rheumatoid arthritis diagnose early and treat to target

... PTPN22 1858T, TNFRII 196R and HLA-shared epitope alleles with rheumatoid factor and anticitrullinated protein antibodies to very early rheumatoid arthritis diagnosis Rheumatology (Oxford) 2008, 47:1208-1212 ... prior to the apparition of clinical symptoms, and leads to the production of various autoantibodies (autoAb) easily detectable in serum These autoAb help to understand pathological mechanisms and ... Results Detection of autoantibodies in RA patient sera by western blot analysis Figure Detection of autoantibodies in rheumatoid arthritis patient sera Autoantibodies in rheumatoid arthritis (RA) patient...

Ngày tải lên: 09/08/2014, 13:22

... psoriatic and rheumatoid arthritis Clin Rheumatol 2007, 26:330-4 Chorus AMJ, Miedema HS, Boonen A, Linden S van der: Quality of life and work in patients with rheumatoid arthritis and ankylosing ... in patients with rheumatoid arthritis: effect on healthrelated quality of life J Rheumatol 2004, 31:58-65 Baerkanovic E, Hurwicz ML: Rheumatoid arthritis and comorbidity J Rheumatol 1990, 17:888-92 ... matoid arthritis, ankylosing spondylitis, peripheral PsA rheuStandard difference scores (s-scores) for patients with and Standard difference scores (s-scores) for patients with rheumatoid arthritis, ...

Ngày tải lên: 18/06/2014, 19:20

... Etiology Cytokine Profile of T Cells in the Joints of Rheumatoid Arthritis and Its Murine Models Takashi Usui Chapter Invariant Natural Killer T Cells in Rheumatoid Arthritis and Other Inflammatory ... Shibata and Yoshimitsu Abiko Chapter 10 Part Chapter 11 The Role of miRNA in Rheumatoid Arthritis 171 Seiji Kawano and Yuji Nakamachi Consequences and Co-Morbidities 187 Rheumatoid Arthritis: A Historical ... the Craniocervical Junction and Atlantoaxial Vertebrae 275 T.M Murphy, L McEvoy and C Bolger Preface Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory arthritis, which features...

Ngày tải lên: 27/06/2014, 16:20

... Trials Clinical reports of 31 randomised trials – 21 in osteoarthritis, in rheumatoid arthritis, and in mixed osteoarthritis or rheumatoid arthritis – were provided for the analysis Full company study ... patients who were randomised and received at least one dose of study medication (intention-totreat population) Of these, 25,903 had osteoarthritis, 3,232 had rheumatoid arthritis, and 10,470 were ... LA, Bradley MD: Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials...

Ngày tải lên: 09/08/2014, 06:22

... with rheumatoid arthritis and systemic lupus erythematosus have increased renal excretion of mitogenic estrogens in relation to endogenous antiestrogens J Rheumatol 2004, 31:489-494 32 Kanda ... peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis Arthritis Rheum 2003, 48:2741-2749 35 Straub RH, Besedovsky HO: Integrated evolutionary, immunological, and neuroendocrine ... ASD and testosterone into downstream steroid hormones in mixed synovial cells ASD and testosterone are major delta androgens (Fig 1) Radiolabeled ASD was converted into 5α-dihydro-ASD, testosterone,...

Ngày tải lên: 09/08/2014, 06:23

... Th1/Th2 cytokine balance in arthritis Arthritis Rheum 1997, 40:2105-2115 Tak PP: Is early rheumatoid arthritis the same disease process as late rheumatoid arthritis? Best Pract Res Clin Rheumatol 2001, ... Gordon C, Buckley CD, Salmon M: Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin Arthritis Research & Therapy ... Emery P: Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with...

