recent advances in pc12 cells

... vibration response In this case, a small damping coefficient was included in the model It is noticeable how the nonlinear stiffness deforms the phase space pattern, and instead of producing an ellipse, ... appropriate monitoring system, it can detect early faults in the gear teeth, or damaging effects caused by changes in the operating conditions 3.2 Discontinuous stiffness Stiffness discontinuities are ... A typical ball-bearing system consists of five contact parts: the shaft, the inner ring, the rolling elements, outer ring and the housing The deformation of each part will influence the Trang...

Ngày tải lên: 19/06/2014, 19:20

... These findings provide information regarding drug-dependentchanges in undifferentiated hESCs indo-In the field of toxicity testing or drug screening, the application of hESCs ispromising since ... characteristicssuch as Z bands and intercalated disks, express various cardiac proteins includingα-cardiac actin, atrial myosin light chain, ventricular myosin light chain, α-myosinheavy chain, atrial natriuretic ... hindered the establishment of these cells.2.3.1 Reprogramming Owing to development of methods introducing reprogramming factors (e.g., OCT4,SOX2, KLF4, C-MYC, NANOG, LIN28, and REX1) to the cells,...

Ngày tải lên: 14/05/2018, 15:15

... signaling cas-cades originating from other receptor systems are involved in modulating Smad signaling [14,27,30,51,52] In the present work, we demonstrate that in PC12 cells NGF-stimulated signaling ... analysed in parental PC12 cells and in stable PC12 cells expressing TbRII-wt under the control of a doxycycline-inducible promoter Figure 2A shows that treatment with TGF-b1 results in C-terminal ... transfection of PC12 cells with TbRII but not TbRI constructs leads to increased responsiveness to TGF-b1 (Fig 2B), again indi-cating that TbRII is the limiting component of TGF-b1 signaling in PC12 cells...

Ngày tải lên: 16/03/2014, 16:20

... bodily origins, including saliva, urine, blood, and breath For use with exhaled breath, the devicemay include a HEMT bonded on a thermo-electric cooling device, which assists in condensing exhaledbreath ... testing In consumer healthcare, diabetics would be able to test theirglucose level, replacing painful and inconvenient finger-prick devices For roadside screening of driv-ing impairment, a point-of-care ... ppm) in N 2 for Trang 101000 ppm The resistance after exposing the nanowires to air was restored to approximately 90% ofinitial level within 2 min[30,31].Similar results can be obtained with InN...

Ngày tải lên: 20/03/2014, 13:06

... maintained in DMEM, containing 2% horse serum, for 24 h before pro-saposin treatment (10 nm for 5 min at 37C) and labelling Cells were rinsed, and fixed in 4% formaldehyde in NaCl⁄ Pifor 30 min ... lipoprotein (LDL) receptor-related protein (LRP-1) [8] The presence of lipid-binding domains in prosaposin and saposins has been well demonstrated [9], and a Keywords lipid domains; PC12 cells; ... also secreted into various body fluids [3], and mRNA and protein levels increase following peripheral nerve injury Exogenous prosaposin promotes axonal sprouting in neural cells and myelin lipid synthesis,...

Ngày tải lên: 24/03/2014, 00:21

... 1RECENT ADVANCES INAUTISM SPECTRUM DISORDERS - VOLUME II Edited by Michael Fitzgerald Trang 2Recent Advances in Autism Spectrum Disorders - Volume IINotice Statements and opinions expressed in ... theill, infirm and elderly was common, see [3,4] From at least one million years ago we see evi‐dence for widespread collaboration in hunting, in sharing food and in looking after increas‐ingly ... example focusing on spinning objects or lining up toys, and seem to derive comfort from precise ordering or regular patterning (see [33]) as seen above Adults in turn, even if high func‐ tioning and...

