prevention and early detection of ovarian cancer

... disease and as an auxiliary means of cancer detection The results provide evidence that the PBMCs and plasma of patients with breast cancer are biochemically distinct from the PBMCs and plasma of ... A B C Fig 1 FTIR-MSP spectra of PBMCs of cancer patients and healthy controls (a) Average of the absorption spectra of PBMC of each study group between 1800 cm−1and 700 cm−1 The spectra are vector ... feasible and efficient tool for the early detection of breast neoplasms An important application of our study is the distinction between benign lesions (considered as part of the non-cancer group) and

Ngày tải lên: 30/09/2020, 11:00

... screening ensures early detection of diabetes and initiation of treatment Our results emphasize the importance of development of interventions to improve early detection and prevention of diabetes ... risk of diabetes diagnosis or treatment and early detection of diabetes The higher possibility of early detection of dia-betes among women attending follow-up screening re-duces their risk of late ... the importance of follow-up screening of women to ensure early detection and initiation of treat-ment for the prevention of late complications caused by diabetes Follow-up screening of these women

Ngày tải lên: 01/11/2022, 08:52

... 1NEAR-INFRARED AUTOFLUORESCENCE IMAGING AND SPECTROSCOPY FOR EARLY DETECTION OF PRECANCER AND CANCER IN THE COLON SHAO XIAOZHUO A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DIVISION OF BIOENGINEERING ... Overview of Colon Cancer Cancer that develops in the colon and rectum is called colon cancer or colorectal cancer Colon cancer is a common type of malignancy, which has uncontrolled growth of the ... the theory of fluorescence imaging and spectroscopy techniques and then introduces the clinical applications of fluorescence imaging and spectroscopy for detection and diagnosis of cancers in

Ngày tải lên: 10/09/2015, 08:29

... regards and blessings to all of those who made this thesis possible Trang 6ABSTRACT Liyun Cao MECHANISM OF TISSUE TRANSGLUTAMINASE UPREGULATION AND ITS ROLE IN OVARIAN CANCER METASTASIS Ovarian cancer ... 96% serous Trang 23ovarian tumors and the breast cancer susceptibility protein type 1 and type 2 (BRCA1 and BRCA2) are mutated in 22% of HGS-OC samples Clear cell ovarian cancers have few TP53 ... binding domain of TG2 induces EMT in 3.2.5 TGF-β1 induces an ovarian cancer stem cell phenotype 107 3.2.6 TG2 is upregulated in ovarian cancer stem cells 110 3.2.7 TG2 induces an ovarian cancer stem

Ngày tải lên: 24/08/2014, 10:58

... formation, and block the invasion and metastasis of ovarian cancer cells Keywords: Ovarian cancer metastasis, Inhibitory short peptide, ABI1, SOS1, EPS8 Background Ovarian cancer has the highest mortality ... agents against ovarian cancer metastasis Methods Cells and antibodies The human ovarian cancer cell lines SK-OV3, HEY, and OVCAR3 were gifted to us by the Department of Biochemistry and Molecular ... techniques and chemotherapy have not effectively improved the survival of ovarian cancer patients [3] Therefore, novel therapeutic strategies tar-geting the metastatic process of ovarian cancer are

Ngày tải lên: 17/06/2020, 17:54

... effect of dual CAR-T targeting PDL1 and MUC16 antigens on ovarian cancer cells in mice Tong Li and Jiandong Wang* Abstract Background: More favorable treatment against epithelial ovarian cancer ... of PD1, anti-MUC16 and PD1-antiMUC16 CAR were obtained The main structures of PD1 and anti-MUC16 are PD-1etco and 4H11-VH-(Gly4Ser)3-4H11-VL The primary structure of PD1-antiMUC16 is tandem of ... balance and protect the epithelium [13] It is expressed in a var-iety of tumor cells and involved in the proliferation and metastasis of tumor cells Studies have shown that 80% EOC express MUC16, and

