monoclonal antibody to her 2 in breast cancer

... and the HER- 2 transcript in human breast cancer Sample 2/ 1/1/3 1/0/0/3 4/1/x /2 3/1/1/3 2/ 1/1/3 2/ 1/1/3 1 /2/ 0 /2 2/1/0/3 ΔCt 4,68 3, 32 2,77 5,81 4,38 4.08 2, 08 2, 57 ΔΔCt 0,94 -0,43 -0,98 2, 07 0,64 ... -0, 72 ΔΔCt 1, 32 0,63 0,76 0,54 2, 93 2, 85 1,14 1,65 Rel expression (%) 1 32 63 76 54 29 3 28 5 114 165 HER- 2 ΔCt 1,63 0,44 0 ,29 -0,11 0,60 -0,69 -1,11 -2, 37 ΔΔCt 3,95 2, 76 2, 61 2, 21 1, 72 1,63 1 ,21 ... Astolfi A, Musiani P, Forni G, Lollini P-L: Combined allogenic tumor cell vaccination and systemic interleukin Page 13 of 13 24 25 26 27 28 29 30 31 32 33 34 12 prevent mammary carcinogenesis in...

Ngày tải lên: 18/06/2014, 16:20

... 75 mg SC (n = 12) (n = 12) (n = 12) (n = 12) 3 12 ( 72) 806 (1 12) 22 0 (58) 26 .7 ( 12. 9) 1.0 (0.5 24 .0) 1.0 (0.5– 12. 0) 144 (144–335) 144 (48–145) 25 80 (665) 828 0 (1690) 423 0 ( 121 0) 24 4 (156) 148 (48) ... = 12) (n = 12) (n = 24 ) (n = 88) (n = 12) (n = 94) 12 Any Adverse Event (100) 12 (100) 12 (100) 24 (100) 74 (84) (100) 77 ( 82) (50) (75) (58) 16 (57) 22 (25 ) (33) 15 (16) (13) (17) ( 42) (29 ) ... nitric oxide synthase inhibitors after intraarticular injection of interleukin-1beta in rats Arthritis Rheum 1999, 42: 2094 -21 02 Richette P, Francois M, Vicaut E, Fitting C, Bardin T, Corvol M, Savouret...

Ngày tải lên: 12/08/2014, 17:22

... FISH when the Her- 2 with a Her- 2 to CEP 17 ratio < 1.8 by counting at least 30 interphase nuclei, and those cases with a Her- 2 to CEP 17 ratio > 2. 2 were scored as positive (Figure 2) In addition, ... found in 35 cases (27 .1%) and discordance in 94 cases ( 72. 9%) [15] Lan et al used FISH to ascertain the prevalence of erb-b2 gene amplification in 22 1 cases of breast cancer specimens read as 2+ in ... cases with Her- 2 status of IHC 3+ or FISH positive are proposed to be treated with herceptin 10 11 12 Parkin DM, Bray F, Ferlay J: Global cancer statistics, 20 02 CA Cancer J Clin 20 05, 55 (2) :74-108...

Ngày tải lên: 09/08/2014, 04:21

... 44 2. 1 2. 1.1 2. 1 .2 2.1.3 2. 1.4 Materials Ligand and inhibitors Antibodies Cell-lines Fresh frozen clinical specimens 44 44 44 45 45 2. 2 2. 2.1 2. 2 .2 2 .2. 3 2. 2.4 2. 2.5 2. 2.6 2. 2.7 2. 2.8 2. 2.9 2. 2.10 ... CHAPTER INTRODUCTION 1.1 1.1.1 1.1 .2 1.1.3 Breast cancer Incidence of breast cancer Classification of breast cancer Aetiology of breast cancer 1 1 .2 1 .2. 1 1 .2. 2 1 .2. 3 1 .2. 4 1 .2. 5 1 .2. 6 HER- 2/ neu-positive ... PP2A BY HER- 2/ neu 77 4.1 77 Overview 4 .2 4 .2. 1 4 .2. 2 4 .2. 3 4 .2. 4 Results 80 Inhibition of HER- 2/ neu signalling using AG 825 80 HER2 /neu signalling regulates tyrosine phosphorylation of PP2A 81 Inhibition...

