new shuttles for drug delivery

... authors have performed this research for the investigation of a new self-assembled bio-material which was synthesized by a simple method and can be applied for encapsulating many types of drug with ... (PTX), an insoluble anticancer agent for controlling drug release Most of the anticancer drugs have limitations in clinical administration because the drug delivery of these agents often requires ... serious side effects For example, Cremophor EL (polyethoxylated castor oil) and ethanol are incor-porating excipients in the pharmaceutical drug formula-tion of Taxol® for inducing drug solubility

Ngày tải lên: 12/12/2017, 10:52

... Trang 1Systems for Drug Delivery Safety, Animal, and Microbial Polysaccharides Trang 3 Systems for Drug Delivery Safety, Animal, and Microbial Polysaccharides ... Polymers: Controlled Delivery of Drugs 122 4.4 Auto-Associative Amphiphilic Polysaccharides as Drug Delivery Systems 124 4.5 Supramolecular Hydrogels: Potential Mode of Drug Delivery 127 4.6 ... Natural Polysaccharides for Drug Delivery 159 5.9 Relevance of Chitosan and Chitosan Derivatives as Biomaterials 160 5.10 Hyaluronic Acid for Anticancer Drug and Nucleic Acid Delivery 161 5.11

Ngày tải lên: 14/05/2018, 15:13

... chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems Adv Drug Deliv Rev 2007;59(11):1162 –76. 32 Borrill Mather G: The Chick embryo; A new drug delivery model for Neuroblastoma ... principle, that the chick CAM model can be used successfully for drug treatment thereby provid-ing a platform of choice for further evaluation of drug efficiency in neuroblastoma Discussion The chick ... This provides an explanation for the greater efficiency of tumour formation by SKNAS cells [7] and the rationale for the use of trypsin to enhance tumour formation for IMR32, Kelly and especially

Ngày tải lên: 24/07/2020, 00:16

... mM The newly synthesized surfactants have been incorporated in PLGA based nanoparticles and are used for drug encapsulation and delivery of cisplatin The drug encapsulation efficiency for newly ... useful in terms of CMC 3.4 Drug delivery The drug delivery application of newly synthesized surfactants was carried out using the well-known anticancer drug cis-platin The drug was encapsulated in ... intersected 2.5 Drug encapsulation in PLGA NPs stabilized with surfactants The novel surfactants have been used for the drug delivery application of cis-platin, a well-known anticancer drug The drug is

Ngày tải lên: 13/01/2022, 00:27

... nanocarrier-mediated drug delivery into the brain Keywords: blood–brain barrier; targeted drug delivery; nanocarriers; transcytosis Trang 21 Introduction Effective delivery of drugs across the blood–brain ... including those intended for therapeutic applications The development of molecular Trojan horses is a promising drug targeting technology that allows for non-invasive delivery of therapeutics ... 1999-4923 www.mdpi.com/journal/pharmaceutics Review Smuggling Drugs into the Brain: An Overview of Ligands Targeting Transcytosis for Drug Delivery across the Blood–Brain Barrier Julia V Georgieva,

Ngày tải lên: 04/12/2022, 16:38

... model for the drug delivery system The construction of robotic fish-like drug delivery system represents a key challenge for the near future Keywords: Bioinspired Technology; Fish Fin; Drug Delivery ... Some Barriers to Overcome for the Successful Development of Drug Delivery Systems 43 Bảng 3 1 Phương án cho hệ thống phân phối thuốc/ Table 3.1 Solutions for drug delivery system 53 Bảng 3 ... in the water is analogous to drug delivery system flowing in the blood A robotic fish inspired drug delivery system is expected to enhance and optimize current drug delivery system 1.2 Tính khoa

Ngày tải lên: 20/03/2024, 14:42

... PACLITAXEL DRUG DELIVERY IMPLANTS FOR CONTROLLED RELEASE POST-SURGICAL TREATMENT AGAINST GLIOBLASTOMA MULTIFORME IN THE BRAIN ONG YUNG SHENG, BENJAMIN MSc, DIC, BEng (Hons) A THESIS SUBMITTED FOR ... ice for 10 minutes before adding 50 µl of 2x Reaction Buffer (containing 10 mM DTT) to each sample 5 µl of the 1 mM DEVD-AFC substrate were then added before incubating at 37oC for 2 hours before ... author would like to thank his group members in the drug delivery lab in particularly, Ms Laiyeng Lee and Mr Jingwei Xie for providing the formulations and other technical support Thanks go to

