phase i and phase ii

... Manchester diagnostic criteria of bilat-eral vestibular schwannoma in addition to numerous other significant findings: intracranial schwannomas in-volving cranial nerves V, VII, and VIII, intracranial ... instability with increasing grade in NF2-associated meningiomas [11] Here, we present an in-depth genomic study of grade I and grade II meningiomas that resided in close proximity in the brain ... tumors and Sanger verification of mutations After WES data processing and filtering, we identified two potentially damaging somatic mutations in the grade I meningioma, and nine somatic mutations in

Ngày tải lên: 20/09/2020, 01:29

... response and survival in stage IIIA/IIIB NSCLC patients. J Thorac Oncol 2007, 2:293 –298. Trang 1031 Yoshida T, Tanaka S, Mogi A, Shitara Y, Kuwano H: The clinical significanceof Cyclin B1 and Wee1 ... Clinical and pathological characteristics of patientsTable 2 Association between CDK-based risk groups and clinicopathological parameters Low High Significance (Chi-square) Low High Significance ... which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/)

Ngày tải lên: 14/10/2020, 16:57

... T I C L E Open AccessThe combination of methotrexate and cytosine arabinoside in newly diagnosed adult Langerhans cell histiocytosis: a prospective phase II interventional clinical trial Xiao ... series with limlim-ited prospective clinical trial [6] In general, the same diagnostic and therapeutic approaches are applied in adults as in chil-dren The classical regimen consisting of vinblastine ... hospital and consultation center in China In addition to hypothalamic pituitary region disease, neurodegenerative disease is also mani-fested as late sequelae with typical findings on magnetic

Ngày tải lên: 30/05/2020, 21:28

... Faculty of Medicine, Chiang Mai University, 110 Intawaroros, Sriphoom, Muang, Chiang Mai 50200, Thailand. 9 Biomedical Engineering Institute, Chiang Mai University, Chiang Mai, Thailand. Received: 13 ... curative options or for which no standard ther-apies with curative intent exist This is consistent with a systematic review of phase II osteosarcoma trials, in which two thirds (67/99) of the trials ... randomized phase II cancer clinical trials J Clin Oncol 2010;28(11):1936 –41. 54 Baey C, Le Deley MC Effect of a misspecification of response rates on type I and type II errors, in a phase II

Ngày tải lên: 17/06/2020, 11:32

... participated in a clinical trial examining tivantinib; e , One patient participated in a clinical trial examining tivantinib and another one received percutaneous ethanol injection treatment (PEIT) Trang ... Clinical Trial Registry (UMIN ID 000006147) Eligible patients were diagnosed as having HCC based on the findings of histopathological examinations, imaging examinations, and/or clinical diagnosis in ... Sciences, Institute of Biomedical and Health Sciences, Hiroshima University; 1-2-3, Kasumi, Minami-ku, Hiroshima, Hiroshima 734-8551, Japan 6 Department of Internal Medicine, Isesaki Municipal Hospital;

Ngày tải lên: 17/06/2020, 18:34

... Pontedera Emilia Ospedale di Guastalla Reggio Emilia Domenico Cristiano Corsi Ospedale San Giovanni Calibita Fatebenefratelli Isola Tiberina Roma Campus Bio-Medico Roma Istituti Clinici di Perfezionamento ... hospitalization or prolongation of existing hospitalization; resulting in persistent or significant disability/incapacity; congenital anomaly/birth defect or other significant medical hazard is ... Ospedaliero Brescia Mario Scartozzi Azienda Ospedaliero Universitaria di Cagliari Policlinico “Duilio Casula” Monserrato Cagliari Camposampiero Cristina Granetto Azienda Sanitaria Ospedaliera Santa

Ngày tải lên: 24/07/2020, 00:24

... and/or peritoneal carcinomatosis, (iii) liver cir-rhosis, previous splenectomy and/or severe respiratory impairment, (iv) chemo- and/or radiotherapy within 2 and 6 weeks prior to trial inclusion, ... symptoms with no other explanation than the administration of the IMP, vii) occurrence of thromboembolic event(s), vii) serious related to the IMP viii) deteriorations in medical monitoring parameters ... clinically investigated for its safety and tolerability, anti-tumor activity, immunological effects, and clinical efficacy in patients with GBM [18] In this study the virus was administered intravenously

Ngày tải lên: 06/08/2020, 03:51

... T I C L E Open AccessA multi-center phase II study and biomarker analysis of combined cetuximab and modified FOLFIRI as second-line treatment in patients with metastatic gastric cancer Xin Liu1†, ... Japanese phase III study (WJOG4007) com-pared treatment with paclitaxel and irinotecan in patients with MGC refractory to treatment with fluoropyrimidine plus platinum This study reported no significant ... fundings participated in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. Availability of data and material The datasets during and/or

Ngày tải lên: 19/09/2020, 21:30

... Quantitative data will be described using their mean, standard deviation and 95%-CI, and if their distri-bution is not Gaussian, by their median, quartiles and range, according to statistical distribution ... Patient position and data acquisition All patients will be irradiated in a supine position Immobilization devices such as stereotactic custom-ized masks will be used to secure the accuracy and ... or fractionated IMRT) Methods/design Study design Design This prospective study is designed as a national, open-label, non-randomized phase II trial and aims to evaluate toxicity and efficacy of

Ngày tải lên: 19/09/2020, 22:06

... organs or critical anatomical sites requiring urgent alternative medical intervention  Patient still fulfills eligibility criteria for this study Patients must also agree to fill an additional consent ... strong rational to combine PARP inhibitors and immune checkpoint in-hibitors Indeed, PARP inhibitors induce DNA damage causing neoantigen increase, leading to a reinforced rec-ognition by the immune ... AccessPrecision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous

