not all proteins are created equal

... used vary considerably amongst these methods, they all share the assumption that all motifs are created equal; that any and all motifs have an equal a priori probability of being a transcription ... computational algorithms used vary considerably amongst these methods, most share a common assumption – that all motifs are equally likely to be transcription factor binding sites Here we argue that ... All Motifs are NOT Created Equal: Structural Properties of Transcription Factor – DNA Interactions and the Inference...

Ngày tải lên: 14/08/2014, 14:21

... presented An isolated electrolyte abnormality does not necessarily constitute a clinically significant complication Finally, fluid balance complications are intricately linked to electrolyte abnormalities ... care center from 1999 to 2001 Am J Kidney Dis 2005, 45:96-101 doi:10.1186/cc8229 Cite this article as: Palmieri TL: Complications of continuous renal replacement therapy in children: are all created ... data on fluid-related complications are presented In summary, Santiago and colleagues have taken the important first step in evaluating the use of CRRT in critically ill children: identifying complications...

Ngày tải lên: 13/08/2014, 20:21

... complexes, which are generally less divergent than proteins that are not part of complexes However, although we find that proteins associated with SSDs and WGDs in complexes are equally functionally constrained ... Clearly, the distributions of the duplicate genes are not random across all functional categories Differences in essentiality between WGDs and SSDs are not due to differences in their functional categories ... quantifiable ways; whole-genome and small-scale duplication derived proteins are enriched for different categories of molecular functions WGD paralogs are functionally less diverse, less likely to...

Ngày tải lên: 14/08/2014, 08:20

... hotspots may not be conserved among closely related primate species [11], and in some cases hotspots are characterized by signatures of concerted evolution [7], whereby duplicated sequences are more ... rearrangement (deletion or duplication) conveys a phenotype or produces a genomic disorder Also, as paralogous sequences are used in NAHR, rather than allelic homologous sequences as in AHR, paralogous ... subsequently in all NAHR crossovers examined at the nucleotide sequence level [2528] Like AHR hotspots, common features shared among NAHR hotspots include clustering within small regions (under...

Ngày tải lên: 14/08/2014, 14:21

... time; = usually; = almost always); a sample item is Are most of your friends responsible?“ The third asset is “Future Aspirations” with two items (response options = not important at all; = somewhat ... options = not at all like you; = a little like you; = mostly like you; = very much like you); a sample item is “You can say ‘no’ to activities you think are wrong.” The fifth asset is “Non-Parental ... Specifically, positive family support, parental acceptance, and communication are among the most influential factors determining life satisfaction among adolescents [55,56] In addition, parental...

Ngày tải lên: 11/08/2014, 23:23

... • All Cats Are Gray (1953) • Storm Over Warlock (1960) • Rebel Spurs (1962) Copyright: Please read the legal notice included in this e-book and/or check the copyright status in your country Note: ... personal use, not use this file for commercial purposes Transcriber’s note: This story was published in Fantastic Universe Science Fiction, August–September 1953 Extensive research did not uncover ... rightly calling it unworked Slitite That started a rush which made ten fortunes overnight for men who were down to their last jets And, last of all, she cracked the case of the Empress of Mars All...

Ngày tải lên: 29/03/2014, 14:20

... athletes are not the only people affected by sexual discrimination Male athletes, female athletes, and society are all harmed by sexual discrimination in sports.First of all, the most noticed ... in sports are football, television, and tradition These three reasons all are causes to sexual discrimination Football is a widely appreciated and closely watched sport in America Football alone ... schools are known to put up their football teams in nice hotels before home games, two to a room, while women are bunked four to a room while out of town(Tarkan 27) Football players daily food allowances...

Ngày tải lên: 02/04/2014, 17:59

... Entry proteins of group I NPV are all approximately 64 kilodalton glycoproteins (GP64), and are referred to collectively as GP64 superfamily proteins [23] Group II NPV and GV encode entry proteins ... GP and AcMNPV GP64 are indicated similarly β-sheets (t) and (u) of VSV G are not present in the protein data base structure (2cmz.pdb) In VSV G, α-helices predicted by PHD are indicated by dashed ... cysteines are critical determinants of secondary structure The cysteines of class III (and class II) penetrenes determined by X-ray crystallography are arranged such that most disulfide bonds are formed...

Ngày tải lên: 20/06/2014, 01:20

... cotranslationally and posttranslationally processed to mature proteins in the ER membrane The core and envelope glycoproteins E1 and E2 form the structural proteins of the virion Non-structural (NS) proteins ... expression [3,15,19] Since many other HCV proteins are also capable of interfering with host cell signalling pathways, we carried out a systematic analysis of all HCV proteins to determine their capacity ... other HCV proteins did not modulate the IFN-β promoter activity This data indicates that serine protease NS3/4A is a specific inhibitor of IFN-β gene expression and other HCV proteins not have...

Ngày tải lên: 20/06/2014, 01:20

... you as the reader of this book — are all part of that story and are all responsible for spreading it far and wide to reach your target customers Whether you are a retailer selling shoes, a firm ... customer is a constant challenge for all companies Equally the cost of getting a new customer to come to you can be painfully expensive Many companies approach this scientifically and use terminology ... titled book: All Marketers Are Liars In it he made the important point that marketing is primarily about telling stories and spreading ideas I'm sure all marketers would agree that fundamentally, marketing...