Ngày tải lên: 05/10/2015, 21:33

... 7LIST OF FIGURES Figure 2.1 Nanoparticle platforms for drug delivery 8 Figure 2.2 Schematic showing minicell formation and bispecific antibody-targeted, drug/siRNA-packaged minicells 11 Figure ... other drug as cephalosporin This study was the primary research on the drug delivery system which was able to carry many drugs and necessary products for food and pharmaceutical fields Therefore, ... Trang 17Figure 2.1 Nanoparticle platforms for drug delivery Nanoparticle platforms are characterized by their physicochemical structures, including polymer-drug conjugates, lipid-based nanoparticles,

Ngày tải lên: 23/10/2015, 15:38

... free drug.10 Later, Abraxane® was introduced as an albumin-functionalized NP for delivery of taxane without cremphor to enhance drug efficiency.11 Trang 2113 5 Targeted drug delivery systems for ... site-specific drug delivery, a major challenge for drug administration Ideally, these “magic missiles” would accumulate at the diseased tissue and locally liberate the necessary amount of drug The drugs ... targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with the diseased tissue The conventional drug delivery system is the absorption of the drug across

Ngày tải lên: 19/05/2016, 10:45

... that drug delivery could confer on established agents such as doxorubicin and amphotericin The disposition of nanoparticles was changed in vivo, but the drug molecular structure was not transformed ... toxicological actions of drugs are primarily related to the plasma concentrations of drugs Thus, the clinician must recognize that the speed of onset of drug action, the intensity of the drug's effect, ... properties of the drug (for example, water or lipid solubility, ionization, etc.) and by the therapeutic objectives (for example, the desirability of a rapid onset of action or the need for long-term

Ngày tải lên: 12/05/2017, 09:53

... uncontrollable release of drugs in conventional drug delivery systems (CDDSs) have led to the development of smart nanocarrier-based drug delivery systems, which are also known as Smart Drug Delivery Systems ... (8) promising nanocarriers for anti-cancer drug delivery Studied up-to-date strategies for cancer site targeting used in SDDSs Various stimulus techniques utilized for drug release at targeted ... Site-specific drug delivery led to a keen interest in the SDDSs as an alternative to chemotherapy Smart nanocarriers, nanoparticles used to carry drugs, are at the focus of SDDSs A smart drug delivery

Ngày tải lên: 15/01/2020, 17:52

... Application of LDH in drug delivery Drug delivery system Drug delivery system refers to the typically the use of nano-carriers as host to accommodate or load therapeutic agents as guest for delivery to ... features of LDH and GO for simultaneous drugs and diagnostic agents delivery systems for use in theranostics applications Keywords: Layered double hydroxides, Graphene oxide, Drug delivery, Gadolinium ... loadbond-ing of aromatic materials such as anticancer drugs onto the sheets [25] In similarity with LDH drug delivery sys-tems, GO-based drug delivery system is also a repre-sentative of a host–guest

Ngày tải lên: 29/05/2020, 15:05

... Barriers to glaucoma drug delivery J Glaucoma 17(2):147–156 5 Bengani LC, Hsu KH, Gause S, Chauhan A (2013) Contact lenses as a platform for ocular drug delivery Expert Opin Drug Del 10(11):1483–1496 ... drug delivery Hydrogel-based contact lenses were used to prepare local drug delivery systems for treating glaucoma which consisted of a swellable polymer hydrogel and commonly used glaucoma drugs ... stability-indicating method was suitable for routine quality control and drug analysis of brimonidine tartrate in BRI/PHEMA drug delivery contact lenses and other pharmaceutical formulations Keywords: Liquid

Ngày tải lên: 29/05/2020, 15:16

... purpose of drug delivery, the requirements for nanoparticulate systems can vary These aspects are discussed in Chapter for injectable delivery, Chapter for oral delivery, Chapter 10 for brain delivery, ... edited by Simon Benita 159 Nanoparticle Technology for Drug Delivery, edited by Ram B Gupta and Uday B Kompella Nanoparticle Technology for Drug Delivery edited by Ram B Gupta Auburn University ... Specialized Drug Delivery Systems: Manufacturing and Production Technology, edited by Praveen Tyle 42 Topical Drug Delivery Formulations, edited by David W Osborne and Anton H Amann 43 Drug Stability:...

