mechanobiology tissue engineering and biomaterials 6

... Performance and Operational Maps Integrated Systems 58 58 61 61 63 64 64 65 6. 1 6. 2 Capstone ... V Moghe Polymers as Biomaterials for Tissue Engineering and Controlled Drug Delivery L S Nair · C T Laurencin Interface Tissue Engineering and the Formulation of Multiple -Tissue Systems H H Lu ... Vol 86, 2004 Tissue Engineering II Basics of Tissue Engineering and Tissue Applications Volume Editors: Kyongbum Lee · David Kaplan With contributions by J P Acker · E S Ahn · S T Andreadis ·...

Ngày tải lên: 27/06/2014, 10:20

... 20 06, 1 26: 663 -67 6 Geoghegan E, Byrnes L: Mouse induced pluripotent stem cells Int J Dev Biol 2008, 52:1015-1022 Vallier L, Touboul T, Brown S, Cho C, Bilican B, Alexander M, Cedervall J, Chandran ... Development and physicochemical characteristics Biomacromolecules 2005, 6: 12 26- 1238 52 Zhu J: Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering Biomaterials 2010, 31: 463 9- 465 6 ... aging and trauma Rejuvenation Res doi:10.11 86/ 1423-0127-17-92 Cite this article as: Chistiakov: Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and...

Ngày tải lên: 10/08/2014, 05:21

... 3.4 .6 PDCA-Gelfoam stimulates vascular infiltration in vivo 56 3.5 Discussion 60 3 .6 Conclusion 62 Chapter HIF-1 and the Potential Roles of PHIs in Bone Tissue Engineering and ... Regeneration 64 4.1 Introduction 65 4.2 Bone development and regeneration 65 4.2.1 Mechanisms of bone formation 65 4.2.2 Bone regeneration during fracture healing 66 4.3 The ... Special thanks go to my lovely friends and wonderful colleagues from the Tissue Modulation Laboratory, the Department of Biomedical Engineering and the NUS Tissue Engineering Programme for their constant...

Ngày tải lên: 09/09/2015, 11:11

... 65 3 .6 Beyond the Scar-in-a-Jar 66 3 .6. 1 Materials and Methods 66 3 .6. 1.1 Procollagen C-proteinase immunoblotting 66 3 .6. 1.2 FITC-labeling of collagen 67 3 .6. 1.3 ... level, siRNA targeting growth factors and keyplayers have been investigated [59, 60 , 66 ], and recently, we and others have suggested the use of 16 microRNAs [67 , 68 ] Interfering with post-translational ... bottleneck in tissue engineering 72 4.1 Biomaterials in tissue engineering 73 4.2 Foreign body response 73 4.3 Biocompatibility 76 4.4 Vascularization of biomaterials...

Ngày tải lên: 10/09/2015, 15:52

... chondrogenic differentiation of ESCs and for cartilage tissue engineering Some of the biomaterials and their associated outcomes in ESC-based cartilage tissue engineering and regenerative medicine are ... phenotypic stability of differentiated cells and tissues, delivery systems and biomaterials for cartilage repair, and survivability and integration of the tissue graft to the host cartilage This review ... Cartilage tissue engineering using hydrogels Cartilage tissue engineering using hydrogels enables the delivery of cells and bioactive agents, including growth factors, peptides and ligands Hydrogels...

Ngày tải lên: 11/09/2015, 09:57

... pp 63 7 -65 7, ISSN 1 465 -3249 Karlsson and Toner (19 96) Long-term storage of tissues by cryopreservation : critical issues Biomaterials, Vol 17, No 3, (February 19 96) , pp 243-2 56, ISSN 0142- 961 2 ... mir-199a and mir-26a (both targeting SMAD1), mir-1 26 (targeting VCAM1 and HOXA9), mir-125b 28 Regenerative Medicine and Tissue Engineering - Cells and Biomaterials (targeting ERBB2), mir-145, and ... Responses to Surface and Architecture of Tissue Engineering Scaffolds 569 Hsin-I Chang and Yiwei Wang Preface Tissue Engineering is the first medical therapy where engineered tissues could potentially...

Ngày tải lên: 28/06/2014, 05:20

... proliferate and differentiate, and form an extracellular matrix, is one area of tissue engineering [2] The goal of scaffold production in tissue engineering is to fabricate reproducible, bioactive, and ... 2009, 5 :63 6 -64 3 13 Landi E, Valentini F, Tampieri A: Porous hydroxyapatite/gelatine scaffolds with icedesigned channel-like porosity for biomedical applications Acta Biomater 2008, 4: 162 0- 162 6 14 ... βtricalcium phosphate Biomaterials 2005, 26: 48 56- 4 865 Figure SEM morphologies of the (a, b) SP and (c, d) MP surfaces Magnification of (a) and (c) is ×1,000 and of (b) and (d) is ×5,000 Figure Images...

