pharmacologic strategies not supported by current evidence

... thereby, to predict which oncogene(s) are the most appropriate target(s) for maximizing tumor cell kill The model The cellular phenotypic entropy is determined by first defining all allowable phenotypes ... chromosome translocation [32] Figure notypic entropy A normal cell, N, is transformed thereby increasing its pheA normal cell, N, is transformed thereby increasing its phenotypic entropy When the oncogene ... SA: DNA damage and mutagenesis induced by procarbazine in _lacZ transgenic mice: Evidence that bone marrow mutations not arise primarily through miscoding by O6 -methylguanine Carcinogen 1997,...

Ngày tải lên: 13/08/2014, 23:20

... conventional ‘Darwinian’ selective mechanism or by some type of de novo response to the presence of the drug Ashworth supported the more logical Darwinian mechanism, by which resistance existing in a small ... synthetic lethality screen, in which the cell, already sensitized to DNA damage by loss of BRCA1/2, is overwhelmed by the combination of a chemotherapeutic agent that causes DNA damage and a compound ... (BRCA2 null) cell line by treating the cells with the drug and identifying the genetic alterations in resistant clones Fascinatingly, the resistance was found to be mediated by deletions within...

Ngày tải lên: 14/08/2014, 08:21

... (longitudinal) Although measured differently, current research shows that, all in all, survivors of gynecological cancer can expect to enjoy a good QoL, not unlike that of peers without a history ... people as they re-evaluate their life [69] Strategies for improving health & QoL in gynecological cancer survivors Long-term cancer survivors are not being routinely monitored for their cancer ... another study reveals that nearly 90% of gynecological cancer survivors report supportive care needs – needs most frequently addressing existential survivorship [23] Studies reinforce the notion...

Ngày tải lên: 05/03/2014, 15:20

... different facets of healthcare provision including, public, private-for-profit, and private not- for-profit sectors By convenience sampling, a minimum of 10 facilities were http://www.human-resources-health.com/content/7/1/21 ... In some countries not all categories of health workers were involved in the supply management of ARVs In Uganda the supply management of HIV/ AIDS pharmaceuticals is mainly by lower to mid-level ... Uganda Total Public Institutions Private not- for-profits Private for profit Academic institutions - 1 2 27 18 Total 13 12 12 17 54 Page of (page number not for citation purposes) Human Resources...

Ngày tải lên: 18/06/2014, 17:20

... occurs five times, over a longer sequence that occurs only twice Other model inference strategies would bypass by this short motif In this paper, we describe initial results of miRNA analysis using ... significance) have been enhanced by new heuristics and an architecture that searches not only the sequence but also the model for candidate phrases The performance has been improved by gathering statistics ... compression, important effects are not taken into account by this measure For example, adding new symbols to a partition increases the coding costs of other symbols by a small amount Furthermore,...

Ngày tải lên: 22/06/2014, 19:20

... this bio-transformation is the CYP2D6 Recent pharmacological and clinical pharmacogenetics evidence suggests that genetic variants and drug interaction by CYP2D6 inhibitors influence plasma concentration ... therapeutic index or applicability to specific societies Such investigations usually are not supported by pharmaceuticals companies and international conferences, although they might be of benefit ... implied by this intriguing example merits further study Pharmacokintetic based studies in lapatinib therapy According to recent studies, it is shown that lapatinib when taken orally with food -not...

Ngày tải lên: 09/08/2014, 04:21

... but she has had no further deterioration Discussion Paraneoplastic syndromes are caused by cancer but are not due directly to local infiltration or metastatic spread They are thought to be due ... biochemistry, pituitary function tests, CT brain and MRI pituitary fossa were all normal She was noted to have an elevated IgG at 21.6 and a raised SMA titre (IgG class >800) Type diabetes mellitus ... excluding non-malignant causes Laboratory based tests are useful if there is no obvious tumour Many but not all patients with paraneoplastic syndromes have identifiable antibodies in their serum Paraneoplastic...

Ngày tải lên: 09/08/2014, 07:22

... were not identified as information needs by the majority of patients Chemotherapy was not an issue for 16 of the patients because they were not referred for chemotherapy and therefore did not ... routinely provided with large amounts of information; however, not all of this information meets their needs and may be discarded if patients not see the content of the information as meeting their ... needs were not being adequately met Therefore, it was clear that previous questionnaires that measured general information needs and specific breast cancer information needs were not appropriate...

Ngày tải lên: 09/08/2014, 10:21

... addition, CR of the colon cancer seen in the transverse and descending colon was also confirmed by colonoscopy and PET-CT after eight rounds of chemotherapy Nevertheless, regional radiotherapy ... activity of an oxaliplatin single regimen for urothelial cell cancer was minimal in phase II studies by Moore et al.[13] and Winquist et al [14] Therefore, we suggest that our case of TCC showed a ... cancer [20,21] There are few reports of FOLFOX therapy for urothelial cancer, only a phase II trial by Lorenzo et al., published in 2004 They used FOLFOX-4 in 18 patients who had previously been treated...

