neurological and cognitive sequelae of cardiac surgery

... and designed the research; analyzed and interpreted the data; performed statistical analysis, handled funding and supervision and drafted the manuscript RRG, DB, OM, have acquired, analyzed and ... stroke Patients and methods Study population and patients characteristics One hundred and ninety patients with a first-ever ischemic stroke of less than 12 hours from symptoms onset, and previously ... http://www.translational-medicine.com/content/9/1/58 Page of Figure Significant correlations between neuroserpin decrease within the first 24 hours and levels of molecular markers of brain damage at 24 hours death both in vitro and in vivo...

Ngày tải lên: 18/06/2014, 19:20

... pressure of arterial oxygen soned that, if the institution of positive pressure ventilation increased the severity of lung injury, the levels of pro-inflammatory cytokines (IL-6 and IL-8) [14] and ... infection and presence of at least two of the SIRS (systemic inflammatory response syndrome) criteria Pneumonia was defined as new infiltrates on a chest radiograph and the presence of at least two of ... hours after intubation, and between 12 and 26 hours after intubation – are shown in Table and Figures 1, 2, 3, The figures show boxplot summaries of actual biomarker levels and of the biomarker levels...

Ngày tải lên: 13/08/2014, 03:20

... Rudin), the diagnosis of schizophrenia was confirmed in a subsample of 660, and the prevalence of schizophrenia in the parents and siblings of these 660 probands was examined (Kendler and Zerbin-Rudin ... flattening of affect, avolition, or asociality), and only 4% had derailment or thought disorder This is consistent with previous reports of relative absence of formal thought disorder and of blunting of ... history of TBI in 11% of patients with schizophrenia, compared with 4.9% of patients with mania, 1.5% of patients with depression, and 0.7% of surgical control subjects Likewise, in a sample of Nigerian...

Ngày tải lên: 10/08/2014, 18:20

... performed and is recommended by most authors.11, 26 The temporary removal of a piece of skull followed by loose closure of the dura and skin layers presumably allows for expansion of the edematous ... valuable At present, in the absence of definite proof of the efficacy of decompressive craniectomy in the treatment of TBI, such as from multicenter, prospective, randomized, controlled trials, these ... effusion after aneurysm surgery and decompressive craniectomy: case report and review of the literature Clin Neurol Neurosurg 2005;107:412-416 26 Winn HR Youmans Neurological Surgery; 5th ed Philadephia...

Ngày tải lên: 25/10/2012, 11:40

... similar case in 1889 and "emphasized the relationship of unawareness of disease and focal cerebral lesions" (Friedland and Weinstein, 1977) Anton was making the point that a lack of awareness could ... Weinstein and Friedland R P (eds.), Advances in Neurology (Vol 18): Hemi-inattention and Hemisphere Specialization New York: Raven, pp 1-13 Gerstmann, J (1942) Problem of imperception of disease and of ... clinical report of lack of awareness of severe loss of sight By underscoring the difference between his case and cases in which imperception of disease might have been explained on the basis of a global...

Ngày tải lên: 11/06/2014, 09:45

... Numerical data of the scores of scales and tests The results are given in terms of mean ( X ) and standard deviation (s) The subindexes and 20 represent the ¯ assessments carried out before and after ... sitting and standing position, which is an essential process in standing balance rehabilitation [24,25] The system calibrates the maximum excursion of the patients and adapts the range of motion of ... neurorrehabilitation service of a large metropolitan hospital Each patient participated in a total of 20 one-hour-sessions of rehabilitation and accomplished a minimum of sessions and a maximum of sessions per...

Ngày tải lên: 19/06/2014, 08:20

... concepts and ideas in Part I of the study WAKY and YEWH collected and analyzed data for Part I KNKF formulated concepts in Part II of the study CBCH, LKCK, LJCK, and LTHY collected and analyzed ... used an ability model of brain function emphasizing different areas of cognitive function In this study, the sub-scores of two general areas, attention and orientation, and five major ability ... address real- Page of time aspects of information processing and enhance dynamic interaction [5] Previous studies have empirically substantiated the usefulness of VR in the relearning of domain-specific...

Ngày tải lên: 19/06/2014, 08:20

... conception and planning of the experiments, performing of all animal experiments, analysis of the data and writing of the manuscript VMH and JMT provided the anti-factor B antibody and performed ... for DAPI and 520 nm for TUNEL fluorescence Data were analyzed by Alpha digi doc 1201 software (Alpha Innotech, San Leandro, CA) Real-time RT-PCR Changes in the expression profiles of pro- and anti-apoptotic ... altered by injection of mAb 1379 The extent of neurological impairment was assessed using a standardized 10-parameter "Neurological Severity Score" (NSS) in normal, sham-operated, and head-injured...

Ngày tải lên: 19/06/2014, 22:20

... industry, state, and federal sponsors, including the U.S Environmental Protection Agency, U.S Department of Energy (Office of Freedom Car and Vehicle Technologies), and U.S Department of Transportation ... subchronic exposure and may precede evidence of neuropathology Future research needs to address the effects of lifetime air pollution exposure and the impact of aging on neuroinflammation and neurotoxicity ... system Band density was quantitated with ImageJ [34] and analyzed as a ratio of GAPDH and a synuclein Results are reported as a percent increase from control TNFa, IL-6, MIP-1a, IL-1b, Ab42, and...