Ngày tải lên: 21/06/2014, 17:20

... animal models Biomaterials 19 96; 17:31-35 Langer R, Vacanti JP Tissue engineering Science 1993; 260 :920-9 26 Hubbell JA Biomaterials in tissue engineering Bio-Technology 1995; 13: 565 -5 76 Mosbach ... different tissues and the clinical applications that tissue engineering can target These chapters therefore cover the breadth of tissue engineering in orthopedics, and can educate all of us Tissue engineering ... and context constitutes the holy trinity for tissue engineering (2), and also governs morphogenesis and development The principles and molecular basis oftissue engineering ofmusculoskeletal tissues...

Ngày tải lên: 27/06/2014, 10:20

... Mikos, and L.V McIntire, Eds, Frontiers in Tissue Engineering, Pergamon, 1998 R Langer and J.P Vacanti, Tissue engineering, Science, 260 , 920 (1993) M.J Lysaght and J Reyes, The growth of tissue engineering, ... Remediation Edited by T.J Bandosz Vol 8: Tissue Engineering: Fundamentals and Applications By Y Ikada INTERFACE SCIENCE AND TECHNOLOGY – VOLUME Tissue Engineering Fundamentals and Applications Yoshito ... component of all tissues and organs and is a nature’s scaffold for tissue and organ morphogenesis, maintenance, and reconstruction following injury Until the mid 1 960 s the cell and its intracellular...

Ngày tải lên: 27/06/2014, 10:20

... applications of tissue engineering and regenerative medicine Modalities may include direct implantation and/ or ex vivo tissue engineering, in combination with biocompatible/biomimetic biomaterials and/ or ... and IL-1α J Cell Physiol 19 96, 166 :585-592 59 Bellows CG, Heersche JN, Aubin JE: Determination of the capacity for proliferation and differentiation of osteoprogenitor cells in the presence and ... cells Tissue Eng 2002, 8:131-144 118 Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK: Electrospun nanofibrous structure: A novel scaffold for tissue engineering J Biomed Mater Res 2002, 60 :61 3 -62 1...

Ngày tải lên: 09/08/2014, 01:21

... regeneration J Periodontol 2005, 76: 160 1- 162 2 Page of (page number not for citation purposes) Head & Face Medicine 20 06, 2: 16 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 Reynolds MA, Aichelmann-Reidy ... microcomputed tomography, and histology for bone tissue engineering Tissue Eng 2005, 11:13 56- 1 367 Weinberg MA, Brai M: Laboratory animal models in periodontology J Clin Periodontol 1999, 26: 335-340 Leib ... 81:98-102 Grande DA, Breitbart AS, Mason JM, Paulino C, Laser J, Schwartz RE: Cartilage tissue engineering: current limitations and solutions Clin Orthop Rel Res 1999, 367 :S1 76- 185 Grande DA, Mason...

Ngày tải lên: 11/08/2014, 23:22

... . 26 2 .6 Bone Tissue Engineering 30 2 .6. 1 Four-Stage Bone Formation in Bone Tissue Engineering 30 2 .6. 2 Strategies in Bone Tissue Engineering .32 xi 2 .6. 2.1 Growth ... Vascularised Bone Tissue Engineering Strategies: Focus on Coculture Systems Journal of Tissue Engineering and Regenerative Medicine 2012 Nov 19 doi: 10.1002/term. 161 7 Yuchun Liu and Swee-Hin Teoh ... Animal Models . 167 7.5.2 In Vitro Studies in Microfluidic Devices . 168 7 .6 Clinical Feasibility 169 7 .6. 1 Large Orthotopic Animal Models . 169 7 .6. 2 Cord Blood Banking...

Ngày tải lên: 09/09/2015, 10:16

... cell-scaffolds constructs 45 3.3.5.3 AlamarBlue 46 3.3 .6 Results and discussions 47 3.3 .6. 1 Porosity and dispensing speed 47 3.3 .6. 2 Modulus and dispensing speed 50 3.3 .6. 3 In vitro cell culture results 52 ... and its characterization 110 6. 2.4 Cell seeding on scaffolds 110 6. 2.5 Morphology of the cell-scaffolds constructs 110 6. 2 .6 PicoGreen® assay 111 6. 2.7 Alkaline phosphate (ALP) activity 111 6. 2.8 ... (a) and compressive strength (b) of PCL/TCP and PCL/TCP(Si) scaffolds with various content of GPTMS referred to TCP 66 Figure 4 .6 SEM images of (a) PCL/TCP and (b) PCL/TCP(Si) scaffolds 67 Figure...

