reactions to selected drugs and biologic agents table 8 4

... of Safety and Emergency Preparedness, PCR Chemical Company, P.O Box 146 6, Gainesville, FL 32602- 146 6; 9 04- 376 -82 46 , Ext 2 84 ; 9 04- 373-7503 (Fax) TEAM-1 ENVIRONMENTAL SERVICES, HAMILTON, ONTARIO, ... Street, Hamilton, Ontario, L8W 3P2 Canada; 905 383 -5550; 905-5 74- 049 2 (Fax) THE BOEING COMPANY, SEATTLE, WASHINGTON Gary D Gordon is a toxicologist and a captain with Boeing’s Security and Fire Protection ... Gary D Gordon, Toxicologist, Haz Mat Response, Security and Fire Protection, The Boeing Company, P.O Box 3707, MS 34- 67, Seattle, WA 981 24- 2207; 253-657 -86 57; 253-6579 988 (Fax); 206- 949 -2529 (Cellular)...

Ngày tải lên: 11/08/2014, 06:22

... profusion, and mark number and time — Quintilian Rhetorician, 189 5 One of my favorite “hand” stories was from a CEO’s spouse, “My husband and I have a reputation for holding hands at corporate and community ... Customers need to see you Your salespeople need to see you and your constituents need to see you 155 HOW TO ACT LIKE A CEO You have to meet customers They like to meet you That means you have to ... meeting, their names and their spouses You have a chicken dinner, talk, shake lots of hands, and pass out praise and a company award You go to bed with a migraine And repeat it tomorrow And when you...

Ngày tải lên: 10/08/2014, 07:21

... 25 M 9.09 16.67 28. 57 37.50 44 .44 50.00 66.67 75.00 80 .00 83 .33 3.23 6.25 11.77 16.67 21.05 25.00 40 .00 50.00 57. 14 62.50 1.69 3.23 6.25 9.09 11.77 14. 29 25.00 33.33 40 .00 45 .46 STRUCTURE—ACTIVITY ... inhibitors Comparing Equations 8. 14 and 8. 10 reveals that the two are equivalent when is infinite Under these conditions the term [S](1 ; [I]/ K ) reduces to [S], and Equation 8. 14 hence reduces to ... substrate concentration at 0, 10, and 25 M concentrations of an inhibitor, and obtain the results shown in Table 8. 1 If we were to plot these data, and fit them to Equation 5. 24, we would obtain a graph...

Ngày tải lên: 13/08/2014, 07:20

... 12 .8 12.1 16 .8 High blood glucose 5 .8 5.6 7.0 Physical inactivity 5.5 5.1 7.7 Overweight and obesity 4 .8 4. 2 8. 4 High cholesterol 4. 5 4. 3 5 .8 Low fruit and vegetable intake 2.9 2.9 2.5 19.1 18. 1 ... region, 20 04 World Low and middle income High income 3.6 4. 0 1.6 Illicit drugs 0 .4 0 .4 0 .4 Tobacco use 8. 7 7.2 17.9 12.6 11.5 19.6 Alcohol use 4. 4 4. 2 6.7 Illicit drugs 0.9 0 .8 2.1 Tobacco use 3.7 3.1 ... attributable to six risk factors for child and maternal undernutrition, and to six risks combined; countries grouped by income, 20 04 14 Table 4: Deaths and DALYs attributable to six diet-related...

Ngày tải lên: 14/03/2014, 09:20

... 78 ix x Misfortunes of War: Press and Public Reactions to Civilian Deaths in Wartime 3 .4 3.5 3.6 3.7 3 .8 3.9 3.10 3.11 3.12 3.13 3. 14 3.15 4. 1 4. 2 4. 3 4. 4 4. 5 4. 6 4. 7 4 .8 4. 9 How Closely ... 88 xiii xiv Misfortunes of War: Press and Public Reactions to Civilian Deaths in Wartime 3 .8 3.9 3.10 3.11 3.12 3.13 3. 14 3.15 3.16 3.17 3. 18 3.19 3.20 3.21 3.22 3.23 4. 1 4. 2 4. 3 4. 4 4. 5 ... 136 Tables 4. 6 4. 7 4 .8 4. 9 4. 10 4. 11 4. 12 5.1 5.2 5.3 5 .4 5.5 5.6 5.7 5 .8 5.9 5.10 5.11 5.12 5.13 5. 14 xv Accuracy of Information Government Is Providing...

