novel aspects of oxidative stress in cardiovascular diseases

... article Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte ... antioxidative capacity and stronger staining of nitrotyrosine were observed in the degenerating regions of OA cartilages as compared with the intact regions from same explants Immunostaining ... maintain the chondrocyte telomere length and proteoglycan remaining in the cartilage explants, suggesting that oxidative stress induces chondrocyte telomere instability and catabolic changes in

Ngày tải lên: 09/08/2014, 06:22

... in AD Furthermore, S-adenosyl-L-methionine, an activator of CBS, is lower in AD brains than in those of normal individuals 6.2 PD neuromodulation of PD To eliminate oxidative elements, continuous ... phaseIII clinical trial reported that high doses of methylcobalamin (vitamin B-12) reduced homocysteine levels in ALS patients [75] An investigation of the levels of CBS-containing Trang 9lanthionine ... Imaging of superoxide generation in the dopaminergic area of the brain in Parkinson’s disease, using mito-TEMPO ACS Chem Neurosci 2013;4(11):1439-45 5 Gella A, Durany N Oxidative stress in

Ngày tải lên: 15/01/2020, 12:10

... Anaplerotic fixation of CO2 by PEPC increased in re-sponse to O3in both groups of seedlings (Figs 5E–5H) dur-ing the growdur-ing season The level of activity decreased in the neoformed flush of the episodic ... immersing the tubes for 5 min in boiling water The colorimetric determination of NO2 −was done by mixing 0.25 mL of incubation medium with 0.25 mL 0.02% N-(1-Naphtyl) ethylenediamine and 0.25 mL of ... is one of the enzymes of this cycle In the present study, GR activity increased two-fold in sugar maple seedlings in re-sponse to increasing O3 stress This enzyme ensures a high level of GSH

Ngày tải lên: 08/08/2014, 00:22

... anxiety, sub-jective appraisal of distress, or coping and PTSS levels in fathers of children with chronic diseases or unintentional injuries Some limited findings exist regarding psycholog-ical symptoms ... months of the treatment in fathers of children with a chronic disease but declining PTSS levels in fathers of children with unintentional inju-ries The second aim of the present study was to examine ... with coping in fathers of children with different chronic diseases, indicating that fathers relying on strategies such as avoidance coping [25], behavioral disengagement, or venting of emotions

Ngày tải lên: 13/08/2014, 18:21

... Washington University School of Engineering, Department of Computer Science and Engineering, 1 Brookings Drive, Saint Louis, Missouri 63130, USA † University of Texas at San Antonio, Department of ... present in our list of 1,663 significant genes. However, TrkB and serpin peptidase inhibitor, clade e (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2) were present in the set of ... being inhibited, resulting in decreased levels of mature BDNF Interestingly, the expres-sion levels of TrkB and PAI-1 were elevated in the AD sam-ples However, TrkB is downregulated following

Ngày tải lên: 14/08/2014, 21:20

... [28-30] According to the free radical or oxidative stress theory of aging [31], oxidative stress incurs when the cellular antioxidant defense systems fail to counteract ROS bringing them back ... assessing cellular susceptibility to oxidative stress Although hMSCs appear to efficiently handle oxidative stress, nevertheless they undergo premature senescence in hMSC behavior in oxidative stress ... following the termination of 1- or 2-h treatment in the presence of H2O2 at concentrations ranging from 50 to 200 µM Cells were obtained from four healthy subjects (passages of subculture spanning

Ngày tải lên: 15/01/2020, 02:05

... UA as a risk of incident CKD [87–91] Definition of CKD in these articles was not precise In one of these articles, serum creatinine of mg/dL was considered the cutoff point [87] In another study ... development of increased urine albumin excretion rate (UAER) on follow-up of normoalbuminuric type diabetic patients for years For every mg/dL increase in SUA, the risk of development of albuminuria increased ... change in serum creatinine in healthy cohort at basal assessment [88] Before the introduction of UA lowering agents, up to a quarter of gouty patients developed proteinuria Histologic examination of

