molecular pharmacology and modeling of vasopressin receptors

... posses-sion and loss of the lic2C gene, the NTHI0683 gene, and the UreABCEFGH operon Global genomic alignments of PittEE against R2846 and R2866 were performed (Figures 10 and 11) PittEE and R2846 ... differences of between 96 and 585 were identified per strain pair Comparisons of each of the NTHi strains with the Rd strain revealed between 107 and 158 insertions and 100 and 213 deletions per ... insertion and deletion sizes were 1,356 and 1,020 base-pairs, respectively, with mean maximum insertions and deletions of 26,977 and 37,299 base-pairs This relatively large number of small rearrangements

Ngày tải lên: 14/08/2014, 07:21

... 1Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment toolsWeichun Huang *† , Joseph R Nevins * and Uwe Ohler ... distances (Figure 5 and Table 2) For example, the observed RTRs for Myc and NFκB were 0.219 and 0.083 at a divergence distance of 1.0, and 0.373 and 0.167 at a diver-gence distance of 2.0 These results ... size of sequence InDel events, and a gamma distribution and invariant rate (Γ+I) for modeling heterogeneity of substitu-tion rates The HKY85 model does not assume equal base fre-quencies and can

Ngày tải lên: 14/08/2014, 08:20

... and Antigenic characterization of full genome of seasonal and pandemic 2009 influenza viruses circulating on campus 6.3.2.1 HA and NA diversity 6.3.2.2 Diversity of internal genes 6.3.3 Pandemic ... Sensitivity of molecular and viral isolation methods for detection of influenza A virus infection during the period of surveillance and the methods employed 77 Table 5.3 Comparison of sensitivity of ... Figure 1-4) The summary of the pandemics of 20th and 21stcentury is presented in table 1.4 Adapted from Schrauwen et al 2014 Figure 1-4: Reassortment and adaptation events of pandemic influenza

Ngày tải lên: 09/09/2015, 08:18

... model of the clay particle and (c) RVE model of nylon 6/clay nanocomposites with 2.5% weight fraction of nano-clay Figure 4.2 (a) Molecular model of gallery layer and (b) Molecular configuration of ... Dependency of elastic modulus of explicit RVE and effective RVE on diameter of clay particle, (for ECNs) Figure 5.6 Dependency of elastic modulus of explicit RVE and effective RVE on the number of silicate ... and (b) tensile strength of epoxy/clay nanocomposites; Effect of number of silicate layers on (c) elastic modulus and (d) tensile strength of epoxy/clay nanocomposites Figure 3.7 Comparison of

Ngày tải lên: 09/09/2015, 11:20

... characterization of the interaction between nsp8 and nsp12 revealed that the interaction is independent of the presence of RNA was subsequently shown that nsp8 interacts with both the N- and C-termini of nsp12 ... mRNAs, MADP1 mRNA and GAPDH Table 3.1: Volumes (in microlitres) of each 50 µM siRNA used in the different Table 3.2: Band densities of MADP1 (normalized with band densities of actin for each ... the 5’-end of the genome and transcribe the leader sequence or it may retain its template and continue transcribing from the 3’-end of the genome This results in the generation of a set of negative-sense

Ngày tải lên: 09/09/2015, 18:54

... 6Table of Contents Declaration i  Abstract ii  Acknowledgements iii  List of Publications iv  Table of Contents v  List of Tables viii  List of Figures ix  List of Symbols xiii  List of Acronyms ... general and favorable option For instance, previous expression for the self inductance of square coils is where n is the number of turns, d o and d i are the outer and inner diameters of the coil, and ... Publications [1] Z Duan, Y.X Guo, M Je, and D.L Kwong, “Design and in vitro test of differentially fed dual-band implantable antenna operating at MICS and ISM bands”, IEEE Trans Antennas Propag.,

Ngày tải lên: 10/09/2015, 09:12

... Trang 1 MOLECULAR TRANSPORT AND STRUCTURE OF DNA IN A CONGESTED STATE ZHU XIAOYING NATIONAL UNIVERSITY OF SINGAPORE 2010 Trang 2 MOLECULAR TRANSPORT AND STRUCTURE OF DNA IN A CONGESTED ... is of paramount importance (9, 10) The ionic strength of the supporting medium provides different screening conditions of DNA From a biophysical point of view, it is of interest to understand ... measurements and mechanical rheometry with consistency Furthermore, Goodman et al used the method of multiple-particle tracking to measure the microviscosity and degree of heterogeneity of solutions of