Ngày tải lên: 30/03/2014, 09:20

... carotenoids (Vitamin A, 2007), vitamin D is synthesized in the skin when in direct contact with UVB radiation (Vitamin D, 2007), and vitamin K is made by bacteria living in the intestines when insufficient ... of vitamin A that they were ingesting (Vitamin A, 2007) Not all vitamins need to be ingested in their final form because the body can synthesize some vitamins from other molecules Vitamin A is ... clothing, moving to temperate climates, and the tradition of keeping infants indoors), increased skin pigmentation, reduced in-utero exposure, and reduced capacity to synthesize vitamin D with increasing...

Ngày tải lên: 31/03/2014, 22:20

... terpenoids in plant cell cultures Strategies for defining pathways and uncovering rate-influencing steps in global metabolism, and applying this information for successful terpenoid metabolic engineering, ... were evaluated for anti-inflammatory activity by using carrageenin induced hind paw oedema in rats, xylene induced ear odema in mice and cotton pellet induced granuloma in rats It was be concluded ... investigations into the molecular mechanisms of action of garlic compounds are lacking, allicin and ajoene have been investigated in two new in vitro models The first used an apoptosis inducing...

Ngày tải lên: 28/05/2014, 15:10

... www.mdpi.com/journal/sensors Review Recent Advances in Nanotechnology Applied to Biosensors Xueqing Zhang, Qin Guo and Daxiang Cui * Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and ... while interacting with its target, thereby leading to high binding affinity and sensitive detection GNPs in biosensors can also provide a biocompatible microenvironment for biomolecules, greatly increasing ... used for a multiplexing detection device of various targets In another study, they examined the quantification of the plasmonic binding events and estimation of ligand binding kinetics tethered...

Ngày tải lên: 28/05/2014, 15:12

... October, 2011 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org Recent Advances in Robust Control ... expense of chattering in the control variable It is shown in Chapter 7 that combining quantitative feedback theory and sliding mode control can alleviate this phenomenon An integral sliding mode controller ... computing and self-organizing systems It is outlined how the robust control problem can be represented in an information theoretic setting using entropy A toolbox for the robust fuzzy control using...

Ngày tải lên: 19/06/2014, 08:20

... for bounding crossterms used in these methods also bring conservativeness Recently, in order to reduceconservatism, the weighting matrix technique was proposed originally by He and al in(He et ... employing a fuzzyLKF combining the introduction of free weighting matrices which improves existing ones in(Li et al., 2004) - (Chen & Liu, 2005a) without imposing any bounding techniques on somecross ... presented involve three tuning parameters However, only one tuning parameter is involved in our approach. recently proposed (Wu & Li, 2007), (Chen & Liu, 2005a), (Guan & Chen, 2004) In next...

Ngày tải lên: 19/06/2014, 08:20

... here to obtain a fuzzy model from (57) By decomposing the nonlinear term 12 1+x t( ) and integring nonlinearities of x t2( ) into incertainties, then (20) is represented by the following fuzzy ... modeling leads to controller cost minimization [7,10,13] An example is the modern integrated circuits (ICs), where increasing package density forces developers to include side effects Knowing ... obtain the following convex optimization problem: minimization γ under the LMI constraints (46) From lemma 1, 2, 3 and 4 yields the following theorem: Theorem 2: The closed-loop uncertain fuzzy...

Ngày tải lên: 19/06/2014, 08:20

... considered in this Chapter include: • Minimum time – resulting in the so-called time-optimal control • Minimum fuel – resulting in the so-called fuel-optimal control • Quadratic performance index ... of nonlinear systems using the neural network based techniques The systems of interest are linear in both control and parameters, and feature time-varying, parametric uncertainties, confined control ... at developing an Trang 14intelligent control design framework to guide the controller design for uncertain, nonlinear systems to address the combining challenge arising from the following: • The...

