quality safety and efficacy of dna vaccines

... the long-term efficacy, safety, and tolerability of risperidone in adolescents with schizophrenia are limited The objective of this study was to evaluate the efficacy and safety of maintenance ... open-label, multicenter evaluation of the long-term safety and efficacy of risperidone in adolescents with schizophrenia Gahan Pandina, Stuart Kushner, Keith Karcher and Magali Haas* Abstract Background: ... in one of two short-term, double-blind, controlled clinical stud-ies (NCT00088075 and NCT00034749) assessing the short-term efficacy and safety of risperidone (Figure 1) [8,9] Inclusion and exclusion

Ngày tải lên: 14/01/2020, 20:36

... newly designed CARs proposed for improving specificity and proliferation of CAR-T cells, offering new insights into improving safety and efficacy of CAR-T cell therapy. Key words： chimeric antigen ... 4Improving the safety and efficacy of CAR-T cell therapy  Given the safety concerns about adoptively transferred T cell therapy, improving safety has emerged as a major focus area of current research ... potency and safety Some strategies were pro-posed to overcome toxicities and optimize tumor recogni-tion specificity, including introducrecogni-tion of safety switches and tuning the affinity of CARs

Ngày tải lên: 15/01/2020, 16:29

... have a better safety profile Trang 4Safety and efficacy of propranolol 0.1% eye micro-drops innewborns Recently an open-label, trial was performed to evaluate the safety and efficacy of propranolol ... administra-tion of propranolol may not only be used to treat IH but also be of help in the treatment of ROP A randomized controlled trial [56] was performed to verify the efficacy and safety of oral ... the oral administration of propranolol did not guarantee adequate safety, further experiments investi-gated the efficacy and safety of topical propranolol, in the form of eye drops, in animal

Ngày tải lên: 20/02/2020, 22:21

... addition of TACE would enhance the efficacy of sorafenib therapy in these patients remains controversial In the present study, we compared efficacy and safety between sorafenib mono-therapy and TACE ... by Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, China (GKZ201604); Scientific Research Fund of Ministry of Health of Guangxi Province ... size and branches of the tumor A mixture of 10–20 mL iodized oil, gelfoam particles with 30–50 mg doxorubicin and 50–100 mg cisplatinum were injected into the arter-ial branches The number of TACE

Ngày tải lên: 06/08/2020, 04:55

... range of clinically insignificant difference, so conclusion on equiva-lent efficacy of BCD-022 and reference trastuzumab was made The equivalence of efficacy confirms biosimilarity of BCD-022 and ... study objective was to compare efficacy and safety of BCD-022 and reference trastuzumab Primary study endpoint was overall response rate (cumulative rate of complete and partial responses) in HER2(+) ... with Herceptin® (F Hoffmann-La Roche Ltd., Switzerland) in combination with paclitaxel The objec-tives of the study were to evaluate efficacy, safety and pharmacokinetics of BCD-022 compared

Ngày tải lên: 20/09/2020, 19:03

... a good safety and tolerability profile over the 12 week treatment period Conclusions: Fluticasone/formoterol had a good safety and tolerability profile and showed statistically superior efficacy ... to salbutamol and faster than that of salmeterol [24-27] Extensive research into the safety and efficacy of these two molecules is widely documented in the literature [19-30], and sug-gests that ... provide clinicians with a new and efficacious treatment for the management of persistent asthma The study presented here evaluated the efficacy and safety of fluticasone and formoterol combination

Ngày tải lên: 23/10/2022, 11:10

... presentation of antigen-derived peptides on MHC-I and MHC-II molecules and, in the presence of costimulatory signals, antigen-specific immune responses The immunogenicity and efficacy of DNA vaccination ... ligands (TLR) and CD40 ligands (CD40L) as adjuvants for DNA vaccines encoding a DEC205-single-chain antibody fused to the ovalbumin model antigen or HIV-1 Gag and assessed the priming efficacy of ... improve prevention and treatment of autoimmunity and to raise the efficacy of vaccines against tumors and infec-tious diseases For targeting of DC in vivo, most of the studies use recombinant protein