Ngày tải lên: 09/08/2014, 06:23

Ngày tải lên: 09/08/2014, 07:20

... Radiographic and joint count findings of the hand in rheumatoid arthritis Related and unrelated findings Arthritis Rheum 1988, 31:44-51 Pincus T, Callahan LF: Quantitative measures to assess, monitor and ... radiologic damage in patients with rheumatoid arthritis in clinical remission Arthritis Rheum 2004, 50:36-42 Emery P, Salmon M: Early rheumatoid arthritis: time to aim for remission? Ann Rheum Dis ... classification of rheumatoid arthritis Arthritis Rheum 1988, 31:315-324 Aletaha D, Smolen JS: The rheumatoid arthritis patient in the clinic: comparing more than 1,300 consecutive DMARD courses Rheumatology...

Ngày tải lên: 09/08/2014, 10:20

... genome-wide linkage analysis of rheumatoid arthritis, including covariates Arthritis Rheum 2004, 50:2757-2765 Horton MA: The αv β3 integrin ‘vitronectin receptor’ Int J Biochem Cell Biol 1997, ... Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4 Am J Hum Genet ... Cancer Inst 1959, 22:719-748 de Vries RR, Huizinga TW, Toes RE: Redefining the HLA and RA association: to be or not to be anti-CCP positive J Autoimmun 2005, 25(Suppl):21-25 Lee YH, Rho YH, Choi...

Ngày tải lên: 09/08/2014, 10:21

... Initiation of rheumatoid arthritis treatments and the risk of serious infections Rheumatology 2010, 49:82-90 53 Hamalainen M, Raunio P, Von Essen R: Postoperative wound infection in rheumatoid arthritis ... corticosteroids on the efficacy and toxicity of chrysotherapy in rheumatoid arthritis J Rheumatol 1994, 21:435-441 Jasani MK, Downie WW, Samuels BM, Buchanan WW: Ibuprofen in rheumatoid arthritis Clinical ... Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis Ann Rheum Dis 2008, 67:656-663 Durez P, Malghem J, Nzeusseu Toukap...

Ngày tải lên: 12/08/2014, 17:22

... in rheumatoid synovial membrane and rheumatoid synovial fluid Arthritis Rheum 1983, 26:479-485 25 Scott DL, Wainwright AC, Walton KW, Williamson N: Significance of fibronectin in rheumatoid arthritis ... overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis Arthritis Rheum 1999, 42:948-953 Yamanishi ... inflammatory diseases Immunol Today 2000, 21:78-82 Firestein GS, Nguyen K, Aupperle KR, Yeo M, Boyle DL, Zvaifler NJ: Apoptosis in rheumatoid arthritis; p53 overexpression in rheumatoid arthritis...

Ngày tải lên: 09/08/2014, 06:23

... referred to as the cyclophosphamide embryopathy, are similar to those seen following prenatal exposure to methotrexate and include growth deficiency, craniofacial anomalies, and absent fingers and toes ... hemorrhage and cystic brain lesions have been seen in preterm infants exposed to indomethacin prior to delivery [27,28] These complications are thought to be related to the extent to which the ... rheumatologists Of 463 pregnancies identified by rheumatologists, detailed data were gathered on 95 pregnancies, 84 of which were determined to have been exposed to a tumor necrosis factor inhibitor...

Ngày tải lên: 09/08/2014, 08:22

... and activating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritis Arthritis Rheum 2004, 50:3878-3887 ... inhibitory FcγRIIb in rheumatoid arthritis Arthritis Res Ther 2007, 9:R51 Wijngaarden S, van de Winkel JG, Jacobs KM, Bijlsma JW, Lafeber FP, van Roon JA: A shift in the balance of inhibitory and ... optimized to improve treatment of arthritis Considering the arthritis- inducing capacity of antibodies characteristic for RA [5], the new opportunity to study surface expression of inhibitory and activating...

Ngày tải lên: 09/08/2014, 10:20

... development of rheumatoid arthritis Scand J Rheumatol 2004, 33:300-306 Kastbom A, Ahmadi A, Söderkvist P, Skogh T: The 158V polymorphism of Fc gamma receptor type IIIA in early rheumatoid arthritis: ... Comorbidities in rheumatoid arthritis Best Pract Res Clin Rheumatol 2007, 21:885-906 Askling J, Dixon W: The safety of anti-tumour necrosis factor therapy in rheumatoid arthritis Curr Opin Rheumatol 2008, ... CL, Toes RE, Huizinga TW: Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study Arthritis...

