parkinson s disease and related disorders

... Access Research Gait dynamics in mouse models of Parkinson's disease and Huntington's disease Address: 1 Division of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, ... modelsNeurodegenerationMovement disordersAmyotrophic Lateral SclerosisSOD1 Abstract Background: Gait is impaired in patients with Parkinson's disease (PD) and Huntington's disease (HD), but gait dynamics in mouse models of ... SOD1 G93A and wild-type control mice at age ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson's disease, Huntington's disease, and amyotrophic

Ngày tải lên: 19/06/2014, 10:20

... Depression Inventory-II, AS apathy scale, LASA linear analogue self assessment, ECOG everyday cognition scale, PD-NMS Parkinson’s disease non-motor symptom questionnaire, PDQ-39 Parkinson’s disease ... topics involved themes such as family relationships, death, and life-threatening events This finding suggests that in this Trang 9sample the most stressful factors in the patients’ and care-givers’ ... axis activation that is asso-ciated with psychosocial functioning [8] and has been shown to be a valuable measure for assessing hyper- and hypocortisolemic traits in patients with depression and

Ngày tải lên: 10/01/2020, 15:07

... hemibody as the disease progresses Progressively, this gait becomes more abnormal and fea-tures such as flexion of the trunk, stopped posture, short steps, and shuffling, the latter associated ... therapies, b) systems that help in the process of monitoring or evaluating users, and c) systems that try to help in the process of diagnosing PD There are several systems whose goal is to help ... present a Kinect-based system that can assess gait by identifying different gait features such as step length and states of the gait cycle by using a Finite-State Machine With respect to systems

Ngày tải lên: 25/11/2020, 13:00

... the disease itself This subject is further discussed in chapter 7 Clusters of parkinsonian signs and subgroups of the disease A question now arising is whether PD constitutes one single and clinicallyhomogeneous ... hallucinations, delusions and sleep disorders Speci Wc cognitive deWcits are also discussed, and the mechanisms for these disorders explored In addition, the book addresses the psychiatric and cognitive side-eVects ... rating scales will meet the needs of all clinicians working with Parkinson’s disease patients. Sergio E Starkstein was Assistant Professor of Psychiatry at Johns Hopkins University, and is now

Ngày tải lên: 28/03/2014, 22:21

... regression SRM - standardized response mean UPDRS - unified Parkinson’s disease rating scale VAS - visual analogue scale Trang 12SUMMARY Parkinson’s disease (PD) is a chronic neurodegenerative disorder ... Progression of Parkinson’s Disease as Evaluated by Hoehn and Yahr Stage Transition Time The 5th American Association of Pharmaceutical Scientists (AAPS)-NUS Student Chapter Scientific Symposium, Singapore, ... Parkinson’s Disease and Movement Disorders, Paris, France, June 7-11, 2009 2 Zhao YJ, Wee HL, Chan YH, Seah SH, Au WL, Lau PN, Pica EC, Li SC, Luo N and Tan LCS Progression of Parkinson’s Disease as

Ngày tải lên: 11/09/2015, 10:05

... development and severity of diseases based on inflammatory processes including atherosclerosis and ischemic stroke, neurodegenerative diseases of aging, and certain cancers The first report of ... flesh, including essential fatty acids from seeds and seed oils, and fibers, such as microcrystalline cellulose, pectins, lignins, cutin-like polymers, and condensed tannins, have been suggested ... acid), substituted cinnamic acids, and stilbenes such as resveratrol, pterostilbene, and piceatannol, and triterpenoids such as ursolic acid and its esters, oleanic acid, alpha-amyrin and betaamyrin,

Ngày tải lên: 25/10/2013, 05:20

... homeostasis is an accepted mechanism in the pathogene-sis of Parkinson’s disease a-Synuclein overexpression and impaired dis-posal contribute to this mechanism However, biochemical alterations associated ... oxidative stress in Parkinson disease pathogenesis Nat Clin Pract Neurol 4, 600–609 6 Lesage S & Brice A (2009) Parkinson’s disease: from monogenic forms to genetic susceptibility factors Hum ... genetic factors variously associated with PD, such as a-synuclein mutations and Keywords dopamine; network enrichment; NF-jB; Parkinson’s disease; SH-SY5Y; a-synuclein Correspondence M Fasano, Department