Ngày tải lên: 02/11/2022, 09:29

... therefore report on safety and efficacy of pretransplant antifibrotics in IPF pa-tients undergoing LTx Pretransplant pulmonary func-tion, functional exercise capacity; and immediate and long-term post-operative ... transplantation (LTx) Methods: Safety and efficacy of antifibrotic drugs in IPF patients undergoing LTx were investigated in a single-centre retrospective cohort analysis Results: A total of nine patients, ... September 2008 and September 2013; and patients were subsequently trans-planted between November 2008 and April 2015 Ninte-danib was started between August 2010 and January 2012; and patients

Ngày tải lên: 04/12/2022, 16:23

... design IMJ, EL, PYK, CH and C-YP contributed to the acquisition of data All authors contributed to the analysis and interpretation of data IMJ and BAH contributed to drafting of the manuscript All ... (5.1–10.0× upper limit of normal [ULN]) and 1 patient with grade 4 (>10× ULN) ALT/AST elevations (Table 6 and Supplementary Table 1) None of the patients were symptomatic, and the 4 of the 5 patients ... 2015;386:1537–1545 Trang 25 14 Lawitz E, Gane E, Pearlman B, et al Efficacy and safety of 12 weeks versus 18 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin for

Ngày tải lên: 04/12/2022, 16:23

... Review and Meta-analysis of Randomized Controlled Trials Assessing Safety and Efficacy of Posterior Pericardial Drainage in Patients Undergoing Heart Surgery, The Journal of Thoracic and Cardiovascular ... results of each meta-analysis done, including confidence intervals and measures of consistency 11-13, fig.2-5 Risk of bias across studies 22 Present results of any assessment of risk of bias ... drainage AND randomized 57 11 posterior pericardium drainage 34 12 posterior pericardium drainage AND randomized 2 13 posterior pericardial chest tube 10 14 posterior pericardial chest tube AND randomized

Ngày tải lên: 26/07/2023, 07:40

... studies for efficacy/safety evaluation of rotavirus vaccine Web-appendix 6 Risk of bias graph Web-appendix 7 Summary of the characteristics of studies included for assessing efficacy/safety of rotavirus ... intussusception and other potential health problems [19] The aim of the present work was to conduct a system-atic review and meta-analysis on the efficacy, safety, and effectiveness of RV5 and RV1 in ... trials assessing efficacy/safety and effectiveness/ impact of rotavirus vaccine Web-appendix 4 Extraction sheet for risk of bias assessment in trials evaluating efficacy/safety of rotavirus vaccine

Ngày tải lên: 24/11/2022, 17:48

... C L E Open AccessEfficacy, safety and feasibility of fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting in pediatric patients receiving moderately and highly emetogenic ... prophylaxis and therapy in pediatric patients between 0.5 and 17 years of age [8] The primary objective of this non-interventional ob-servation study was to evaluate the efficacy, safety and feasibility ... 145 mmol/L), and calcium (≥2.0 mmol/L - 2.6 mmol/L) Clinically-relevant elevations of > 1.5 and > 2.5 times the normal values of hepatic and kidney parame-ters, and decreases of potassium

Ngày tải lên: 17/06/2020, 18:56

... Randomised and treated (with RBV): N=12 Randomised and treated (without RBV): N=9 Discontinued: N=1 (lost to FU) Discontinued: N=1 (lost to FU) Not randomised and treated N=7 Not randomised and ... severity Discussion This was a proof-of-concept study performed to explore the efficacy and safety of the 2-DAA combination of the HCV NS3/4A PI simeprevir and the HCV NS5B NNI TMC647055 administered ... <25 IU/mL undetectable at the actual end of treatment and follow-up); and the presence of HCV NS3/4A, NS5A and/or NS5B variants at baseline and at time of failure in patients not achieving SVR