Ngày tải lên: 19/06/2014, 08:20

... ( ) S t = in ( ) 0 a finite time less than or equal to S t η In other words, by maintain the condition in ( ) equation (11), S t will approaches the sliding surface ( ) S t = in a finite time, ... varying hyperplane in ℜ on which the tracking error vector 2 e t ( ) decays exponentially to zero, so that perfect tracking can be obtained asymptotically Moreover, if we can maintain the following ... converter models In section 4, a detailed overview of WNN methods is presented Robust control is introduced in section 5 to increase the robustness against noise by implementing the error minimization...

Ngày tải lên: 19/06/2014, 08:20

... However, due to parametric uncertainties and modeling inaccuracies chattering can be observed which causes a major problem in applying SMC alone In general, the chattering enhances the driver fatigue ... chattering behavior remain unresolved Implementing QFT during the sliding phase of a SMC controller not only eliminates chatter but also achieves vibration isolation In addition, QFT does not diminish ... discontinuity is highly dependent on the parametric uncertainty of the system In order to satisfy sliding conditions and for the system trajectories to remain on the sliding surface, the following...

Ngày tải lên: 19/06/2014, 08:20

... are continuous The four case sliding surfaces are shown in fig 15, those are continuous also The three case continuously implemented control inputs instead of the discontinuous input in Fig 12 ... depicted in Fig 6 As can be seen, the trajectories are continuous The four case sliding surfaces are shown in fig 7, those are continuous The three case continuously implemented control inputs instead ... )G y is a nonlinear output feedback gain satisfying the relationship (37) and (49), G Δ is a switching gain of the state, G is a feedback gain of the output feedback integral 1 sliding surface,...

Ngày tải lên: 19/06/2014, 08:20

... August, 2011 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org Recent Advances in Vibrations ... Trang 1RECENT ADVANCES IN VIBRATIONS ANALYSIS Edited by Natalie Baddour Trang 2Recent Advances in Vibrations Analysis Edited by Natalie Baddour Published by InTech Janeza Trdine 9, 51000 ... the traveling wave incident upon a discontinuity due to geometric or kinetic constraints is described by the local wave reflection and transmission matrices Combining these matrices in a progressive...

Ngày tải lên: 19/06/2014, 19:20

... defined in the region xx0 to distinguish it from the one defined in the region x<x0 Combining Eqs (2.35) and (37), one can determine the ampltitude of the wave that rises at the loading point ... )1 0 1( ; )1 1 1 ( ; )1 1 Defining v as the wave injected by the applied load, the difference in amplitudes between the incoming and outgoing waves at the loading point is 2 D 1 D * 2l R * ... Now by applying the global wave transmission coefficient defined in Eq (2.25) to C i in the above equation, the displacement at any point in span i of the string can be expressed in terms of...

Ngày tải lên: 19/06/2014, 19:20

... Immunohistochemical staining A) Positive cytoplasmic immunostain for chromogranin in the pheochromocytoma; B) Immunostain for S-100 protein shows intense dark staining of elongated nuclei of sustentacular cells ... Phospholipase A2 and Signaling Pathways in Pheochromocytoma PC12 Cells Alexey Osipov and Yuri Utkin Programmed Cell Death Mechanisms and Pheocromocytomas: Recent Advances in PC12 Cells 85 Davide Cervia ... different types of cells Epinephrine secreting cells have smaller, moderately electron-dense granules that are closely applied to their limiting membranes Norepinephrine secreting cells' granules...

Ngày tải lên: 27/06/2014, 17:20

... 4 – – – bind to peptidoglycan-like structures [41] and a chitinbinding domain (InterPro acc no.: IPR001002) [42,43] This type of chitin-binding domain corresponds to carbohydrate-binding module ... have a domain structure consisting of a class I chitin-binding domain (InterPro acc no.: IPR001002; CBM 18 according to the CAZy classification) [44], comprising eight disulfide-linked cysteines [43] ... N-acetylglucosamine binding proteins containing the disulfide-rich domain of wheat germ agglutinin J Mol Evol 33, 283–294 Coutinho PM & Henrissat B (1999) Carbohydrateactive enzymes: an integrated...

Ngày tải lên: 07/03/2014, 12:20