pa u par and pai 1 levels in normal and ra synoviocytes

... Research Institute All participants gave their written informed consent before participation in this study Participants Patients receiving outpatient medical care at the rheumatology clinics of ... were log-transformed to achieve normality Parametric testing between two matched or unmatched groups was performed using the paired or unpaired t test, respectively Parametric testing among three ... groups was Page of 12 (page number not for citation purposes) Arthritis Research & Therapy Vol No Collins et al Figure BLyS protein and BLyS isoform mRNA levels in normal individuals, and RA, and...

Ngày tải lên: 09/08/2014, 07:20

... preparation All authors read and approved the final version of the manuscript Competing interests The authors declare that they have no competing interests Page of 9 10 11 12 13 14 15 16 17 18 19 ... management Curr Opin Rheumatol 20 01, 13 :3 41- 344 Noel B: Risks and benefits of statins in lupus erythematosus Arch Intern Med 2004, 16 4 :10 7 -10 8 Bruce IN: Cardiovascular disease in lupus patients: should ... Therapy 2 011 , 13 :R 117 http://arthritis-research.com/content /13 /4/R 117 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 Page of patients: study in 11 37 patients with 6-year follow-up Circulation 19 99,...

Ngày tải lên: 12/08/2014, 17:22

... IFIGs and chemokines in particular patients; consequently, all values were expressed as medians with 25th and 75th percentiles and interquartile ranges (IQRs), and comparisons were conducted using ... chemokine ligand; CXCL, C-X-C chemokine ligand; IFIG, IFN-inducible gene; IFIT, interferon-induced protein with tetratricopeptide repeats; IL, interleukin; IP -10 , interferon-inducible protein 10 ; ... normal trafficking and localization of certain populations of immune cells in the body; hence, they may impair the normal function of such cells In cutaneous lupus erythematosus, MIG and IP -10 have...

Ngày tải lên: 09/08/2014, 13:22

... exclusively responsible for clearance of individual pathogens, aberrant phagocytic machinery and uptake capacity could still contribute to inadequate responses to harmful pathogens 10 11 12 13 ... http://arthritis-research.com/content /10 /5/R 114 Table Demographic and clinical characteristics of systemic lupus erythematosus patients Characteristic Systemic lupus erythematosus patients Control individuals Number 63 31 Female ... cells in the pathogenesis of systemic lupus erythematosus Future Rheumatol 2008, 3:269-280 21 Banchereau J, Pascual V: Type I interferon in systemic lupus erythematosus and other autoimmune diseases...

Ngày tải lên: 09/08/2014, 13:22

... have no competing interests Received: January 2 011 Revised: 11 March 2 011 Accepted: 15 April 2 011 Published: 15 April 2 011 References Kotzin BL: Systemic lupus erythematosus Cell 19 96, 85:303-306 ... stimulus Defense response 19 2 17 6 963 887 7.36 × 10 -11 7.69 × 10 -10 Immune response 15 9 792 2.45 × 10 -9 Response to stress 14 7 872 2.39 × 10 -4 Response to pest/pathogen/parasite 97 5 01 2.09 × 10 -5 ... protein -1 and C-jun N-terminal kinase in systemic lupus erythematosus patients Neuroimmunomodulation 2006, 13 :19 4-204 Lehmann AR: The xeroderma pigmentosum group D (XPD) gene: one gene, two functions,...

Ngày tải lên: 12/08/2014, 15:23

... X-linked immunodeficient mice spontaneously produce lupus-related antiRNA helicase A autoantibodies, but are resistant to pristaneinduced lupus Int Immunol 2003, 15 :11 17 -11 24 Zhuang H, Narain ... Textbook of Rheumatology 15 th edition Edited by: Koopman WJ, Available online http://arthritis-research.com/content /11 /1/ R27 10 11 12 13 14 15 16 17 18 19 20 21 Moreland LW Philadelphia: Lippincott Williams ... U1 –70 k protein and can induce anti -U1 –70 k antibodies in a mouse model [14 ,15 ] Human vaccination of a live attenuated Towne vaccine, a recombinant CMV glycoprotein B vaccine or a glycoprotein...

Ngày tải lên: 09/08/2014, 01:22

... battery and measures of depression, fatigue, pain, and perceived cognitive failures were investigated Materials and methods Subjects Participants in this study included 13 Depressed-SLE participants, ... citation purposes) tains 15 pain-related words divided into sensory and affective categories in a pain-rating index Individuals are asked to give each description of pain a rating from ('none') ... Depressed-SLE participants Correlations between the cognitive impairment in DepressedSLE participants and measures of fatigue, pain, and perceived deficits were not found Interestingly, in a prior study...

