small organic molecules as drugs and prodrugs

... cancer cases have been associated with single base missense mutations in the small GTPase KRAS4b [2] KRAS4b acts as a central relay for signals originating at receptor tyrosine kinases such as the ... analysis using FlowJo soft-ware (Tree Star Inc., Ashland, OR) RAS-GTP pull-down assay The RAS-GTP pull-down assay was performed using the RAS Activation Assay Biochem Kit (BK008, Cystoskele-ton, Inc ... causes and if C19 decreases the activation of KRAS4b and their effectors Results: C19 showed high cytotoxicity in the colorectal cancer cell lines HCT116 and LoVo, with a stronger effect in KRAS-dependent

Ngày tải lên: 03/07/2020, 00:51

... (b) and 4,4’-bipyridine (c) Adsorption data is shown as closed circles and desorption data as vertical bars under vacuum pressure (b) data is shown as closed circles and desorption data as ... COPPER – BASED METAL – ORGANIC FRAMEWORKS AS EFFICIENT AND RECYCLABLE CATALYSTS FOR THE OXIDATIVE AMINATION REACTIONS III Aim and objectives 1 Characteristics of the Cu2(BDC)2(BPY) and Cu3(BTC)2 ... by Hofmann and Küspert in 1897,2 the porous structures have illustrated with a vast number of applications in various fields such as adsorption, separation and purification as well as catalysis.3

Ngày tải lên: 26/01/2021, 23:31

... Cu(NO3)2.3H2O and H2BDC was dissolved in DMF and then heated at 110oC in an isothermal oven for 36 hours to form a blue powder The BET surface areas of 625 m2/g and Langmuir surface areas of m2/g ... ligands, and materials [70] On the other hand, many scientists have focused on fine-tuning catalytic systems to improve their activities as well as to make themselves can work with inexpensive and ... of porous materials have been increasingly studied such as nanotubes [1], mesoporous silicas [2], mesoporous carbons [3], microporous and mesoporous metal-organic frameworks (MOFs) [4] since

Ngày tải lên: 10/01/2017, 16:33

... Clar's empirical scheme is based on the appearance of the absorption bands and designates the first three bands in the spectrum of phenanthrene as the a, p, and /3 bands, re- Table 1.2 Labeling ... the 2p, and the 2p,, AOs, xo and yo, on oxygen and the 2p, AO, y,, on carbon The '(n,n*) state and the three components TI To, and T - , of the '(n,n*) state may then be written as and For an ... in-phase for excitation into the plus state and out-of-phase for excitation into the minus state; cf Equation (1.26) From the coordinates x,, and y, or y, and z, depicted in Figure 1.9, it is easy

Ngày tải lên: 07/07/2018, 11:36

... Clar's empirical scheme is based on the appearance of the absorption bands and designates the first three bands in the spectrum of phenanthrene as the a, p, and /3 bands, re- Table 1.2 Labeling ... the 2p, and the 2p,, AOs, xo and yo, on oxygen and the 2p, AO, y,, on carbon The '(n,n*) state and the three components TI To, and T - , of the '(n,n*) state may then be written as and For an ... in-phase for excitation into the plus state and out-of-phase for excitation into the minus state; cf Equation (1.26) From the coordinates x,, and y, or y, and z, depicted in Figure 1.9, it is easy

Ngày tải lên: 10/07/2018, 09:58

... areas of Europe and America Ioyrish (1974) reported gastric ulcer and various types of wounds were also treated by honeybee's product (Hymenoptra) in some areas of Soviet Russia Newlands and ... 24-Parganas spider, dried up and makes Fever into powders The powder lnixed with leaf juice of Tulasi (OCiI11UI11 sanctum) 6 Carapace and Cheliceral Applied Munda Sagar Island 24:.Parganas and makes ... Uses/type of disease Applied locally with mustard oil in case of Rheumatism Applied in a case of recurnng Cold and Cough In the case of Paralysis Applied in the case of Insomania and Epi lepsy

