... surprise then, given the prohibitive cost of bringing a drug to market, that the accuracy and certainty of these predictions face considerable scrutiny The purpose of this article is to discuss the ... influence the rate of drug metabolism (54) However, refinement of these models and incorporation of empirical correction factors to account for the systematic under prediction can reliably enhance predictions ... the established models used for the liver (22,23,28,29) This is due in part to the heterogeneous expression of enzymes along the GI tract and the fact that in vitro techniques for isolating the
Ngày tải lên: 11/05/2020, 11:45
... 5:41X4X4: (3) The results of the analysis of variance, goodness-of-fit, and the adequacy of the models are summarized in Table 3 The determination coefficient (R2 D 0.967) was showed by ANOVA of the quadratic ... to judge the ex-perimental error, the suitability of the model, and the statistical significance of the terms in the model This is usually done with the help of a computer, using either a statistics ... to check the significance of each coefficient, which in turn may indicate the pattern of the interactions between the variables The smaller was the value of P, the more significant was the cor-responding
Ngày tải lên: 16/12/2017, 02:24
Handbook of parameter vaules for the prediction of radionuclide transfer
... depostion is a result of the complex interaction of the chemical form of the element, the development of the plant and the amount of rainfall Rainfall intensity appears to be of minor importance ... repositories In all these applications, the reliability of the predictions of the models depends on the quality of the data used to represent radionuclide transfer through the environment Ideally, ... reduction of activity in a specific medium The Trang 19to the medium considered; for example, for the reduction of activity in game, losses of radionuclides from the root layer of the soil, fixation
Ngày tải lên: 01/06/2018, 15:04
A regression-tree multilayer-perceptron hybrid strategy for the prediction of ore crushing-plate lifetimes
... each model The RMSE and the MAE for the nine models built by subsets are the corresponding averages of the nine models, whereas in the case of the training time, it is the sum of the nine training ... end of the plate and there was no rotation of the form after pouring (Fig 1b) The new, highly efficient method permitted the molten metal to enter from the end and the side of the plate The supply ... method, the type of cast plate, and the percentages of iron and manganese in the chemical composition of the plate The influence of the first two inputs is great, whereas the influence of the second
Ngày tải lên: 13/01/2020, 05:39
Elucidating adolescent aspirational models for the design of public mental health interventions: A mixed-method study in rural Nepal
... separate sheets of poster paper, and index cards were developed for the 74 sub-themes For each theme, the participant was given the set of corresponding index cards and was asked to rank the items ... sub-themes 8 Causes of violence—9 sub-themes 9 Causes of alcoholism—7 sub-themes 10 Causes of suicide—9 sub-themes In accordance with recommendations for transparency and availability of qualitative ... 10 themes and 74 sub-themes were identi-fied, which became the basis for the card ranking and rat-ing tasks The themes were: Trang 4 1 Qualities of an ideal person (Raamro maanchhe)—8 sub-themes
Ngày tải lên: 14/01/2020, 20:31
Serum and urine FGF23 and IGFBP-7 for the prediction of acute kidney injury in critically ill children
... years The exclusion criteria were the pres-ence of congenital abnormality of the kidney, discharge from PICU before sampling, and unexpected discharge from the PICU or withdrawal of therapy The ... partici-pated in the design of the study and coordination YL had primary responsi-bility for study design, performing the experiments, data analysis, interpretation of data, and writing of the manuscript ... °C for 15 min and the supernatants were used for the measurement The FGF23 level was quantified by the human enzyme-linked Cloud-Clone Corp, USA), according to the manufac-turer’s protocol The
Ngày tải lên: 20/02/2020, 21:14
ECPred: A tool for the prediction of the enzymatic functions of protein sequences based on the EC nomenclature
... using the subsequences of the query se-quences and the extracted probabilistic profiles The size of the feature vector is the same as the number of prob-abilistic profiles (i.e., the number of clusters) ... higher-than-positive-cut-off scores for the query protein, the main class with the maximum prediction score will be given as the prediction and the algorithm continues with the models for the descendants of that ... maximum prediction score will be given as the prediction and the algorithm continues with the models for the descendants of the corresponding subclass EC number (if there are any); c if the prediction
