sarcomas of soft tissue and bone

... presence of lymphoma, malignant melanoma, neurofibroma, or other soft-tissue tumor; 2) soft-tissue lesions caused by direct infiltration from primary lesion or bone metastasis; 3) presence of lymph ... uptake was focal and greater than that of surrounding healthy muscle and subcutaneous soft tissue CT-positive soft-tissue lesions were defined as obvious nodules, masses, or abnormal tissue structures ... primary soft-tissue tumors, and lymphoma, may increase 18F-FDG uptake in soft tissue [18, 53], leading to false positive results Conversely, factors that decrease 18F-FDG uptake by soft tissue

Ngày tải lên: 03/07/2020, 02:55

... the use of computers and software solutions to aid doctors in the analysis, diagnosis and treatment of various ailments and conditions. Often, this aid comes in the form of digital imagery of various ... segmentation of soft tissue since it can handle any of the cavities, splitting or merging normally found in such tissue Examples of such objects are veins, arteries and brains However, ... Microsoft Excel. All CT datasets were obtained courtesy of the Department of Radiology of the National University of Singapore Hospital (NUH). These come with varying degrees of resolution and slice

Ngày tải lên: 30/09/2015, 14:24

... and Mimics 381 18 Deep Vascular Tumors 430 19 Osteochondroid Lesions of Soft Tissue 447 20 Myxoid Tumors of Superficial Soft Tissue 468 21 Myxoid Tumors of Deep Soft Tissue 484 22 Plexiform Soft ... Epithelioid Tumors of Soft Tissue 230 12 Soft Tissue Lesions with Clear or Granular Cells 256 13 Pleomorphic Soft Tissue Tumors 282 14 Small Round Cell Tumors 304 15 Benign Adipose Tissue Tumors 335 ... Soft Tissue 484 22 Plexiform Soft Tissue Tumors 511 23 Soft Tissue Tumors with Giant Cells 524 Index 545 v PREFACE There are more than two hundred types of soft tissue tumors, including many

Ngày tải lên: 20/01/2020, 10:46

... scale of collagen fibers present in most soft tissues, whilst the collection onto a rotating mandrel may provide an aligned mesh consisting of nanofibers Scaffolds made of aligned electrospun nanofibers ... multi-cellular processes of tissue formation, and ultimately facilitating the restoration of structure and function of damaged or dysfunctional tissues In order to overcome basic drawbacks of traditional ... basic function of natural tissues Synthetic hydrogels offer the ability to mimic various distinctive requirements of an ECM-like physicochemical environment and to sustain cellular and tissue function

Ngày tải lên: 02/11/2022, 11:40

... RANKL-induced bone loss (a) ATF3 expression in CD11b positive cells in bone marrow of control and CD11b-Cre;ATF3fl/fl male mice (n =​ 4) (b) BV/TV of femurs, and (c) BV/TV and (d) Oc.S/BS of vertebrae of ... pivotal regulators of cell differentiation and function of osteoblasts and osteoclasts during skeletogenesis and bone remodeling4 Runx2 is a cell-specific member of the Runt family of transcription ... ATF3 in mice led to the prevention of receptor activator of nuclear factor-κB (RANK) ligand (RANKL)-induced bone resorption and bone loss, although neither bone volume nor osteoclastic parameter

Ngày tải lên: 19/11/2022, 11:38

... as well as the risk of severe pneumonitis, especially in pre-treated patients Abbreviations BS: Bone sarcomas; BSTS: Bone and soft tissue sarcomas; BSTTSG: Bone and Soft Tissue Tumor Study Group; ... and Soft Tissue Tumor Registry reported by the Musculoskeletal Tumor Committee of the Japanese Orthopaedic Association, only 591 cases of bone sarcoma (BS) and 1509 cases of soft tissue sarcomas ... status and future prospects J Clin Oncol 1995;13:2865–8 Svancarova L, Blay JY, Judson I, et al Gemcitabine in advanced adult softtissue sarcomas A phase II study of the EORTC Soft tissue and Bone

