... Trang 1STRUCTURE-PROPERTY RELATIONSHIP OF CRYSTALLINE POLY(LACTIC ACID)S: DFT/DFPT STUDIES AND APPLICATIONSLIN TINGTING NATIONAL UNIVERSITY OF SINGAPORE 2011 Trang 2STRUCTURE-PROPERTY RELATIONSHIP ... properties of PLA are determined by the polymer primary structures, conformations, the crystal structures and the degree of crystallinity Hence, a study on the relationship of structure and property ... chain primary structures, conformations and packings; crystal structures and the degree of crystallinity etc Hence, an understanding on the relationship of structure/morphology and property is...
Ngày tải lên: 09/09/2015, 18:56
... metastasis and cell mechanics In view of the importance of structure-property relationship of cancer cell mechanics, we will then review the components and structures of cells including cytoskeleton, ... Young’s modulus of isolated nucleus of 10A and MCF-7 97 MCF-Fig 6.6 Lamin A/C structure of isolated nucleus of (A) MCF-10A and (B) MCF-7 (intensity profile corresponds to the line section of fluorescence ... and mechanical properties of cancer cells Before we attempt to understand the structure-property relationship of cancer cells, we will first take a look at the structure of a eukaryotic cell Fig...
Ngày tải lên: 14/09/2015, 08:48
Study on dislocation cell structure, dislocation density-fatigue property relationship of a structural steel
... (a) Sketch of dislocation structure of the virgin specimen (b) Sketch of dislocation structure of the specimen deformed at a strain amplitude of 0.4% (c) Sketch of dislocation structure of the specimen ... microstructure or the dislocation structure of the damaged specimens Therefore, there is a lot of attention on the fatigue behavior of several types of steel as well as the evolution of microstructure ... Magnification of 0.2 µmFigure 6 Dislocation structure of the specimens deformed by cyclic loading at ε a = 0.6% (a) Magnification of 1 µm (b) Magnification of 0.2 µm Figure 7 Dislocation structure of the...
Ngày tải lên: 05/07/2022, 11:18
Báo cáo khoa học: Structure–function relationship of novel X4 HIV-1 entry inhibitors – L- and D-arginine peptide-aminoglycoside conjugates pptx
... spectrometry The second step of the synthesis involved full protection of the remaining amino groups with Cbz, achieved by the reaction of benzylchloroformate (CbzCl) in the pres-ence of sodium carbonate ... groups (Cbz and NO2) by hydrogenation using Pd⁄ C (10%) Of the three sets of compounds of 6- and 9-mers of l-, d- and l⁄ d-enantiomers of arginine chains and their aminoglycoside conjugates (neamine, ... (EC50 of 70, 31, and 40 lm, respectively) By contrast, the antiviral activity of the free non-amer arginine R9 (EC50 of 33 lm) was similar to that of its aminoglycoside conjugates The EC50 of Fig...
Ngày tải lên: 16/03/2014, 06:20
Báo cáo y học: "What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?" ppsx
... the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine? Address: 1 Department of Pediatrics, Division of Infectious Diseases, University of California ... will focus on the relationship between the structure of the Tat protein and its function as a secreted factor To this end we will summarize some of the exogenous functions of Tat that have been ... the second exon of Tat is important to the stability of the structure The last NMR study of Tat to be reported was the first report of a NMR structure for a full-length Tat and was performed using...
Ngày tải lên: 12/08/2014, 23:21
Processing structure property relationship in electrospun polymer nanofibers
... Trang 1PROCESSING-STRUCTURE-PROPERTY RELATIONSHIP IN ELECTROSPUN POLYMER NANOFIBERS RYUJI INAI (M Eng), KIT A THESIS SUBMITTED FOR THE DEGREE OF Ph.D OF ENGINEERING DEPARTMENT OF MECHANICAL ENGINEERING ... Molecular Structure of 2-2-3 Structure-property Relationship of PLLA Fibers 20 Trang 4POLYMER FIBERS AND THEIR 3-2-5 Scanning Electron Microscopy (SEM) and Transmission (5) Electrospinning of Ultra-fine ... that of amorphous PLLA nanofibers To further study structure formation of polymer nanofibers, post-processing was applied to the as-spun PLLA nanofibers Based on XRD and DSC analysis, the model of...
Ngày tải lên: 12/09/2015, 08:19
Comparatives study on sequence structure function relationship of human short chain dehydrogenases reductases
... five groups of human SDRs 53 Figure 13: The location of the conserved and variable residues in the template structure of group 1 of human SDR was identified by Talana 54 LIST OF TABLES Table ... STRUCTURE-FUNCTION RELATIONSHIP OF SEQUENCE-HUMAN SHORT-CHAIN DEHYDROGENASES/REDUCTASES A thesis submitted to the School of Biotechnology, International University in partial fulfillment of ... analysis of homologous sequences and sequence-structure-function relationships in the human SDR family was performed using bioinformatics Our goal was to gain insight into the mechanisms of action of...