Ngày tải lên: 04/06/2014, 15:15

... investigated magnetically retainable drug delivery systems, an approach as yet clinically unexploited despite the intense need for the development of novel i-a delivery modalities Thus, our aim ... per group, Page of 10 (page number not for citation purposes) was necessary for at least two reasons First, there was a need to perform these control tests for the correct evaluation of the action ... changing the material of the microparticle matrix In this respect, new formulation strategies could be found for very active compounds (for example, p38 MAPK or interleukin-1-beta inhibitors [pralnacasan]),...

Ngày tải lên: 09/08/2014, 14:20

... INTRODUCTION delivery of drug In time-controlled delivery, the drug is released in a pre-determined rate while in target-controlled delivery, the drug is delivered to a specific site The delivery ... been developed as a drug delivery system (DDS) for many peptide and protein drugs (Chan and Heng, 1998) An ideal DDS is able to control the drug concentration at the target site for a desired period ... both new opportunities and new challenges For commercial use, microspheres are formulated into pharmaceutically acceptable oral delivery systems, such as tablets, capsules and dry powder for reconstitution...

Ngày tải lên: 13/09/2015, 20:39

... Microneedles 2.1 Microneedles in Transdermal Drug Delivery Transdermal drug delivery is an alternative method for delivery of DNA/protein based drugs These drugs which have sophisticated compounds ... are designed for transdermal therapies to deliver drugs such as insulin and heparin On the other hand, microneedles can also be used for local delivery of other drugs, for example, drugs in anti-restenosis ... varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic system and the continuous delivery...

Ngày tải lên: 14/09/2015, 11:17

... Rationale for the Choice of Equipment and Method Employed 112 A1.1 Rationale for Choosing FB Hammer Mill 112 A1.2 Rationale for Choosing Laser Diffraction for Particle Sizing 113 A1.3 Rationale for ... rate of drug appearance in the blood is determined by the absorption rate of the drug whereas for Class II drugs, the rate of dissolution plays a greater role In the case of Class IV drugs, both ... B FBO Jet Mill 136 B1 Rationale for the Choice of Equipment and Method Employed 136 B1.1 Rationale for Choosing FBO Jet Mill 136 B1.2 Rationale for Choosing SEM for Particle Sizing 137 B1.3 Choice...

Ngày tải lên: 17/09/2015, 17:19

... photoluminescence, afford additional advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study the cellular drug delivery, in vitro ... suitable candidates for a nanoparticle-based drug delivery system to improve their pharmacological performance For this purpose, a “longboat delivery system” has been prepared for the platinum warhead ... nanohorns for the enhancement of their dispersibility This approach is also true for CNTs [72] Polymeric drug conjugates, as a new class of systems, have been envisaged for tumor tissue-specific delivery...

Ngày tải lên: 20/06/2014, 22:20

... transition metals and any drug molecule in general from a delivery are major factors that ultimately determine the success or failure of that vector when applied to targeted drug delivery One of the ... nanoparticles for therapeutic applications Nat Rev Drug Discov 2010, 9:615-627 Davis ME, Chen Z, Shin DM: Nanoparticle therapeutics: an emerging treatment modality for cancer Nat Rev Drug Discov ... Pt(IV) prodrug-PLGA-PEG nanoparticles Proc Natl Acad Sci USA 2008, 105:17356-17361 Rieter WJ, Pott KM, Taylor KML, Lin WB: Nanoscale coordination polymers for platinum-based anticancer drug delivery...

Ngày tải lên: 21/06/2014, 02:20