Ngày tải lên: 04/12/2022, 10:35

... with soft-tissue sarcoma Ann Oncol 2004;15:1261–6 13 Yoon SS, Segal NH, Park PJ, Detwiller KY, Fernando NT, Ryeom SW, et al Angiogenic profile of soft tissue sarcomas based on analysis of circulating ... standard of care after doxorubicin-failure or intolerance Main subtypes of soft tissue sarcoma are: liposarcoma (25-30%), leiomyosarcome (25-30%) and synovial sarcomas (10%) Angiogenesis is of ... tumour tissue as a prognostic factor of soft tissue sarcomas Br J Cancer 2001;84:1610–5 10 Graeven U, Andre N, Achilles E, Zornig C, Schmiegel W Serum levels of vascular endothelial growth factor and

Ngày tải lên: 30/09/2020, 13:05

... understand the risk: benefit ratios of available agents and combinations Keywords: Systematic review, Pazopanib, Soft tissue sarcoma Background Soft tissue sarcomas (STS) are a heterogeneous group of ... identification of only a small number of RCTs and the lack of comparability in terms of sample size, study design, and patient populations across both the RCTs and non-randomised studies The patient ... later line treatment of patients with advanced/metastatic soft tissue sarcoma is to delay disease progression and maintain quality of life for as long as possible The use of an anti-tumour treatment

Ngày tải lên: 05/11/2020, 05:59

... malignant bone and soft tissue tumors, and to evaluate the prognostic significance of the sN-CAD levels Methods: We examined the level of serum sN-CAD using an ELISA in 80 malignant bone and soft tissue ... sN-CAD is a biomarker for malignant bone and soft tissue tumors, and a potentially valuable pre-therapeutic prognostic factor in patients with bone and soft tissue sarcoma Keywords: Sarcoma, Cadherin, ... significance of the sN-CAD levels metastatic cancer patients with musculoskeletal metastases The details of the clinicopathological features of 73 patients of the bone and soft tissue sarcoma

Ngày tải lên: 05/11/2020, 06:47

... of a bone-mimicking plate coupled with a soft-tissue layer and a marrow layer In order to simplify the computation procedure, we consider the bone layer as an isotropic solid while the soft-tissue ... assessment of bone characteristics in the recent reports However, our understanding of wave interaction with bone tissues is still far from complete since the propagation of ultrasonic waves in bones ... consists of a transversely-isotropic cortical bone plate sandwiched between the soft-tissue and marrow layers, were computed using a semi-analytical finite element [7] However, wave propagation and

Ngày tải lên: 28/06/2021, 11:28

... 5.0.9) and an output of percentage sequence identity and percent sequence similarity was generated [26] Location of the b strands (bA- bJ) and the a helices (aI and aII) in zebrafish FABP1a and FABP1b ... National Institute of Health (to CT and BT), the Natural Sciences and Engineering Research Council of Canada (to JMW), and the Izaak Walton Killam Memorial Scholarship (to R-ZL and MKS) Tissue-specific ... Tissue-specific expression of fabp1a, fapb1b and fabp10 mRNAs during embryonic and larval development, and in adult zebrafish The tissue-specific distribution of fabp1a, fabp1b and fabp10 gene transcripts

Ngày tải lên: 07/03/2014, 12:20

... clinical and bone histomorphometric studies of bone metabolism; effects of contraception and lifestyle on bone density in adolescents; mineralization density of bone; bone histomorphometry of women ... Dialysis, and Transplantation, the Journal of the American Society of Nephrology, and American Journal of Kidney Diseases and is a reviewer for Circulation, New England Journal of Medicine, Annals of ... the University of Sao Paulo in 1992 Dr Jorgetti is a member of the Brazilian Society of Nephrology, Brazilian Society for Bone and Mineral Metabolism, and American Society for Bone and Mineral Research

