optimization in coreference resolution is not needed

... viral infection depends on the integrity of this network of cytokines, which is tightly regulated [19] This in vivo situation led us to query whether the administra-tion of meliacine to HSV-2 infected ... meliacine, a plant antiviral, ameliorate the severity of the herpetic infection in female mice infected intravaginally with HSV-2, we wanted to investigate whether the administration of meliacine ... combination of both in Vero cells since no published data is available with this herpesvirus; ii) the effect of CDM on interferons action. Results HSV-2 plaque formation Since there is no published

Ngày tải lên: 20/06/2014, 01:20

... control substance in this context, because it is an inhibitor of P-glycoprotein rather than MPTP, and is devoid of calcineurin-inhibiting properties [23]. We hypothesized that an increase in steady-state DW m underlies ... at 37 °Cin an atmosphere of 5% CO 2 . Immunocytochemical staining of P-glycoprotein Cytospins of GLC4 and GLC4 ⁄ P-glycoprotein cells were incubated for 1 min with hematoxylin for staining of nuclei. ... accumulates in cells as a con- sequence of P-glycoprotein inhibition, resulting in an apparent increase in DW m . We also subsequently tested whether P-glycoprotein pumps are involved in the accu- mulation

Ngày tải lên: 30/03/2014, 08:20

... 1Open AccessResearch Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: Putative CD81 binding region 1 is not involved in CD81 binding Katharina B Rothwangl1, Balaji ... unable to interact with CD81 This region is conserved across genotypes, underlining its signifi-cance Finally, we have determined that the first putative CD81 binding region is not a CD81 binding region, ... implicating them as being directly involved in E2 binding to CD81 In conclusion, we have determined that the second and third putative CD81 binding regions are responsible for mediating E2 binding

Ngày tải lên: 20/06/2014, 01:20

... and intrapartum transmission to 8% Assuming breastfeeding transmission risk is unaffected, an addi-tional 14% acquire infection postnatally, bringing the total transmission rate to 22% In this ... oral zidovu-dine were effective in reducing transmission [2,3] A land-mark study in Uganda demonstrated that single-dose nevirapine was effective in reducing mother to child HIV transmission [4] ... But it is easy to misinterpret these numbers because of shifting denominators Transmission rates are expressed as the number of infected infants divided by the number of infants born to HIV-infected

Ngày tải lên: 20/06/2014, 08:20

... class, the main method is automatically executed The main method takes the string provided as input and parses it as an integer into the input variable: int input=Integer.parseInt(args[0]);... ... ANIMAL is an object table, you can select from it as if it were a relational table. This is consistent with the examples of inserts and selects shown earlier in this chapter. However, that is not ... structures for Java In this section, you will see how to use that syntax to create and use objects A simple program for printing the word “Oracle” is shown in the following listing: public class

Ngày tải lên: 07/08/2014, 14:20

... obtain information on documented infections since diagnosis of SLE Major infections were defined as infections requiring hospital admission and intravenous administration of antibiotics In total, ... regression model This finding is in line with a previous study on major infections in SLE patients in the Hopkins Lupus Cohort [32] Renal insufficiency is a possible risk factor for infections How-ever, ... mannose-binding lectin-associated serine protease; MBL = mannose-binding lectin; SLE = systemic lupus erythematosus. Trang 2SLE [7] and in the occurrence of infections in SLE [8-10].Mannose-binding

Ngày tải lên: 09/08/2014, 08:23

... expression is highly variable in this fibroproliferative dis-ease with the only consistent finding being down-regu-lated Wnt 11 mRNA expression in disease tissue As Wnt-11 signalling is independent ... dual kinase mechanism involving CKI (casein kinase-1) and GSK-3β (glycogen synthase kinase-3β) [30-32] CKI, which is recruited to the destruction complex by the axin binding protein diversin [33], ... reproduction in any medium, provided the original work is properly cited. Trang 2for DD, including alcoholism, trauma, diabetes, smoking,and epilepsy, but their exact role in the disease is not clear

