molecular docking in structure based design

... respectively, in T cruzi gGAPDH) were selected for the following reasons (a) They are involved in the two phosphate–anion binding sites: Thr225 in the Pi site (for inorganic phosphate-binding site) ... electron-density map in the inverted conformation (data not shown) Inhibition of T cruzi gGAPDH Inhibitor design All structures of 1,3-BPGA analogues are given in Table Inhibitors were designed from ... required Using information on the 3D structure of the enzyme– inhibitor complex, we introduced structural modifications in HOP and determined the respective inhibitory effects of the resulting compounds...

Ngày tải lên: 20/02/2014, 02:21

... SYMBOLS B&CM Binarization & Context Modeling CABAC Context Adaptive Binary Arithmetic Coding CAVLC Context Adaptive Variable Length Coding CIF Common Intermediate Format FSM Finite State Machine GOP ... Coding Engine Bypass Arithmetic Coding Engine Encoder De-binarizer Regular Arithmetic Decoding Engine Bitstream syntax element Context Modeler syntax element Decoder Bypass Arithmetic Decoding ... Engine Figure 2.2: CABAC entropy coder block diagram 14 The encoding/decoding process using CABAC comprises of three stages, namely binarization, context modeling and binary arithmetic coding...

Ngày tải lên: 16/10/2015, 15:36

... Implementing an 8-bit Processor -based Design in an FPGA Figure Initial placement of components on the schematic sheet, Sheet1.SchDoc Wire the design initially, as shown in Figure 2, by using the ... Generic.IntLib to join the buses Modify the parameter text to read [9 0] on both sides of the joiner by using inline text editing mode Place a GND power port (from the Wiring toolbar) on the EA pin ... Implementing an 8-bit Processor -based Design in an FPGA Set a memory model by clicking on C Compiler in the Build Options list, selecting Memory Model and choosing Small: variables in DATA from...

Ngày tải lên: 17/08/2012, 09:12

Ngày tải lên: 17/10/2013, 19:15

... computer modeling in biotechnology These include silicon bionanodevices, carbon nanotube-biomolecular systems, lipoprotein assemblies, and protein engineering of gas-binding proteins, such as ... Coomassie blue staining Electrophoresis was carried at 4C The + symbol indicates boiling in loading buffer containing 2% SDS for prior to loading in the gel Lane 7, lysate of noninduced bacteria ... biological interest of the structure In the case of viral fibers, examine whether the structure may contain regions implicated in receptor binding or interaction with other biomolecules The structure...

Ngày tải lên: 04/06/2014, 15:06

... effects of molecular crowding on the properties of biomolecules are unclear There is increasing interest in crowding on the structure, stability and transportation of biomolecules, in order to ... to the scattering from inter-DNA interference; in particular those involving samples with higher plasmid and/or lower salt concentrations Inter-DNA interference may obscure the information on ... Chapter1 Introduction chain statistics in the semi-dilute regime can be analyzed with scaling concepts Scaling in polymer physics is based on the existence of a certain, unique length scale within...

Ngày tải lên: 11/09/2015, 10:06

... 1.6 DESIGNING THE TEACHING MODULE IN CREDIT -BASED TEACHING 1.6.1 Concept of designing the teaching module in credit -based teaching Design of teaching module in credit -based teaching is to structure ... 1.6.3 Principles of designing the teaching modules in credit -based teaching Principle of ensuring independence of teaching contents; ensuring flexibility in structure; ensuring regular inverse ... of designing and organizing the modules designed in credit -based teaching for Pedagogical course, not yet interested in designing and organizing the modules designed in credit -based teaching...

Ngày tải lên: 15/06/2016, 18:03

... process of interaction in transmitting information Communicating is to understand information and what the information are being conveyed by others Communication can take on many forms including gestures, ... vocalizations (including pitch and tone), in addition to speech and written communication In turn, a smiling, nodding face indicates that the listener is interested in what we are saying and encourages ... Turn-taking in Conversation CA provides a pattern of temporal turn-taking which offers cues for determining who is going to speak and who is going to listen during conversation in which turn-taking...

Ngày tải lên: 19/12/2013, 10:39

... uncovering the influences and inspirations in modern graphic design steven heller and mirko ilic´ packaging and unpackaging design Graphic design is a composite of many influences and inspirations ... Art Director/Designer: Emek No two fingerprints are alike, yet the fingerprint is a venerable recurring motif in graphic design The English began using them to identify criminals in 1858, and ... traits, it remains a trademark of social regimentation When combined with the fingerprint, as in “Printed in USA,” these two forms fuse into a cautionary message In this poster, activist designer Emek...