Ngày tải lên: 29/03/2014, 18:20

... **P < 0.01 Figure Cytostatic and cytotoxic effects of CD437, LND and BA treatment on ADF cells CD437, BA and LND exert both cytostatic and cytotoxic effects on ADF cells (A) Mitotic index analysis ... with drugs at the selected concentration and after additional 24 or 48 hours were stained with μg/ml Hoechst 33 342 , μg/ml Propidium iodide (PI, Sigma-Aldrich, 81 845 , St Louis, MO) and μM acetomethoxy ... were not detectable 6, 24 and 48 hours after the treatment with CD437 and LND either at the IC50 or higher doses However, several AVO-positive cells were detectable 6, 24 and 48 hours after treatment...

Ngày tải lên: 18/06/2014, 15:20

... (12.3) 98. 3 1,2 (12.9) 82 .2 (6.2) 87 .1 ( 14 .8) 84 .3 1,2 ( 18) 81 .5 (23 .4) 72.2 (20 .8) 74. 9 1,2 (22 .8) (5)1,2 97 .8 1,2 (12.9) 96.2 (13 .4) 81 .8 (7.3) 81 .8 (15.5) 80 .8 (19.2) 79.3 (23.9) 70.3 ( 24. 6) ... (12) 82 .5 (5 .8) 88 .5 2,3 (15.5) 86 .6 ( 18. 4) 82 .9 (22.2) 74. 5 (20.1) 76 .4 1,2 (19.5) (6)1,2 102.5 2,3 (12) 101 .8 2,3 (13 .8) 81 .7 (6 .8) 90.6 2,3 (17) 88 .4 (21.9) 85 .1 ( 24. 6) 74. 2 (23.1) 77 .8 1,2 ... 1,2 (6 .4) 171 .4 (6.7) 66.2 1,2 (11.5) 11.9 (4. 9) 40 .1 2,3 (7 .8) 171 .8 (6 .8) 67.3 1,2 (11.6) 12 .8 (6.6) 41 .8 (8. 3) 172.3 (5 .8) 713 (12 .4) 14. 6 3 ,4 (5.9) 39.3 (7 .8) 172.2 (6 .4) 65 .8 (11.5) 13 .8 (6.6)...

Ngày tải lên: 20/06/2014, 00:20

... wavelengths between 320 and 40 0 nm and is ~1000-fold less efficient in producing skin redness than is UV-B The wavelengths between 40 0 and 700 nm are visible to the human eye The photon energy in the ...

Ngày tải lên: 07/07/2014, 01:20

... and/ or release of vasoactive mediator(s), or cytokines, that diffuse to the dermal vasculature to evoke vasodilatation The action spectrum for sunburn erythema includes the UV-B and UV-A Photons ... factor-κB (NF-κB)-dependent gene transactivation can augment release of several proinflammatory cytokines including interleukin (IL) 1B, 1L-6, IL -8, vascular endothelial growth factor, prostaglandin ... they absorb incident energy both in the Soret band, around 40 0 nm (short visible), and to a lesser extent in the red portion of the visible spectrum ( 580 –660 nm) This results in the generation of...

Ngày tải lên: 07/07/2014, 01:20

... sensitive to UV-B, UV-A, and visible wavelengths Diagnostic confirmation of phototoxicity and photoallergy can often be obtained using phototest procedures In patients with suspected phototoxicity, ... drug photosensitivity involves first and foremost the elimination of exposure to the chemical agents responsible for the reaction and minimization of sun exposure The acute symptoms of phototoxicity ... tetrapyrrole or porphyrin, and the nonmetal chelated porphyrins are potent photosensitizers that absorb light intensely in both the short (40 0 41 0 nm) and the long ( 580 –650 nm) portions of the...

Ngày tải lên: 07/07/2014, 01:20

... eliminates exposure to porphyrinogenic agents Erythropoietic protoporphyria originates in the bone marrow and is due to a decrease in the mitochondrial enzyme ferrochelatase secondary to numerous gene ... Treatment of PCT consists of repeated phlebotomies to diminish the excessive hepatic iron stores and/ or intermittent low doses of the antimalarial drugs chloroquine and hydroxychloroquine Long-term remission ... erythrocyte protoporphyrin Detection of increased plasma protoporphyrin helps to differentiate lead poisoning and iron-deficiency anemia, in both of which elevated erythrocyte protoporphyrin levels...

Ngày tải lên: 07/07/2014, 01:20

... of these modalities continues to be excellent Further Readings Lim HW et al: Sunlight, tanning booths, and vitamin D J Am Acad Dermatol 52 :86 8, 2005 [PMID: 1 585 8 48 0 ] Miller AJ, Mihm MC Jr: Melanoma ... Phototherapy and Photochemotherapy UV can also be used therapeutically The administration of UV-B alone or in combination with topically applied agents can induce remissions of psoriasis and atopic ... effects of long-term UV-B phototherapy and PUVA photochemotherapy mimic those seen in individuals with chronic sun exposure and include skin dryness, actinic keratoses, and an increased risk of skin...