Ngày tải lên: 11/08/2014, 08:20

... EE, which bind both ERs in an agonistic mode [23,24] This finding is in line with an earlier onset of arthritis in mice when treated with the ERα/β antagonist ICI 182780 [10] Harris and colleagues ... setting Discussion Our main finding is that estrogen-mediated suppression of inflammation as seen in the TT-DTH response and in experimental arthritis is mediated via ERα but not ERβ The mechanisms ... clinical signs in collagen induced arthritis (CIA) in WT mice This was associated with reduced inflammatory infiltrates and decreased levels of proinflammatory cytokines in CIA joints Conclusions:

Ngày tải lên: 12/08/2014, 14:21

... transgenesis boosts early HIV gene expression in infected primary T-cells, but not in macrophagesFigure 5 hCycT1 transgenesis boosts early HIV gene expression in infected primary T-cells, but not in ... amino acid (tyrosine-261; cytosine-261 in hCycT1) [18-21] Intriguingly, rat and mouse CycT1 have a 96% sequence homology and both contain tyrosine-261 [4] While ectopic expression of hCycT1 in ... surmount intrinsic limitations in the HIV-1 repli-cation cycle in small animals by stable introduction of critical human transgenes into the genome of laboratory rodents using transgene or knock-in

Ngày tải lên: 13/08/2014, 05:21

... plays a facilitating role in binding to DC-SIGN and/ or other lectins in vivo, in combination with other carbo-hydrates on gp120 A better definition of the binding domain(s) for lectins such as DC-SIGN ... the individual 386 carbohydrate is not essential for C-type lectin binding and DC-mediated transmission Discussion The carbohydrate component of Env, comprising ~50% of its molecular weight, is ... folding of a gp120 variant lacking the 385–418 disulfide bond, suggesting that it plays an auxiliary role in protein folding in the presence of this disulfide bond The 386 carbohydrate was not

Ngày tải lên: 13/08/2014, 06:20

... adenosine residues into inosines, leading to the unwinding of the RNA duplex [11] Inosine-containing RNAs are not translated as they are retained in the nucleus [12] In mice about 35% of overlapping ... sense-antisense overlap does not include any protein-coding region, which makes it unlikely that in this subgroup of COPs the antisense transcript plays a role in regulating the coding region ... expression is not linked to transcript degradation pathways An interesting observation, which may hint at an alternative interference mechanism between sense and antisense tran-scripts, is the significant

Ngày tải lên: 14/08/2014, 14:21

... giving support to the assumption of random mating This result is in agreement with those obtained by Ruiz et al (1991) in a Spanish natural population of D buzzatii However, our analysis is based ... was studied in more detail This analysis was performed with heterozygous individuals obtained by crossing flies from homozygous stocks Trang 3These stocks were obtained through consanguineous crosses ... first instar larvae were seeded in 5 culture bottles (100 larvae each) containing 40 cc of culture medium for each cross, in low density conditions and maintained at 25°C Thirty-two third instar

Ngày tải lên: 14/08/2014, 20:20

... sleeping sickness (Trypanosoma brucei), American trypanosomiasis (Trypanosoma cruzi) and leishmaniasis (Leishmania spp.), diseases that affect more than 30 million people, mainly in the developing ... strand-switch domain (+) were found to be maintainedfor more than 100 generations (5 months) in the absence of the selective drug In contrast, chromosomes lacking this domain (-) were unstable and disappeared ... respectively The array in chromosome 3 is distinctive; it is organized in units of 120 bp, with an AT con-tent of only 49% Despite this, it is related to the other repeats, for example, sharing 53% identity