Ngày tải lên: 09/08/2014, 10:20

... VH3-74* 01 VH4-4*03 VH4-30.4* 01 2-2* 01 VH4-34* 01 VH4-59 1- 26* 01 VH5- 51* 01 2-2* 01 VH5- 51* 01 2-2* 01 VH5- 51* 01 4-4* 01 5*02 B C D VH3-07 VH3-23 VH3-33 VH3-72* 01 VH4-59*02 VH5- 51* 01 VH5- 51* 01 2 -15 3-22 6 -13 * 01 ... 3-22 6 -13 * 01 5-5* 01 5-24* 01 2-2* 01 6 -13 * 01 6*02 4*02 6*02 4*02 3 1 1 4*02 6*02 5*02 4*02 4*02 4*02 3*02 2 (1) 1 (1) 5(3) 1 11 3 (1) 3*02 6*03 4*02 4*02 4*02 1* 01 4*02 13 (10 ) 3 (1) 1 3(2) 2* 01 6*03 3*02 ... 1- 26* 01 VH2-5*02 VH3- 21* 01 VH3-30*03 2-8* 01 VH3-30*03 2-8* 01 VH3-30.3* 01 3-3* 01 VH4-30 .1 2-2* 01 5* 01 VH2-5*02 VH3 -15 * 01 VH3- 21* 01 VH3-23* 01 VH3-23* 01 3 -10 *02 VH3-30*03 VH3-30*03 VH3-33* 01 5-24*01...

Ngày tải lên: 09/08/2014, 01:21

... Hs0 019 42 61_ m1 Interferon, alpha-inducible protein 27 (IFI27) Hs002 714 67_m1 Interferon, gamma-inducible protein 30 (IFI30) Hs0 017 3838_m1 Interferon-induced protein 35 (IFI35) Hs00 413 458_m1 Interferon induced ... Hs00382744_m1 Interferon-induced protein with tetratricopeptide repeats (IFIT5) Hs002027 21_ m1 Interferon, alpha-inducible protein (IFI6) Hs002425 71_ m1 Interferon, gamma-inducible protein 16 (IFI16) Hs0 019 42 61_ m1 ... (IL4R) Hs0 016 6237_m1 Prostaglandin E synthase (PTGES) Hs00 610 420_m1 Interferon-induced protein with tetratricopeptide repeats (IFIT1) Hs 019 114 52_m1 Interferon-induced protein with tetratricopeptide...

Ngày tải lên: 09/08/2014, 01:22

... effective preventive strategies for normal individuals is simple and neat, but might be wrong or incomplete 10 11 12 Several questions remain unanswered in our search for a successful approach to the ... Division of Rheumatology, Allergy and Immunology, Bulfinch 16 5, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 0 211 4, USA Tel: +1 617 726 2870 or +1 617 732 50 81; fax: +1 617 726 2872; ... incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: comparison with the Framingham Study Am J Epidemiol 19 97, 14 5:408- 415 Badui E, Garcia-Rubi D, Robles...

Ngày tải lên: 09/08/2014, 01:22

... Blood 19 97, 90 :11 09 -11 14 Davies KA, Peters AM, Beynon HL, Walport MJ: Immune complex processing in patients with systemic lupus erythematosus In vivo imaging and clearance studies J Clin Invest 19 92, ... systemic lupus erythematosus Arthritis Rheum 19 94, 37 :13 80 -13 85 14 Suzuki H, Matsui Y, Kashiwagi H: Interleukin -1 receptor antagonist gene polymorphism in Japanese patients with systemic lupus erythematosus ... systemic lupus erythematosus Arthritis Rheum 19 82, 25 :12 71- 1277 16 Jonsson H, Nived O, Sturfelt G: Outcome in systemic lupus erythematosus: a prospective study of patients from a defined population...

Ngày tải lên: 09/08/2014, 01:24

... [interquartile range] AI: 1. 63 [1. 31 1. 88] in SLE patients versus 1. 50 [1. 26 1. 73] in control individuals, P = 0 .15 7; data not shown) The AI was determined once for each patient and control individuals ... TGF- 1 activation indices and lymphocyte apoptosis in SLE patients and control individuals were compared using the Mann-Whitney U test Clinical associations were compared using the Mann-Whitney U ... accelerated atherosclerosis in systemic lupus erythematosus Arthritis Rheum 20 01, 44:23 31- 2337 26 Bruce IN: Cardiovascular disease in lupus patients: should all patients be treated with statins and...

Ngày tải lên: 09/08/2014, 08:22

... Therapy 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Vol No Yamasaki et al human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein J Clin Invest 19 96, 97:2 619 -2626 ... anti-RPA-positive human autoimmune sera in ELISA with mAbs against RPA32 and against RPA70 was compared Spearman r = 0.9524, p = 0.0 011 (d) Titration curves of anti-RPA-positive human sera Titration ... pristane-induced lupus J Immunol 2000, 16 5 :10 36 -10 43 Rubin RL: Enzyme-linked immunosorbent assay for anti-DNA and antihistone antibodies including anti-(H2A-H2B) In Manual of Clinical Laboratory Immunology...