Ngày tải lên: 25/11/2020, 14:35
Development of predictive models for the coalescence of fused deposition modeling fibers
... varied along the length of the fiber, and temperature at cross section was uniform which means the temperature at the core of the fiber was the same as the temperature at the fiber surface The model ... is the major axis and b is the minor axis (as shown in Fig 3.3) For this study, the values for these axes are 0.2 mm and 0.1 mm 3.2.2 Temperature profile of the fiber Since the diameter of the ... Trang 1DEVELOPMENT OF PREDICTIVE MODELS FOR THE COALESCENCE OF FUSED DEPOSITION MODELING FIBERS A Thesis presented to the Faculty of the Graduate School at the University of Missouri-Columbia
Ngày tải lên: 26/03/2021, 09:13
longitudinal measurement and hierarchical classification framework for the prediction of alzheimer s disease
... ACC Therefore, the patch size w was fixed at 5 for the subsequent experiments Effectiveness of the use of longitudinal data To assess the effectiveness of the use of longitudinal data, the ... scale the intensity values of voxels to the range of [0, 100] Finally, for the simplicity of the proposed method, MRI data obtained before the missing time points were used as the missing data For ... In the voxel-based approach, the features are defined at the level of the MRI voxel, which is simple and intuitive in terms of the interpretation of the results However, the main limitations of
Ngày tải lên: 04/12/2022, 15:05
Luận văn development of predictive models for the coalescence of fused deposition modeling fibers
... ь0пdiпǥ iп FDM The bonding quality is influenced by the size of the network formed between adjacent fibers and the strength of the bond, which relies on the molecular diffusion of the polymer chains ... radius of the cylindrical filament before the sintering process occurs The bonding length is then calculated accordingly.The limitation of the Pokluda model is based on the assumption of two ... indicating that the temperature at the core of the fiber was the same as at the fiber surface The model was only applied to the bottom layer adjacent to the platform Heat transfer between the fiber
Ngày tải lên: 24/07/2023, 17:04
Numerical simulation for the assessment of groundwater safe yield in red river delta, viet nam
... located Therefore in this thesis, the Pleistocene aquifer is the main area of interest It was decided to use the Visual MODFLOW for the setting up of a numerical model of the Nam Dinh Area The 3D ... commune before joining the ocean The Ninh Co River is a tributary of the Red River, located near the center of the southern districts of Nam Dinh The river originates from the north of X uan Truong ... 2.1) Figure 2.1: The outline map of Nam Dinh Province Trang 22Nam Dinh represents the southernmost edge of the RRD, which is located on the western coast of the Gulf of Tonkin Therefore, its physical
Ngày tải lên: 22/03/2017, 22:36
Dynamic simulation based method for the reduction of complexity in design and control of recirculating aquaculture systems
... surplus amount of the input water that dilutes the fish tank to achieve the set point of the stocking density Simultaneously we increase the set point of the level for the calculation of the water ... struc-tures and of the respective grading There are many structural variants of the systems, also in the case of scheduling and con-trol decisions for the available number of volumes of tanks (comprising ... achieve the set point of the stocking density Simultaneously we increase the set point of the level for the calculation of the water output With this surplus water inlet we can achieve the prescribed
Ngày tải lên: 27/09/2019, 10:20
Resilience or hope Incremental and convergent validity of the resilience scale for adults (RSA) and the Herth hope scale (HHS) in the prediction of anxiety and depression
... result, the increase of the prediction in step four of the model is notably larger (ΔR2 ) than with the Total Score of the RSA in that final step The models with the six RSA scales in the last ... estimates of incremental validity were explored Table 3 summarises the results for the models accounting for the greater amount of variabil-ity of the outcome variables As expected, the total amount of ... explained in the dependent variables is the same in the models com-pared The ΔF (F Change) of all the steps in the two groups of models compared (including models with HHS scales in the fourth
Ngày tải lên: 10/01/2020, 14:28
Integration of soil solarization, arbuscular Mycorrhizal fungi, Trichoderma Viride, Azotobacter Chroococcum and soil amendments for the management of carnation (Dianthus caryophyllus L.)