Ngày tải lên: 13/02/2014, 17:41

Ngày tải lên: 15/02/2014, 15:20

... making a purchasing decision The insight gained from perceptual mapping and conjoint analysis can be a valuable asset in marketing decision making These techniques can help you gain insight into ... nonorthogonal designs, choice designs, conjoint designs, design efficiency, orthogonality, balance, and coding If you are interested in choice modeling, read this chapter first Efficient Experimental Design ... 480 Designing the Choice Experiment, More Choice Sets 482 Examining the Subdesigns 493 Examining the Aliasing Structure ...

Ngày tải lên: 18/02/2014, 07:20

... interrupt sharing imposes more challenges in virtualization system for inter guest isolation both in performance and robustness A group of guest sharing interrupt is depending on a set ... released into the market have improved interrupt remapping technology that will reduce latency from the time the HW interrupt is triggered to when the actual interrupt handler in the guest is invoked ... guest is invoked Interrupt latency is one of the primary bottlenecks in a virtualized environment By using streamlined MSI-X interrupt technology with IOMMU interrupt remapping latency will be...

Ngày tải lên: 19/02/2014, 18:20

... Boguslavsky, Leonid Iomdin, and Victor Sizov 2004 Multilinguality in ETAP-3: Reuse of Lexical Resources In Proceedings of Workshop Multilingual Linguistic Resources, COLING, pages 7–14 P (X(v)|X(ρ(v))) ... corpus As shown in Table 1, the HMTM approach outperforms the baseline solution both in terms of BLEU and NIST metrics Ondˇej Bojar 2008 Exploiting Linguistic Data in Mar ´ chine Translation ... contexts in t-trees carry more information relevant for correct lexical choice, compared to linear contexts in the surface sentence shapes, mainly because of long-distance dependencies and coordination...

Ngày tải lên: 20/02/2014, 09:20

Ngày tải lên: 21/02/2014, 08:20

... proposed model This model regards discourse understanding as the process of unifying various kinds of partial information, including contextual information [post *noo']))])]]] [prag [ [ r e s t r ... 8.a Initial DRS (N.B.1} Referencemarkers for the indexicals are directly anchored to objectsin the world, but the anchoringinformation is not shown here Now let (3a) represent a discourse-initial ... performative-honorific)me." IN. L) Our DICRIwith NFC also explain the failure of coindexing "song keisan-gengogaku-she "in (4b) with a universally quantified expression °done me" (every ) in a previous utterance,...

Ngày tải lên: 21/02/2014, 20:20

... case in the IBM models, we will try to design a distortion model based on the structures of the sentences In particular, we are interested in using the trees produced by syntactic parsers The intuition ... Nagao, 1994) The line SDM:Parsing (SDM standing for Structure- based Distortion Monolink”) shows the results obtained by using P-sets from the trees produced by these parsers The line SDM:Adjacency ... α in the range [0.5,0.9] were giving good results, which lead to think that α can be set mostly independently from the training corpus We still need to train the concepts probabilities (used in...

Ngày tải lên: 22/02/2014, 02:20

... ball is dropped into the spinning wheel; when the wheel stops spinning, the ball will come to rest in one of the thirty-eight numbered bins, defining the winning number The winning number and all ... compressed into the individual chapters Chapter Preface Building Skills in Object-Oriented Design, Release 2.1.1-Python Fit and Finish We include several fit-and-finish issues in Fit and Finish This includes ... follow a realistic problemsolving trajectory so that beginning designers are exposed to the decisions involved in creating a complete design In our experience, all problems involve a considerable amount...

Ngày tải lên: 22/02/2014, 05:20

... by dividing the set of InL variables into sorts Taking results from work in automated theorem proving (Cohn 1984, Walther 1985), the use of sorted variables in InL was first presented in Calder ... performed in two machine instructions, viz taking the bitwise conjunction of two model" set encodings and testing for zero (el Proudian & Pollard 1985) Such a model set encoding is obviously linear in ... makes it easier to pinpoint aspects of the grammar which are inelegant or inefficient Finally, the notion of typing represents a further step towards the goal of making local structures reflect...

Ngày tải lên: 22/02/2014, 10:20

... protein was incubated at °C (continous line) and at 75 °C (dashed line) for 24 h The heat-treated protein eluted at a retention volume corresponding to the dimer, resembling the wild-type protein ... of monomeric Bet v protein stored °C (continuous line) and after heat-induced dimerization (dashed line) qualitatively coincide, indicating a near-identical secondary structure content (B) Time ... physicochemical principles, and points to the existence of temperature-induced intramolecular rearrangements in Bet v In other words, although CD spectra indicate that the secondary structures of...

Ngày tải lên: 06/03/2014, 11:20