Ngày tải lên: 15/01/2020, 21:33

... autophagy inhibition sensitized choriocarcinoma cell towards oxidative stress Chloroquine, a clinically used lysosomal inhibitor, was also effective in blocking autophagy In the context of choriocarcinoma, ... oxidative stress, implying a protective role of iASPP against oxidative stress through autophagy in choriocarcinoma Conclusions: iASPP regulates growth and the cellular responses towards oxidative stress ... concomitantly hindered autophagy in choriocarcinoma cells Autophagy inhibition per se had no effect on the growth of choriocarcinoma cells but increased the susceptibility of choriocarcinoma cells to oxidative

Ngày tải lên: 17/06/2020, 18:38

... role of oxidative stress We also aimed at evaluating the role of protein kinase C (PKC) in the putative glucose-induced, oxidative stress-mediated impairment of the NO-cGMP signalling in VSMC, since ... signalling, underlining the role of oxidative stress in this phenomenon Our working hypothesis was that high glucose increases in a short-term oxidative stress by a PKC-induced activation of NADPH ... endothelial and in the media layers of the aorta, indicating the occurrence of a PKC-mediated increase of oxidative stress in VSMC, the main component of the media [40] Furthermore, acetylcholine induced

Ngày tải lên: 02/11/2022, 08:46

... in increasing HIF-1α in the SE offspring Considering the protective effect of HIF-1α , its increase in the brains of SE offspring may be an adaptation to protect against increased oxidative stress ... by increased nitrotyrosine levels, a direct product of oxidative stress, in the brains of SE mothers However, SE mothers and adult SE offspring had quite distinct changes, in markers of brain inflammation ... suggesting cigarette smoke is a direct cause of oxidative stress regardless of the other responses Cotinine levels in P20 offspring in this study are similar to those reported in human infants of

Ngày tải lên: 04/12/2022, 14:50

... School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China bSchool of Pharmacy, Key Laboratory of Minority Medicine Modernization, Ministry of Education, Ningxia Medical ... the oxidative stress scenario, the indices inter-preting oxidative stress were tracked to further assess the defensive activity of LFP-05S against etiologic oxidative stress The targets of the oxidative ... end-product of lipid peroxidation that accumulates during aging process and oxidative stress and they hence, represent a promising aging marker The LFP-05S feeding reinforced the clearance of lipofuscin

Ngày tải lên: 01/01/2023, 13:38

... long-chain specific acyl-CoA dehydrogenase It was involved in the initial step of mitochondrial beta-oxidation of straight-chain fatty acids and in the maintenance of an internal steady state of lipid ... Processing’ 113 and 75 proteins were involved in translation and folding, sorting and degradation of ‘Genetic Information Processing’ respectively In ‘Metabolism subcategory’, large proportion of ... roles of oxidative stress and antioxidant defensing system in sclerotia formation of Polyporus umbellatus Bing Li1, Xiaofang Tian2, Chunlan Wang1, Xu Zeng1, Yongmei Xing1, Hong Ling1, Wanqiang Yin3,

Ngày tải lên: 19/03/2023, 15:29

... involved in this extracellular efflux of UA [74] ABCG2 is also expressed in the liver and intestine [75] As UA excretion falls in cases of CKD, compensatory increase in intestinal secretion of ... hand, some early clinical studies Trang 12 denied UA as a risk of incident CKD [87-91] Definition of CKD in these articles was not precise In one of these articles, serum creatinine of 2 mg/dL was ... development of increased urine albumin excretion rate (UAER) on follow-up of normoalbuminuric type 1 diabetic patients for 6 years For every 1mg/dL increase in SUA, the risk of development of albuminuria

Ngày tải lên: 26/07/2023, 07:40

... elaborated some physics concepts to me, sharinghis profound knowledge I also thank fellow PhD students in block S16, Taolin, Qinglin,Feng Ling, Liu Sha, Lina, Qin Chu, Qiao Zhi and so on, for their ... different choices of the system parameters Theresults are of interest to studies concerning anomalous transport Finally, we summarizethe main results of this thesis and offer an outlook in Chapter 7 ... quantum walk in a finite chain 73 5.3 Re-interpretation of transfer matrices chain 82 5.4 Comparison of rotation angles between two different energies 84 5.5 Relation between integrated

