novel polymorphisms in coronary artery disease

... http://www.translational-medicine.com/content/7/1/42 Effects of platelet inhibiting treatment in coronary artery disease When investigating possible effects of platelet-inhibiting treatment with Repeated ... measurements of fibrinogen-binding or expression of P-selectin Presented results are the mean-% of fibrinogen-binding and Pselectin expression ± SEM Reference values (obtained earlier during routine analysis ... function In this study, platelet adhesion to albumin, collagen and fibrinogen was investigated in the presence of soluble platelet activators including adenosine 5'-diphosphate (ADP), adrenaline,...

Ngày tải lên: 18/06/2014, 15:20

... the disease As parametric linkage analysis requires a precise genetic model in order to determine the linkage of the disease mutation to the marker, it is useful for investigating linkage in a ... atherosclerotic lesion including endothelial cells lining the lumen of coronary artery, the vaso vasorum as well as in newly formed vessels In addition, the expression was especially high in macrophage ... disease usually involves the interaction of several disease- causing genotypes, each conferring additional risk to disease susceptibility In additional, the environment also plays a role in disease susceptibility...

Ngày tải lên: 10/09/2015, 15:51

... Santa Rosa, CA) for treating single de novo lesions in patients with symptomatic coronary artery disease has been examined in the first four trials of the ongoing ENDEAVOR clinical trials program ... circumflex coronary artery; LAD, left anterior descending coronary artery; LVEF, left ventricular ejection fraction; RCA, right coronary artery a Indicates patients who received zotarolimus-eluting ... Association; CABG: coronary artery binding graft; CK: creatine kinase; MACE: major adverse cardiac events; MI: myocardial infarction; PES: paclitaxel-eluting stent; ZES: zotarolimus-eluting stent; ST:...

Ngày tải lên: 25/10/2012, 11:18

... circumflex coronary artery; LAD, left anterior descending coronary artery; LVEF, left ventricular ejection fraction; RCA, right coronary artery a Indicates patients who received sirolimus-eluting stents ... Short- and long-term clinical outcome after drug-eluting stent implantation for the percutaneous treatment of left main coronary artery disease: insights from the Rapamycin-Eluting and Taxus Stent ... PES in unselected Turkish patients with coronary artery disease However, despite our study and several others in which the SES and the PES have been compared, uncertainty still remains regarding...

Ngày tải lên: 26/10/2012, 08:57

... the second is attained through a network of blood veins Fig The coronary artery network of the heart 4 Coronary Artery Disease – New Insights and Novel Approaches The coronary artery system consists ... by insulin Hepatic VLDL production is stimulated in response to reduced insulin action, resulting in increased release of VLDL into the blood under fasting conditions, while it is suppressed in ... ester from HDL to Apo B-containing lipoproteins by catalyzing the transfer of insoluble esters in the reverse transport of Chol Thus, CETP is involved in maintaining the balance between the LDL-C,...

Ngày tải lên: 08/03/2014, 00:20

... understanding of coronary artery disease and is split into three main sections: Epidemiology and pathophysiology of coronary artery disease where the spectrum of the disease will be described in relation ... that it is not globally inclusive Coronary artery disease mortality 2.1 Defining coronary artery disease mortality Detailing mortality data may seem straightforward since the presence/absence ... Zealand These findings are cause for concern, indicating that decades of progress in reducing deaths from CAD appear to be stalling Changes in lifestyle factors in the young (increasing obesity...

Ngày tải lên: 17/03/2014, 00:20

... sources overlapping or mimicking precordial symptoms originating in the heart [10,11] These are mainly due to the coexistence of gastroesophageal reflux (GER), aspirin-induced gastrointestinal tract ... placebo in the improvement of HRQL relating mainly to gastrointestinal symptom relief In a multivariate analysis, van Rossum et al also did not find any influence of clinical data on changes in the ... COGENT Investigators: Clopidogrel with or without omeprazole in coronary artery disease N Engl J Med 2010, 363:1909-17 43 Juurlink DN: Clopidogrel with or without omeprazole in coronary disease...

Ngày tải lên: 20/06/2014, 15:20

... 56 Coronary disease on angiography 61 61 Angina pectoris 70 71 Percutaneous coronary intervention 42 41 Coronary- artery bypass grafting 38 40 Percutaneous coronary intervention or coronary- artery ... england journal of medicine original article Angiotensin-Converting–Enzyme Inhibition in Stable Coronary Artery Disease The PEACE Trial Investigators* abstract background The writing committee for ... Criteria.* Inclusion criteria Age 50 yr or older Coronary artery disease documented by at least one of the following: Myocardial infarction at least mo before enrollment Coronary- artery bypass grafting...

