oral mucosal drug delivery systems

... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... numerous types of protein drug [21 – 23] 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development 15.6.1 Polyketals Polyketal - based drug delivery systems are under development ... a drug delivery system for kinetic control Dissolution of drug is too slow Drug and/or formulation is physically removed from the site of action too rapidly Metabolism or excretion of the drug...

Ngày tải lên: 25/10/2013, 08:20

... and Systems for Drug Delivery and Targeting Table 5A Formulation systems for controlled drug release and drug targeting eg low solubility salt MODIFICATION OF DELIVERY SYSTEM PULSATILE DRUG DELIVERY ... advances in the Chemical Aspects of Drug Delivery Systems New materials for drug delivery and targeting are reviewed and a representative range of excipients and delivery systems is considered in depth ... to the oral cavity is of particular interest for our research, a brief review of achievements in this field will be given 5.1 Oral mucosal drug delivery systems The accessibility of the oral cavity...

Ngày tải lên: 28/03/2014, 10:20

... application of carbon nanotubes as target carriers in drug delivery systems for cancertherapies Keywords: carbon nanotubes, cancer therapies, drug delivery systems, target chemotherapy Introduction Cancers ... used in drug delivery systems.These functionalization methods provided candidatetechniques, and there are great possibilities for them to be used in the construction of drug delivery systems ... advantages for tracking and real-time monitoring cap-of drug delivery efficacyin vivo Intracellular drug delivery To study the cellular drug delivery,in vitro experimentshave unique advantages,...

Ngày tải lên: 20/06/2014, 22:20

... effectiveophthalmic drug delivery systems, but the knowledge in this field is rapidlyexpanding Systems range from simple solutions to novel delivery systemssuch as biodegradable polymeric systems, corneal ... Pharmaceutical Products, Nigel A Halls 65 Multiparticulate Oral Drug Delivery, edited by Isaac Ghebre-Sellassie 66 Colloidal Drug Delivery Systems, edited by Jorg Kreuter 67 Pharmacokmetics Regulatory ... toprovide maximal benefit, improvements in ocular drug delivery are essential.Drug delivery is no less vital than drug discovery Although many drugs can be safely delivered by eye drops, effectivetreatment...

Ngày tải lên: 10/08/2014, 00:20

... of timolol by prodrugs as a means to reduce systemic drug load Invest Ophthalmol Vis Sci., 28:487 Copyright © 2003 Marcel Dekker, Inc General Considerations in Ocular Drug Delivery 105 105 Narurkar, ... retina, compliance, and the advantages of the use of drug delivery systems, are discussed in other sections of this text Intravenous and oral therapy are used in the treatment of generalized ... ocular drug therapies using systemically administered drugs II OVERVIEW OF BLOOD-OCULAR BARRIER TRANSPORT BIOLOGY The parenteral and oral routes are the principal routes for the systemic delivery...

Ngày tải lên: 10/08/2014, 00:20

... changes in the pathophysiology of the eye is the diffusivity ofdrugs in the vitreous Changes in drug diffusivity will be most significantwhen drugs of different molecular weight are used to treat different ... by changes to the drug diffusivity However, thetime at which the peak concentration occurred increased as the drug diffu-sivity decreased because the average time required for a drug molecule toreach ... the injectionlocation and the retinal permeability of the drug If the drug has a low retinalpermeability, then the half-life of the drug in an aphakic eye is highly depen-dent on the distance...

Ngày tải lên: 10/08/2014, 00:20

... protein drugs, Adv Drug Delivery Rev., 8:331–339 81 Chiou, G C Y (1994) Systemic delivery of polypeptide drugs through ocular route, J Ocul Pharmacol., 10:93–99 82 Morgan, R V (1995) Delivery ... (1998) Ophthalmic drug delivery systems—recent advances, Prog Retinal Eye Res., 17:33–58 95 Robinson, J C (1993) Ocular anatomy and physiology relevant to ocular drug delivery Drugs Pharm Sci., ... Extent of Drug Incorporation The drug may be loaded onto the polymer matrix in a variety of ways The most common approach is to incorporate the drug into mucoadhesive drug delivery systems, as...