Ngày tải lên: 09/09/2015, 08:16

... pattern was observed in minimal medium containing 1 mm pantoate, a substrate of PS, except that the growth of cells containing MM2281 or the negative control was stimulated (Fig 3B) In our hands, the ... archaeal isoform of PS, which utilizes the same substrates as bacterial PS, but forms ADP instead of AMP and has distinct kinetic properties This supports the view that the intermediates of pantothenate ... control in two independent experiments indicates that expression of MM2281 partially complements the auxotrophic phenotype of E coli AT1371 PS activity of recombinant MM2281 The MM2281 protein was

Ngày tải lên: 07/03/2014, 05:20

... EhADH2, indicating the presence of two catalytically independent domains, the N-terminal domain, display-ing ALDH activity, and the C-terminal domain, con-taining an iron-binding domain, which is involved ... bind close to the Fe–S clusters, blocking the access of ROS In this regard, a preliminary docking analysis with coenzymes in the 3D model of EhPFOR suggested that the CoA-binding site was, indeed, ... hand, a set of antioxidant enzymes (including SOD but not Cat) have been iden-tified in the parasite [35,36] Interestingly, in vitro, higher PFOR reactivation was observed in virulent than in nonvirulent

Ngày tải lên: 15/03/2014, 23:20

... observed in human VLCADD [5] In fact, in both mice and humans, clinical symptoms become mainly evident as a consequence of triggers such as fasting, resulting in the accumulation of long-chain acylcarnitines, ... mice Fasting induced a significant increase in both genotypes; however, this was more evident in the VLCAD KO mice (Fig 3A) Interestingly, the MCT diet also induced AOX gene expression in WT mice ... 24 h of fasting, both genotypes showed a signifi-cant increase in the expression of AOX with the MCT diet As shown in Fig 3B, under nonfasting conditions, the expression of CYP4A1 was higher in

Ngày tải lên: 15/03/2014, 23:20

... kinetics of the CoQ-oxidizing module were obtained by titrating with a specific inhibitor of the CoQ-reducing module, malonate (0–3.125 l M ) The kinetics of the CoQ-reducing module were obtained ... CoQ-oxidizing modules Effect of Cd2+on the kinetics of the CoQ-oxidizing module (A) and CoQ-reducing module (B) Effect of Cu 2+ on the kinetics of the CoQ-oxidizing module (C) and CoQ-reducing module ... protein Increasing the amount of added Cu2+ ions to 10 nmolÆmg protein)1 did not further increase the amount of TBARS formed (Fig 6B) Effects of Cd2+and Cu2+ions on the control of fluxes in oxidative

Ngày tải lên: 16/03/2014, 02:20

... CaM/C24W complex [67]. The binding of the C20W peptide of the Ca 2+ -pump CaM-binding domain to only the C-terminal lobe of CaM demonstrates that Ôwrapping aroundÕ a CaM binding domain, as seen in the complexes ... N-terminal end of the binding domain peptides and charge comple- mentarity of binding surfaces determine the binding orien- tation of the peptide in complex with CaM. The second interesting feature ... for- mation with fragments of the K + -channel (c) insertion of CaM between two domains of the anthrax exotoxin (d) binding of Ca 2+ ions to only one EF-hand pair and (e) binding of CaM in an extended conformation

Ngày tải lên: 17/03/2014, 09:20

... which introduces an overview of involving in main knowledge of chapter two The concepts of sentence stress are identified clearly according to many points of view Some functions of sentence stress ... sentence stress while speaking Some of them about 12.5% often use sentence stress in communication, representation, and reading 25% of them rarely use sentence stress in English speaking competence ... aware of the essence of sentence stress to them in their study 46 Question 5: Students’ opinion in producing accurate sentence stress Figure 5: The effectiveness of producing accurate sentence stress

Ngày tải lên: 17/03/2014, 16:12