structures evolution and application to drug design

... databases to efficiently store and manage data The other is to invent useful bioinformatics algorithms and tools to analyze the data and generate new knowledge for biological and medical use With ... increasingly used to advance drug discovery A large variety of specialties and general-purpose bioinformatics databases have been developed to store, organize and manage vast amounts of biomedical and genomic ... as the basis for further knowledge discovery in drug target search analysis; drug pharmacokinetics and pharmacogenetics studies; and drug design and testing TTD (http://bidd.nus.edu.sg/group/cjttd/ttd.asp)...

Ngày tải lên: 15/09/2015, 22:19

... CB644-Petlyuk-v1 June 15, 2004 Distillation Theory and Its Application to Optimal Design of Separation Units Distillation Theory and Its Application to Optimal Design of Separation Units presents a clear, ... to problems of flowsheet synthesis and to optimal design calculations DistillDesigner software allows refinement and confirmation of the algorithms of optimal design A sample of this software is ... students and specialists in the design and operation of separation units in the chemical, pharmaceutical, food, wood, petrochemical, oil-refining, and natural gas industries, and for software designers...

Ngày tải lên: 01/04/2014, 11:27

... is studied to achieve very low range sidelobes for potential application to spaceborne rain radar In the paper [11], timedomain weighting of the transmitted pulse is used and is able to achieve ... that it is impossible to design a set of codes with ideal impulsive autocorrelation function and ideal zero cross-correlation functions, since the corresponding parameters have to be limited by certain ... zero autocorrelation sidelobe zero mutual cross-correlation peaks during Zero Correlation Zone We also present and analyze a method to construct such ternary codes and subsequently apply them to...

Ngày tải lên: 21/06/2014, 17:20

... according to relations (1) and (2) Incremental state vector at the origin and the extremity of the beam are denoted by ∆ n S O and ∆ nS E respectively, according to the definition (A.3) These ˆ vectors ... simulation and comparison tool for tree and stand growth, silvicultural treatments and timber assortment, in: Proc Connection between silviculture and wood quality through modelling approaches and simulation ... by INRA-FMN and Région Aquitaine We wish to thank Alexia Stokes and Neal Harries for their corrections and language review We also thank two anonymous reviewers for their comments and suggestions...

Ngày tải lên: 08/08/2014, 01:22

... - PEG and PAMAM - Pluronic Use the SRB staining method , dyed fluorescent dye MTT and FDA / EB to assess cytotoxicity in vitro Using UV-Vis and HPLC to assess the ability to carry drugs and release ... increase the drug 's ability to carry PAMAM On that basis, we propose the topic "Research polyamidoamine dendrimers modified by biocompatible polymers ( PEG and Pluronic ) application to drug carrier ... Particularly anti-cancer drugs are not only toxic to cancer cells but also toxic to the healthy cells Many scientific reports indicate that the encapsulation of drugs to treat cancer or nano polymer...

Ngày tải lên: 28/04/2016, 17:48

... shopping, and psychographic portrait of customers A number of drawbacks and benefits pertaining to the tools have been pointed out and discussed Both the research models and the tools, while diverse to ... included into this study 12 The overview of tools for measuring customer satisfaction excluded practical advice on how to develop these tools and how to analyse collected data, due to the general ... innovativeness, and interpersonal communication, and according to this could be classified into innovators, early adopters, early majority, late majority, and laggards (Figure 6) Innovators seek newness and...

Ngày tải lên: 04/11/2013, 10:15

Ngày tải lên: 12/01/2014, 21:44

... 3, and 10 kPa and annealed at 600 8C (b) WO3 nanoparticles deposited at kPa and annealed at 400 and 600 8C results for the sensors made of WO3 nanoparticles deposited at 1, 3, and 10 kPa and ... nanoparticles deposited at kPa and annealed at 400, 600, and 800 8C, respectively Please cite this article in press as: D Meng, et al., Preparation of WO3 nanoparticles and application to NO2 sensor, Appl ... where Ra and Rg were the electrical resistances in air and in air including NO2, respectively Results and discussion Fig 2(a) shows XRD patterns for WO3 nanoparticles deposited at 1–10 kPa and annealed...

Ngày tải lên: 20/03/2014, 13:06

... which the drug is added to the aqueous buffer surrounding the receptor (or cell or tissue) and the total drug added is assumed to be in aqueous solution and in equilibrium with the receptor 2.9 ... Unbound Drug and Drug Action The biological or functional response to receptor activation can be assumed to be directly proportional to the number of receptors (R) occupied by a given ligand (L) ... for total drug except that free (unbound) drug values are substituted for total drug values Free volume and free clearance are always equal to or greater than the values calculated from total drug...