Ngày tải lên: 19/09/2020, 22:10

... HDACi vorinostat, in combination with the EGFR-tyrosine kinase inhibitor gefitinib, induced synergistic inhibition of prolifera-tion, migration and invasion as well as induction of apoptosis, in ... A, Minton S, Sullivan D Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC ... hydration will be re-quired prior and after cisplatin administration Antiemetic prophylaxis with dexamethasone and palonosetron before cisplatin will be also administered Toxicity due to cis-platin

Ngày tải lên: 20/09/2020, 18:51

... with an oxaliplatin-base regimen were also eligible for inclusion in this study Study design This study was a single-arm Phase II open-label non-randomized multi-institutional clinical trial investigating ... Díaz-Rubio E, Cervantes A, Humblet Y, André T, et al Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal ... al Biweekly cetuximab in combination with FOLFOX-4 in the first-line treatment of wild-type KRAS metastatic colorectal cancer: final results of a phase II, open-label, clinical trial (OPTIMIX-ACROSS

Ngày tải lên: 22/09/2020, 23:39

... preoperative radiotherapy (SCPRT) and/or fluorouracil (5FU)-based CRT in a future randomised phase III trial Trial registration: Clinical trial identifier BACCHUS: NCT01650428 Keywords: FOLFOXIRI, FOLFOX, ... trial Trang 3Patients with histologically confirmed adenocarcinoma of the rectum require specific tumour and patient criteria for inclusion A staging MRI is mandated The lists of inclusion and ... Multicenter Randomized Phase II Clinical Trial Comparing Neoadjuvant Oxaliplatin, Capecitabine, and Preoperative Radiotherapy With or Without Cetuximab Followed by Total Mesorectal Excision in

Ngày tải lên: 22/09/2020, 23:59

... combination with gemcitabine demonstrating promise in phase II studies, but minimal impact on OS in subsequent phase III randomised trials Limited benefit has been demonstrated with the addition ... post-SIRT imaging at 8 weeks intervals and no patient had progressive disease within the liver on initial follow-up CT imaging With lim-ited radiological response on gemcitabine, it would seem reasonable ... (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link

Ngày tải lên: 23/09/2020, 00:13

... analysis This phase II study investigates the feasibility of com-pleting a phase III trial and a full companion economic evaluation In the phase II design there will be no formal cost-utility analysis, ... analysis focuses on feasibility outcomes and those which will inform decisions about moving forward to and planning a phase III clinical trial Feasibility out-comes include recruitment rates, and ... as per site (Toronto, Calgary) will be calculated Criteria to move forward to phase III RCT To move forward to the phase III intervention, we have identified pre-specified criteria which must

Ngày tải lên: 29/09/2020, 16:07

... treatments, (ii) the absence of standard of care in this setting and (iii) the choice of the primary endpoint The proposed trial design is a complex one, integrating randomization, stratification and ... other signaling pathways, plays a key-role in sarcoma biology Regorafenib (RE) has recently been shown to be effective in imatinib and sunitinib-refractory GIST in a phase III trial Methods/design: ... application of 4 parallel placebo-controlled randomized phase II trials This could be discussed point by point Most of phase II trials assessing the activity of a new drug in STS are not randomized

Ngày tải lên: 30/09/2020, 13:05

... Battistoni F, Gavasci M, Rocci L, Tirindelli MC, Altomare V, et al: Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients Clin Canc Res ... Medizinisches Zentrum Ulm, Ulm, Germany 15 Frauenklinik und Poliklinik der Technischen Universität München, Munich, Germany 16 Frauenklinik Grosshadern, Universitätsklinik der Ludwig-Maximilians-Universität, ... Categorical variables are summarized by absolute and relative frequencies Continuous variables are summarized by descriptive statistics of mean, standard deviation, minimum, median, and maximum Time-to-event

Ngày tải lên: 05/11/2020, 01:05

... peroxiredoxin [8] TryPs were originally identied and characterized in Crithidia fasciculata [812] and these have been subsequently identied and studied in a variety of trypanosomatids [1318] Additional ... TryX indicating that formation of an intramolecular disulde is important for interaction with TryX In contrast, this mutant displayed signicant activity with dithiothreitol (65% of wild-type) ... genomic DNA of L major Friedlin strain using forward primer containing an NdeI site and reverse primer containing a BamHI site (Table 3) The 525 bp PCR-product was digested with NdeI and BamHI and...

Ngày tải lên: 23/03/2014, 07:20

... TNF on interferon-inducible gene expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced ... downregulated in vivo but was upregulated upon TNF stimulation in vitro Meanwhile, IFI genes such as IFIT1, IFIT3, OAS1, ISG15 and IRF7, and IL8RA were upregulated in vivo, but IFIT1, IFIT3, OAS1 and IL8RA ... erythematosus II: IL-12 production in vitro is correlated negatively with serum IL-10, positively with serum IFN-gamma and negatively with disease activity in SLE Cytokine 1998, 10:148-153 Calvano SE, Xiao...

Ngày tải lên: 09/08/2014, 01:22

... TNF on interferon-inducible gene expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced ... downregulated in vivo but was upregulated upon TNF stimulation in vitro Meanwhile, IFI genes such as IFIT1, IFIT3, OAS1, ISG15 and IRF7, and IL8RA were upregulated in vivo, but IFIT1, IFIT3, OAS1 and IL8RA ... erythematosus II: IL-12 production in vitro is correlated negatively with serum IL-10, positively with serum IFN-gamma and negatively with disease activity in SLE Cytokine 1998, 10:148-153 Calvano SE, Xiao...

Ngày tải lên: 09/08/2014, 13:22