overview bridging basic science and clinical medicine

... including selectins and selectin-ligands, integrins and their recep- tors, and other cell-cell and matrix-binding molecules [240,242] However, ordered expansion and redistribu- tion from and into the ... CSC markers, CSC targets, and the preclinical and clinical evaluation of the CSC-eradicating (curative) potential of various drugs However, although diverse CSC markers and targets have been identified, ... role in SC homing and SC self-renewal Anumber of SC receptors and their ligands regulate qiuesence, self-renewal, proliferation, differentiation, and homing of SC Relevant ligands areexpressed...

Ngày tải lên: 02/11/2022, 09:03

... the realities of clinical research and clinical practice in terms of opportunities, costs, and liabilities based upon informants’ clinical, research, and/ or administrative and leadership experiences ... companies, clinical research organizations, and other organizations that have recruited and trained community healthcare providers for clinical trials and clinical research networks and/or have ... Explanatory and practical clinical trials: Two options for clinical trials in community settings [7,42] Explanatory clinical trials: Practical clinical trials: Hypothesis and design Hypothesis and study...

Ngày tải lên: 10/08/2014, 10:23

... believe that clinical research is valued by colleagues or patients. 3 Develop and articulate clinical research principles that value clinicians and patients and with a clear set of standards that ... Compass Lexecon, Oakland, CA, USA. Authors ’ contributions MB, GR, and KK designed the study and drafted the manuscript EQ, CB, ST, MC, and HP guided study design and read and revised the manuscript ... NIH roadmap Science 2003, 302: 63-4, 72. 2 Zerhouni EA: US biomedical research: basic, translational, and clinical sciences JAMA 2005, 294(11): 1352-8. 3 AAMC ’s Task Force II on Clinical Research:...

Ngày tải lên: 10/08/2014, 10:23

... Prof Dr Michael J Parnham PhD Director of Preclinical Discovery Centre of Excellence in Macrolide Trang 4PEGylated Protein Drugs: Basic Science and Clinical ApplicationsEdited by Francesco M Veronese ... century 1 Francesco M Veronese, Anna Mero and Gianfranco Pasut Protein PEGylation, basic science and biological applications 11 Gian Maria Bonora and Sara Drioli Reactive PEGs for protein ... antibodies, peptides and proteins, polymer therapeutics, andoligonucleotides and cell therapy will all play an important and complementa- ry role in the prevention, control and cure of diseases...

Ngày tải lên: 29/03/2014, 08:20

... normal mammary gland development and the formation of breast carcinomas We hypothesise... ductal side branching and the alveolar development of the mammary gland whereas chimeric ... regenerate the entire gland. .. that the dye Hoechst 33342 is toxic to cells; perhaps cells that can efflux the dye are able to form mammary glands and mammospheres simply because ... (Smalley and Clarke 2005) 7 Cell Surface Markers A more appropriate method may be the. .. through the Wnt pathway to increase SC self-renewal 2 Mammary Gland Development Mammary gland...

Ngày tải lên: 15/03/2014, 09:20

... ADVANCESIN VETERINARYSCIENCEAND COMPARATIVEMEDICINE,VOL.39 Overview: Bridging Basic Science and Clinical Medicine W JEAN DODDS Hemopet, Santa Monica, California 90403 I Background A Basic and Applied ... Advances in Veterinary Science and Comparative Medicine Volume 39 Veterinary Medical Specialization: Bridging Science and Medicine Advances in Veterinary Science and Comparative Medicine Edited by ... modalities in clinical veterinary medicine This has fostered the development of veterinary specialization, which brings existing knowledge from the basic sciences and clinical human medicine to clinical...

Ngày tải lên: 29/03/2014, 15:20

... characterized by glandular fever and the massive expansion of virus-specific T cells (Vetsika and Callan, 2004) Pooled data from 18 clinical studies revealed a significant link between IM and an elevated ... and Stem Cell and Other Therapies disease initiation method, with a single and defined myelin peptide allows for the observation and measurement of changing T cell specificities over time (Vanderlugt ... (Rudick and Sandrock, 2004) Clinical studies with Natalizumab have shown this drug to have high efficacy in terms of its ability to prevent disease relapses and progression (Chaudhuri and Behan,...

