parasite dampening and disturbing immune responses

... Control of Innate and Adaptive Immune Responses during Infectious Diseases Julio Aliberti Editor Control of Innate and Adaptive Immune Responses during Infectious Diseases ... pathogen recognition, initiation and expansion of immune responses, neutralization of toxic elements and elimination of replicating organisms and finally healing and remodeling of damaged tissues ... powerful immune response takes place in order to contain dissemination of the parasite and prevent mortality Once parasite proliferation is contained by IFN- -dependent responses, nevertheless, parasite...

Ngày tải lên: 05/03/2014, 23:20

... cellular and humoral immune responses and are protected from immune- mediated inflammation in various models, such as experimental colitis, T-cell mediated hepatitis, glomerulonephritis and experimental ... exerts various direct effects on cells involved in the immune and inflammatory responses However, the connection between leptin, immune responses and inflammation in vivo is complex Indeed, leptin/leptin ... inflammatory state and could thus favor different immune and inflammatory responses To investigate the relative contributions of direct and indirect effects of leptin on the immune system in a...

Ngày tải lên: 09/08/2014, 08:22

... immunogens and adjuvants Innate immune sensors The nucleic acid binding TLRs appear to play pivotal roles in SLE TLR7 and TLR8 bind to single-stranded RNA, TLR3 to double-stranded RNA, and TLR to ... These and other observations discussed below indicate that innate immune recognition plays a key role in the initial development and amplification of the immune response to both nucleic acid and ... [10,11] DNA and Toll-like receptor activation Several mechanisms serve to promote the specificity of responses to nucleic acids, so that innate immune cells sense and respond to viral and bacterial...

Ngày tải lên: 09/08/2014, 10:21

... GM-CSF and cardiotoxin substantially enhanced the immune responses after intramuscular DNA immunization The advantage of tattoo treatment is the low price of the tattoo device and a standardized ... DNA in the absence of adjuvants using a tattoo device elicited much stronger and more rapid humoral and cellular immune responses than intramuscular needle delivery together with molecular adjuvants ... after intradermal injection [7,8] and gene gun delivery [8] DNA vaccines delivered by tattoo were able to induce both cellular [6,7] and humoral antigen-specific responses [6,8] Compared to intra-muscular...

Ngày tải lên: 14/08/2014, 19:22

... and FT conceived the study, and participated in its design and coordination and helped draft the manuscript All authors read and approved the final manuscript Competing interests CB, CG, MM and ... guidelines, and all applicable local laws and regulations The study protocol and amendments were approved by an institutional review board and an independent ethics committee Study design and treatments ... combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity Journal of Translational Medicine 2010 8:71 Submit your next manuscript to BioMed Central and take full advantage...

Ngày tải lên: 18/06/2014, 16:20

... proinflammatory immune responses As possible markers of these changes in the immune system we investigated the proinflammatory cytokines IL-6 and TNF-a and measured the lymphocyte cell count Materials and ... Medicine and Toxicology 2010, 5:18 http://www.occup-med.com/content/5/1/18 deprivation and thereby an induction of proinflammatory immune responses [7-9] Cytokine levels correlate with fatique and ... disturbances and chronic sleep debt [1-6] To investigate the long-term influence of chronic sleep debt and circadian disruption on the immune system we compared cytokine production and lymphocytes...

Ngày tải lên: 20/06/2014, 00:20

... infected Ectoparasites Lice, mites, ticks and other arthropods Heligmosomoides polygyrus Ixodes hexagonus Figure Categories of parasites, using the broader definition to include fungi and ectoparasites ... By targeting innate immune responses, the parasite is also reducing cytokine-based stimulation of the adaptive immune system Moreover, similar effects were exerted by ectoparasites, in particular ... recognized for the regulation of immune responses The effect of parasites, for example, has been to dampen, rather than fully ablate, immune responsiveness, and the degree of immunosuppression...

Ngày tải lên: 06/08/2014, 19:20

... 63-68 Corthier, G Cellular and humoral immune response in pigs given vaccine and chronic hog cholera viruses Am J Vet Res 1978, 39, 1841-1844 Davis, W C., M J Hamilton, and Y.H Park Ruminant leukocyte ... Jeong, and B K Park Enhancement of host immune responses of sows using a non-specific immunomodulator p.22 Proceed 15th International Pig Veterinary Society Congress, Birmingham, England, 5-9 ... J H Gillespie, F W Scott, and J E Barlough Hagan and Brunners microbiology and infectious diseases of domestic animals pp.729-740 8th ed Comstock Pub Assoc., Ithaca and London, 1988 Yoon, I J.,...

Ngày tải lên: 07/08/2014, 14:23

... venom immunotherapy33 and decreases the production of sulfidoleukotrienes by human PBLs.34 IFN-c also downregulates transforming growth factor b and procollagen I and III and decreases fibrosis ... prepared as above, and an amount containing 10 mg of pEGFP was administered intranasally to mice After 1, 3, and days, the mice were euthanized and the lungs were removed and fixed in buffered ... were treated therapeutically with CIN and then challenged with OVA and euthanized 18 hours later Lungs were removed, and single-cell suspensions were prepared and plated as described above In this...

Ngày tải lên: 08/08/2014, 21:20

... cells might limit anti-tumour or microbial immune responses A strategic manipulation of TR cells might thus be used either to enhance or to dampen immune responses as required The identification ... S, Holland G, Thompson-Snipes L, Leach MW, Rennick D: Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4+ TH1-like responses ... control immune responses Most recently, several groups have demonstrated that glucocorticoid-induced tumour necrosis factor family related protein (GITR) is predominantly expressed at both the RNA and...