Ngày tải lên: 14/08/2014, 20:22

... makethis fit into my larger plans? Is there a creative way of handlingthis situation so it has meaning for me?” If there is, then this chal-lenge is your friend If there isn’t, then it is not a ... when we are in the Creative mind-set, we mine the power inherent in the decision and use it to shape theoutcomes we want This power is what makes life inspiring andworthwhile It is in these deeper ... that is central to this A man is not idle because he is absorbed in thought There is a visible labor and there is an invisible labor. Victor Hugo Trang 36book These steps are like the evil twins

Ngày tải lên: 20/01/2020, 07:52

... and the CEO’s Risk Appetite 109 Executive Compensation and the Risk-Taking Behavior of CEOs 113 Incentive Compensation, Risk Taking, and the Financial Crisis of 2007–2009 118 Incentive Compensation ... it is typically based on overcoming some hur-dle defi ned in accounting terms; for example, net income rising by 6 percent over last year’s fi gure, total revenues increasing by a predetermined ... of Franklin Raines, who left his posi-tion as CEO of Fannie Mae under pressure in December 2004 (During his tenure, Fannie Mae not only helped to lay the foundations of the housing crisis and Fannie

Ngày tải lên: 20/01/2020, 08:12

... released guidelines assisting their annotators in marking the ground truths of interest in the corresponding tasks, such as mentions or coreferential chains Since most of the works in English coreference ... clustering in [13] The entity-mention model treats coreference resolution as a supervised clustering problem by determining whether a mention belongs to a preceding cluster or not This involves ... general domain, the goal of a coreference resolution system in the clinical domain is to produce all coreferential chains for a given document, where each chain contains mentions referring to the

Ngày tải lên: 22/01/2020, 02:53

... makethis fit into my larger plans? Is there a creative way of handlingthis situation so it has meaning for me?” If there is, then this chal-lenge is your friend If there isn’t, then it is not a ... when we are in the Creative mind-set, we mine the power inherent in the decision and use it to shape theoutcomes we want This power is what makes life inspiring andworthwhile It is in these deeper ... that is central to this A man is not idle because he is absorbed in thought There is a visible labor and there is an invisible labor. Victor Hugo Trang 36book These steps are like the evil twins

Ngày tải lên: 03/03/2020, 09:55

... and the CEO’s Risk Appetite 109 Executive Compensation and the Risk-Taking Behavior of CEOs 113 Incentive Compensation, Risk Taking, and the Financial Crisis of 2007–2009 118 Incentive Compensation ... it is typically based on overcoming some hur-dle defi ned in accounting terms; for example, net income rising by 6 percent over last year’s fi gure, total revenues increasing by a predetermined ... of Franklin Raines, who left his posi-tion as CEO of Fannie Mae under pressure in December 2004 (During his tenure, Fannie Mae not only helped to lay the foundations of the housing crisis and Fannie

Ngày tải lên: 03/03/2020, 10:10

... seen in the Columbia ecotype [12] Furthermore, flowering was neither delayed in myb33.myb65 nor pro-moted in mir159ab indicating MYB33/MYB65 are not major players in determining flowering-time in ... lines Staining was carried out on ten individual rosettes per time point, at ten-day interval during plant growth; only the first and last staining results are shown Trang 4two-fold increase in ... of indistinguishable severity (Fig 5d), indicating that the up-regulated expression of MYB33/65 in 35S-P0(Col) was not a major factor in the observed P0-induced symptoms Additionally, TuMV in-duced

Ngày tải lên: 22/05/2020, 04:35

... feeding (right panels, center) The development of M sexta larvae is indistinguishable on OPR3-RNAi and wild-type plants (right panel, bottom) Resistance against larval feeding is thus maintained ... defensive PPO in tomato, implying that tomato plants may be able to distinguish between attack by S exigua or M sextaon basis of different GOX levels in insect OS Our findings are consistent with ... activity by induction of proteases that are insensitive to PI-II inhibition [74] These findings imply the existence of additional defense trait(s) in tomato for induced resistance against S exigua

Ngày tải lên: 27/05/2020, 01:22