... parts of the Himachal Pradesh (Chandel and Katoch, 2001) Soil-borne pathogens are difficult to control due to repeated cultivation of the crop in the same piece of the land Use of chemicals in the ... agents, soil amendments and chemicals for management of the disease Materials and Methods Soil amendments Soil amendments were evaluated to find their effect on the incidence of Fusarium wilt of ... amendments were mixed thoroughly in the upper 15cm soil layer Soil was then irrigated to saturation level and left for the decomposition for two weeks before planting the carnation cuttings Root dip
Ngày tải lên: 14/01/2020, 18:16
INNOVATE: A prospective cohort study combining serum and urinary biomarkers with novel diffusion-weighted magnetic resonance imaging for the prediction and characterization of prostate
... value for ex-clusion of aggressive disease [22] and will therefore form the reference for the index tests when mp-MRI is nega-tive (Likert score 1-2/5) The posinega-tive predicnega-tive value of ... investigate the use of VERDICT MRI We envision that application of VERDICT MRI will improve the specificity of mp-MRI, reduce the number of indeterminate examination results and provide evaluation of the ... recog-nised as potential robust biomarkers in the detection of various types of cancer The ability to screen for these miRNAs and to perform FLIM of the epidermal growth factor receptor (ErbB)
Ngày tải lên: 20/09/2020, 18:24
Establishment of multifactor predictive models for the occurrence and progression of cervical intraepithelial neoplasia
... to the random forest model method Therefore, a total of 13 models were established for predicting the occurrence and progression of CIN (7 models for predicting CIN progression and 6 models for ... one of the risk factors for the progression of CIN [23] Compared to CIN patients, the average age of SCC pa-tients was greater, and the parity was significantly more than that of the CIN cases For ... Fig 2 the weight of factors in model12 the ROC curve of model12 Fig 3 the roles of CSNK1A1 in Wnt signaling pathway Trang 9years old, regardless of the level of cervical lesions, therate of spontaneous
Ngày tải lên: 05/11/2020, 08:17
The conflation of building simulation (BS) and computational fluid dynamics (CFD) for the prediction of thermal performance of facade for naturally ventilated residential buildings in singapore
... month of the year exceeds the maximum of the other years 136 Figure 6.6 The cumulative amount by which the horizontal global radiation for each month of the year falls below the minimum of the ... the minimum of the other years 134 Figure 6.2 The number of hourly instances that the horizontal global radiation for each month of the year exceeds the maximum or falls below the minimum of ... minimum of the other year 134 Figure 6.3 The cumulative amount by which the dry bulb temperature for each month of the year exceeds the maximum of the other years 135 Figure 6.4 The cumulative...
Ngày tải lên: 14/09/2015, 13:58
A model for the prediction of subgrade soil resilient modulus for flexible pavement design
... Jersey, the first asphaltic roadway was constructed (Microsoft Encarta, 2004) The use of asphalt and the popularity of the automobile triggered the dawn of design methods The aim of these design ... thickness of subgrade soil support in flexible pavement This is well noticeable when the soil support values are low, especially in the case of the Illinois soils “Recognition of the importance of the ... fulfillment of the requirements for The Master of Science Degree in Civil Engineering The University of Toledo December 2004 Subgrade soil plays a very important role in the construction of roadways Before...
Ngày tải lên: 04/07/2016, 17:20
Báo cáo sinh học: "On the relevance of three genetic models for the description of genetic variance in small populations undergoing selection" docx
... accounted for in the simulation The analytical models of Verrier et al [14] and Chevalet [3] will then be described, each corresponding to a different choice of hypotheses for the algebraic formalization ... used for the MC simulations 4.1 Effect of number of loci Table I presents the values of RV[30] provided by the three models when ] [30 decreasing the number of loci L (with multiallelic loci in the ... in the case of 1000, 100 and 10 multiallelic loci controlling the selected trait, in order to check the effect of linkage on the prediction of genetic variance over time in the FFM The effect of...
Ngày tải lên: 09/08/2014, 18:22
Báo cáo sinh học: "Hierarchical folding of multiple sequence alignments for the prediction of structures and RNA-RNA interactions" doc
... ∪ σint to denote the partition of the base pairs of the first sequence, σ1, the base pairs of the second sequence, σ2, and the interacting base pairs, σint Furthermore, for the partial structure ... details, see [25] The PETfold score is the sum of the evolutionary accuracy values plus the average sum of the thermodynamic accuracy values For the evolutionary part, we compute the expected accuracy ... secondary structure prediction of the OxyS-fhlA complex, i.e., the secondary structures of OxyS and fhlA and the interaction between them, as predicted by our algorithm The result of the prediction without...
Ngày tải lên: 12/08/2014, 17:20