prognostic and predictive factors in breast cancer second edition

... efficacy and influence patient outcomes Cisplatin and carboplatin are alkylating compounds that exert their cytotoxic action by binding to DNA and forming strong inter- and intra-structural cross links, ... outcome in advanced non-small-cell lung cancer Clin Lung Cancer 2009;10(2):118 –23. 28 Yin Z, et al ERCC2, ERCC1 polymorphisms and haplotypes, cooking oil fume and lung adenocarcinoma risk in Chinese ... Immunohistochemistry and genotyping was performed to test ERCC1, IIIβ-tubulin, COX-2, CD4, CD8 and ERCC1 (C8092A and N118 N) and MDR1 (C3435T and G2677 T) gene polymorphisms, as possible predictive and prognostic

Ngày tải lên: 06/08/2020, 06:06

... no staining = 0, faint staining = 1, weak to moder-ate staining = 2 and strong staining = 3, in line with published studies [27, 28] Positive staining was defined as membrane/cytoplasmic and/or ... manual scoring according to standard guidelines as follows: 0 = no staining, 1 = weak staining, 2 = moderate staining and 3 = strong staining for IGF1R, p-IGF1R and SphK1 Trang 6in line with previous ... AccessInsulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer Aleksandra M Ochnik1,2* and Robert C Baxter1 Abstract Background: Targeting

Ngày tải lên: 06/08/2020, 03:26

... nuclear number and 3 for intensity of nuclear staining), positive staining visible in cytoplasm was not taken into account Original magnification of x200 (B) Negative GASC1 immunostaining in nuclei ... Trang 1prognostic and predictive marker in invasivebreast cancer Bozena Berdel1, Kaisa Nieminen1, Ylermi Soini1,2,3, Maria Tengström4, Marjo Malinen3,5, Veli-Matti Kosma1,2,3, Jorma J Palvimo3,5and ... studies on cell lines and meta analysis of human breast cancer sets This study aimed to evaluate the prognostic and predictive value of GASC1 for women with invasive breast cancer Methods: All

Ngày tải lên: 05/11/2020, 07:44

... gemcitabine alone or gemcitabine and cisplatin as first-line chemotherapy In addition to the combined gemci-tabine/cisplatin regimen, metastatic disease and ECOG performance status were prognostic factors ... derived from serum albumin and peripheral lymphocyte count, were prognostic factors for OS in patients undergoing first-line chemotherapy of platinum/gemcitabine com-bination [23] In the ABC-02 trial, ... three important prognostic factors, namely tumor response, NLR, and biliary drainage requiring both PTCD and internal stenting for both PFS and OS MLR was the only significant predictive factor

Ngày tải lên: 30/05/2020, 21:37

... by ddPCR and correlations to clinical factors in breast cancer Mahmood Faraz1, Andreas Tellström1, Christina Edwinsdotter Ardnor1, Kjell Grankvist2, Lukasz Huminiecki3,4, Björn Tavelin1, Roger ... Hedman1and Ingrid Ljuslinder1* Abstract recently shown to predict early and late relapse in stage I-II breast cancer and used these assays to analyzeLRIG1 in twelve healthy individuals, 34 breast ... both in-creased and dein-creased copy numbers in breast cancer In our previous studies, in which fluorescence in situ hybridization (FISH) was used to determine gene copy numbers, LRIG1 showed increased

Ngày tải lên: 30/05/2020, 21:38

... adjuvant breast cancer treatments, and follow-up data, including any recurrence and death Clinical data was obtained from the UW Hospital and Clinics Cancer Registry and manual chart review ER, PR, and ... de-differentiation and in-duces high-grade phenotypes These findings provide important insight into how CA arises and how it imparts high-grade phenotypes and worse clinical outcomes in human breast cancer ... fea-tures to tumors, leading to worse clinical outcomes Discussion Our findings provide important insight into the origin, frequency, and the clinical correlates of CA in human breast cancer CA was previously