Ngày tải lên: 11/04/2014, 10:03

... to convolve the signal x with a random waveform and randomly under-sample the result in time-domain The random convolution is performed through a random pre-modulation in the Fourier domain and ... signal x by a wide-band signal c = (cl )1 l N ∈ CN , with |cl | = and random phases, before projecting the resulting signal onto m vectors of the basis Φ The measurement vector y thus satisfies ... Universal and efficient compressed sensing by spread spectrum and application to realistic Fourier imaging techniques Gilles Puy∗1,2 , Pierre Vandergheynst1 , R´mi Gribonval3 and Yves Wiaux1,4,5...

Ngày tải lên: 20/06/2014, 20:20

... guidelines and consists in the following three steps: to improve the Lipschitz constant of the level sets of u far from F(u), to carry this interior gain to the free boundary, to rescale and iterate ... the vectors Vi , i = 1, ,n − 1, involves only the Lipschitz continuity of A Construction of the family of subsolutions and application to the free boundary problem For the application to our ... The following two lemmas are similar to [5, Lemmas and 3], respectively Lemma 2.3 Let η0 > be fixed and w and z as in Lemma 2.2 Then there exist r0 = r0 (η0 ) and t0 = t0 (λ,Λ,n) > such that, if...

Ngày tải lên: 22/06/2014, 22:20

... (xm ) converges to x with respect to | · |n if and only if (xm ) converges to x with respect to · n Consequently the condition (ii) is satisfied with respect to · n On the other hand, we also have ... Fr´chet space and let C,D : X → X be two operators Suppose that the following hypotheses are fulfilled: (a) C is a compact operator; (b) D is a contraction operator with respect to a family of ... theorem and application and it follows that b(t) = t (1 − L)2 ω2 (t,s)ds − 0, → as t − ∞ → (4.24) Furthermore, it follows from (4.23) and (H3 )(iii) that +∞ b(s)ds < +∞ (4.25) On the other hand,...

Ngày tải lên: 22/06/2014, 22:20

... distortion after signal reconstruction DK again contains two components, the distortion due to the signal a approximation DK , and the distortion due to quantization q DK The distortion due to ... and the number of descriptions varies We fix the total number of atoms to 600 and vary the number of descriptions between and 4, as well as the number of atoms per description We use 11 bits to ... approximation, and yet correlated to provide robustness to channel erasures We propose to achieve this construction by partitioning the dictionary into blocks of similar atoms Each atom of a block...

Ngày tải lên: 22/06/2014, 22:20

... profiles, histone modification profiles, and DNA binding data for transcription factors and histone-modifying proteins This large compendium of datasets provides an unprecedented opportunity to investigate ... used to predict to which class each transcript in the testing set belongs We repeated the procedure for all 160 bins, and 100 different random splitting of the transcripts into training and testing ... may be instructive to build a simpler linear regression model to explore to what extent the chromatin features are redundant, and to what extent they are interacting in a combinatorial fashion Specifically,...

Ngày tải lên: 09/08/2014, 22:23

... 12 DrugProperties (a) PCA DRUGS DRUGS DRUGS CCA/Biclustering PROTEINS Drug- Properties Drug- Properties DRUGS DRUGS (c) Protein-Properties Labeler: Transfers label on columns of previous datset to ... and the total number of proteins sensitive to either property (upper triangle, union) The diagonal is the total number of proteins that were sensitive to the particular drug property descriptor ... split the drug treatments into distinct populations Those proteins which illustrated sensitivity to the aromaticity of the drug are then labeled aro-sensitive and this label is propagated to the...

Ngày tải lên: 09/08/2014, 22:24

... knowledge to operate at this level.) (Customer focus - at this level: thể person will adapt products and services to customer feedback; Design and monitors interfaces between his/her group and customer ... supervision or assistance to ensure that the output to be delivered adheres to the standards as specified (Customer focus skill - Investigates and takes action to meet customers’ current and future needs ... level to design job profile Both five-level system and four-level system can also be the benchmarking tool to design standard criteria in recruitment, performance management, training and compensation...

Ngày tải lên: 26/03/2015, 08:44

... are assumed to lie and the whole Pareto optimal set does not have to be generated with equal accuracy In papers [9] and [10], two reference point interactive methods are proposed to use single ... is created above is used to add to niching values in Step 10 during generations • Step 3: Calculate the distance of each solution in archive to Pc and store these values to a list lv 36 L Nguyen ... distributed along the Pareto front (the front is biased for solutions for − which f1 (→) is near to one); and second, the x density of the solutions is lowest close to the Pareto front and highest away...

Ngày tải lên: 13/08/2015, 10:00

... Velocity history at μ=0.4 Figure 6.10 Pressure and vertical velocity contours at the steady state ( μ=0.4 ) Figure 6.11 Velocity history at μ=0.5 Figure 6.12 Pressure and vertical velocity contours ... operations in the weak and strong form to overcome the shortcomings of the FEM, FVM and FDM, and combines the gradient smoothing operation in the weak and strong form to solve the Fluid-structure ... would like to express deepest gratitude and appreciation to my two supervisors Associate Professors Tan Beng Chye Vincent and Professor Liu Gui Rong for their dedicated guidance, support and continuous...

Ngày tải lên: 09/09/2015, 18:58