proteomics analysis of human nonalcoholic fatty liver

... inoculation of mice 63 2.13 Enzyme-linked immunosorbent assay (ELISA) 64 3 DENDRITIC CELL-DERIVED IFN-γ-INDUCED PROTEIN 3.1.1 Proteomics analysis of DCIP induction by TNF-α 67 3.1.2 Verification of proteomics ... Up-regulation of MG11 in a murine acute lung injury model 85 3.1.8 Up-regulation of MG11 in an influenza A virus-infected lung 4 PROTEOMICS STUDIES OF TNF-α AND/OR 4.1.6 Up-regulation of apoLs in ... model 86 14 Up-regulation of MG11 in an influenza A virus-infected model 88 15 NMR structure of the N-terminal SAM domain of human DCIP 97 16 Representative 2-D gels of NHBE cell lysates 104

Ngày tải lên: 11/09/2015, 16:05

... Trang 1PROTEOMICS ANALYSIS OF PSEUDOMONAS PUTIDA IN BIODEGRADATION OF AROMATIC COMPOUNDS CAO BIN NATIONAL UNIVERSITY OF SINGAPORE 2007 Trang 2PROTEOMICS ANALYSIS OF PSEUDOMONAS PUTIDA ... inhibition of p-cresol to the cometabolic transformation of carbazole in the presence of salicylate by P putida ATCC 17484 The research conducted here was an initial demonstration of the power of proteomics ... ortho-on 800 mg/L of benzoate while no meta-cleavage pathway enzymes were observed in Trang 9the 2-DE gel profiles of P putida grown on 100 mg/L of benzoate The activation of both the ortho-

Ngày tải lên: 12/09/2015, 08:19

... Figures and Illustrations Figure 1: Anatomy of the Human Spinal Column 1 Figure 2: Anatomy of the Human Lumbar Spine 1 Figure 3: Anatomy of the Human Lumbar Facet Joint 2 Figure 4: Facet ... structures that provide a range of stability as well as mobility of the lumbar spine section (Figure 2) Figure 1: Anatomy of the Human Spinal Column Figure 2: Anatomy of the Human Lumbar Spine Trang ... frequency of 100 Hz similar to that of the Vicon system and MTS machine to ease matching of all data during analysis Six human cadaver spines from our local Asian population were used in this part of

Ngày tải lên: 02/10/2015, 17:14

... The diagnosis rate of nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), continues to increase in Western and Eastern countries [1,2] Fatty liver diseases are ... is capable of stimulating migration of human monocytes in chronic liver injury induced by free fatty acids [36] HSP90AA1 is one of the nine critical genes related to the pathogenesis of hepatocellular ... pathogenesis of NAFLD and NASH We performed further pathway analysis Effects of knockdown of ARRDC3 on inflammasome- associated pathways in human hepatocytes are shown in Figure 4 Most of inflammasome-associated

Ngày tải lên: 15/01/2020, 11:26

... represents the most severe histologic form of nonalcoholic fatty liver disease (NAFLD), which is defined by fat accumulation in the liver exceeding 5% of its weight Uniform criteria for diagnosing ... components of NASH are steatosis, hepatocellular ballooning, and lobular inflammation; fibrosis is not part of the histologic definition of NASH However, the degree of fibrosis on liver biopsy ... symptoms of fatigue, malaise, and abdominal discomfort • The presence of any of the following, especially with a history of abnormal AST/ALT, should lead to a work-up for NAFLD/NASH: — Presence of

Ngày tải lên: 22/01/2020, 00:33

... used USS to determine liver pathologies including fatty liver, estimated liver volume and shear velocity (a marker of liver stiffness or fibrosis) There were no known cases of liver disease in this ... included USS-assessed fatty liver, estimated liver volume and shear velocity, a variant of elastography (a marker of liver fibrosis) (N = 1 215) and blood-based markers of liver pathology [alanine ... of the right lobe of the liver was used to measure liver stiff-ness (or fibrosis), using standard protocols [22, 23] and this was used as our main indicator of liver fibrosis The right lobe of

Ngày tải lên: 27/02/2020, 12:40

... contributors 1 Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health, Department of Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, ... detection of activity of alkaline phosphatase using a Lumi-Phos kit (Pierce Biotechnology) The visu-alized bands of western blot were quantified with Bio-Rad QUANTITY ONE software The volumes of target ... 210029, China 2 Department of Gastroenterology, The first affiliated hospital of Nanjing medical university, 300 GuangZhou Road, Nanjing 210029, China 3 Analysis Center of Nanjing Medical University,

