meta analysis of clinical trials

... Statistical aspects of the analysis of data from retrospective studies of disease J Natl Cancer Inst 1959, 22:719-748 DerSimonian R, Laird N: Meta-analysis in clinical trials Control Clin Trials 1986, ... improve the statics precision of the outcomes in the clinical trials that compared these two techniques Meta-analysis of randomized trials allows a more objective appraisal of the evidence, which may ... Journal of Experimental & Clinical Cancer Research BioMed Central Open Access Research Brachytherapy for cervix cancer: low-dose rate or high-dose rate brachytherapy – a meta-analysis of clinical trials

Ngày tải lên: 01/11/2022, 09:08

... pairwise meta-analysis was then conducted Heterogeneity of treatment estimates between trials in pairwise meta-analysis was assessed usingc2 test and the corresponding I2 statistic I2thresholds of ... Australia;6Department of Hygiene and Epidemi-ology, University of Ioannina School of Medicine, Ioannina, Greece; 7 Department of Primary Education, University of Ioannina, Ioannina, Greece;8Cumming School of Medicine, ... complex condition with several options for treat-ment, of which some have not been directly compared in trials, a network meta-analysis offers the potential to compare all therapeutic strategies

Ngày tải lên: 04/12/2022, 14:54

... RESEARCH Optimal dose of perineural dexmedetomidine to prolong analgesia after brachial plexus blockade: a systematic review and Meta-analysis of 57 randomized clinical trials Hai Cai1, Xing Fan1, ... optimal dose of perineural DEX that maximizes the analgesic benefit while minimizing associated perioperative risk Since the publication of the previous meta-analysis, a large number of papers have ... published focusing on different doses of peripheral DEX for BPB The objective of current systematic review and meta-analysis was therefore to define the optimal dose of perineural DEX that prolongs

Ngày tải lên: 12/01/2022, 22:20

... papers, or animal studies, meta-analysis and systematic reviews Page of 12 Statistical analysis The statistical analysis of the pooled data were performed using Review Manager software (version 5.1, ... RESEARCH ARTICLE Open Access Comparative efficacy of Neuraxial and general anesthesia for hip fracture surgery: a meta-analysis of randomized clinical trials Xinxun Zheng, Yuming Tan, Yuan Gao and ... patients retrospectively Moreover, all of the included Design randomised trials serious Risk of bias randomised trials randomised trials serious no serious risk of bias no serious inconsistency serious

Ngày tải lên: 13/01/2022, 00:40

... Taken together, a large number of studiesconsistently reported a beneficial effect of the addition of racecadotril to a wide range of standard treatments.Meta-analysis of placebo-controlled and add-on ... review ofthe field (Fig.1) Therefore, we have performed a system-atic review of reported randomized trials on the effects ofracecadotril in children with acute diarrhea and performed a meta-analysis ... by one of the authors were cross-checked by members of the Dept of Pharmacology ofthe Johannes Gutenberg University (Mainz, Germany) aspart of medical writing support raceca-Statistical analysis

Ngày tải lên: 20/02/2020, 22:05

... adjuvant trials of pancreatic cancer [28], the number of included trials in that study was compara-tively small (12 trials); additionally, among the 12 trials, one was the adjuvant trial of periampullary ... survival as a surrogate endpoint for overall survival in adjuvant trials of pancreatic cancer: a meta-analysis of 20 randomized controlled trials Run-Cong Nie1†, Xue-Bin Zou2†, Shu-Qiang Yuan1†, Ying-Bo ... evidence of 20 ran-domized controlled trials, we performed a rigid meta-analysis to evaluate whether DFS could be used as a surrogate endpoint to measure the effect of the adjuvant therapy of pancreatic

Ngày tải lên: 30/05/2020, 21:36

... assessment, lack of declaration of conflict of interest, and inappropri-ate use of meta-analysis [24,25] Consequently, we believed there was still a need for a high quality systematic review of interventions ... a number of methodological issues in many of reviews that we appraised, including the lack of duplicate assessment of study eligibility, inclusion of stud-ies other than RCTs, lack of publication ... received a judgement of unclear risk of bias For other potential sources of bias, we judged as un-clear or high risk of bias in 18 studies (e.g declarations of potential conflicts of interest or funding