Ngày tải lên: 19/06/2014, 22:20

... lesion site (3 and dpi, arrows) followed by a complete restoration of the BBB integrity at the later time points (14 and 20 dpi) (B) and (C) are representative illustrations of MRI and histological ... the opening of the BBB On the other hand, the pronounced but delayed upregulation of AQP4 participates in the resolution phase of edema [11] (Figure 8) Page 10 of 16 Our knowledge of AQP4 involvement ... an important passage of plasma proteins (IgG) and water (rapid increase of ADC), while AQP4 expression could be regarded as insufficient to handle such opening of the BBB and subsequent water...

Ngày tải lên: 19/06/2014, 22:20

... of rats exposed to an animal model of depression This activation occurs with increased levels of the pro-inflammatory cytokine IL-1b and of one of the main enzymatic sources of inflammatory and ... production of proinflammatory cytokines, expression of COX-2 and, as a co-factor, activity of indoleamine 2,3-dioxygenase (IDO), which reduces levels of 5-HT, a hallmark of depression On the other hand, ... and interpretation of data and revising the manuscript critically; LB and EB contributed to acquisition, analysis and interpretation of CMS model and behavioural data; JAM and JRC revised the...

Ngày tải lên: 19/06/2014, 22:20

... immune studies and analysis KJK contributed to the design and execution of the surgical studies GLC contributed experimentally DB contributed to design and analysis of the study and wrote the ... temporal and spatial profiles of IL-1α and IL-1β expression after cerebral ischemia Findings We report here that in mice, as early as 4h after reperfusion following ischemia induced by occlusion of ... [1] In particular two pro-inflammatory members of the IL-1 family of cytokines, IL-1α and IL-1β, are considered the major effectors of injury, and inhibiting their signalling with the IL-1 receptor...

Ngày tải lên: 19/06/2014, 22:20

... basis of standard blood and urine tests, X-film of the chest and temperature controls In table are presented the values of CRP and NT-PBNP of three determinations for all of the patients of the ... something new to the understanding of the elevation of CRP and NT-PBNP in the acute phase of stroke both CRP and NT-PBNP are markers of brain edema in stroke at baseline and after 48 hours respectively ... diabetes, and hyperlipidemia Operations were made with the SPSS software, version 10 (Chicago, IL) This study was made with the informed consent of patients and/ or relatives, and the authorization of...

Ngày tải lên: 08/08/2014, 16:23

... the polymerized state of the MT, one monomer consists of 40% α-helix, 31% β-sheet and 29% random coil The α-tubulin consists of four α-helixes, four β-sheets, and two random coils, while the ... backgrounds, like black holes and spacetime foam, and the brain mechanics presented in section Presence or lack of quantum coherence and its cause, the existence of an infinite number of possible equilibrium ... our proteins, our DNA, etc, and also that is what everything else we 29 use, i.e., the “apparatus”, is made of Of course, protons and neutrons are mainly made of up (u) and down (d) constituent...

Ngày tải lên: 10/08/2014, 00:21

... Animal care and experimental procedures were in accordance with the National Institute of Health Guide for the Care and Use of Laboratory Animals and the protocol was Gibson et al Journal of Biomedical ... effects of TBI Specifically, Stelzer and Shi [17] found that NMDA and glutamate altered GABAAR currents in acutely isolated hippocampal cells, and this effect was dependent on the presence of Ca2+ ... against cognitive deficits after TBI [32] Statistical Analysis Protein bands of approximately 60 kDa (α1), 53 kDa (α2), 53 kDa (α3), 51 kDa (α5), 50 kDa (β3), and 45 kDa (γ2) were identified and...

Ngày tải lên: 10/08/2014, 05:21

... EL and HA: carried out the immunofluorescence assays and drafted the manuscript; JLB and MS: conceived the envelope-derived tagged ligands while; JLB, HA, ML and JT: generated, optimized and ... step-size of μm with a specimen magnification of 100× Deconvolution was performed through Huygens professional software (Scientific Volume Imaging, Hilversum, The Netherlands) with 0% background offset ... ligands for the detection and the study of transporters of interest We previously reported an HTLV Env RBDbased immunoadhesin (HRBD) that serves as a uniquely useful extracellular ligand of the...

Ngày tải lên: 10/08/2014, 05:21

... Penningroth Professor and Head of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa Donald C Rojas, Ph.D Associate Professor of Psychiatry, University of Colorado ... time of publication and consistent with general psychiatric and medical standards, and that information concerning drug dosages, schedules, and routes of administration is accurate at the time of ... Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Thomas A Gennarelli, M.D Professor and Chair, Department of Neurosurgery, Medical College of Wisconsin,...

Ngày tải lên: 10/08/2014, 18:20

... medical complications, and course of recovery); time of onset and types of neurobehavioral changes that occurred during the acute and postacute phases of recovery; and results of neuroimaging, electrophysiological, ... both the degree of orientation and recall of newly learned material The length of PTA is one of the best indicators of the severity of injury and is a clinically useful predictor of outcome Furthermore, ... electrophysiological, and neuropsychological testing delineating the location and extent of injury and pattern of cognitive and memory impairment associated with it Medical and psychiatric records...

Ngày tải lên: 10/08/2014, 18:20