Ngày tải lên: 06/08/2020, 05:52

... pertinent marker for the detection of their correspond-ing ovarian metastases Detection of ovarian metastases by a combination of markers Figure 3 also shows that the use of one marker would not ... in 100% of tumor cells in 4 out of 10 ovar-ian metastases To investigate whether a combination of markers would enable the detection of 100% of tumor cells in all ductal and lobular ovarian metastases, ... metastases Table 2 Localization and morphology of ovarian metastases derived from patients diagnosed with invasive breast cancer Localization of ovarian metastases Morphology of ovarian metastases Multiple

Ngày tải lên: 19/09/2020, 21:34

... determining cut-off value of TNR in detection of breast cancer b TNR of BSGI distribution in breast malignant and benign disease c Sensitivity of BSGI, US, MMG and MRI for detecting breast cancer d ... leading type of new cancer cases and the second leading cause of cancer related deaths in fe-males worldwide [1] During the past 30 years, the inci-dence and mortality of breast cancer in Chinese ... We investigated the sensitivity and specificity of each method of detection and compared the biological profiles of the four imaging methods Results: A total of 357 women received a final surgical

Ngày tải lên: 21/09/2020, 01:57

... Trang 2Ovarian cancer is the fifth most common cancer type in women and is the most lethal gynecologic malignancy [1] The most abundant histological subtype of ovarian cancer, high-grade serous ovarian ... for epigenetic therapy for cancer [6, 7] Effective treatment of cancer relies on the identification of key molecular targets of cancer growth and subsequent development of therapeutic agents against ... histological type and maintain the genomic features and reminiscent heterogeneity of corresponding patients’ pri-mary tumors [11–13] Furthermore, results from treatment of ovarian cancer PDXs have

Ngày tải lên: 04/12/2022, 10:31

... EBSS) (G) Immunofluorescence analysis of Cyto-ID staining of OV202 Sh1 cells treated with 20 μM of AACOCF3 and 20 μM of PG545 showing increase in autophagy (H and I) Immunoblot analysis of LC3BII ... associated with loss of HSulf-1 and activation of cPLA2 (A) Immunoblot analysis with anti-LC3B antibody in OV202 NTC, Sh1, Sh2 and Cl7 cells (B) Immunoflourescence analysis of OV202 NTC and Sh1 cells ... significantly lower number of LDs and higher number of AVs (Fig. 2E) Quantitation of LDs and AVs in 25 cells is shown in Fig. 2F and G Furthermore, transient downregulation of cPLA2 expression with

Ngày tải lên: 04/12/2022, 15:11

... immobilization of proteins from cells and derivatization of glycans to protect sialic acids; (2) release of N-glycans by PNGase F and quantification of N-glycans by isobaric tags; (3) release and quantification ... prostate cancer [2], ovarian cancer [3 4], rheumatoid arthritis [5], diabetes [6], and cardiac dis-eases [7 8] Studies reveal that cancer cells often display their glycans at different levels of structures ... acids, and sequentially releasing N- and O-linked glycans for MS analyses [14, 49, 50] Glycoprofiling on ovarian cancer serum found that unique N-glycans were present in cancer patient [4] Profiling

Ngày tải lên: 04/12/2022, 16:18

... expression of thousands of genes [9,12,13] Another challenge is that the specificity and sensitivity of a given RNA profiling platform are affected by the abundance and variability of the globin ... an improved detection sensitiv-ity of nearly 4-fold, a reduction of the globin artifact by 5-fold and an increase in statistical power (signal to noise) of more than 3-fold The loss of correlation ... tissue for the understanding of disease and the development of disease treatments It is a ubi-quitous tissue that interacts throughout the body and literally acts as a sensor of physiological conditions

Ngày tải lên: 18/06/2014, 16:20

... several cancers, including ovarian cancer [4-7] Moreover, mutations may be one of the major factors contributing to the origin of ovarian cancer stem cells Emerging evidence suggests that ovarian cancer ... gemcitabine and taxotere on the viability of A2780 and C200 ovarian cancer cells The viability of A2780 and C200 cells treated with genis-tein (10–25 μM), cisplatin (250 nM), gemcitabine (2 – 50 nM) and ... which is one of the key pathway contributing to drug resistance in ovarian cancer [3] Pretreatment of cisplatin resistant ovarian cancer cells Schematic diagram of potential mechanism of genistein