Ngày tải lên: 27/06/2014, 00:20

... angiotensinconverting enzyme inhibition on coronary atherosclerosis Circulation 2000, 102:1748-1754 The PEACE Trial Investigators: Angiotensin-converting-enzyme inhibition in stable coronary artery disease ... events with Perindopril in stable coronary Artery disease Investigators: Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomized, ... representing improvement in statin-related secondary prevention consisting of: 1) provision of a statin sample, or 2) provision of a statin prescription, or 3) increasing the dosage of a statin within...

Ngày tải lên: 11/08/2014, 05:22

... deemed clinically significant [12] This means that a minimum clinically significant increase in recent disease activity score is associated with approximately 46% increase in risk of CAD in the interval ... tied to a clinic visit TC was measured in plasma using a commercial assay (Boehringer Mannheim kit 236691 Indianapolis, IN) and recorded in mmol/L As there are only small, clinically insignificant ... factors for CAD in a chronic relapsing-remitting disease such as SLE Our findings also underpin the importance of adequate control of SLE disease activity while minimising corticosteroid use, and highlight...

Ngày tải lên: 12/08/2014, 18:20

... ticlopidine in unstable angina suggested a benefit similar to aspirin (119) However, at this point, interest turned to the use of ticlopidine in combination with aspirin for patients undergoing coronary ... patients in these studies did undergo coronary intervention, the main focus for recruitment was known coronary disease or an ACS event Returning to the original data supporting the use of aspirin in ... issue when investigating the effects of oral and in vitro administration of aspirin to help define aspirin ‘resistance’ (88) Dose of aspirin: The dosing of aspirin highlights one of the main difficulties...

Ngày tải lên: 22/12/2014, 21:54

... they even in the decision making process?? Cor Angio Treatment Methods Selection • Medical ? • Surgery? • Intervention? To intervene or not??? Coronary disease AAA Complex Trade-offs • Clinical ... pharmacodynamics and pharmacokinetics • • Decreased vascular compliance Increased myocardial stiffness -adrenergic responsiveness + impaired sinus node Decline in creatinine clearance, hepatic metabolism ... ability for maintaining clopidogrel adherence? Goals of Coronary Revascularization • • • • Positively impact longevity/mortality Improvement in health status/symptoms Ability to influence either...

Ngày tải lên: 30/08/2015, 11:43

... Singapore Coronary Artery Genetics Study xv SCES: Singapore Chinese Eye Study SCES: Singapore Chinese Eye Study SCHS: Singapore Chinese Health Study SiMES: Singapore Malay Eye Study SINDI: Singapore ... disorders featuring coronary artery disease or myocardial infarction in OMIM[11] No MIM No Mendelian disorders featuring coronary artery disease or myocardial infarction #615812 ABDOMINAL OBESITY-METABOLIC ... featuring coronary artery disease or myocardial infarction in OMIM [11] No MIM No Mendelian disorders featuring coronary artery disease or myocardial infarction 42 #616233 CHARCOT-MARIE-TOOTH DISEASE, ...

Ngày tải lên: 09/09/2015, 08:17

... Chineses and Indians living in Singapore In addition, the rare alleles of three individual polymorphisms were also found to lower CAD risk in male Chinese and/or Indians, which is independent ... cholesterol and long-chain fatty acids as substrates As such ACAT2 is a very important enzyme in the intestinal cholesterol absorption and in the production of apoB-containing lipoproteins in the liver ... of ACAT2 polymorphisms, submitted Chew-Kiat, Heng Xuelian He, Hongyuan Yong, Association of three lipoprotein lipase polymorphisms with Coronary artery disease in Chinese and Asian Indians, submitted...

Ngày tải lên: 14/09/2015, 09:00

... Artery Disease Chapter1: Introduction to Coronary Artery Disease 1.1 Definition of coronary artery disease( CAD) Coronary artery disease (CAD) is one of the most common diseases related to the ... per minute SD: standard deviation sec: second SM: smoking µl: microlitre UV: ultraviolet Vs.: versus Chapter1: Introduction to Coronary Artery Disease Chapter Introduction to Coronary Artery Disease ... 7) In Trinidad (West Indies), a survey showed that the incidence of the first CAD was 16.4 per 1000 person-years in men of Indian origin, 6.8 per 1000 in men of African origin, 6-5 per 1000 in...

Ngày tải lên: 30/09/2015, 14:23

... cardiovascular disease in the Indian subcontinent Indian J Med Res 2006; 124:235 [8] Critchley J, Liu J, Zhao D, et al Explaining the increase in coronary heart disease mortality in Beijing between ... myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease FRISC Study Group Fragmin during Instability in Coronary Artery Disease N Engl J Med 2000; ... are seen in nuclear studies Clinical features Coronary artery disease could be manifesting as a continuum from stable angina to acute coronary syndrome Angina pectoris is a discomfort in the chest...

Ngày tải lên: 20/02/2014, 08:20