Ngày tải lên: 11/09/2015, 10:06

... TR & Seol D-W (20 04) Hypoxia inhibits tumor necrosis 5146 15 16 17 18 19 20 21 22 23 24 factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation Cancer Res 64, ... oxygen distribution in breast cancers by computerized O2 tension measurements Cancer Res 51, 3316–3 322 Semenza GL (20 03) Targeting Hif-1 for cancer therapy Nat Rev Cancer 3, 721 –7 32 Kim M, Park S-Y, ... (20 03) Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosisinducing ligand ⁄ Apo -2 ligand on apoptosis and on regression of breast carcinoma in vivo Cancer...

Ngày tải lên: 30/03/2014, 03:20

... 1 .21 -11.8 1. 124 1.717 0.44-6.65 0.115 2. 120 0.68-15.35 0.1 02 3.471 1.14-10.57 0.001 2. 139 1 .28 -11 .21 1 .23 9 2. 819 0.91-8.75 0.110 2. 143 1 .22 -17.95 0.087 1 .25 3 1.18-16.13 1. 124 4.743 1.70-7 .28 ... improve survival in breast cancer? A meta-analysis J Clin Oncol 20 00, 18: 122 0- 122 9 24 Sotiriou C, Wirapati P, Loi S, et al: Gene expression profiling in breast cancer: understanding the molecular ... Inst 20 05, 97:419- 424 21 Rutqvist LE, Rose C, Cavallin-Stahl E: A systematic overview of radiation therapy effects in breast cancer Acta Oncol 20 03, 42: 5 32- 545 22 Van de Steene J, Soete G, Storme...

Ngày tải lên: 09/08/2014, 09:20

... (0.63-4.08) 1 .28 -1.78 0 .29 0 RIA 1Gy 13.33 ± 7 .26 12. 36 (2. 51 -29 .00) 9.58-15. 52 0.971 RIA 2Gy RIA 8Gy 18 .20 ± 7. 82 17.79 (4.17- 32. 08) 14.40 -22 .43 0.996 29 .70 ± 10.05 30.44 (9. 02- 44.10) 24 .83-34.40 ... observed Initial DNA damage levels in breast cancer patients Radiation-induced apoptosis in breast cancer patients Initial DNA damage was determined as radiationinduced double-strand breaks (DSB) in ... radiation-induced fibrosis, edema, and neuropathy in breast cancer patients Int J Radiat Oncol Biol Phys 20 02, 52: 120 7- 121 9 27 Coles CE, Moody AM, Wilson CB, Burnet NG: Reduction of radiotherapyinduced...

Ngày tải lên: 09/08/2014, 09:20

... 20 07, 2: 25 http://www.ro-journal.com/content /2/ 1 /25 25 26 31 27 28 29 30 32 33 38 67 11 12 10 16 39 34 20 15 22 48 42 24 51 52 53 47 43 44 55 46 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 ... 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 3056 Substrate binding Leucine ... Val- 82 to Ser-89 Val- 121 8 to Leu- 123 8 Exon Proline rich FAT domain Asp-1373 to Pro-13 82 ATM protein NO controls NO BC American BC (± IBTR) Ser-1966 to Ala -25 66 ATP-binding site (1); Val -27 16 to...

Ngày tải lên: 09/08/2014, 10:21

... growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system Cancer Lett 19 92, 64 :24 9 -25 6 Hill SM, Blask DE: Effects of the pineal hormone melatonin ... Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer Cancer Res 20 02, 62: 2971 -29 75 Publish ... MS: Light in the built environment: potential role of circadian disruption in endocrine disruption and breast cancer Cancer Causes Control 20 01, 12: 279 -28 7 Hansen J: Increased breast cancer risk...

Ngày tải lên: 10/08/2014, 09:20

... fibronectin Other ligands, such as collagen and laminin are known to bind to α1, 2, α10 and α11 subunits of β1 integrin family that contain the αA-domain Laminin is also found to bind to non-αA-domain ... cells during the process of metastasis 61 Integrin αL 2 and mucin (MUC1) can bind to ICAM-1 to mediate breast cancer cells adhesion 62, 63 Similarly, integrin α4β1 interacts with VCAM-1 to mediate ... adhesion of renal cancer cells 64 and melanoma cells 65 to endothelium 1 .2. 4 Integrins in cancer Due to the signalling effects, integrins have critical roles in cancer progression Integrins expressed...