Ngày tải lên: 29/09/2020, 16:18

... evaluate the expression of the target of interest Only 32 studies (63%) using TMAs reported the number of cores, and 37 studies (73%) reported the diameter of the cores In 43 of the studies (37%) ... limited value in evaluation of early breast cancer be-cause of limited spatial resolution, non-visibility of tumors with low18F-FDG avidity, and low specificity [7]. Imaging of tumor hypoxia could ... could profoundly alter biomarker status, N = 10), or (4) the prevalence of the target of interest was not reported and could not be derived from the published data (N = 20) All references of the

Ngày tải lên: 05/11/2020, 05:34

... constitutive elements of international human 3.2 Business culture of P&G Vietnam company 6 CHAPTER 4: THE CURRENT SITUATION OF HUMAN RESOURCES OF 4.1 Human resource recruitment policy of P&G Vietnam ... 1UNIVERSITY OF TECHNOLOGY AND EDUCATION FACULTY FOR HIGH QUALITY TRAINING 🙦🙦🙦🙦🙦 COURSES: HUMAN RESOURCES MANAGEMENT TOPIC: ANALYSIS OF HUMAN RESOURCE MANAGEMENT ACTIVITIES OF P&G VIETNAM ...  2.2.1 The concept of international human resource management International human resource management is a part of the human resource management process, especially because of international factors,

Ngày tải lên: 07/06/2022, 11:02

... collection of analysis for use means only one of the three must be used; Organizational analysis, Personal analysis or task analysis 1 Organizational analysis includes the assessment of the adequacy of ... those policies of Apple Inc? 23 3.1 The weaknesses of Human Resources policies of Apple Inc that need to improve 23 3.2 The strengths can be learnt from Human Resources policies of Apple Inc ... contributed to the product of this assignment Trang 3TABLE OF CONTENT1 Introduction of Apple Inc 4 1.1 A brief history of Apple Inc 4 1.2 Organization structure of the company 6 1.3 What does

Ngày tải lên: 22/09/2022, 23:10

... collection of analysis for use means only one of the three must beused; Organizational analysis, Personal analysis or task analysis.1 Organizational analysis includes the assessment of the adequacy of ... those policies of Apple Inc? 23 3.1 The weaknesses of Human Resources policies of Apple Inc that need to improve 23 3.2 The strengths can be learnt from Human Resources policies of Apple Inc 25 ... whocontributed to the product of this assignment Trang 3TABLE OF CONTENT1 Introduction of Apple Inc 4 1.1 A brief history of Apple Inc 4 1.2 Organization structure of the company 6 1.3 What does

Ngày tải lên: 22/09/2022, 23:10

... and protein quantita-tive analysis services were performed by professionals at the Protein Analysis and Research Center/Proteomics Core of Indiana University School of Medicine, co-located at ... mapping of rat and human proteins Due to the lack of protein-protein interaction data cov-erage in Rat, we map all Rat protein-encoding genes to their human gene homolog to take advantage of large ... changes of f1 and f2 respectively are the same set of proteins that pass FL_vs_L with and same q-value filter and a FC threshold of f1/f2 independently In fact, no Trang 5proteomics search software

Ngày tải lên: 01/11/2022, 08:32

... therapeutic effects of the exercise modalities for the management of nonalcoholic fatty liver disease (NAFLD) A total of 61 sedentary obese men with NAFLD were randomized into one of the following ... School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, 305-8575, Japan 6Faculty of Sports Health Care, Inje University, Gyeongsangnamdo, 50834, Republic of Korea 7Faculty of Health ... 33, 1190–1200 (2012). 4 Arase, Y et al Multivariate analysis of risk factors for the development of type 2 diabetes in nonalcoholic fatty liver disease J Gastroenterol 44, 1064–1070 (2009).