Ngày tải lên: 09/08/2014, 01:23

... impaired mammary gland development and reduced numbers of natural killer (NK) and NK T cells These phenotypes in CIStransgenic mice are remarkably similar to those observed in STAT5a KO and/ or STAT5b ... including macrophages and Bacterial lipopolysaccharide (LPS) triggers innate immune responses through Toll-like receptor (TLR4) Other bacterial pathogens including proteoglycans and CpG-DNA also activate ... were abnormally accumulated in the thymus and spleen and produced high levels of BAFF/BLyS and APRIL, resulting in the aberrant expansion of B cells and autoreactive antibody production SOCS1-deficient...

Ngày tải lên: 09/08/2014, 06:23

... IRD patients and from six non-IRD patients were cultured with antigens and a mitogen control and supernatants assayed for IFNγ and IL-10 During the first episodes of IRD, PBMC from P1 and P2 produced ... cell responses after commencing ART We used PPD as an antigen to investigate pathogen-specific cytokine responses because we and others have shown that IRD associated with infection by Mtb and ... count of 48/ μL and plasma HIV RNA level >100,000 copies/mL He developed fever on day 11 of ART and sputum collected on each of the following days yielded M celatum Chest radiography and a computer...

Ngày tải lên: 10/08/2014, 05:21

... and PHIS-01 are required to stimulate immune responses None of these two compounds stimulates reaginic immune responses, nor induces autoimmune lupus-like syndromes Most importantly, phytol and ... elicit cellular immune responses involving Th1 cells, and CTLs Such responses are required to control chronic infectious diseases associated with viruses and intracellular pathogens, and also for ... Formulation: Assessment of Safety and Efficacy in the Induction and Protective Immune Responses to Lethal Bacterial infections in Mice J Immune Based Therapies and Vaccines 2006, 4:5 Bendavid A,...

Ngày tải lên: 11/08/2014, 10:23

Ngày tải lên: 11/08/2014, 10:23

... induced immune responses and the conferred protection in mice after genetic immunisation with cDNA encoding the structural proteins of RVFV The elicited immune responses towards the N, GN, GC and ... and a human virus isolate of RVFV attenuated in cell culture by 5-fluorouracil treatment, MP12 [13,14] Although Clone 13 and MP12 were shown to be safe and immunogenic in mice and in cattle and ... Ethics Committee of Umeå University, Sweden Evaluation of immune response To evaluate and compare the immune responses after vaccination and infection, eight animals were vaccinated with cDNA encoding...

Ngày tải lên: 12/08/2014, 04:21

... lymphoproliferation and cytokine responses to innate and allergic stimulation Lymphoproliferative responses and Th1 (IFN-γ, IL-12) as well as Th2 (IL-13) cytokine responses to innate and allergic stimuli ... the results and drafted the manuscript MC and HH carried out part of the experiments DP participated in study design and data analysis MWG, DG, SW and EL contributed to study design, and draft ... Brigham and Women's Hospital and Harvard Pilgrim Health Care, Boston, MA Isolation of CBMC and lymphocyte proliferation Cord blood samples were collected from the umbilical vein after delivery and...

Ngày tải lên: 12/08/2014, 16:20

... virus-specific humoral and cellular immune responses in controllers and progressors (A) Antibody titer against the SIV-p27 and SIV-gp130 protein were determined in serum of controllers (blue) and progressors ... of cellular immune responses by ICS was focused on Gag PBMC and BAL cells were stimulated with a Gag-peptide pool and those from Mamu-A1*001 positive animals additionally with the immune dominant ... genotypes and reviewed the manuscript WI performed the SIV proviral load analyses CSH carried out ELISA and ELIspot experiments and reviewed the manuscript TS, RS and CSH designed and coordinated...

Ngày tải lên: 13/08/2014, 01:20

... Engineering and Biotechnology, India and Dr Q Duong Hong, Institute of Biotechnology, Hanoi, Vietnam, and Falko G Falkner, Baxter Bioscience, Austria for providing H5N1 virus-derived DNA constructs and ... Alexander N Zakhartchouk, University of Saskatchewan, Canada for providing the human adenovirus vector and Mia Brytting, Swedish Institute for Infectious Disease Control and Mikael Berg and Siamak ... Institute of Molecular and Cell Biology, my deepest thanks for all your help and encouragement Last but not least, sincere appreciation and thanks to my family for their patience and support all these...

Ngày tải lên: 11/09/2015, 09:58

... 1.4.3.1 Humoral immune response 39 1.4.3.2 Cellular immune response 41 CHAPTER 2: MATERIALS AND METHODS 2.1 Antibodies and synthetic peptides 44 2.2 Viruses 45 2.3 Mice and immunization 46 ... virus (clade 1) was generated and characterized Firstly, the baculovirus-expressed and purified recombinant HA (rHA) was shown to elicit neutralizing humoral and T cell responses in the mouse model ... mouse model 63 III 3.2 Memory T cell responses against SARS structural nucleocapsid (NP) and accessory 3a protein in SARSrecovered patients 67 3.2.1 CD4+ and CD8+ T cell response in SARS individuals...

Ngày tải lên: 11/09/2015, 09:58

... humoral and cellular immune responses against these two viral infections in sections 1.4.2 and 1.4.3 1.4.1 Clinical Features of SARS and H5N1 influenza Clinical presentations of both SARS and H5N1 ... viral and cellular membrane, and consequently the viral entry Effect on cellular response of host [ref(s)] The S protein was known to be responsible for inducing host immune responses and is ... Coronaviridae, genus Coronavirus and cause respiratory and enteric diseases in humans and other animals Three serologically distinct groups of coronaviruses have been identified Group I and II contain mammalian...

Ngày tải lên: 11/09/2015, 09:58