neuroendocrine neoplasms of the lung

... Trang 1Chapter 085 Neoplasms of the Lung (Part 19) Further Readings Black C et al: Population screening for lung cancer using computed tomography: Is there evidence of clinical effectiveness? ... surveillance of the patient with lung cancer: What do you do after surgery? Respirology 12:16, 2007 [PMID: 17207020] American College of Chest Physicians: Diagnosis and management of lung cancer: ... 355:1822, 2006 [PMID: 17065645] Trang 11Waller D et al: Chemotherapy for patients with non-small cell lung cancer: The surgical setting of the Big Lung Trial Eur J Cardiothorac Surg 26:173, 2004 [PMID:

Ngày tải lên: 07/07/2014, 02:20

... cell neuroendocrine carcinoma (LCNEC) of the lung, a subtype of large cell carcinoma (LCC), is characterized by neuroendocrine differentiation that small cell lung carcinoma (SCLC) shares Pre-therapeutic ... Among subtypes of LCC, the prognosis of LCNEC was poorer than others even if at early stages [6,7] like SCLC However therapeutic stra-tegies of LCNEC and SCLC differ from each other The former needs ... and the number of male accounts for over 80% for all groups The majority of patients remained at stages from IA to IIB and accordingly had the extent of the primary tumor (T1 and T2) and of regional

Ngày tải lên: 10/08/2014, 09:22

... inflating the prior variance of the proportion of smokers in the cohort This should not affect results substantially because it is the prior mean of the bias parameters that dictates the magnitude of ... describes the probability the analyst would assign to the observed data given the parameters How to move forward from here? Basic rules of probability theory imply the Baye-sian theorem This theorem ... for the distribu-tion of the propordistribu-tion in the cohort, one based on an application of CAREX [29,30] which is a computer assisted information system for the estimation of the numbers of

Ngày tải lên: 20/06/2014, 00:20

... changes The number of inflammatory cells in BALf and lung tissue of the left (day 0–90) and right lung (day 0–7) Figure 4 The number of inflammatory cells in BALf and lung tissue of the left ... y Trang 10The number of inflammatory cells in BALf and lung tissue of the left (day 0–90) and right lung (day 0–7)Figure 5 The number of inflammatory cells in BALf and lung tissue of the left ... Finally, in the case of single lung transplantation, the changes in the native lung after transplantation of the con-tralateral side are not well established, especially on the long term Therefore,

Ngày tải lên: 12/08/2014, 15:21

... even these nodules may already be malignant, and therefore late in the course of the disease. Tumor cells have been found in the peripheral blood and bone marrow of patients with lung cancer of ... perhaps other regional de- letions. By the time the stage of severe SD/CIS is reached, there is extensive loss of 3p and persistent loss of the 9p and 17p regions. Methylation Recently, there has ... increased incidence of sq- uamous metaplasia and dysplasia in the lungs of smokers. In 1979, Auerbach and colleagues described a range of histologic abnormalities in the lungs of smokers, from basal

Ngày tải lên: 12/08/2014, 18:20

... (below the medium value as cut-off ) in 39% of the LAC samples and 2% of the benign samples Furthermore, in a separated analysis the LAC with stage I (n = 59) was compared with a subgroup of benign ... and a sensitivity of 93% was obtained (Table 4) A ROC curve based on the TreeBagger model of the remaining 20% of LAC samples and 20% of the benign samples resulted in an AUC of 0.90 (Fig.4) In ... value as cut-off ) in 46% of the LAC samples and in none of the benign samples Finally, we investigated whether a classifier could sep-arate benign disease from the combined group of LAC, CRC

Ngày tải lên: 17/06/2020, 16:58

... since the beginning of the century • Age, race, sex, tobacco, diet, specific genetic syndromes • More than 80% of cases between 60-80 years of age, rare under 40 • African-American of both sexes Epidemiology/Risk ... inactivated in 75% of all pancreatic cancers Molecular Genetics • DPC4 is on Chromosome 18q The Chromosome is missing in 90% of all pancreatic cancers, the gene inactive in 50% The mutations are ... Neoplasms of the Pancreas Vic V Vernenkar, D.O St Barnabas Hospital Dept Of Surgery From Greenfield’s Surgery 2006 4th edition Introduction

Ngày tải lên: 13/08/2020, 09:13

... All of these results are consistent with those of the discovery set, and confirmed their performance as their diagnosis markers in another set of tumors We subsequently examined the potential of ... an IHC score of 2 as positive (Table 1) Validation with an independent group of patients confirmed the performance of the novel markers We further assessed their performance of these markers ... However, one of the drawbacks in transcrip-tome analysis, including CAGE, of solid tissue is that the profiling target consists of heterogenous cells In the present study, the profiled tissues

Ngày tải lên: 20/09/2020, 18:07

... information on the basis of the third edition of the International Classifications of Diseases for Oncology (ICD-O-3) We included all cases of invasive carcinoma (behavior code/3) of the breast (C500-509) ... metastasis at the time of diagnosis Tumor grade The tumors of the NEC group were of significantly higher histologic grade than those of the IMC-NOS group (P < 0.0001) (Table 1) Most of NEC tumors ... Background: Neuroendocrine carcinoma (NEC) of the breast is a rare type of carcinoma that has not been well studied or characterized Of the limited number of studies reported in the literature,

Ngày tải lên: 05/11/2020, 01:27

... payers, and others Indeed, effective January 1, 2004, the Commission on Cancer of the American College of Surgeons mandated the use of the checklist elements of the protocols as part of its Cancer ... reproduction or other use of any substantial portion of these protocols for commercial purposes without the written consent of the College The CAP also authorizes physicians and other health care ... Programs Therefore, it becomes even more important for pathologists to familiarize themselves with these documents At the same time, the College cautions that use of the protocols other than for their

