKNOWLEDGMENTS This report has been reviewed in draft form by individuals chosen for their diverse ... technology-related findings and recommendations identified by the committee They pertain to gasification, gas purification, turbines, and fuel cells Gasification Finding Under current conditions in the United ... University, Pittsburgh, Pennsylvania RAMON L ESPINO, University of Virginia, Charlottesville ENRIQUE IGLESIA, University of California, Berkeley EDWARD S RUBIN, Carnegie Mellon University, Pittsburgh,...

Ngày tải lên: 29/03/2014, 13:20