Ngày tải lên: 15/02/2014, 01:20

... nervous system neurons A recent study analyzed the enteric nervous system in PD and found that both Meissner’s and Auerbach’s plexuses were affected already in early stages of disease and terminal ... components Signal intensities were scored using a semiquantitative scale with five steps (–,+),+,++ and +++) Scores were based on several sections ⁄ animal and several animals ⁄ observation and confirmed ... large intestines Adh3 shows low and ubiquitous expression in all tissues and Aldh1 is observed at low to moderate levels in esophagus, stomach and jejunum, but not in rectum The apparent signal

Ngày tải lên: 16/03/2014, 11:20

... mechanisms of many disease processes and will continue to impact our understanding of disease pathogenesis This mini-review will examine the previous studies of genes for ROCO or LRRK2 homologs in slime ... 6diseases [46] and is expected to contribute to an under-standing of the disease mechanisms in vivo The application of BAC transgenics is especially advantageous over conventional transgenics ... tools for dissecting the specific neuronal functions of LRRK2 (e.g dopamine transmission) and likely pre-symptomatic (or early) events of the disease process They should also be use-ful in testing

Ngày tải lên: 23/03/2014, 04:20

... 399 Parkinson’s Disease Society Carers’ assessment (FS46) London: Parkinson’s Disease Society, 2003 Ref ID: 19945 400 Buchanan S,Willis E Carers’ guide London: Parkinson’s Disease Society, 2004 ... improves dyskinesias in Parkinson’s disease: a prospective study using single-dose challenges Movement Disorders 2005; 20(2):151–157 Ref ID: 19993 229 Parkinson’s disease 256 257 Koller W, Lees A, ... disturbances and excessive daytime sleepiness in Parkinson’s disease Neurology 2004; 63(8 (Suppl 3)):S35–S38 Ref ID: 19898 323 Chaudhuri KR, Forbes A, Grosset DG et al Diagnosing restless legs

Ngày tải lên: 31/03/2014, 13:20

... (60 seconds) is accomplished Best value is registered. Time is registered in seconds, and gaitspeed is calculated as meters per second (m/s) A digital stopwatch is used In the study by Smithson ... Zwinderman AH: Prospective assessment of falls in Parkinson's disease. Journal of Neurology 2001, 248:950-958. 3. Gray P, Hildebrand K: Fall risk factors in Parkinson's disease J Neurosci Nurs 2000, 32:222-228. ... performance tests The PT (MHN) assessed the patient with clinical perform-ance tests, and the same PT assessed all patients in all test situations The tests were out of practical reasons per-formed

Ngày tải lên: 19/06/2014, 08:20

... epidemiological studies, nonsteroidal antiinflammatory drugs have shown protective effects in reducing the risk of neurodegenerative disease such as Alzheimer's disease [8,18] and PD [19] In the present study, ... ANOVA showed significant differences, pairwise comparisons between means were tested by Bonferroni post hoc testing Statistical significance was set at p < 0.05 for all analyses Results Valdecoxib ... TH-positive neurons than the WT mice (#p < 0.05 and ##p < 0.01, respectively) Nissl staining showed similar trends and statistical results (Fig 2C &2D), which indicates a true loss of the TH-positive

Ngày tải lên: 19/06/2014, 22:20

... process in Parkinson’s disease Neuroscience 2000, 95:425-432 Vila M, Jackson-Lewis V, Guegan C, Wu DC, Teismann P, Choi DK, Tieu K, Przedborski S: The role of glial cells in Parkinson’s disease ... M, Ichinose H, Togari A: Changes in cytokines and neurotrophins in Parkinson’s disease J Neural Transm Suppl 2000, 277-290 56 Hirsch EC, Hunot S: Neuroinflammation in Parkinson’s disease: a target ... atypical and idiopathic parkinsonism Neurosci Lett 2008, 441:158-162 Nagatsu T, Sawada M: Biochemistry of postmortem brains in Parkinson’s disease: historical overview and future prospects J Neural

Ngày tải lên: 19/06/2014, 22:20

... long-term results Stem cells are viewed as a possible source of neurons for cell-based therapies of neurodegenerative disorders, such as Parkin-son's disease and Alzheimer's disease [15] Neural stem ... dopaminergic neurons in a rat model of Parkinson's disease Abstract Although gait change is considered a useful indicator of severity in animal models of Parkinson's disease, systematic and extensive gait ... analysis in animal models of neurological deficits is not well established The CatWalk-assisted automated gait analysis system provides a comprehensive way to assess a number of dynamic and static