Ngày tải lên: 18/10/2022, 14:15

... in the sum of the maximum diameters of the target lesions, which is the current standard for assessing the re-sponse of solid tumors to anticancer therapy [20] However, for targeted therapies, ... funded by the National Natural Science Foundation of China in the analysis, and interpretation of data, in the writing of the manuscript (81571750), the Natural Science Foundation of Guangdong ... identified on the basis of the follow-ing CT findfollow-ings: the appearance of new lesions or metastasis, the appearance of new intratumoral nod-ules, or an increase in overall tumor size of greater

Ngày tải lên: 20/09/2020, 01:35

... Inhibition of proliferation of LXF-289 lung tumor cells Effects of P2 receptor agonists The influence of the different P2 receptor agonists is shown as percentage inhibition of the proliferation of LXF-289 ... percentages of the cells in the G0 ⁄ G1, S and G2 ⁄ M phases of the cell cycle after treatment with 20 lM or 100 lM ATP for 24 h The gating used for the quantification of the cells in the G0 ⁄ G1 ... downregulation of the proliferation of LXF-289 cells This is indicated by the fact that blockage of either pathway by the inhibitors for p38 MAPK and ERK1 ⁄ completely reversed the inhibitory effect of ATP

Ngày tải lên: 07/03/2014, 12:20

... Consequently, the ultimate effect of p73 isoforms in cancer progres-sion is attributed to the TA⁄ DM ratio, rather than the overexpression of a specific p73 isoform or a specific class of p73 isoforms ... processes Therefore, all of these issues should be addressed in the future Taken together, our findings make it clear that there is a link between the expression of Sp1 and p73 isoforms in lung cancer ... focused on the identification of novel transcriptional factors that control the use of the p73 P1 promoter and, subsequently, the relative expression of p73 iso-forms in lung cancer by using lung cancer

Ngày tải lên: 29/03/2014, 09:20

... in the epithelium of the developing lung and gut As there was no information available about the localiza-tion of Wnt signaling in the developing lung, we first ana-lyzed embryos of the TOPGAL ... Note the heterogeneity of staining intensity in the endoderm The inset shows immunolocalization of ␤-catenin in the nuclei of distal epithelial cells (g) E15.5 whole lung (h) Section of E15.5 lung, ... example, in the small intestine, Tcf4 is required for the rapid proliferation of the embryonic intervillus epithelium that gives rise to the crypts [7] These contain the stem cells of the adult

Ngày tải lên: 06/08/2014, 18:20

... above the superior extent of the PTV and continuing on every CT slice to at least 10 cm below the inferior extent of the PTV For patients with tumours located in the mid- or lower zones of the lungs, ... to the authors of such articles, one should also consider the publication of the recalculated data These data can be used to improve our dose-effect models, which aid the fur-ther improvement of ... influencing the display of the dose distribution, can be left to the institutions preference RTOG trial 0236 defined a set of parameters to quantify the conformity of the dose and PTV coverage The same

Ngày tải lên: 09/08/2014, 09:22

... numbers Further studies are needed to address this question Major limitations of the study are the fact that the majority of patients received immunosuppressive therapies at the time of BAL Therefore, ... study, the correlation of cytokine and chemokine levels with signs of lung fibrosis was studied Finally, by follow-up investigations of the clinical data, lung function, and HR-CT scores, the predictive ... defined either by worsening of HR-CT (≥ 3) or by changes of the predicted FVC, DLCO-SB, or TLC values for ≥ 10% during a follow-up of 2.5 years End-stage ILD was defined either by death or by the

Ngày tải lên: 09/08/2014, 14:22

... adju-vant chemotherapy group received the planned 3 cycles of chemotherapy The exploratory analysis of these results showed the patients with clinical stage II and T3N1 disease derived the greatest ... 21 [31] The studies of first-line therapy with these agents showed objective RR of 54.8 to 81.6% and PFS of 9.7 to 13.3 months among patients with these mutations [31,32] Therefore, the IPASS ... Unfortunately, NATCH could not determine the superiority of either neoadjuvant or adjuvant chemotherapy over each other It is recommended to wait for the results of the ongoing trials in Asia and Europe

Ngày tải lên: 10/08/2014, 22:21

... we analyzed the regulation of the expression of the known TLR adaptor proteins in small-airway epithelial cells To examine the impact of different TLR ligands on the expression of the adaptor ... provide further insight in the role of TLRs in the immune response of the lung epithelium to viral and bacterial infections and their contribution to virus and bacteria induced exacerbations of pulmonary ... barrier function, the airway epithelium plays an important role for the immune response in the lung [1] Thus, the lung epithelium is a major source of cytokine, chemokines and other inflammatory

Ngày tải lên: 11/08/2014, 08:21

... noted that the success in predicting the degree of associations depends on the validity of the measures used in the study, usefulness of the underlying theory used to derive the hypotheses and ... co-morbidities and degree of severity of their lung disease and other chronic conditions, rather than the age of the patient Clinicians’ expectations about the degree of associa-tion between HUI3 ... All the other authors participated in the formulation of the a priori hypotheses and contributed to the drafting of the manuscript. Authors ’ information MJS is an investigator at the Faculty of

Ngày tải lên: 12/08/2014, 01:21

... independent of the study design The networks generated from the input of tran-scriptional data yields networks based on the known functions and interconnectivity of the affected genes Therefore, ... downregulation of the transcriptome and a greater num-ber of affected genes in the A/J strain compared to the B6 was found Some gene networks altered during the early and late resolution phases of the lung ... Lending to the title of this network was the alteration of genes under the higher level function of behavior and nervous system development and function These genes including D site of albumin

Ngày tải lên: 12/08/2014, 11:22