Ngày tải lên: 18/07/2019, 07:17

... efficiency was obtained when pH of 100 µL of sample solution was adjusted to 7.5 and 5 mg of the sorbent was used Eluent solvent was 10 µL metha-nol Linear dynamic range was found to be between 0.1 and ... factor and the highest extraction efficiency, various volume of metha-nol, as the eluent, between 5 and 20 µL were examined CBZ peak area was increased with increasing the vol-ume of eluent up to and ... found to be between 0.1 and 50 µg L−1 and limit of detection for 10 measurement of blank solution was 0.05 µg L−1 This extraction method was coupled to HPLC and was successfully employed for the determination

Ngày tải lên: 29/05/2020, 13:11

... of at least two days between vaccination and dexamethasone, which is given as premedication one day prior to each dose of pemetrexed Assessments Standard clinical and laboratory safety assessments ... ≥1000/μL, lymphocyte count ≥0.8 × 10 9 /L, ALT and AST ≤2.5 times ULN in patients without liver metastases and ≤5 times ULN in patients with liver metastases, serum creatinine ≤2 mg/dL, creatinine ... mor-tality in both men and women and the incidence of the disease is increasing globally [1] Approximately 85% of patients with lung cancer have non-small cell lung can-cer (NSCLC) and 40% of these

Ngày tải lên: 14/10/2020, 16:26

... Trang 6Danh mục các ký hiệu, các chữ viết tắt MOFs: Metal-Organic Frameworks NMO: N-methylmorpholine oxide GC-MS: gas chromatography-mass specstrocopy NMR: Nuclear magnetic res BTC: 1,3,5-benzenetricarboxylic ... of optimal conditions was investigated on broad substrate scope To the best of our knowledge, C-H activation reactions using bidentate directing groups, which are increasingly gaining importance, ... N-H amines using 8-aminoquinoline as bidentate directing group The optimal reaction conditions involve the use of Cu_MOFs (25 %), N-methylmorpholine oxide (NMO) as an oxidant, secondary or primary

Ngày tải lên: 23/01/2021, 11:09

... on both SBUs and organic linkers along with the advantages of easy separation and recycling [3] The merits of diversified metal clusters and designable and tailorable organic ligands give a rise ... excellent yields were achieved and the VNU-21 was reused and recycled many times without catalytic degradation Zirconium-based metal-organic framework MOF-808 was synthesized, and sulfated with aqueous ... synthesis of quinazolinone and their derivatives New iron-based metal organic framework, VNU-21, and Zirconium-based MOF, MOF-808 were synthesized, characterized and employed as efficient heterogeneous

Ngày tải lên: 26/01/2021, 08:39

... self-assembly process from building blocks: metals (red spheres) and organic ligands (blue struts) Transition metal ions such as copper, zinc, nickel, iron are frequently used as the inorganic ... ethers as acylating source assisted by Cu-MOF-74 as a recyclable catalyst was explored by Lieu and co-workers (Scheme 1 6) This transformation occurred in ease condition with the aid of DMSO as ... Cambridge Structural Database (CSD) and MOF entries since 1972 [5] The inset shows the MOF self-assembly process from building blocks: metals (red spheres) and organic ligands (blue struts) 2 Figure

Ngày tải lên: 08/03/2021, 20:15

... on both SBUs and organic linkers along with the advantages of easy separation and recycling [3] The merits of diversified metal clusters and designable and tailorable organic ligands give a rise ... excellent yields were achieved and the VNU-21 was reused and recycled many times without catalytic degradation Zirconium-based metal-organic framework MOF-808 was synthesized, and sulfated with aqueous ... synthesis of quinazolinone and their derivatives New iron-based metal organic framework, VNU-21, and Zirconium-based MOF, MOF-808 were synthesized, characterized and employed as efficient heterogeneous

Ngày tải lên: 18/04/2021, 20:01

... include report andessay writing, communication and presentations, library and informationsearches, referencing, reflective practice, and action research Aims and objectives Aim •To explore and develop ... journal and a lecture, a reflective diary, awork-based report (based on research methods, analysis of findings,recommendations for change), and a presentation based on this report note-The course has ... detail the assessmentcriteria for their particular modules and lead discussions on assignmentwriting However, a range of opportunities for enhancing other areasassociated with the nurturing and development