Ngày tải lên: 09/09/2015, 08:17

... (TPP1, TIN2 and hRap1) include those that bind to the telomeric DNA through interaction with the directly interacting proteins TIN2 binds to TRF1 and TRF2 hRap1 binds to TRF2 (Blasco, 20 07) 1.1 .2: ... 1968 to 20 02, Singapore experienced an almost three-fold increase in breast cancer incidence (Sim et al., 20 06) The breast cancer incidence pattern in Singapore is rapidly becoming similar to populations ... a 22 x 22 coverslip and incubated in a humidified chamber for 1hr at 37°C After washing thrice with washing solution, secondary antibody (20 µl) in blocking solution was applied on a 22 x 22 ...

Ngày tải lên: 12/09/2015, 08:16

... 11 ii 1 .2. 2 .2 Mig -2 involved in mitogenic signaling cell cycle control 12 1.3 Recent studies on mig -2 15 1.3.1 Mig -2 gene involved in cell adhesion 15 1.3 .2 Integrin signaling pathway in cell ... It binds to integrin to promote cross-linking of the actin cytoskeleton and formation of dense bodies (Schaller, 20 00) UNC-1 12 is recently identified as a new binding partner for integrinlinked ... recruiting and activating different intracellular signaling and adaptor proteins ECM binding initiates clustering of integrins in the plane of the membrane and reorganization of the actin cytoskeleton,...

Ngày tải lên: 05/10/2015, 22:15

... 23 2. 1 .2 Antibodies 24 2. 1.3 Primers 25 2. 2 Methods 26 2. 2.1 Construction of ERp29-expression vector 26 2. 2 .2 Generation of ERp29-overexpressing single ... listed in Table 2- 2) 2. 2 .2 Generation of ERp29-overexpressing single stable clones in MDA-MB231 and BT549 breast cancer cells To create ERp29-overexpressing clones, ERp29-pcDNA3.1 vector obtained ... protein -29 (ERp29) is a chaperone protein that functions in the unfolding and escort of secretory proteins Like other reticuloplasmins, ERp29 is believed to be involved in carcinogenesis In breast...

Ngày tải lên: 13/10/2015, 15:55

... resistance of BRCA cancer cells to PARP inhibition, there is evidence to suggest that PARP inhibitors may be useful in treating tumors in combination with cytotoxic drugs by increasing the sensitivity ... disorders [ 52] Furthermore, PARP-1 inhibitors seem to protect against the cardiotoxicity of doxorubicin and the nephrotoxicity of cisplatin [53, 54] The use of PARP-1 inhibitors in combination with ... PARP inhibitors in cancer therapy Pharmacol Res 20 05; 52: 25 -33 Tentori L, Leonetti C, Scarsella M, et al Systemic administration of GPI 15 427 , a novel poly(ADP-ribose) polymerase-1 inhibitor, increases...

Ngày tải lên: 31/10/2012, 16:57

... thousand women, increasing the individual risk over 20 years (age 50 to 70) from one in 22 to one in 19. 12 Berrino F et al Survival of Cancer Patients in Europe: The EUROCARE -2 Study IARC Scientific ... Co-ordinating Group Cancer Services Co-ordinating Group 20 00 22 Dewar JA, Twelves CJ, Thomson CS for the Scottish Breast Cancer Focus Group and the Scottish Cancer Therapy Network Breast Cancer in ... with breast symptoms Women with symptoms which could be due to breast cancer should be referred to the breast care team Routine breast examination, including self-examination, for asymptomatic...