Ngày tải lên: 16/03/2014, 21:20

... T, Tanioka H, Fujita S: Detection of human herpesvirus and human herpesvirus in the submandibular gland, parotid gland, and lip salivary gland by PCR J Clin Microbiol 1996, 34:2320-2321 Lautenschlager ... Luca D, Mirandola P, Ravaioli T, Dolcetti R, Frigatti A, Bovenzi P, Sighinolfi L, Monini P, Cassai E: Human herpesviruses and in salivary glands and shedding in saliva of healthy and human immunodeficiency ... Brytting M, Bjerregaard L, Julander I, Linde A: Shedding of cytomegalovirus and herpesviruses 6, 7, and in saliva of human immunodeficiency virus type 1-infected patients and healthy controls Clin...

Ngày tải lên: 09/08/2014, 06:22

... Array production and assay Synovial and myelin antigen arrays were produced using a robotic arrayer The arrayer printed peptides and proteins representing candidate antigens in RA and MS on the ... encephalomyelitis (EAE) using myelin and myelin and synovial antigen arrays (a, b) Synovial and (d, e) myelin arrays were produced by printing synovial and myelin peptides and proteins in ordered arrays ... (IgM, IgG and IgG subclasses) of the initial and expanding autoantibody responses in rodent models, as well as human RA and MS Autoimmune responses are well established to target both native and linear...

Ngày tải lên: 09/08/2014, 13:22

... leading to hemorrhage and perivascular microgliosis and astrocytosis The Dutch and Iowa mutations both reduce the negative charge of Ab and stimulate the formation of amyloid fibrils and attachment to ... cerebrospinal fluid (CSF) and plasma of young transgenic mice and healthy human Measures in PDAPP refer to Ab 1–x, in Tg2576, APP23 and humans to the sum of Ab1–40 and Ab1–42, and in tgArcSwe they ... that metal ions like Zn2+ and Cu2+ play a role in Ab biology, and possibly in AD pathogenesis Both ions bind APP and Ab with high affinity, and stimulate Ab aggregation and oxidizing effects of...

Ngày tải lên: 16/02/2014, 09:20

... pharmacology and physiology, data interpretation, and manuscript review TGH designed the study, and participated in the collection and analyses of data, data interpretation, and manuscript preparation and ... between the major axes of the left and right paw images during peak stance Gait data were collected and pooled from both the left and right forelimbs, and the left and right hind limbs Measures of ... light: 12-hour dark schedule with ad libitum access to food and water Handling and care of mice were consistent with federal guidelines and approved institutional protocols Experimental groups MPTP...

Ngày tải lên: 19/06/2014, 10:20

... patient brain and show an increased production of inflammatory markers such as COX-2, PGE2 and also increased levels of the pro-inflammatory cytokines IFN-γ and IL-12, TNF-α, IL-1α, IL-1β and IL-6 ... 15 fold more Aβ1–40, and 20 fold more 1– 42) but there was considerable slice-to-slice variation in soluble and insoluble Aβ levels within and between genotypes The TgAPPsw and PS1/APPsw mice express ... formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors Neuroscience 1994, 61:745-54 Cacabelos R, Alvarez XA, Fernandez-Novoa L, Franco...

Ngày tải lên: 19/06/2014, 22:20

... seems to act as a negative regulator of CTLA-4 function and dissociates from CTLA-4 upon ligand binding The ligands are the dimeric CD80 and the monomeric CD86 Binding of CD80 to the divalent ... CD28 and CTLA-4 CD28 and CTLA-4 have distinct functions during T cell activation Triggering of CD28 enhances raft accumulation and the accumulation of transcription factors, such as AP-1 and nuclear ... rheumatoid arthritis (RA) and other autoimmune diseases 50 The human CD28 and CTLA-4 genes map to chromosome 2q33 and are separated by about 60 kilobases The homologies between CD28 and CTLA-4 strongly...