Ngày tải lên: 11/09/2015, 10:06

... not normal and their findings broadly confirm those of Miles and McCue (1984) and Hartzell et al (1986) who find evidence of non-normality in terms of skewness and kurtosis, and Myer and Webb ... colleagues from Dept of Finance Hong Kong University of Science & Technology, especially Prof Sudipto Dasgupta, Prof John Wei, Prof Kalok Chan, Prof Jonathan Batten, Dr Junbo Wang and Sophie Ni ... variance of the stochastic variableRjtequals to the variance of the product of two stochastic variables D jt * and dyjt, which are correlated When one or both of the coefficients of variation of the

Ngày tải lên: 11/09/2015, 16:07

... 1CHARACTERIZATION AND MODELING OF MICROWAVE SPIRAL INDUCTORS AND FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING NATIONAL UNIVERSITY OF SINGAPORE 2005 ... Measured and simulated results of the real part of Y3−1 (a) and ω)( 1 1 3 − − Y imag (b) on Inductor 1 with improved models……… 39 Fig 2.19: Real part of input impedance of Inductor 3 and Inductor ... return loss of EBG-fed slot antenna and reference antenna …… 117 Fig 6.5: Simulated and measured return loss of reference antenna ……… 117 Fig 6.6: Simulated and measured return loss of EBG-fed

Ngày tải lên: 12/09/2015, 09:42

... CHARACTERIZATION, AND MODELING OF SILICON MULTI-GATE DEVICES ZHAO HUI A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING FACULTY OF ENGINEERING ... applied at the terminals of the test key for measuring the I-V characteristics of the N and P drivers and the DUT, and, the C-V measurement of N and P-type SNW DUTs The I-V of Driver devices help ... devices help in deciding the values of LOW and HIGH and the levels of PGn, PGp, NGn, and NGp pulses in the table The drivers are SNW devices with gate length of 0.35μm and a larger diameter to source/sink

Ngày tải lên: 12/09/2015, 11:29

... of the PRNN Network 156 7.4 Modeling of HRV Signals 157 7.4.1 Validation of the Signal Model 165 7.5 Modeling of EEG Signals 167 7.5.1 Validation of the Signal Model 170 7.6 Comparison of ... 6.4 Modeling of HRV Signals 127 6.4.1 Validation of the Signal Model 133 6.5 Modeling of EEG Signals 136 6.5.1 Validation of the Signal Model 139 6.6 Conclusion 141 Chapter 7 Nonlinear Modeling ... analysis of the results of the classifiers is presented and the performances of the classifiers are evaluated in terms of classification accuracy Similarly, the ability and effectiveness of the

Ngày tải lên: 13/09/2015, 21:13

... 1GRAIN COALESCENCE AND MODELING OF NANOSIZED ZIRCONIA IN SOLID-STATE SINTERING YU POH CHING NATIONAL UNIVERSITY OF SINGAPORE 2009 Trang 2GRAIN COALESCENCE AND MODELING OF NANOSIZED ZIRCONIA ... over the past few years, especially to my husband, who tolerate my negligence in family and proof read my thesis Trang 4Grain Coalescence and Modeling of Nanosized Zirconia in Solid-State Sintering ... Coalescence Trang 12Grain Coalescence and Modeling of Nanosized Zirconia in Solid-State Sintering X LIST OF FIGURES Figure 1-1 Inter and intra-agglomerates pore (a) before and (b) after sintering .3 Figure

Ngày tải lên: 14/09/2015, 08:24

... Trang 1PH.D Candidature: Fu Nai Yang Supervisor: Assoc Prof Victor C Yu Degree: M.Sc Zhongshan Univetsity Department: Institute of Molecular and Cell Biology (IMCB), Department of Pharmacology, ... Pharmacology, NUS Thesis Title: Molecular Function and Regulation of the Bax-associating Protein MOAP-1 Year of Submission: 2007 Trang 2MOLECULAR FUNCTION AND REGULATION OF THE BAX-ASSOCIATING PROTEIN ... BAX-ASSOCIATING PROTEIN MOAP-1 Fu Nai Yang INSTITUTE OF MOLECULAR AND CELL BIOLOGY NATIONAL UNIVERSITY OF SINGAPORE 2007 Trang 3MOLECULAR FUNCTION AND REGULATION OF THE BAX-ASSOCIATING PROTEIN MOAP-1 Fu

Ngày tải lên: 14/09/2015, 12:54

... linings of all the glands which open into the digestive tube, including those of the liver and pancreas, the epithelium of the auditory tube and tympanic cavity, the trachea, bronchi, and alveoli of ... urinary bladder and part of the urethra, and the follicles of the thyroid gland and thymus (Stain However although well defined by fate maps, due to the close proximity and the nature of the mechanistic ... Contents Acknowledgement ii Table of Contents iii Summary ixii List of Abbreviations ix List of Tables ixi List of Figures xii List of Publications and List of Conference Participation