Ngày tải lên: 09/08/2014, 10:23

... two groups Aggressive treatment in early arthritis Early arthritis clinics One approach to improving early referral and treatment of rheumatoid arthritis is to use early arthritis clinics, in ... associations with rheumatoid arthritis: loci with strong associations 4 • POCKET REFERENCE TO EARLY RHEUMATOID ARTHRITIS Socioeconomic burden of rheumatoid arthritis Rheumatoid arthritis is a chronic ... REFERENCE TO EARLY RHEUMATOID ARTHRITIS rheumatoid arthritis One study of several databases noted that the percentage of patients with undifferentiated arthritis that evolved into rheumatoid arthritis...

Ngày tải lên: 22/03/2014, 09:20

... Consortium on Rheumatoid Arthritis Families: Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22–620 W allele Arthritis Res ... Association of rheumatoid arthritis treatment response and disease duration with declines in serum levels of IgM rheumatoid factor and anti-cyclic citrullinated peptide antibody Arthritis Rheum ... contributed to the conception of the study and to the analysis and interpretation of data and was the main contributor to the preparation of the manuscript SGM contributed to the acquisition and analysis...

Ngày tải lên: 09/08/2014, 01:22

... by PBMCs from RA patients to that by * IL-18BP * IL-12+IL-18 IL-12+IL-18BP IFN-γ (ng/ml) Effect of IL-12 and IL-18 on rheumatoid arthritis synovium cells (a) Rheumatoid arthritis synovium cells ... with rheumatoid arthritis Arthritis Rheum 2001, 44:275-285 Aizawa Y, Akita K, Taniai M, Torigoe K, Mori T, Nishida Y, Ushio S, Nukada Y, Tanimoto T, Ikegami H, Ikeda M, Kurimoto M: Cloning and ... chronic rheumatoid synovitis? Arthritis Rheum 1990, 33:768-773 Panayi GS, Lanchbury JS, Kingsley GH: The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis...

Ngày tải lên: 09/08/2014, 01:23

... anti-Sa-negative rheumatoid arthritis DMARD, disease-modifying anti-rheumatic drug; RA, rheumatoid arthritis; RF, rheumatoid factor Errors are shown as standard deviations Data from [5] Serum reactivity to ... between autoantibodies and inflammatory arthritis Science 2002, 297:1689-1692 Schaller M, Burton DR, Ditzel HJ: Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human ... peptide, and IgM rheumatoid factor (RF) as prognostic markers of disease severity in early polyarthritis patients [abstract] Arthritis Rheum 2003, 48 Suppl:S666 Available online http:/ /arthritis- research.com/content/6/2/86...

Ngày tải lên: 09/08/2014, 01:23

... citrullinated peptide (CCP) and immunoglobulin-A rheumatoid factor predict the development of rheumatoid arthritis Arthritis Rheum 2003, 10:2741-2749 Jawaheer D, Gregersen PK: Rheumatoid arthritis The genetic ... citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis Rheumatology 2003, 42:677-680 R307 Arthritis Research & Therapy 10 11 12 ... autoimmune disease: a failure to protect? Rheumatology 2000, 39:1060-1066 Wernhoff P, Olofsson P, Holmdahl R: The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis...

Ngày tải lên: 09/08/2014, 01:23

... association with C5aR and FcgRIII-mediated cell activation resulting in innate cell mediator activation and the production of inflammatory cytokine interleukin-1 and TNF-α, leading to joint destruction ... of the inhibitor of apoptosis family (cIAP-1, XIAP and survivin, which directly bind to and inhibit caspases), was strikingly reduced Dr Brigitte Mueller-Hilke (University of Rostock, Germany) ... susceptible and resistant rat strains Several loci that control the onset of arthritis, the severity and chronicity of the disease, and autoantibody production have been identified and been confirmed...

Ngày tải lên: 09/08/2014, 01:23