Ngày tải lên: 04/12/2022, 10:40

... number and ratio of quantitative protein, Table 1 The statistical analysis of the quantitated result of broiler liver proteins via SWATH technology. Figure 2 Statistical analysis of the quantitative ... intensity of P11501 was higher than that of Q90593 in the SWATH analysis but lower than that of Q90593 in the MRM analysis The minor discrepancy between the two is probably because different numbers of ... example, inhibition of active human ERK in Hct 15 cells by PD98059 increases expression of the human HPGD protein40 while inhibition of mouse ERK1/2 using U0126 decreases the expression of mouse CYBB41

Ngày tải lên: 04/12/2022, 14:59

... 1The role of peroxisome proliferator-activated receptor in the treatment of non-alcoholic fatty liver disease Non-alcoholic fatty liver disease (NAFLD) has been defined as a spectrum of histological ... Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver disease in humans Its main characteristic is excessive accumulation of triglycerides in the hepato-cytes without consumption of ... resistance is regarded as the most important Fig 1 Natural history of nonalcoholic fatty liver disease NAFLD – nonalcoholic fatty liver disease, NASH – non-alcoholic steatohepatitis, HCC – hepatocellular

Ngày tải lên: 04/12/2022, 16:14

... area of the keyaminoacidscomparedtothetotalsurfaceareaoftheprotein; c) the occurrence ofclusters ofkey amino acids The occurrence of clusters that are made up of one or more different types of ... purification of fusion-tag proteins [1–4] butalsofornativelymetal binding pro-teins[5–7].Itoffersmanyadvantageswhencombinedwitha His-∗ Corresponding author at: Department of Biotechnology, University of ... wereidentified inatleastone oftheIDAeluates(94%ofthetotalHCPs)and109 HCPswereidentifiedinatleastoneoftheNTAeluates(29%of to-talHCPs),with88HCPs(23%)identifiedelutingfrombothligands A totalof 13HCPs were identified

Ngày tải lên: 25/12/2022, 01:56

... number of cirrhosis due to NASH; (C) Death number of cirrhosis due to NASH; (D) DALYs number of cirrhosis due to NASH; (E) Incidence number of liver cancer due to NASH; (F) Prevalence number of liver ... number of liver cancer due to NASH; (B) DALYs number of liver cancer due to NASH. NASH: nonalcoholic steatohepatitis; DALYs: disability-adjusted life years Tianyue Zhang et al Journal of Cancer ... diagnosis of nonalcoholic fatty liver disease (NAFLD), cirrhosis, or hepatocellular carcinoma (HCC) Tobari M and Hashimoto E Gut and Liver, Published online January 3, 2020 Trang 19Median of M2BPGi

Ngày tải lên: 06/05/2024, 16:12

... normal human liver tissues and human liver tissues with hepatocellular carcinoma This workflow was then applied to differential analysis of the N-glycoproteome of HCC and normal human liver tis-sues ... glycoproteomics analysis cannot be achieved Methods: In this study, a comprehensive analysis of the difference of N-glycoproteome between hepatocellular carcinoma (HCC) and normal human liver ... the HCC patients of advanced stage by surgical operation The utilization of human tis-sues was complied with guidelines of Ethics Committee of the Hospital The isolated human liver tissue was

Ngày tải lên: 02/11/2022, 09:30

... against NAFLD in humans, whereas another epidemiological study supported a correlation of the e4 allele with increased pathogenesis of fatty liver disease [34] As the human apoE2 isoform of apoE is ... are expressed as milligrams of triglycerides per gram of tissue ± SEM Histological analysis of liver samples At the end of the 24-week period, mice were sacrificed, and liver and visceral fat specimens ... metabolic abnormalities [12,13] Nonalcoholic fatty liver disease (NAFLD) is a spectrum of metabolic abnormalities ranging from simple accumulation of triglycerides in the liver (hepatic steatosis)...

Ngày tải lên: 05/03/2014, 23:20

... Histopathology of pediatric nonalcoholic fatty liver disease Hepatology 2005;42:641-649 32 Angulo P Nonalcoholic fatty liver disease N Engl J Med 2002;346:1221-1231 33 Adams LA, Angulo P Role of liver ... of nonalcoholic steatohepatitis as a cause of advanced liver disease Liver Transpl 2001;7:608-614 80 McCullough AJ The clinical features, diagnosis and natural history of nonalcoholic fatty liver ... hepatic vein Nonalcoholic fatty liver disease in children 73 Adams LA, Sanderson S, Lindor KD, Angulo P The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients...

Ngày tải lên: 22/03/2014, 10:20