Ngày tải lên: 22/03/2014, 09:20

... Maurice and Erwan Magueur is greatly appreciated This work was supported by grants from the Lorraine Region and Urban Community of Grand Nancy (CUGN) and from the French Ministry of Research and ... concentrations of a common food pollutant, B[a]P, caused a rapid, direct and profound inhibition of adipose tissue lipolysis stimulated by epinephrine, dobutamine, salbutamol, BRL37344 and ACTH This ... and Higher Education PI is a recipient of a Research Fellowship from the French Ministry of Research and Higher Education, and FTY and BEB are Directors of Research at the ´ ´ Institut National

Ngày tải lên: 30/03/2014, 11:20

... lapse and morbidity. Open placement of pins has led to fewer complications including avoidance to injury to superficial radial nerve and less damage to tendons and soft tissues. Malunion and late ... com- prised of 70 men and 11 women and the mean age was 38. 47 years. 57 of them were involved in heavy labour,3 were students and rest were involved in office work. The mechanism of injury was ... fractures of the distal radius has been documented previously[2]. This could be because external fixation alone d oes not expand crushed cancellous bone and cannot work with- out soft tissue hinges

Ngày tải lên: 20/06/2014, 04:20

... sampled from the stands in Busschewald and Sprakensehl REFERENCES Ashworth EN, Rowse DJ, Billmyer LA (1983) The freezing of water in woody tissues of apricot and peach and the relationship ... defolia- tion and drought, supposed to be one of the causal factors for the several events of decline of sessile and pedunculate oak (Quercus petraea [Matt] Liebl, and Q robur ... (Sakai and Larcher, 1987). Since insect defoliation is one of the pri- mary causal factors of oak decline in north- ern Germany, and since the majority of oak stands investigated

Ngày tải lên: 08/08/2014, 18:21

... processes of generalized osteoporosis and associated with osteoclast activation [3-5] Skeletal maintenance occurs by a tightly coupled process of bone remodeling consisting of a process of bone resorption ... systemic bone turnover In addition, bone loss also takes place focally as a consequence of the arthritic disease process Markers of bone turnover provide an integrated measure of systemic turnover, and ... markers of bone and cartilage turnover, the correlations between the markers and bone mass and joint damage, and the associations between changes in biochemical markers and changes in BMD and joint

Ngày tải lên: 09/08/2014, 01:24

... Figure 3 Prognostic value of TATI concentrations in tumour tissue and serum. ROC curves showing estimations of the prognostic value of t-TATI in surgically obtained tissue (A) and s-TATI drawn at different ... collection of tissue samples and data. AB participated in the conception of the study, BN assisted with the TMA construction and revision of the manuscript, UHS participated in revision of the manuscript, ... in the conception and design of the study, LBJ participated in the collection of tissue samples, data and revised the manuscript, KJ participated in the conception and design of the study, statistical

Ngày tải lên: 09/08/2014, 09:21

... activity, and the combination of CS and GS showed almost no resorption. Discussion Bone turnover is the result of a tightly balanced and coordi- nated action of bone-resorbing and bone-forming ... ligand (RANKL), and OPG/RANKL ratio in human osteoarthritis subchondral bone osteoblasts. Expression and production of OPG (a), expression of RANKL (b), and expression ratio of OPG/RANKL (c) of ... reduce bone resorption. The additive effect of both compounds at inhibiting bone resorptive activity could then be explained by the sum of the effect of CS on the OPG and RANKL and the effect of

Ngày tải lên: 09/08/2014, 10:21

... synovial tissue (per gram of tissue). Effects of HU-210 on ERK1, ERK2, and p38 MAPK activation in fibroblast-like cells Levels of phosphorylated and total ERK1, ERK2 (p44 and p42, respectively), and ... as a percentage of expression of the internal control, β-actin. Data are presented as mean ± standard error of the mean of the expression of CB 1 and CB 2 protein in four OA and four RA patients, ... aspirin and all cytokine inhibitors 10 to 14 days prior to surgery. Histology of synovial biopsies and levels of cytokines Haematoxylin and eosin histology was performed on 26 of the OA and 9 of the

Ngày tải lên: 09/08/2014, 10:23