Ngày tải lên: 10/09/2015, 15:51

... Literature Review 6 2.1 Introduction of Tissue Engineering 6 2.2 Biomaterials for Tissue Engineering . 7  2.2.1 Requirements and Classification of Biomaterials ... integrate with the host native tissues 2.2 Biomaterials for Tissue Engineering Biomaterials is one important component in tissue engineering and regenerative medicine and the applications of these ... donor organs and tissues available This severe organ shortage led to the inception of Tissue Engineering Tissue Engineering is about developing new approaches to encourage tissue growth and repair...

Ngày tải lên: 11/09/2015, 09:10

... biomedical engineering and materials science have given rise to the remarkable new cross-disciplinary field of tissue engineering [ 26] Tissue engineering field is the development and manipulation ... start to age and demand better quality-of-life standards, people will expect science and engineering to develop and implement strategies that address the challenges of disabling diseases and disorders ... Background and progress on tissue engineering, especially corneal tissue engineering and the status use of the electrospinning will be extensively reviewed in chapter Chapter Chapter Background and...

Ngày tải lên: 14/09/2015, 09:33

... 20.7-34.5 300-500 0.21-0.34 PEG 67 -69 - 72 - 1.05 - - - PCL-PLA 61 -68 - 55 - - - - - PCL-PEG 60 -67 - 69 - - - - - PCL-PEG-P 59 -69 - 69 - - - - - 58 -67 - 67 - - - - - 58 -65 - 68 - - - - - DL-PLA CL PLA-PCL-P ... phous 173-178 6- 12 41.4-55.2 3-10 1.4-2.8 55 -60 12- 16 1.271.34 1.25 27 .6- 41.4 3-10 1.4-2.8 60 -65 >24 1.24 55.2-82.7 5-10 2.8-4.2 PGA 185-225 25 -65 6- 12 1.53 >68 .9 15-20 >6. 9 PCL 58 -68 - 70 >24 ... different porosities (75% and 90%) and four different pore size distributions (

Ngày tải lên: 14/09/2015, 10:20

... PCL-PEG Raw 63 .5 33000 1 .6 62 44.44 PCL-PEG Scaffold 65 .3 3 360 0 1.7 61 .8 44.30 PCL-PEG-PCL Raw 64 .4 30000 1.8 48 34.41 PCL-PEG-PCL Scaffold 65 .6 31700 1.7 47.2 33.84 PEG-PCL-PLA Raw 62 .5 41000 ... stiffness, yield strength and yield strain from 23.78 to 46. 68 MPa, 1.9 to 3 .6 MPa and 2. 36 to 4 .64 %, respectively for PCL-PEG scaffold, and from 27.83 to 54 .63 MPa, 2.15 to 4.22 MPa and 2.87 to 5.51%, ... stiffness, yield strength and yield strain of 55.19 MPa, 4. 26 MPa and 5.52%, respectively for PCL-PEG and 64 .57 MPa, 4.98 MPa and 6. 48%, respectively for PCL On the other hand, scaffolds with widest...

Ngày tải lên: 14/09/2015, 10:23

... producing 66 % porosity resulted in compressive stiffness, 1% offset yield strength and yield strain of 34.87 MPa, 2 .69 MPa and 3.5%, respectively for PCL scaffold, and 29.8 MPa, 2.3 MPa and 2.98%, ... width (in x- or ydirection) and porosity varied from 500 to 1000µm and 50 to 66 %, respectively Besides, the process parameters (liquefier temperature, extrusion pressure and deposition speed) were ... pattern formed complex polygonal pores The pore height (in zdirection) and porosity varied from 500 to 2500µm and 66 to 60 %, respectively due to the change of pattern from 0/90 to 0/30 Likewise,...

Ngày tải lên: 14/09/2015, 10:23

... for I time and viewed under the CLM The emission and excitation wavelengths were set at 510 nm – 560 nm and 488nm, respectively for FDA, whereas for PI they were set at 560 nm – 60 0nm and 543nm, ... 2-angle, 3-angle and 6- angle patterns, respectively 90o 120o 60 o 120o 90o 150o 0o A 30o 0o 0o B 60 o D Figure 3.4: Various lay-down patterns of scaffolds A): 0/90o, (B): 0 /60 /120o, (C): 0/30 /60 /90/120/150o ... 0 /60 /120° and 0/30 /60 /90/120/150°) using two polymers (PCL and PCL-PEG) The process conditions i.e liquefier temperature, extrusion pressure and deposition speed were set at 90°C, 4.0 bars and...

Ngày tải lên: 14/09/2015, 11:12

... nutrients and metabolic waste, and tissue integration and vascularization b) Biodegradable or bioresorbable with a controllable degradation and resorption rate to match cell /tissue growth in vitro and/ or ... scaffold family that could cater broad tissue engineering applications 1.3 Significance of Hypothesis Tissue engineering leads to new medical therapies for injury and organ disease through use of living ... Fundamental understanding of interactions between cells and their living environments, such as extracellular matrix, is critical for design and development of efficient tissue engineering devices...

Ngày tải lên: 14/09/2015, 11:12