Ngày tải lên: 21/09/2020, 11:21

... are rising incidence of breast cancer in India and more importantly high death rates among breast cancer patients One of the leading causes of high breast cancer deaths is lack of awareness and ... facil-ities in India is not well equipped with required human resources and training for cancer screening leading to late detection of cancer So, this intervention was to test screening of breast cancer ... The second sec-tion was used to assess the women’s knowledge regard-ing breast cancer, sign and symptoms, risk factors, Breast Self-Examination (BSE), and Clinical Breast Examination (CBE) using

Ngày tải lên: 23/09/2020, 01:21

... triiodothyronine (T3) and breast cancer incidence as well as breast cancer mortality We now investigated prediagnostic T3 levels in relation to specific prognostic factors in breast cancer Methods: ... analysed at baseline for total T3 and TSH in women born in 1928 and 1941 and examined in 1983 and 1984 In women born in 1935 (examined from 1990 to 1992), total T3 was measured in a subset of all ... nodes and vascu-lar invasion in patients with thyroid pathology [7] This finding was in line with a recent experimental study that showed an increased invasiveness and formation of metastasis in breast

Ngày tải lên: 14/10/2020, 13:36

... gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro Qingming Jiang†, ... up-regulation in invasive cancers, including breast cancer After silencing of MTA1 gene, we investigated the alteration of tumor cells invasiveness using Boyden chamber assay men-tioned in Albini’s[20] ... efficiently inhibit the invasion and proliferation in MDA-MB-231 cells The shRNA interference targeted against MTA1 may have potential therapeutic utility in human breast cancer Background Breast cancer

Ngày tải lên: 10/08/2014, 10:21

... Singapore as having the highest incidence and mortality of breast cancer in Asia In addition, Singapore Cancer Registry reported that breast cancer is the top cancer type affecting females, as ... as well as invasion capacity During EMT, increased level of extracellular components including collagens and fibronectin is observed These proteins stimulate integrin signaling and induce the ... upon in vivo tumor induction by oncogene myc These cells lacked epithelial-cytokeratins and E-cadherin while expressing mesenchymal-vimentin and fibronectin Considering its involvement in cancer

Ngày tải lên: 13/10/2015, 15:55

... ANCOVA models, indicat-ing Defense Mechanisms and Copindicat-ing Styles associated with Care and Overprotection, adjusted for significant confounding factors and other cancer prognostic factors, are ... processes following breast cancer surgery Method Participants Inpatients were recruited between September 2011 and June 2012 during hospitalization in the Breast Cancer Unit of the European Institute ... patients with breast cancer Methods: One hundred and ten women hospitalized for breast cancer surgery were administered questionnaires assessing coping with cancer, defense mechanisms, and memories

Ngày tải lên: 10/01/2020, 13:42

... susanne.hultsch@fimm.fi 1 Institute for Molecular Medicine Finland, FIMM, Helsinki Institute for Life Sciences (HiLIFE), University of Helsinki, Helsinki, Finland Full list of author information is available ... cathepsin D and its lysosomal maturation Cathepsins are lysosomal proteins that help to maintain the homeostasis of cell metabolism and are involved in apoptotic signaling as well as in lysosomal ... resistance and lipid reprogramming in breast cancer Susanne Hultsch1* , Matti Kankainen1, Lassi Paavolainen1, Ruusu-Maaria Kovanen1, Elina Ikonen2, Sara Kangaspeska1,3, Vilja Pietiäinen1and Olli

Ngày tải lên: 03/07/2020, 01:52

... enhancing anti-cancer efficacy We investigated the glucose-dependent growth-inhibitory properties of everolimus, metformin and the combination in breast cancer cell lines Methods: The breast cancer ... required to investigate metformin and everolimus sensitivity in relation to the p53 status in breast cancer models Interestingly, the combination of everolimus and metformin effectively inhibited ... settings and efficacy is limited Moreover, toxicity, includ-ing fatigue and mucositis limit clinical use [1] mTOR sig-naling is central in the integration of cellular signals involved in growth and