Ngày tải lên: 10/08/2014, 00:20

... (2000) Bispecific Mab aided liposomal drugdelivery J Drug Target, 8(4):257–266 160 Cristiano, R J., and Roth, J A (1995) Molecular conjugates: a targeted genedelivery vector for molecular medicine ... perform and bypasses the needfor complex viral or non viral delivery systems Subretinal or intravitrealinjections are common routes of delivery to the affected area Preparativeamounts of neurotrophic ... ther-apeutically active drugs This is a fascinating technology that has the poten-tial of being a tailor-made delivery system that will improve the therapeuticindex of a number of drugs mod-Another...

Ngày tải lên: 10/08/2014, 00:20

... changes in the pathophysiology of the eye is the diffusivity ofdrugs in the vitreous Changes in drug diffusivity will be most significantwhen drugs of different molecular weight are used to treat different ... by changes to the drug diffusivity However, thetime at which the peak concentration occurred increased as the drug diffu-sivity decreased because the average time required for a drug molecule toreach ... the injectionlocation and the retinal permeability of the drug If the drug has a low retinalpermeability, then the half-life of the drug in an aphakic eye is highly depen-dent on the distance...

Ngày tải lên: 10/08/2014, 03:20

... (1990) Intestinal mucosal transport ofinsulin, Int J Pharm., 62:53 51 Su, K S E (1991) Nasal route delivery of peptide and protein drug delivery.In: Peptide and Protein Drug Delivery V H L Lee ... effective systemic delivery oftopically instilled peptides in the eye Their findings suggest that systemicdelivery of peptide drugs is superior to the parenteral route, especially whenthe drug is potent ... circulation may well be possible in the nearfuture We hope that novel drug delivery systems will be developed todeliver potent polypeptide drugs through the ocular route 4 Akerlund, M., Kostrzewska, A.,...

Ngày tải lên: 10/08/2014, 03:20

... (2000) Bispecific Mab aided liposomal drugdelivery J Drug Target, 8(4):257–266 160 Cristiano, R J., and Roth, J A (1995) Molecular conjugates: a targeted genedelivery vector for molecular medicine ... perform and bypasses the needfor complex viral or non viral delivery systems Subretinal or intravitrealinjections are common routes of delivery to the affected area Preparativeamounts of neurotrophic ... ther-apeutically active drugs This is a fascinating technology that has the poten-tial of being a tailor-made delivery system that will improve the therapeuticindex of a number of drugs mod-Another...

Ngày tải lên: 10/08/2014, 03:20

... oligonucleotide therapeutics: drug deliveryand targeting Adv Drug Delivery Rev., 18:115–131 167 J W Jaroszewski, and J S Cohen (1991) Cellular uptake of antisense godeoxynucleotides Adv Drug Delivery Rev., ... Section 201(p)) New drugs require INDs for conductingclinical investigations and NDAs for marketing approval The terms drugand new drug are inclusive of the drug substance and the drug product It ... approved drug 9 Radiation sterilization is used for a drug product (21 CFR200.30) Trang 26C Combination Drug and DeviceIt is possible to have as a new ophthalmic delivery system a combination of a drug...

Ngày tải lên: 10/08/2014, 03:20

... nanocapsule delivery system to investigate the capacity of temporal release of antiangiogenetic drug and anticancer drug in vitro. We found that the drug release profiles of the encapsulated drugs, ... tumor cells. Although the developed drug delivery systems could, to some extent, alleviated the drug resistance effects of many anticancer drugs and deliver drug in high pay-load to tumor sites, ... therapy drug delivery systems with simultaneous antiangiogenesis and anticancer activities are urgently desired. 113 Herein, we hypothesize that drug delivery system under controllable drug release...