Ngày tải lên: 18/10/2022, 13:51

... and proportion of wetlands measured at different scales Each zone included the area of all smaller zones, and as such was highly correlated with previous zones Thus, only one scale was used as ... explained by wetlands measured at different landscape scales was assessed by determining regression coefficients (r2) for each scale independently, as well as for the total and terrestrial watersheds ... season/years and Trang 7hydrologic categories showed an increase in the proportion of the total variability explained by wetlands measured at small landscape scales (50–100 m) Only in the case

Ngày tải lên: 18/10/2022, 22:44

... ap-plicability of miRNAs, either as a biomarker or therapeutics, in lung cancer treatment 2 miRNA Biogenesis and Function miRNAs are a class of non-coding, endogenous, stranded small RNA molecules composed ... precursor miRNAs (pre-miRNAs) consisting of approximately 60 –120 nucleotides by a ribonu-clease (RNase) III displaying endonuribonu-clease activity (the Drosha RNase) and the protein DGCR8 (Pasha) ... processes such as differentiation and apoptosis miRNAs that are downregulated in cancer, such as let-7, function as oncosuppressors and can suppress tumour development byregulating oncogenes and/or genes

Ngày tải lên: 04/12/2022, 15:44

... metal ions (Zn2+and Cu2+) and organic molecules (methy-lene blue and rhodamine B) Special emphasis is also put on the selec-tivity and reversibility of the adsorption process and on the ambient ... size of 38 nm was calculated, whereas the specific surface area was decreased to 36 m2.g− 1 and the pore size increased to 119 nm after an increase of the molar ratio of MTMS and TMPA to 7:3 ... centers was kept at a constant value of 34.9 mmol, and an increasing molar% of MTMS (10%, 20%, and 30%) was substituted by TMPA In the first step of the two-step acid-base approach CTAB and urea

Ngày tải lên: 20/12/2022, 22:05

... many diseases involving preventing and reversing neuronal and vascular cell injury pellagra and some neurodegenerative diseases [81] such as Alzheimer’s disease, Parkinson’s disease and other ... ethers as acylating source assisted by Cu-MOF-74 as a recyclable catalyst was explored by Lieu and co-workers (Scheme 1 6) This transformation occurred in ease condition with the aid of DMSO as an ... self-assembly process from building blocks: metals (red spheres) and organic ligands (blue struts).Transition metal ions such as copper, zinc, nickel, iron are frequently used as the inorganic

Ngày tải lên: 08/09/2024, 21:16

... on both SBUs and organic linkers along with the advantages of easy separation and recycling [3] The merits of diversified metal clusters and designable and tailorable organic ligands give a rise ... reaction time, the catalyst was removed by filtration The solution phase was transferred to a new and clean reactor New phenylacetic acid was added, and the resulting mixture was subsequently stirred ... from β-ketoesters and benzamides, and for the synthesis of benzimidazoles from β-ketoesters and o-phenylenediamines and glycerol was used as green solvent for this reaction It was possible to reutilize

Ngày tải lên: 08/09/2024, 23:43

... technical and administrational staffs of Department of Chemical and Biomolecular Engineering Last but not the least; I would like to thank my family for their forever understanding and support ... discussion and help throughout my work and their valuable comments to this thesis as fellow scientists I am thankful for the research scholarship from National University of Singapore, and the assistance ... *COOH Pathway when Adsorption as *COOH is Least Affected by H* and *O-species 2S4 Observations of *OCHO* as an Inhibiting Species at High Potentials 50 2S5 *CHO as one of Surface Blocking Species...

Ngày tải lên: 28/09/2015, 13:38

... H, but to other C's, as well as to N, O, or X These compounds include alkanes (C and H), haloalkanes (C, H, and X), alcohols and ethers (C, H, and O), and amines (C, H, and N) [graphic 1.5] (4,5,9,11,12/98)(1,9,10/99) ... reactions are the core of organic chemistry They convert one class of organic molecules into another class and permit the synthesis of new molecules from those which already exist Organic chemical reactions ... petroleum and natural gas and have a variety of commercial uses Examples are methane (CH4 ) (the major component of natural gas) and propane (CH3 CH2 CH3 ) that are cooking and heating fuels Gasoline,...

Ngày tải lên: 22/03/2014, 14:20