Ngày tải lên: 09/08/2014, 08:22

... mediated by intracellular, nucleic acid binding TLRs, stimulating B-cell maturation and pDC secretion of IFN-α These findings provide a new framework for understanding lupus pathogenesis and suggest ... production in primary human monocytes J Immunol 2006, 17 6:7438-7446 35 Peng SL, Moslehi J, Craft J: Roles of interferon-gamma and interleukin-4 in murine lupus J Clin Invest 19 97, 99 :19 3 619 46 ... surrounding activating TLRs for treatment of infectious and oncologic diseases, and in particular in vaccine development, assures an enduring interest in TLR therapeutics that extends to autoimmunity [67]...

Ngày tải lên: 09/08/2014, 10:21

... ester transfer protein) inhibitor torcetrapib added to a statin, compared with placebo plus statin, quantitative HDL levels increased 72 .1% in 12 months in the torcetrapib/statin group, but atherosclerotic ... oxidation, including oxidized lipids and serum amyloid protein Such changes have been shown to occur in acute infection, in acute ‘trauma’ of surgical interventions, and in chronic inflammation ... cholesterol levels, triglycerides, lipoprotein (a), apolipoproteins A -1 and B, and HDL density subfractions The Atherosclerosis Risk in Communities (ARIC) Study Circulation 20 01, 10 4 :11 08 -11 13 Barter...

Ngày tải lên: 09/08/2014, 10:23

... cells in autoantibody production in murine lupus Clin Exp Immunol 2006, 14 5: 513 - 519 Liu MF, Wang CR, Fung LL, Wu CR: Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus ... SN: Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus Adv Exp Med Biol 2007, 6 01: 113 -11 9 Miyara M, Amoura Z, Parizot C, Badoual C, ... Immunol 2005, 6 :11 42 -11 51 β Marie JC, Letterio JJ, Gavin M, Rudensky AY: TGF- 1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells J Exp Med 2005, 2 01: 10 61- 1067...

Ngày tải lên: 09/08/2014, 13:22

... Hs0 019 42 61_ m1 Interferon, alpha-inducible protein 27 (IFI27) Hs002 714 67_m1 Interferon, gamma-inducible protein 30 (IFI30) Hs0 017 3838_m1 Interferon-induced protein 35 (IFI35) Hs00 413 458_m1 Interferon induced ... Hs00382744_m1 Interferon-induced protein with tetratricopeptide repeats (IFIT5) Hs002027 21_ m1 Interferon, alpha-inducible protein (IFI6) Hs002425 71_ m1 Interferon, gamma-inducible protein 16 (IFI16) Hs0 019 42 61_ m1 ... (IL4R) Hs0 016 6237_m1 Prostaglandin E synthase (PTGES) Hs00 610 420_m1 Interferon-induced protein with tetratricopeptide repeats (IFIT1) Hs 019 114 52_m1 Interferon-induced protein with tetratricopeptide...

Ngày tải lên: 09/08/2014, 13:22

... cells in patients Although CD4+ T cells are pathogenic in murine, and apparently in human, lupus [2], the contribution of individual Th-cell subsets to disease remains unclear, particularly in humans ... Daejeon 3 01- 1 31, Republic of Korea Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA 10 11 12 13 14 15 16 17 18 Authors’ contributions ... [14 -16 ], as well as murine lupus models [17 ,18 ] Increased levels of IL -17 also have been found in blood and tissues of patients with inflammatory bowel disease and psoriasis [19 ,20], suggesting...

Ngày tải lên: 12/08/2014, 12:20

... 85 31 5.3 3.63 13 10 Pred 12 .5 mg/d MMF g/d 6.0 12 .0 74 0.6 45 58 27 0 .11 15 11 Pred 50 mg/d 3.54 9.4 47 0.9 29 10 1 34 NA 12 Pred 15 mg/d, HCQ 200 mg/d, Aza 10 0 mg/d 5. 21 11. 6 31 0.25 12 10 9 ... http://arthritis-research.com/content /12 /3/R 91 Page of 12 Figure Phenotypic analysis of mature FLDCs and mature mDCs Mature FLDCs expressed medium levels of CD11c and CD123, whereas mature mDCs expressed high levels of CD11c but only ... systemic lupus erythematosus Clin Immunol 2004, 11 3:4 -13 Yurasov S, Wardemann H, Hammersen J, Tsuiji M, Meffre E, Pascual V, Nussenzweig MC: Defective B cell tolerance checkpoints in systemic lupus...

Ngày tải lên: 12/08/2014, 12:20