Ngày tải lên: 05/11/2020, 01:01

... Statistical analysis The end-point of the meta-analysis was overall survival, defined as the time from treatment to the last follow-up or death Results regarding the overall survival in the meta-analysis ... prevention of peritoneal recurrence The purpose of a meta-analysis is to supply an exhaustive and neoteric summary of all relevant RCTs concerning the topic, and to provide guidance for future clinical ... of cancer of the stomach Int Surg 1980, 65:387–399 Yan TD, Black D, Suqarbaker PH, Zhu J, Yonemura Y, Petrou G, Morris DL: A systematic review and meta-analysis of the randomized controlled trials

Ngày tải lên: 05/11/2020, 07:47

... Open Access Physical and psychosocial benefits of yoga in cancer patients and survivors, a systematic review and meta-analysis of randomized controlled trials Laurien M Buffart1*, Jannique GZ van ... to systematically review the evidence from randomized controlled trials (RCTs) and to conduct a meta-analysis of the effects of yoga on physical and psychosocial outcomes in cancer patients and ... on both physical and psychosocial outcomes The aim of the present study is to conduct a systematic review and meta-analysis of the effects of yoga in cancer patients and survivors, focusing on

Ngày tải lên: 05/11/2020, 07:54

... adverse effects of dezocine We conducted a meta-analysis of randomised controlled trials (RCTs) to assess the efficacy of dezocine on SIC in order to provide a reference for clinical practice ... of 10 current meta-analysis, publication bias and metaregression were not assessable because they were usually only performed when at least 10 studies were included in the meta-analysis The meta-analysis ... section can have a high risk of bias, low risk of bias and unclear risk of bias depending on the actual content of the included study [23] This meta-analysis included a total of RCTs published between

Ngày tải lên: 13/01/2022, 00:41

... blood loss, duration of operation, and quality of surgical field during Orthognathic surgery: a systematic review and meta-analysis of randomized controlled trials J Oral Maxillofac Surg 2017;75(1):73–86 ... outcomes of this meta-analysis Outcome Number of studies Number of participants Low-target High-target RR or MD 95% CI Hterogeneity/I2 P value Mortality 322 316 0.86 0.14 to 5.37 44% 0.88 Length of ... Therefore, the goal of the current meta-analysis is to evaluate the association between intraoperative hypotension and the incidence of POD or POCD undergoing surgery Page of 10 Reviews and Meta-Analyses

Ngày tải lên: 13/01/2022, 00:45

... Flow chart of the selection of studies Page of 11 version 15 (College Station, Texas) and Comprehensive Meta-analysis software version (Biostat, Englewood, NJ) Results A flow diagram of the literature ... 2019;366:l4898 24 DerSimonian R, Laird N Meta-analysis in clinical trials Control Clin Trials 1986;7:177–88 25 Egger M, Davey Smith G, Schneider M, et al Bias in meta-analysis detected by a simple, graphical ... implementation of the manuscript, to the analysis of the results, writing of the manuscript, editing and approving the final version of the manuscript All authors agree on the accuracy and integrity of the

Ngày tải lên: 13/01/2022, 01:36

... Each of the following items of risk of bias was graded as “high risk of bias”, “uncertain risk of bias” or “low risk of bias”: random sequence generation, allocation conceal-ment, blinding of participants ... rate of shivering [9–20] The value of I2= 0% indicated no het-erogeneity The result of this study indicated that the re-current rate of shivering of tramadol was significantly higher than that of ... can’t assess the clinically significance of hypotension and brady-cardia, because of lack of research data Tramadol is a well-established agent in treatment of shivering The mechanism of anti-shivering