Ngày tải lên: 14/09/2015, 14:06

... example, has a value of α of 4.04 Å3, which is 19 times greater than that of helium (0.21  Å3) and 10 times that of neon (0.39  Å3) Argon and krypton have α values of 1.64 Å3 and 2.48 Å3, respectively, ... coefficient of 1.4 and an oil/gas partition coefficient of 97, and for sevoflurane these values are 0.69 and 53, respectively [64] Xenon’s properties of cardiovascular stability, rapid onset and emergence ... (nACh) receptors and 5-hydroxytryptamine type (5-HT3) receptors Neuronal nACh receptors, composed of α4β2 subunits, and homomeric α7 subunits are inhibited by xenon, whereas α4β4-containing receptors...

Ngày tải lên: 13/08/2014, 20:22

... Identification of the initiation codons in GmPDIL-3a and Gm-PDIL-3b mRNAs (A) Schematic representation of the structure of GmPDIL-3a and GmPDIL-3b mRNAs The putative ORFs (gray boxes) of GmPDIL-3a and GmPDIL-3b ... S1 Comparison of intron–exon structures of GmPDIL-3a, GmPDIL-3b and orthologs of other plants Fig S2 Multiple amino acid sequence alignment of GmPDIL-3a, GmPDIL-3b and orthologs of other plants ... and CD analysis of recombinant GmPDIL-3a and GmPDIL-3b Table S1 List of primers for ATG-mutagenesis of GmPDIL-3a and GmPDIL-3b This supplementary material can be found in the online version of...

Ngày tải lên: 18/02/2014, 11:20

... McAlexander GlaxoSmithKline, 709 Swedeland Rd, King of Prussia, PA 19406, USA I.M McFadzean Sackler Institute of Pulmonary Pharmacology, Division of Pharmaceutical Sciences, School of Biomedical and ... continue to increase our understanding of the physiological mechanisms of acute and chronic cough, including from the point of view of peripheral and central sensitizations of the cough reflex From the ... Cough sensors II: Opioid and cannabinoid receptors on vagal sensory nerves In: Chung KF, Widdicombe JG (eds) Pharmacology and therapeutics of cough, Handbook of experimental pharmacology, vol 187...

Ngày tải lên: 06/03/2014, 14:20

... region between b and b¢ in GmPDIL-1, and between b and b¢ and b¢ and a¢ in GmPDIL-2, the structure of these regions may be protease resistant The activity of recombinant GmPDIL-1 and GmPDIL-2, which ... [34] In the case of GmPDIL-2, 10 of the 11 introns had TTNAN, and the eighth intron possessed CTNAN Promoter regions of around kb and 1.5 kb upstream of each start codon of GmPDIL-1 and GmPDIL-2 ... between a and b and b¢ and a¢ (Fig 1C) In the case of GmPDIL-2, Lys175, Glu43, Glu62, Glu68 and Glu135 were identified by N-terminal sequencing of the enzymatic digest fragments, respectively, and Glu541...

Ngày tải lên: 07/03/2014, 05:20

... parameters of CYP719A3, the amount of nandinine produced was estimated by using the calibration curve of (S)-scoulerine (pmol versus peak area) and the absorption ratio of (S)-scoulerine and (S)-nandinine ... absence of NADPH or removal of O2 by the glucose ⁄ glucose oxidase ⁄ catalase system [7] clearly inhibited the CYP719A2 and CYP719A3 activities Substrate specificity and affinity of CYP719A2 and CYP719A3 ... concentration of 0.4 lm (Fig 3) Expression of CYP719A2 and CYP719A3 genes in E californica plants: tissue specificity and their response to methyl jasmonate (MeJA) We examined the accumulation of mRNA of...

Ngày tải lên: 07/03/2014, 10:20

... of (-)-MDA Nevertheless, (-)-MDA also substitutes, and the psychopharmacology of racemic MDA might be viewed as comprised of the hallucinogenic and entactogenic properties of the (-)-isomer and ... produces CNS stimulation and euphoria, fenfluramine is more of a sedative and dysphoric A detailed comparison of the pharmacology of fenfluramine and MDMA may be necessary to understand exactly how MDMA ... COMPOUNDS A comparison of MDMA to d-amphetamine, MDA, and DOM can provide an understanding of the pharmacology of MDMA and its abuse liability While there are differences between MDMA and amphetamine...

Ngày tải lên: 22/03/2014, 23:20