Ngày tải lên: 07/07/2014, 01:20

... due to failure to control for confounding factors such as sunscreen stability and frequency of application Since no prospective studies are available to address this issue, it seems reasonable to ... spectra, and the specific biochemical events orchestrating these changes are only partially understood, although UV-A seems to be primarily involved Chronologically aged, sun-protected skin and photoaged ... help to explain the leathery texture and the blotchy discoloration of sun-damaged skin UV-A is important in the pathogenesis of photoaging in human skin, and ROS are likely involved The dermis and...

Ngày tải lên: 07/07/2014, 01:20

... (2 54 .85 5) 2. 788 * (2 .4 38, 3.117) 1 .45 0 * (1.262, 1.6 38) 2.707 * (2 .42 5) docetaxel 79 1. 087 (0 .46 3) 1. 087 (0 .87 1, 1.302) 0.109 (-0.209, 0 .42 7) 1.073 (0 .89 0) doxorubicin 101 1.0 74 (0 .44 5) 1.0 74 ... docetaxel 18 0. 588 (4 .80 5) 0. 587 (0.370, 0 .80 5) -0.773 (-1 .43 1, -0.115) 0.591 (0 .40 1) doxorubicin 41 1.036 (0.021) 1.036 (0.762, 1.309) 0.032 (-0 .4 08, 0 .47 1) 1.0 14 (0. 782 ) 5-fluorouracil 44 1.320 ... paclitaxel 42 ,0 38 2 28 * 79 * 12 * docetaxel 36, 983 79 18 17 * procarbazine asparaginase 1, 287 6 ,41 4 1 b) teniposide 151 0 etoposide 28, 2 64 31 25 doxorubicin 47 ,83 4 101 41 6-mercaptopurine 9,170...

Ngày tải lên: 10/08/2014, 10:21

... Pretreatment, and Decon Basic Behavior of Chemical Agents To Decontaminate or Not To Decontaminate Types of Chemical Agents Chapter Biological Agents and Toxins Introduction Potential Biological Warfare Agents ... vehicle to the motel After a short meeting, Martinez went to his Room 14 and Mathews and Gary Yarbrough went up to their rooms on the second floor At dawn, an F.B.I agent called Room 14 and told ... the agents Mathews was armed with at least one automatic weapon Attempts at negotiations continued on through the day and into December 8, 1 9 84 Mathews then refused to negotiate any more or to...

Ngày tải lên: 11/08/2014, 06:22

... Denise Nevins, Civil Defense Coordinator, Meridian Medical Technologies, Inc., 10 240 Old Columbia Road, Columbia, MD 21 046 ; 41 0-309- 147 7 or 80 0-6 38- 8093; 41 0-309- 147 5 (Fax); http://www.meridianmeds.com ... or DS2; steam and ammonia in confined areas; M258A1, M 280 , soap and water Detection in the field: Draeger Phosphoric Acid Ester 0.05a tube, M18A2, M256A1, M8 and M8A1 alarms, M8 and M9 paper Carcinogen: ... in food stores as a 5% solution under various brand names, and as a 14 to 19% solution at commercial laundries Undiluted, household bleach is harmful to skin and clothing, and corrosive to metals...

Ngày tải lên: 11/08/2014, 06:22

... it to operate continuously for up to four months Contact: Environmental Technology Group, Inc., 140 0 Taylor Avenue, P.O Box 9 84 0, Baltimore, MD 21 2 84 - 9 84 0; 41 9-321-5370; 41 0-321-5255 (Fax) Biological ... blood, and choking agents and warn responders or military troops through both audible and visible alarms This detector is currently in use by U.S and NATO forces It weighs only eight ounces, and ... coverage, and the higher the toxic effects Dosage is a very important factor in relation to biological agents Chemical agents have an “effective dose,” the amount of a substance that may be expected to...

Ngày tải lên: 11/08/2014, 06:22

... standards 47 1, 47 2, and 47 3 reflect the latest technical knowledge and hands-on experience of people who actually work with hazardous materials NFPA 47 1: Recommended Practice for Responding to ... 0 380 1; 603 -43 6-1236 or 80 0- 344 -44 58; 603 -43 6-1392 (Fax) Experienced responders maintain incident vigilance and discipline in order to control the response effort To control the scene, nonessential ... technician, and incident commander levels The potential threat of terrorist activity led to a Tentative Interim Amendment (TIA) to Standard 47 2 during 1997 According to the NFPA, “a TIA automatically...

Ngày tải lên: 11/08/2014, 06:22