Ngày tải lên: 13/01/2022, 01:37

... = 0%, with 12 trials included] Sub-analysis in the settings of off-pump included trials, but only one of them reported one patient died in each group (Fig 6) Sensitivity analysis of studies randomized ... low due to the problems of inconsistency and the risk of bias The overall quality of evidence of other outcomes was moderate due to the risk of bias Discussion In this meta-analysis, we found that ... this meta-analysis Firstly, heterogeneity due to clinical and methodological diversity was inevitable which may affect the reliability of the analysis results especially in meta-analyses of transfusion

Ngày tải lên: 13/01/2022, 01:52

... therapy for insomnia (ICBT-i) in adults Design: A meta-analysis of ICBT-i Data sources: Systematic searches of randomised controlled trials of ICBT-i were performed in the PubMed, EMBASE, PsycINFO ... controlled trials (RCTs) were included in the referenced meta-analysis; therefore, the effects of ICBT-i may have been underestimated Consequently, the current study re-evaluated the efficacy of employing ... Research Internet-based cognitive–behavioural therapy for insomnia (ICBT-i): a metaanalysis of randomised controlled trials Yuan-yuan Ye,1 Ni-ka Chen,2 Jia Chen,3 Juan Liu,1 Ling Lin,1 Ya-zhen Liu,1

Ngày tải lên: 04/12/2022, 14:55

... CI Meta-analysis was used to combine the results of trials using a random-effects model Unit of analysis issues Different pain measurement scales (VAS and NPRS) were converted to a scale of 0–10 ... conclusions on theeffect of LLLT in LBP Our objective was to conduct an updated systematic review of the efficacy of LLLT, including LA, for the treatment of CNLBP METHODS This meta-analysis was performed ... included LA trials, two of which used a ‘lower’ dose (see online supplementary data file appendix D) Sensitivity analysis Results were robust to exclusion of trials considered at ‘higher risk of bias’

Ngày tải lên: 04/12/2022, 15:13

... Rennie D, Stroup DF: Improving the quality of reports of meta- analyses of randomised controlled trials: the QUOROM statement Quality of Reporting of Meta- analyses Lancet 1999, 354:1896-1900 20 ... any study, this is a rate of 0.2% over the course of an average treatment period of at least year Discussion Meta- analysis of small studies is problematic [63] because of possible inadequacies ... numbers of patients and events increase the risk of chance findings [64] The ideal is meta- analysis of high-quality, large, randomised trials [63], but without them we have to make the best of the...

Ngày tải lên: 09/08/2014, 08:23

... Rennie D, Stroup DF: Improving the quality of reports of meta- analyses of randomised controlled trials: the QUOROM statement Quality of Reporting of Meta- analyses Lancet 1999, 354:1896-1900 Jadad ... Proceedings of the Annual Meetings of the American Society of Clinical Oncology (through 2005) were systematically searched for evidence relevant to this meta- analysis The selection of studies ... overall value of this form of therapy for DCIS patients Finally, none of these trials was sufficiently powered to detect differences in overall survival Similar rate of distant metastases and...

Ngày tải lên: 09/08/2014, 10:21

... the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996, 17:1-12 DerSimonian R, Laird N: Meta- analysis in clinical trials Control Clin Trials 1986, ... outcomes of analysis Fourth, we included in our meta- analysis trials that were performed on populations that had a different profile of risk factors Fifth, we analyzed only the effect of antibiotic ... reduction of occurrence of negative outcomes [36] Another limitation of our meta- analysis is that the effect of prophylactic antibiotics administered via the respiratory tract on the length of the...

Ngày tải lên: 13/08/2014, 03:20

... dosing In trials of to weeks, 88% of the doses were 200 mg daily In trials of 12 weeks' duration, 46% of doses were 200 mg and 46% were of 400 mg daily In trials of 24 weeks or longer, 92% of doses ... because of adverse events or lack of efficacy This systematic review and meta- analysis of celecoxib in osteoarthritis and rheumatoid arthritis was conducted using information from company clinical ... expected in clinical practice, where the population may be sicker, or take more medications, than in clinical trials Using company clinical trial reports removes some of the problems of selective...

Ngày tải lên: 09/08/2014, 06:22