Ngày tải lên: 10/08/2014, 05:21

... Neuschwander-Tetri BA, Caldwell SH Non-alcoholic steatohepatitis:... interpretation of steatosis and steatohepatitis Semin Diagn Pathol 19 98; 1 5: 246–58 7 Diehl AM, Goodman Z, Ishak ... hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors Hepatology 19 90; 1 2: 11 06 10 17 Beckett AG, Livingstone AV, Hill KR Acute alcoholic hepatitis Br ... Non-alcoholic steatohepatitis: a study of 49 patients Hum Pathol 19 89; 2 0: 594–8 7 Wanless IR, Lentz JS Fatty liver hepatitis (steatohepatitis) and. .. non-alcoholic steatohepatitis J Hepatol

Ngày tải lên: 10/08/2014, 15:20

... L.: Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview Arnulf, I.: Sleep and wakefulness disturbances in Parkinson s disease ... outstanding scientists and clinicians, Toshiharu Nagatsu, Yoshikuni Mizuno, Japan (Award of the WFN Research Group on Parkinsonism and Related Disorders) , Saskia Biskup, Germany and Andrew B Singleton, ... Disease and Parkinsonism seen at the Columbia-Presbyterian Medical Center from 1949 to 1964 Nearly 85% had classic Parkinson s Disease and 13% had post-encephalitic associated Parkinsonism This...

Ngày tải lên: 14/02/2014, 17:20

... ISBN 1-85070-943-2 Extrapyramidal disorders Atlases Parkinsonism Atlases Movement disorders Atlases I Title II Series [DNLM: Parkinson Disease atlases Basal Ganglia Diseases atlases Movement Disorders ... in Spain by T.G Hostench, S. A Contents Foreword Preface Acknowledgements Section A Review of Parkinson s Disease and Related Disorders Section Parkinson s Disease and Related Disorders Illustrated ... Parkinson s disease ©2004 CRC Press LLC Figure 11 Posture in later-stage Parkinson s disease Figure 12 Parkinson s disease: Impaired fist clenching Figure 13 Parkinson s disease: Tremor illustrated...

Ngày tải lên: 14/03/2014, 22:20

... PARKINSON S DISEASE Figure 16 Parkinson s disease: dystonic posturing of the big toe secondary to dopa therapy 15 16 AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 17 Parkinson s disease: ... Posture in later-stage Parkinson s disease AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 12 Parkinson s disease: impaired fist clenching 11 12 AN ILLUSTRATED POCKETBOOK OF PARKINSON S ... RD, Bakay RA Neurosurgical horizons in Parkinson s disease Neurology 1993;43:l–7 Parkinson' s disease Any discussion of the clinical characteristics of Parkinson s disease must take into account...

Ngày tải lên: 14/03/2014, 22:20

... Figure 14 Positive glabellar tap Persistent blinking is a feature of Parkinson s disease, but is also seen in Alzheimer s disease Figure 15 6-[18F]-fluorodopa–PET scan appearance in a normal subject ... cells (astrocytes and macrophages) Debris and a few vascular channels can be seen (Luxol fast blue–H & E) Figure 24 CT of a patient with a Parkinsonian syndrome shows multiple lacunar infarcts ... Histological sections from Parkinson' s disease with dementia showing cortical Lewy bodies stained with ubiquitin (immunochemistry preparation, left; silver impregnation, right) Figure 28 Histology...

Ngày tải lên: 09/08/2014, 16:21

... normal subject (left) compared with that in Parkinson' s disease (middle) and in progressive supranuclear palsy (right) (11C-raclopride is a selective reversible antagonist of D2 receptors) Figure ... degeneration shows atrophy of the putamen with rarefaction and gliosis (H & E) Figure 35 Transverse section of midbrain in striatonigral degeneration shows pallor of the substantia nigra ©2004 CRC Press ... (lower) basis pontis secondary to olivopontocerebellar atrophy in multiple system atrophy Figure 38 Histological sections of basis pontis (arrowed) show the normal complement of pontine neurons in...

Ngày tải lên: 09/08/2014, 16:21