Ngày tải lên: 09/08/2014, 01:23

... cov(X,R) the genetic covariance between the proband, X , and a relative, R For individuals X and R we Wray and Goddard Genome Medicine 2010, 2:10 http://genomemedicine.com/content/2/2/10 Page of 13 define ... numbers of risk alleles and compare this with the model Wray and Goddard Genome Medicine 2010, 2:10 http://genomemedicine.com/content/2/2/10 Page of 13 1.0 the same models were 10, and 4, respectively ... disease in grandoffspring of diseased grandparents; λOP, recurrence risk of disease in offspring of diseased parents; λR, recurrence Wray and Goddard Genome Medicine 2010, 2:10 http://genomemedicine.com/content/2/2/10...

Ngày tải lên: 11/08/2014, 12:20

... inhibition of BLyS, APRIL, and the heterotrimers by atacicept is consistent with the observed effects of atacicept and/ or murine TACI-Ig in preclinical and clinical studies In mice and monkeys, atacicept ... (BAFF) -and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor (TNF) family and are important regulators of B-cell maturation, survival, and function [1,2] The TNF ligands ... analyses and correlation studies for the BLyS, APRIL, and heterotrimer serum levels in patients with SLE and RA, and co-wrote the manuscript JLE helped design the heterotrimer assay and assisted...

Ngày tải lên: 12/08/2014, 12:20

... possible clinical benefit to organ transplantation and revascularization procedures The clinical experience is limited to patients with RA and ITP Yet the rapidity of action and the extent of clinical ... rheumatoid arthritis (RA), FLSs expand in numbers, acquire immune cell features, produce proinflammatory cytokines and enzymes, and contribute to the inflammatory process and the eventual destruction ... to MTX R788 (100 mg twice a day): ACR20, 50, and 70 responses (66%, 43%, and 28%) R788 (150 mg every day): ACR20, 50, and 70 responses (57%, 32%, and 14%) Genovese et al [48] R788 months, 100...

Ngày tải lên: 12/08/2014, 15:22

... enlargement and an enhanced compliance and mucus cell metaplasia [75] with activation of MMP-2, -9, -12, -13, and -14 and cathepsins B, S, L, H, and K in this model Parallel to protease-based and extracellular ... subepithelial fibrosis and mucus metaplasia combined with an eosinophil-, lymphocyte-, and macrophage-rich inflammation and increased hyperresponsiveness [73] Since asthma and COPD pathogenesis ... to guinea pigs, rabbits, and dogs, and also rats and mice have been used Guinea pigs have been reported to be a very susceptible species They develop COPD-like lesions and emphysema-like airspace...

Ngày tải lên: 12/08/2014, 18:21

... between humans and dogs than between humans and rodents [85] Familial copper storage disorders in Bedlington and West Highland white terriers are usually associated with early subclinical disease ... lamp current 17 mA Standards used are 3, and 12 ppm prepared from 1000 ppm stock standard in 0.2 M HNO3 Peak area is read with a read delay of s, and a read time of s Standard reference materials ... transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin Physiol Rev 1985, 65:238-309 DiDonato M and Sarkar B Copper transport and its alterations...

Ngày tải lên: 13/08/2014, 13:20

... period of one day and basic reproduction numbers R0 = 1.5, 3.0, 4.5, and 6.0 With these assumptions, the contact intensity and the shedding rate can be Table 2: Time categories and translation ... same basic reproduction number and have the same underlying contact structure Average deviations are shown for the whole range of S and R0 The average deviations were normalized by the basic ... the ingested dose and the infection risk as derived in Haas et al [18] and used in several other publications [22-24] Details describing how the following assumptions 1, 3, and translate into...

Ngày tải lên: 13/08/2014, 16:20