Ngày tải lên: 27/06/2014, 23:20

... Engagement Plan UX IT’S NOT ALL ABOUT THE USER Brought to you by Liljedal & Ivmark i! I’m H dal lilje ders an @ Engagement Plan Hi! I’m Ali Engagement Plan UX Engagement IT’S NOT ALL Plan ABOUT THE ... BUSINESS DEVELOPMENT ENGAGEMENT PLAN Engagement Plan AWARENESS ADOPTION ADVOCACY LOYALTY © Creuna 2011 15 ENGAGEMENT PLAN Engagement Plan AWARENESS ADOPTION ADVOCACY LOYALTY © Creuna 2011 16 Engagement ... WITH YOUR SERVICES Engagement Plan AWARENESS ADOPTION ADVOCACY LOYALTY © Creuna 2011 22 LISTEN TO YOUR CUSTOMERS, THEY’RE YOUR GREATEST ASSET Engagement Plan AWARENESS ADOPTION ADVOCACY LOYALTY...

Ngày tải lên: 11/07/2014, 21:17

... spreading, it will The essential conclusion is that not all worldviews are created equal People with worldviews that are private, that are embarrassing to share or that belong to people who don’t like ... customer Not just a potential customer, but a potential customer who is just like all the other potential customers out there Of course, all customers are not the same, but they’re not all different ... ARE YOUR GLASSES? We are not all the same The mass market is dead Instead we are faced with collections of individuals We may all be created equal, but our worldviews are different Long before...

Ngày tải lên: 27/07/2014, 14:01

... RAGE ligands are characteristically overexpressed in RA and psoriatic arthritis, compared to healthy controls [7-9] S100A8/A9 (calprotectin) and S100A12 (calgranulin C, EN-RAGE) levels are significantly ... the RAGE 82S allele had higher levels of inflammation, or a greater likelihood of complicating cardiovascular (CV) events [19] Most S100 proteins have a mass between and 14 kDa, and are characterized ... alternate receptors are implicated [25] In addition, recombinant S100 ligands may contain Page of 11 (page number not for citation purposes) contaminating endotoxin, and their effects may not always be...

Ngày tải lên: 09/08/2014, 13:22

... AtJ20 proteins exhibited similar phenotypes as described above (Additional file 1) Localization of the three DnaJ proteins In order to examine the localization of the three small DnaJ proteins, ... although the three DnaJ proteins are localized in the chloroplasts, most of the genes related to thylakoid membranes were not affected by lacking of one of the small DnaJ proteins (Additional file ... DnaJ mutant This indicates that chloroplasts are at least one of the compartments containing these small DnaJ proteins in Arabidopsis It should be noted that the size of each DnaJ protein in chloroplasts...

Ngày tải lên: 12/08/2014, 03:21

... number of responding T cells Modulation of cell cycling and apoptosis are the hallmark of HTLV-1 as several virus-encoded proteins such as Tax, HBZ, p13, p30 and p12 interfere with cell cycling ... changes that depend on the T cell phenotype and tax expression [8,9] Cell morphology was therefore analyzed in all infected and uninfected clones and compared between cells derived from in vivo ... that, in chronically HTLV-1 infected patients, infected CD4 + cells are positively selected for tax expression and cell cycling whereas infected CD8+ cells and uninfected CD4+ cells are negatively...

Ngày tải lên: 12/08/2014, 23:23

... 2008, doi:10.1186/1742-4690-7-67 Cite this article as: Jeang: Intelligence and ambition are distributed equally around the globe Retrovirology 2010 7:67 Submit your next manuscript to BioMed Central ... Barbarotto P, Niederstadt L, Beimforde N, Denner J, Miller K, Kurth R, Bannert N: Lack of evidence for xenotropic murine leukemia virus-related virus (XMRV) in German prostate cancer patients Retrovirology...

Ngày tải lên: 13/08/2014, 01:20

... patients with sepsis and may not be associated with higher short-term mortality after infection - indeed it is not all bad news Competing interests The authors declare that they have no competing ... creatinine levels are not routinely available Thus, the higher risk of acute kidney injury in diabetes could be confounded by higher prevalence of chronic kidney disease Finally, discrimination ... Critical Care Vol 13 No Yende and van der Poll even well designed observational studies cannot tease out acute and chronic organ dysfunction For instance,...

Ngày tải lên: 13/08/2014, 15:21

... diagrams visually transparent, only time will tell how quickly it will filter into general use Several presentations focused on evaluating and developing novel techniques for X-ray crystallography ... Grenoble, France) DeLucas presented novel crystallographic techniques for studying drug design based on analyzing the structures of the proteins the drugs are intended to target He described the application ... and lysine side chains are chemically blocked, the sample is trypsinized and peptides containing free amine groups (present at the newly generated peptide amino termini) are removed Quantification...

Ngày tải lên: 14/08/2014, 08:21

... 197 4Proteins are powerful / Amanda Rondeau p cm (What should I eat?) Summary: A simple introduction to the protein food group and why proteins are important for us to eat ISBN 1-57765-836-1 Proteins ... ? ? ?? ? ? Did you know beans are in the protein group? Beans are vegetables that have protein That is why they are in both the vegetable and protein groups Beans are good in tacos or soup 15 ... connected to the bones that allows us to move nuts a hard-shelled seed that usually can be eaten protein a substance found in all living plant and animal cells quail a small, short-tailed bird with...

Ngày tải lên: 07/07/2015, 22:39