Ngày tải lên: 11/09/2015, 09:58

... SEMINAR REPORT OF DRUG DELIVERY SYSTEMS Topic: Hydrogels as Drug Delivery Systems Reporter: Nguyen Van Tu Supervisor: Dr Le Thanh Dung Dr Ha Cam ... topic of drug delivery In the drug delivery topic, the search for subtopics of proteins and genes resulted in 1674 and 284 references, respectively - S C Lee, I K Kwon and K Park, Adv Drug Delivery ... HOOK INTRODUCTION Various Systems to be applied Attract much attention DDSs Hydrogels: worth concerning Each System possesses particular characteristics DDSs: Drug Delivery Systems SOME FIGURES The...

Ngày tải lên: 07/06/2017, 14:46

... release of drugs in conventional drug delivery systems (CDDSs) have led to the development of smart nanocarrier-based drug delivery systems, which are also known as Smart Drug Delivery Systems (SDDSs) ... Site-specific drug delivery led to a keen interest in the SDDSs as an alternative to chemotherapy Smart nanocarriers, nanoparticles used to carry drugs, are at the focus of SDDSs A smart drug delivery ... gene delivery with higher transfection efficiency [109] Hsiao et al designed and constructed a MSN-based theranostic drug delivery sys-tem which can be used for cancer imaging along with drug delivery...

Ngày tải lên: 15/01/2020, 17:52

... result in the drug having low bioavailability, making the preparation of self-microemulsifying drug delivery systems rational Besides, the amine group in the molecular structure of the drug (Fig ... and sev-eral other herbal drugs such as curcumin (Zhang et al., 2012), silymarin (Wu et al., 2006) or baicalein (Liu et al., 2012) Self microemulsifying drug delivery systems (SMEDDS) has been ... determination of the drug release was not quite suitable for SMEDDS In this study, the drug diffusion through dialysis membrane was used for the investigation However, the driving force of drug diffusion...

Ngày tải lên: 20/01/2020, 07:31

... increase drug delivery efficacy and reduce side effects, and to improve the drug therapeutic effect by controlling the rate of drug delivery Hydrogel-based contact lenses were used to prepare local drug ... and their potential uses as drug delivery carriers have also been reported in recent research [8 10] Ophthalmic drug delivery via PHEMA contact lenses could improve the delivery efficiency by increasing ... Barriers to glaucoma drug delivery J Glaucoma 17(2):147–156 5 Bengani LC, Hsu KH, Gause S, Chauhan A (2013) Contact lenses as a platform for ocular drug delivery Expert Opin Drug Del 10(11):1483–1496...

Ngày tải lên: 29/05/2020, 15:16

... and acylated chitosan have been used in drug delivery systems [17,18] Researchers reported on the goals of using chitosan as an excipient for drug delivery systems [19e23] Therefore, the main objective ... 58 59 60 61 62 63 64 65 Drug delivery properties of chitosan 3.1 Anionic drug delivery properties When a technique of drug discharge cannot be achieved by using a simple drug dissolution process ... deliver drugs in tumor cells [79] Delivery of 5-fluorouracil for cancer treatment Delivery of insulin for diabetics Chitosan was also used in the preparation of films for drug delivery systems...

Ngày tải lên: 02/11/2022, 11:37

... dosage/delivery systems An ideal drug delivery system should pose two important elements: controlled and targeted delivery In this regard, NPs have emerged as the potential and effective drug delivery systems ... Antimicrobial Drug Delivery Over the last few decades, considerable studies have been done on the development of new drug delivery system to overcome the limitations caused by the conventional dosage/delivery ... infections The review also focused on the development of nanoparticle systems for antimicrobial drug delivery and use of these systems for delivery of various antimicrobial agents, giving an overview...

Ngày tải lên: 04/12/2022, 15:47

... transdermal drug delivery systems and revealed their implications over the other administration routes PLGA-based transdermal drug delivery systems PLGA-based microneedles for transdermal drug delivery ... routes, including intravenous drug delivery, pulmonary drug delivery, transdermal drug delivery, etc Further to enhance the loading efficiency and specificity of the drug delivery carrier, PLGA surface ... desired drug dosage and the therapeutic window is one of the primary criteria to be considered while designing drug delivery systems (DDS) By employing nanomaterials as a base for drug delivery...

Ngày tải lên: 04/12/2022, 15:56