mechanisms of phototoxic and photoallergic reactions

... objectives of the thesis: The aim of the studies is to gain fundamental understanding of the role ofhydrophobic and polar sequence on folding mechanism of proteins and aggre-gation of peptides ... study of both folding and aggregation processes Trang 3fun-In this thesis, we use a tube model to study the role of hydrophobic andpolar sequence on folding mechanism of proteins and aggregation of ... 1MINISTRY OF EDUCATION VIETNAM ACADEMYGRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY ——————— NGUYEN BA HUNG THE ROLE OF HYDROPHOBIC AND POLAR SEQUENCE ON FOLDING MECHANISMS OF PROTEINS AND Trang

Ngày tải lên: 09/01/2020, 15:39

... objectives of the thesis: The aim of the studies is to gain fundamental understanding of the role ofhydrophobic and polar sequence on folding mechanism of proteins and aggre-gation of peptides ... study of both folding and aggregation processes Trang 3fun-In this thesis, we use a tube model to study the role of hydrophobic andpolar sequence on folding mechanism of proteins and aggregation of ... 1MINISTRY OF EDUCATION VIETNAM ACADEMYGRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY ——————— NGUYEN BA HUNG THE ROLE OF HYDROPHOBIC AND POLAR SEQUENCE ON FOLDING MECHANISMS OF PROTEINS AND Trang

Ngày tải lên: 15/01/2020, 09:17

... species, route of admin-istration, and nutritional status of the animals According to the administered dose of streptozotocin, duration of the administration, and developmental stages of animals ... 2 diabetic subjects and are presently used as oral anti-diabetic drugs The use of these synthetic ligands has increased the understanding of PPAR-γs mechanism of activation and subsequent biologi-cal ... screening PPAR-γ ligands has been developed In this assay, a ligand of PPAR-γ is conjugated to fluorescein and is used as the displacement probe Ligands, agonists, and antagonists of PPAR-γ will displace

Ngày tải lên: 22/01/2020, 16:33

... by western blot and analyzed by ImageJ. Trang 5showed the quantity of t-Src, p-Src, t-EGFR and p-EGFRanalyzed by software of ImageJ (Figure 1D) The cell via-bility of group A, B and C did not show ... 50 of dasatinib and the inhibition on the activity of Src, Akt, FAK The inhibition levels of p-Src, p-Akt and p-FAK were measured when cells were treated with dasatinib at the dosage of 1uM and ... migration and invasion Inhibition of this pathway is one of the mechanisms of action of dasatinib In MDA-MB-231 human metastatic breast cells, dasatinib also showed the inhibition of cell proliferation,

Ngày tải lên: 05/11/2020, 06:36

... organisms and their dysregulation in the case of diabetes In this paper, the results of a study of functional defects in the adenylyl cyclase (AC) signaling mechanisms of two classes of hormones ... activity of the G proteins was expressed as pmol [8-3H]GppNHp per mg of membrane protein 2.6 Conditions of experiments The effects of hormones (in vivo and in vitro) and non-hormonal activators of AC ... of hormone and GppNHp, reflecting the functional coupling in the whole signaling chain (from receptor to Gs protein and AC); NaF-inducing activation of Gs protein and as a consequence of AC; and

Ngày tải lên: 02/11/2022, 10:44

... USE OF TRICHODERMA HAMATUM FOR BIOCONTROL OF LENTIL VASCULAR WILT DISEASE: EFFICACY, MECHANISMS OF INTERACTION AND FUTURE PROSPECTS Sạd A El-Hassan*, Simon R Gowen, Barbara Pembroke School of ... number of conidial spores and an increase in the vegetative growth of T hamatum, and a decrease in the hyphal formation and sporulation of F oxysporum f sp lentis Electron and light microscopical ... antibiosis by production of antifungal enzymes, complex mechanisms of mycoparasitism, competition for key nutrients and/or ecological niches, growth promotion, and a combination of these effects This

Ngày tải lên: 24/12/2022, 14:01

... understanding key biological processes such as protein folding, allosteric transitions, ligand-binding mechanisms, and the effects of mutations on protein structure and function [9], [88-90].A standard ... interactions and stability of 16 colossolactone derivatives 3.1.1 Molecular docking of colossolactones into the ATP-binding site and the allosteric pocket of EGFR The active and inactive states of EGFR ... nm²), and interaction energy (IE), offering a comprehensive view of the binding stability and conformational dynamics These parameters collectively help evaluate the strength and nature of ligand

Ngày tải lên: 23/07/2025, 00:30

... ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence Sebastien Cagnol1 and Jean-Claude Chambard2 Department of Anatomy and Cellular Biology, Faculty of ... known as p42 ⁄ p44MAPK, respectively, and officially named MAPK and 3) are two isoforms of extracellular signal-regulated kinase (ERK) that belong to the family of mitogen-activated protein kinases ... of autophagy, such as induction of LC3 and conversion of LC3-I to LC3-II [48,49,118], induction of beclin [48], induction of BNIP-3 [66] and activation of G-interacting protein (GAIP) by phosphorylation