Ngày tải lên: 24/11/2022, 17:48

... transfected with μg of the FLC, 0.8 μg each of the N and P, and 0.1 μg of the L support plasmids in a volume of 100 μl of Opti-MEM per well Transfection was carried out with Lipofectamine 2000 (Invitrogen, ... (A) and LRT (B) of AGMs rHPIV1 wt and non-ts rHPIV1 mutants were assigned a shut-off temperature of 40°C for the purposes of this schematic The limit of detection for the mean sum of daily virus ... transfected with μg each of the FLC and the pCL-Neo-BCI-T7 plasmid (expressing T7 polymerase under the control of a eukaryotic promoter) [30], 0.2 μg each of the N and P, and 0.1 μg of the L support

Ngày tải lên: 18/06/2014, 18:20

... minimization of the predicted side effects, and then treated four patients with repeated doses of rh-HGF in order to evaluate the safety, pharmacokinetics and clini-cal efficacy of FH therapy ... points The primary endpoint of interest was the safety of repeated doses of intravenous rh-HGF, which was evalu-ated on the basis of the occurrence, frequency, and severity of adverse events All patients ... intravenously for 14 days, and urinary excretion of albumin and protein was measured before (day 1), during (days 7 and 14), and 7 and 14 days after HGF administration Repeated doses of rh-HGF induced

Ngày tải lên: 18/06/2014, 19:20

... of the hepatic artery, and the presence of any vascular occlusion or changes in the flow patterns We will monitor lung toxicity by assessing the necessity of reintubation and the occurrence of ... be expanded The data safety monitoring committee can recommend stoppage of the study for reasons of patient safety at any time Whenever adverse events occur, the principal investigator and the ... EKG, PS, and PP supported the design of the study with their knowledge and experience MHD is the principal investigator of the study and the sponsor ’s representative All authors have read and approved

Ngày tải lên: 18/06/2014, 22:20

... compliance Compliance was assessed by capsule count at visits 3, 4, and and review of subject diary Efficacy and Safety Variables Efficacy and safety measurements assessed Adverse events During the study, ... Canada) Appropriateness of Measurements The efficacy and safety assessments used in this study were standard for OA and are widely used and recognized as reliable, accurate, and relevant WOMAC scores ... common form of arthritis, and it is often associated with significant disability and an impaired quality of life Clinical and radiographic surveys have found that the prevalence of OA increases...

Ngày tải lên: 26/10/2012, 09:48

... effects of remifentanil compared with those of alfentanil [8] and fentanyl [9] are similar; remifentanil also has a safety profile similar to that of other opioids [8-10] The predictable offset of ... maximum rate of 60 µg kg-1 h-1 and/ or additional boluses and/ or increases in the infusion rate of propofol up to a maximum dose of mg kg-1 h-1 to attain and then maintain optimum analgesia and sedation ... and sedation beyond day 3, propofol was discontinued and replaced with midazolam in accordance with local transitioning protocols The infusion rates of fentanyl and morphine and bolus doses and...

Ngày tải lên: 12/08/2014, 20:20

... dose of 20 mg during the course of the study All 14 subjects who were randomized to placebo and completed weeks of treatment had their "dose" of blinded medication "increased" to 20 mg The rate of ... by a clinical evaluation by a child and adolescent psychiatrist Specification of abuse disorder (abuse vs dependence), age of onset of symptoms, and length of illness were based on data obtained ... a group of youths who were at risk for ongoing substance abuse, the dose of fluoxetine used in this study was limited to a maximum of 20 mg/day Although the efficacy of higher doses of fluoxetine...

Ngày tải lên: 13/08/2014, 18:21

... vour 7.3.6 Dietary and handling impacts on texture 7.3.7 Impact of aquaculture handling and killing procedure on post-mortem quality 7.3.8 Effect of feeding on post-mortem quality and technological ... assistance is required, the services of a competent professional should be sought Library of Congress Cataloging-in-Publication Data Handbook of seafood quality, safety, and health applications / edited ... oxidation in ordinary and dark muscle of fis Effects of bleeding and perfusion of yellowtail on post-mortem lipid oxidation of ordinary and dark muscles Conclusions References Blackening of crustaceans...

Ngày tải lên: 29/05/2014, 16:40