Ngày tải lên: 14/02/2014, 22:20

... 6a.7.5 Prognostic information 6a.8 References 22 1 22 3 22 3 22 4 22 6 22 7 22 8 22 8 23 0 23 2 23 5 23 7 23 8 23 8 23 8 23 9 24 1 24 2 24 3 24 8 24 9 Appendix Quality assurance A1.1 Definitions A1 .2 How to calculate ... d i t i o n 25 4 25 5 25 7 25 9 25 9 25 9 25 9 26 0 26 4 26 4 26 4 26 4 26 5 26 8 26 8 26 8 26 9 27 3 27 8 28 0 28 2 28 4 28 4 28 6 28 7 29 0 29 0 29 1 29 1 XIII Roman_pages 20 -09 -20 05 T A B L E 21 :01 O F Pagina XIV C O ... Imaging in Breast Diagnosis 5. 12 Sentinel Lymph Node Biopsy Procedures 5.13 References XII 197 199 20 0 20 0 20 2 20 2 20 3 20 3 20 3 20 4 20 4 20 4 20 5 20 6 20 7 20 7 20 8 20 8 20 8 20 9 20 9 20 9 21 1 21 2 21 3 21 3...

Ngày tải lên: 15/03/2014, 00:20

... oncoprotein, suggesting a novel approach to the targeted therapy of HER2 -overexpressing cancers (Li et al, 20 07) Targeted Apoptosis in Breast Cancer Immunotherapy 35 Targeted apoptosis in clinical ... Emerging targeted therapies for breast cancer J Clin Oncol, Vol 28 , No 20 , (Jul 20 10), pp (3366-3379), ISSN 07 32- 183X Ashkenazi, A (20 08) Targeting the extrinsic apoptosis pathway in cancer Cytokine ... C.C (20 08) Unraveling the Biologic and Clinical Complexities of HER2 Clin Breast Cancer, Vol 8, No 5, (Oct 20 08), pp (3 92- 401), ISSN 1 526 - 820 9 Targeted Apoptosis in Breast Cancer Immunotherapy...

Ngày tải lên: 23/03/2014, 17:20

... angiotensin II type 1, interleukin and C-C chemokine receptors Chemokines [27 ,28 ] and angiotensin II [29 ] have both shown growth-inhibiting properties with different cancers Interestingly, an ... growth factors and steroid hormones Progestin administration causes an initial increase in cell proliferation lasting about 12 24 h and subsequent GPR30 and progestin (Eur J Biochem 26 9) 24 89 inhibition ... distributed in brain and peripheral tissues Biochem Biophys Res Commun 22 8, 28 5 29 2 15 Filardo, E.J., Quinn, J.A., Bland, K.I & Frackelton, A.R Jr (20 00) Estrogen-induced activation of Erk-1 and Erk-2...

Ngày tải lên: 24/03/2014, 00:21

... 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 Facione NC and Dodd MJ: Women's narratives of help-seeking behavior for breast cancer Cancer Practice 1995, 3 :21 9 -22 5 Lannin DR, Mathews HF, Mitchell ... Fabbrocini G et al.: Assessment of delay in obtaining definitive breast cancer treatment in southern Italy Breast Cancer Res & Treat 20 01, 66 :20 9 -21 5 Montazeri A, Haji-Mahmoodi M and Jarvandi S: Breast ... 170) < cm 2 5 cm ≥ cm Nodal involvement (n = 165) No Yes P No (%) 84 (67.8) 19 (46.3) 40 ( 32. 2) 22 (53.7)) 2 = 6. 02, df = 0.01 19 (15.1) (4.5) 74 (58.7) 19 (43 .2) 33 (26 .2) 23 ( 52. 3) 2 = 11.1,...

Ngày tải lên: 28/03/2014, 14:20

... gland Breast Cancer Res 5, 20 8 21 5 27 Henning T, Kraus M, Brischwein M, Otto AM & Wolf B (20 04) Relevance of tumor microenvironment FEBS Journal 27 2 (20 05) 2 15 ª 20 04 FEBS J E Celis et al 28 29 ... Bienz M & Clevers H (20 00) Linking colorectal cancer to Wnt signaling Cell 103, 311– 320 82 Brown AM (20 01) Wnt signaling in breast cancer: have we come full circle? Breast Cancer Res 3, 351–355 ... Schoch C (20 03) Gene expression profiling as a tool for the diagnosis of acute leukemias Semin Hematol 40, 28 1 29 5 FEBS Journal 27 2 (20 05) 2 15 ª 20 04 FEBS Translational research in breast cancer...

Ngày tải lên: 30/03/2014, 15:20