Ngày tải lên: 23/10/2015, 15:38
Inhibitory effects against α-glucosidase and α-amylase of the flavonoids-rich extract from Scutellaria baicalensis shoots and interpretation of structure–activity relationship of its eight
... equivalents/ µg’ The assign‑score method refined for assessment of structure–activity relationship of flavonoids Structure–activity relationship for eight individual flavo-noids was performed using ... biological activities of flavonoids, such as their hydrolytic enzyme inhibitory effects against α-amylase and α-glucosidase, in that establishment of structure– activity relationships of many such individual ... types of effects must be helpful to fully clarify the comprehensive structure–activity relationship of flavonoids And this will certainly have some reference significance for estab-lishing structure–activity...
Ngày tải lên: 29/05/2020, 13:53
Synthesis fungicidal activity and structure activity relationship of acylaminocycloalkylsulfonamides against botrytis cinerea
... close to proton of C9-He So proton of C9-He affected by protons of C10-He and C10-Ha, which signal showed coupling splitting of triplets, and protons of C9-He affected by protons of C14-He, which ... of 0 min, and then 90% A~10% B in the range of 0 to 2.0 min, 50% A in the range of 2.0 to 4.0 min, 10% A~90% B in the range of 4.0 to 4.2 min, 10% A in the range of 4.2 to 5.2 min; velocity of ... IV-31 Trang 5compound IV-3, the proton of CH-SO2 showed doublet of doublets (dd), instead of ddd, and corresponding split-ting of proton on CH-N was doublet of triplets (dt) (Fig. 7) However, there...
Ngày tải lên: 19/03/2023, 15:24
Báo cáo khóa học: The structure–function relationship in the clostripain family of peptidases potx
... shows the structure of BDD (C) Effect of substrate (BAEE) on the time course of inactivation of ChC by BDD (pH 7.6, 25 C) No BDD (h); BDD, 16.97 l M (w); BDD, 16.97 l M in the presence of 1 m M ... of protein structures J Appl Crystallog 26, 283–290. 37 Sippl, M.J (1993) Recognition of errors in three-dimensional structures of proteins Proteins 17, 355–362. 38 Kleywegt, G.J (1996) Use of ... assay of enzymatic activity Initial rates of inactivation were deduced from plots of log (% of activity remaining) vs time (min) for several dye concentrations and the slopes and intercepts of secondary...
Ngày tải lên: 23/03/2014, 12:20
nanotechnology for cancer therapy, 2007, p.810
... treatment of cancer Among the various approaches considered, nanotechnology offers the best promise for targeted delivery of drugs and genes to the tumor site and alleviation of the side effects of ... Department of Radiology University of Utah Salt Lake City, Utah Ji Hoon Jeong Department of Pharmaceutics and Pharmaceutical Chemistry University of Utah Salt Lake City, Utah Sangyong Jon Department of ... University of Utah Salt Lake City, Utah Geoffrey von Maltzahn Harvard–MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, Massachusetts S P Vyas Department of...
Ngày tải lên: 04/06/2014, 14:30
Báo cáo khoa học: Protein transport in chloroplasts ) targeting to the intermembrane space pptx
... processed even in the absence of exogenous ATP The yield of pTic22 import in the absence of ATP varied between 20–50% of that in the presence of ATP The import of pMGD1 was efficient only at FEBS ... shown of the influence of thermolysin pretreatment of chloroplasts on the import of pTic22, pMGD1 and pSSU in the presence of ATP, derived by 2D densitometry evaluation (AIDA image analyser) of five ... form of OE33 on the import of any of the three preproteins A slight decrease of import efficiency was observed at 10 lm mOE33, but this effect was much weaker than at the same concentrations of...