Ngày tải lên: 10/08/2014, 22:20

... there is evidence, however, that they are regulated differentially and may not be interchangeable in all cellular contexts [10-13] Intriguingly, it has been reported that activated MEK1 but not MEK2 ... BioPharma/AstraZeneca) is another second-generation potent inhibitor of MEK1/MEK2 [86] AZD6244 selectively inhibits purified active MEK1 and MEK2 with an IC 50 of 14 nM by a mechanism not competitive with ... (ERK) activation by regulating formation of MEK1-ERK complexes Mol Cell Biol 2002, 22:6023-6033 11 Wu X, Noh SJ, Zhou G, Dixon JE, Guan KL: Selective activation of MEK1 but not MEK2 by A-Raf from...

Ngày tải lên: 10/08/2014, 22:20

... proved that deflocculation by sonication in a short time was reversible and microbial cells were not injured The results also agreed with other investigations carried out by Banks and Walker (1977) ... to stand at 80°C for h The alditol acetates were prepared by the reduction of the hydrolyzed sugars with sodium borohydride followed by acetylation with pyridine/acetic anhydride 1:1 (v/v) at ... flocculating test Deflocculated sludge was prepared by letting 75 ml of activated sludge to be suspended in 225 ml of distilled water followed by sonication for The sludge suspension was centrifuged...

Ngày tải lên: 05/09/2013, 09:08

... others A useful framework often presented by many teacher trainers is: • Warm-up • Presentation • Controlled practice • Free practice • Feedback Many current EFL textbooks adopt this kind of curricula ... clearly express not only the course requirements but one's own personal philosophy to assessing learners For instance, students need to know from the first class that you will not accept late ... quizzes By explicitly stressing this kind of seemingly trivial information, the teacher can save a lot of valuable class time and create a more productive atmosphere Conclusion In conclusion, by being...

Ngày tải lên: 06/09/2013, 10:10

... be classified in to denotational meaning and only focus on verb - one in the open classes or full word-forms connotative meaning 2.2.2.2 Phrase b1, Denotative meaning or Denotation In Oxford Advanced ... 1.3.2 Objectives may know a lot of English lexical items by learning vocabulary - to analyze grammatical word-lists by heart but they not know how to use them in Vietnamese features of WIRHs ... Jackson and Amvela b2, Connotative meaning or Connotation [13] also consider idioms as a special kind of collocation involving In [13,p.57] Amvela and Jackson point out that “connotations two or more...

Ngày tải lên: 26/11/2013, 13:31

... expressions which not have suitable counterparts in other language This means that it is not possible to translate these expressions by applying typical translational methods and strategies Translation ... material in one language by equivalent textual material in another language” _Catford (1965: 20)_ Very much similar to this definition is “Translation is made possible by an equivalent of thought ... 28 2.1.2 Translation by paraphrase using unrelated words…………………………… 30 2.1.3 Single terms are formed by the help of prefixes…………………………… 31 2.1.4 Single terms are formed by the help of suffixes………………………………...

Ngày tải lên: 11/12/2013, 23:51

... Chapter II: Popular Strategies and procedures applied in the translation of Water Sector terms into Vietnamese 27 Strategies applied in the translation of single terms 27 Strategies applied ... air-hostess However, such restricted repertoires are not languages, just as a tourist phrase book is not grammar Knowing a restricted 'language' would not allow the speaker to communicate effectively ... Chapter II: Popular Strategies and procedures applied in the translation of Water Sector terms into Vietnamese Strategies applied in the translation of single terms 1.1 Translating by a more specific...

Ngày tải lên: 11/12/2013, 23:55

... another example, refers the weather may be rain or not, and the word Possible means Có thể and rain means mưa, but we cannot say that rain or not – it is possible because in weather forecast not ... Translating by cultural substitution 13 3.1.4 Translating by using a loan word plus explanation 14 3.1.5 Translating by using a paraphrase 14 3.1.6 Translating by omission ... background for this study What is translation? Often, though not by any means always, it is rendering the meaning of a text into another language in the way that the author intended the text...

Ngày tải lên: 11/12/2013, 23:55

... Singapore last July (not in last July) • They are coming back next Thursday (not on next Thursday) • People go home every Easter (not at every Easter) • They’ll have a party this evening (not in this ... No (11): * I went to school BY the bus (ON) 46 Seventy students chose BY This can be easily understood They have learnt the rule BY + transportation”, for example: by car/ taxi / bus They didn’t ... it (iii) An object can be related to a line or a surface, supported by or attached on it AT as the most “neutral” place preposition, denotes place as a point of orientation, disregarding its physical...

Ngày tải lên: 18/12/2013, 10:04