Ngày tải lên: 19/09/2020, 21:43

... expression and chemokine secretion in breast cancer cell lines over expressing IRX2 a Recombinant IRX2 protein expression in BT-549 and Hs578T cells that were transduced with retro-virus containing ... correlated and inversely correlated genes Interestingly, 6 out of 60 defined genes belonged Benjamini: 0.001) Among the inversely correlated involved in the regulation of chemokine secretion by mediating ... suppressing protein and repressor of migration and chemokine expression, we stably expressed a c-terminal HA-tagged IRX2 protein in IRX2-deficient BT-549 and Hs578t breast cancer cell lines Successful

Ngày tải lên: 22/09/2020, 22:44

... doi:10.1038/cr.2008.316. 27 Donovan J, Slingerland J Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer Breast Cancer Res 2000;2(2):116 ... Hospital and Yangpu Hospital at surgery, immediately fixed in formalin, and then dehydrated and embedded in paraffin Immunohistochemical staining Tissue microarrays (TMAs) were constructed containing ... performed using SPSS 22.0 software (SPSS Inc.) Results Immunohistochemical tissue staining An analysis was made of a tissue obtainment containing 497 breast cancer patients and 40 benign breast tumor

Ngày tải lên: 22/09/2020, 23:31

... AccessExploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation Garth H Rauscher1*, Jacob K Kresovich1, Matthew Poulin2, Liying ... effect in breast cancer In addition, we illustrate the power of combining publicly available whole-genome databases with a candidate gene approach to study cancer epigenetics Keywords: Breast cancer, ... effects in breast cancer development and illustrate the power of combining whole-genome epige-nome and transcriptome profiles with examination of in-dividual gene regions Methods Source of samples Breast

Ngày tải lên: 23/09/2020, 00:02

... studies investi-gating progesterone transcriptional signalling and PR binding in the context of estrogen-mediated signalling Indeed, most studies of PR DNA binding have been per-formed in T-47D breast ... enrichment of genes involved in the EGFR pathway (NETPATH; p = 4.17 × 10−10), and in intracellular and chemokine signalling pathways such as MAPK and IL6 signalling (p = 0.008087 and p = 4.58 × 10−5, ... significantly enriched in the proges-terone alone PR binding sites The estrogen pretreated, progesterone treated PR binding sites were distributed predominantly in introns and distal intergenic regions,

Ngày tải lên: 23/09/2020, 00:12

... protocol in-cludes: 1) homogenizing tissue by grinding in mortar with liquid nitrogen; 2) binding the homogenized tissue to the RNeasy Mini spin column; and 3) eliminating any trace amount of DNA using ... invasive, or infiltrating [1, 9], breaking through the ductal of glandular walls where they originated and growing into surrounding breast tis-sues The invasive capacity is influenced by interactions ... gene set in breast cancer Our findings identify the negative correlation of MMP11 and HPSE2 in breast cancer pro-gression, which provides novel insight into the optimization of breast cancer treatment

Ngày tải lên: 30/09/2020, 10:59

... corresponding log-Figure 4 DNA damaging agents MMC and Taxol inhibit YY1 expression but induce FEN1 expression A and B YY1 and FEN1 expression in MDA-MB-231 breast cancer cell line in response ... indicating SNPs do not influence the binding capacity of the contained transcriptional factors To reveal what proteins correspond to this band, we excised the band and identified the proteins with ... motif in the FEN1 promoter region A Sequence alignment of the conserved YY1 binding motif in different proteins B EMSA analysis of YY1 binding to the YY1 binding motif in the FEN1 promoter Recombinant

Ngày tải lên: 30/09/2020, 13:43

... prototype and include galectins 1, 2, 5, 7, 10, 11, 13, 14 and 15 Those with two distinct CRDs in tandem connected by a linker region (tandem-repeat type) are galectins 4, 6, 8, 9 and 12 Galectin-3 is ... an increasing interest in the development of galectin-specific inhibitors for the treatment of cancer Because galectins exert both intracellular and extracellu-lar functions, a better understanding ... consisted of 20 injections of 2 μL ligand into protein, with an interval of 130 seconds between injections All experiments were performed at least in triplicate Data was analyzed and fitted using the

Ngày tải lên: 30/09/2020, 14:46