Ngày tải lên: 23/03/2014, 07:20
drug targeting, strategies, principles, and applications
... extinction coefficient of TNB of 13,600 By comparing the number of mols of TNB released with the number of mols of antibody, the number of mols of RNase conjugated per mol of antibody can be determined ... ability of the IT to inhibit the incorporation of 3H-thymidine or 3H-leucine into the target cells (29) The potency of the IT is defined as the concentration of IT that inhibits 50% of the thymidine/leucine ... inoculation of the tumor cells or at different intervals of time (
Ngày tải lên: 10/04/2014, 22:17
báo cáo khoa học: "Adenovirus-mediated siRNA targeting Bcl-xL inhibits proliferation, reduces invasion and enhances radiosensitivity of human colorectal cancer cells" ppt
... overexpression of Bcl-xL was correlated with prognosis of colorectal cancer (CRC) patients The aim of this study was to investigate the association of Bcl-xL expression with invasion and radiosensitivity of ... integral part of the preoperative treatment of rectal cancers However, only a minority of patients achieve a complete pathologic response to therapy because 13 of radioresistance of these tumors ... mock Figure.3 Effects of Ad/shBcl-xL on the proferation and colony formation of CRC cells A The proliferation of LoVo cells was measured by MTT assay The cell proliferation of LoVo infected with...
Ngày tải lên: 09/08/2014, 02:21
Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps
... percentage of inhibition of proliferation of duplicate cultures relative to the incubation without liposomes (defined as 0%) Treatment of AA with liposomes and ex vivo proliferation assay of LN cells ... indicating a continuous activation of T cells, probably because of the presence of an Mt depot at the base of the tail However, in the PLN the percentage and absolute number of CD134+ T cells were decreased ... Results Expression of CD134 on CD4+ T cells during AA To study the expression of CD134 and CD4 during AA, Lewis rats were immunized with Mt in adjuvant The first signs of inflammation of the paw joints...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice" doc
... (Sigma-Aldrich, Buchs, Switzerland) The use of this dye allowed the detection of the microparticles at a wavelength in the NIR domain, where the autofluorescent background of fur and collagen is negligible ... measurement of an excitation wavelength of 710 to 760 nm and an emission wavelength of 810 to 875 nm The acquisition time was set at seconds The fluorescence intensity was expressed as the number of photons ... injection of 100 μL of mg/mL mBSA emulsified 1:1 with Freund's incomplete adjuvant (Sigma-Aldrich) On day 16 after the first immunisation, half of the mice were implanted on the external part of the...
Ngày tải lên: 09/08/2014, 14:20
báo cáo khoa học: " The Washington Needle Depot: fitting healthcare to injection drug users rather than injection drug users to healthcare: moving from a syringe exchange to syringe distribution model" pps
... tension between the supporters of the program: the VCH, VANDU and the PHS The hard-line approach of the PHS was in direct contravention of the wishes of VCH and VANDU both of which formally registered ... effectiveness of distributing clean syringe equipment as made evident by an open letter written to the Office of National Drug Control Policy by Ranking Member Henry A Waxman on behalf of the Congress of ... carries an official "performance target" of 90% written at the top of the form The separation of syringe retrieval and distribution through the WND results in the retrieval rate (the number of needles...
Ngày tải lên: 11/08/2014, 18:21
Advanced control strategies for automatic drug delivery to regulate anesthesia during surgery
... and the professional dedication to the field of ’Process Systems Engineering’ I would like to convey my sincere thanks to A/Prof Chen Fun Gee Edward (Head of the Department) and A/Prof Ti Lian ... 46 3.3 Schematic representation of the MPC scheme for regulation of BIS 52 3.4 Schematic representation of basic concept of MPC 54 3.5 Setup of a feedback controller for hypnosis ... the loss of BIS signal (t = 120 – 200 min): (a) effect of EC50 , (b) effect of γ and (c) effect of ke0 72 3.13 BIS response and controller output in the absence of BIS signal...
Ngày tải lên: 14/09/2015, 08:25
Báo cáo sinh học: " In vivo transcriptional targeting into the retinal vasculature using recombinant baculovirus carrying the human flt-1 promoter" potx
... investigate the action of regulatory factors of vascular endothelium [17] The cells were transduced at a multiplicity of infection (MOI) of 100 in the presence or absence of mM butyrate, a histone ... experiments will address the nature of the proteins that affect the silencing of baculovirus vectors in mammalian cells Finally, this study provides the proof of principle of baculovirus mediated gene ... Levels of expression of GFP and induction ration (indicated on the right) as determined by the mean fluorescence intensity in the presence or absence of butyrate Values are means ± SD of four...
Ngày tải lên: 18/06/2014, 18:20
Báo cáo y học: "Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthriti" pps
... cohorts (one-third of patients no response, one-third of patients partial response, and one-third of patients good response) Identification of clinical predictors and development of molecular biomarkers ... integrated analysis of cytokine and autoantibody profiles in baseline samples derived from all three cohorts of etanercept new-start RA patients Combined autoantibody and cytokine profiles are most ... independent cohorts of patients with RA The workflow of the studies is outlined in Figure Materials and methods Patient sera Pretreatment sera from three cohorts of patients with the diagnosis of RA based...
Ngày tải lên: 09/08/2014, 14:21