Ngày tải lên: 20/06/2014, 07:20

... clearly lowers the dose of cisplatin and radiation treatment needed to suppress the growth of ovarian cancer cells Apoptosis is normally a carefully balanced system of checks and balances In cancer ... gynecological cancer and the fifth most common cause of cancer mortality in women in the United States: in 2009 it is estimated that 21,550 women will be diagnosed with ovarian cancer and 14,600 ... improve ovarian cancer therapeutics A targeted PLGA nanoparticle formulation of curcumin is feasible and may improve the in vivo therapeutic efficacy of curcumin Background Ovarian cancer is

Ngày tải lên: 20/06/2014, 07:20

... Published: 9 August 2011 Trang 101 American Cancer Society Cancer Facts and Figures 2011 [http://www. cancer.org/Cancer/OvarianCancer/DetailedGuide/ovarian-cancer-key-statistics], Accessed in August ... III, and 15 cases detected at stage IV, in a total of 89 staged cancers We have also observed a slight predominance of poor staged cancers, as 43.8% of cases had a better prognosis profile (I and ... of the HLA-DR α and β Chains in Ovarian and Other Cancer Cancer Biol Ther 2004, 3:1021-7. 25 Inai K, Shimizu Y, Kawai K, Tokunaga M, Soda M, Mabuchi K, et al: A Pathology Study of Malignant and

Ngày tải lên: 20/06/2014, 08:20

... 36-h exposure Ash and oak survival was high irrespective of desiccation treatment, whereas survival of beech and especially of birch was impaired by drying The effect of rough-handling was minor ... the allocation of dry mat-ter between shoots and roots (figure 2b and table II) R/S ratios of uncut ash, beech and oak seedlings were between 2.5 and 3.8, whereas the majority of the dry matter ... the fine root bio-mass and there was no consistent pattern in the way under-cutting affected lateral and fine root biomass of birch and beech on the one hand and oak and ash on the other Thus,

Ngày tải lên: 08/08/2014, 14:21

... microRNAs [22-24]; and regulation of transcription at the levels of individual genes and chromatin remodeling [24-27] Eukaryotes all share the main features of cellular architecture and the regulatory ... group of eukaryotes primitive, a presymbiotic archezoan Rather, taking into account the small genomes and high rate of evolution characteristic of most of the protist groups thought to be early ... Plantae and many groups of Chromalveolata additionally have cyanobacteria-derived plastids [76,77] Th e gene comple-ment of eukaryotes is an uneven mix of genes of apparent archaeal origin, genes of

Ngày tải lên: 09/08/2014, 20:21

... mortality from that cancer, and the rationale for the early detection of breast cancer is similar. Fifty years ago, there was no established method for the detection of breast cancer at an early stage ... $40,000 offered, detection of early breast cancer, especially in may be used over 3-year period. the areas of biological or immunological methods for the detection of early- stage breast cancer. New ... de- Mammography and Beyond: Developing Technologies for the Early Detection of Breast Cancer Committee on Technologies for the Early Detection of Breast Cancer Sharyl J. Nass, I. Craig Henderson, and Joyce...

Ngày tải lên: 05/03/2014, 12:20

... sensitivity of 89% and a specificity of 97% for the detection of early stage ovarian cancer. Furthermore, the sensitivity and the specificity of this panel in distinguishing between normal and mucinous ... sensitivity of 94% and a specificity of 94% for serous ovarian carcinoma in its early stage, and a sensitivity of 98% and a specificity of 98% for endometrioid ovarian carcinoma in its early stage ... cases of ovarian cancer are shown. Early: early- stage cases; Late: late-stage cases; N/A: not assessed Novel biomarker panels have also been investigated for the early detection of ovarian cancers...

Ngày tải lên: 22/03/2014, 11:20