Ngày tải lên: 29/03/2014, 08:20

... analysis of U.S and foreign media and public opinion reactions to incidents of collateral damage involving civilian deaths in recent U.S wars and military operations It is part of a larger RAND Project ... Peterson (AF/XOO) and conducted within the Aerospace Force Development Program of RAND Project AIR FORCE understand-RAND Project AIR FORCE RAND Project AIR FORCE (PAF), a division of the RAND ration, ... Gallup Poll of Iraq, RAND colleague William Stanley for comments on an earlier version of this monograph, and careful reviews by Professor Richard C Eichenberg of Tufts University and RAND colleague

Ngày tải lên: 29/03/2014, 18:20

... shifts of the three species on the left hand side of Schemes 1 and 2, the two neutral and one positively charged forms of the Fig 2 CD detection of the AP form of ThDP on BAL Inset: pH dependence of ... 1Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps Natalia S Nemeria, Sumit Chakraborty, Anand Balakrishnan and ... basis of the accumulated understanding of enzyme mechanisms, such proton transfers are likely to be mediated by general acid⁄ base catalysts, such as His, Asp and Glu, and perhaps Cys, Lys and

Ngày tải lên: 29/03/2014, 23:20

... moiety of tyrosine Fig 3 Placement of BH 4 in the catalytic site of PAH and TH Distance-energy diagrams obtained after docking BH 4 into the active sites of PAH(A) and TH(B) Total energies of candidate ... of PAHwith bound substrate analogs has been employed to elucidate ligand binding to the active site of this enzyme Multiple sequence alignment and knowledge of the crystal coordinates of PAHand ... Trang 1Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase

Ngày tải lên: 31/03/2014, 07:20

... Trang 1Computer simulations of neural mechanismsexplaining upper and lower limb excitatory neural coupling Huang and Ferris Huang and Ferris Journal of NeuroEngineering and Rehabilitation 2010, ... strength of self-inhibition and theh constant modulates the strength of reciprocal inhibition between the flexor and extensor neu-rons.τ1andτ2are time constants that affect the shape and intrinsic ... patterns of contralateral CPGs (upper left and lower right, upper right and lower left) were in-phase while bilateral CPGs (upper left and upper right, lower left and lower right) were out-of-phase

Ngày tải lên: 19/06/2014, 08:20

... motor commands, sensorimotor synchronization, maintenance of sensorimotor associations and tuning of the magnitudes of muscle activities An overview of recent advances in our understanding of the ... contribution of cerebellar circuitry in the elaboration and shaping of motor commands is provided, with a discussion on the relevant anatomy, the results of the neurophysiological studies, and the ... spontaneously between 10 and 50 Hz In absence of motion, high rates of discharges of about 40–50 Hz are common [25] During motion, firing rates increase and decrease above and below the baseline

Ngày tải lên: 19/06/2014, 08:20

... Trang 8A REVIEW OF THE CHEMICAL AND PHYSICAL MECHANISMSOF THE STORAGE STABILITY OF FAST PYROLYSIS BIO-OILS ABSTRACT Understanding the fundamental chemical and physical aging mechanisms is necessary ... (PyNe) and the National RenewableEnergy Laboratory (NREL), as a necessary means to collect and compare the known chemistry andphysical mechanisms of the storage instability of bio-oils Because of ... concentrations of the alcohol and the acid, an equilibrium constant of 2corresponds to a conversion of 59 mol % of the reactants; an equilibrium constant of 4corresponds to a conversion of 67 mol

Ngày tải lên: 19/06/2014, 14:02

... 2macrophages and resident microglia to sites of CNS inflammation Detailed knowledge of expression patterns is crucial for the understanding of therapeutic modulation and the validation of CCR1, CCR2 and ... results of the present study and from previous ones on the role of CCR1 and its ligand CCL3 in the pathogenesis of MS [39,40,42] and EAE [22,44,46], have provided evidence for an important role of ... formation of focal areas of demyelination [31] and axonal injury and loss [32] Our results demonstrate a prominent accumulation of monocytes and macrophages expressing CCR1, CCR2 or CCR5 mRNA within and

Ngày tải lên: 19/06/2014, 22:20

... pathophysiological mechanisms of obesity-induced androgen deficiency and hypogonadism-induced obesity remain the subject of intense investigation Several hypotheses have discussed the relationship of androgen ... endothelium dysfunction and ED [130,131], the concept of androgen deficiency reinforces the important role of androgens in vascular health and erectile function Summary and conclusions Visceral ... visceral and peripheral fat further diminishes the levels of testosterone and increases the levels of estradiol (E2), which further contributes to preferential deposition of more visceral fat and...

Ngày tải lên: 18/02/2014, 06:20

... units of A will be those of k and 18 Reaction Mechanisms of Inorganic and Organometallic Systems £a will have the energy units of R The k is determined by experiments at several temperatures, and ... the physical chemistry aspects of reaction kinetics Rate For the general reaction the reaction rate and the rate of disappearance of reactants and rate of formation of products are related by In ... units of k depend on the rate law and must give the right-hand side of Eq (1.3) the same units as the left-hand side A simple example of the need to define the rate in order to give the meaning of...

Ngày tải lên: 01/04/2014, 10:37

... and experimental evidence regarding the role of Type D personality in potential mechanisms of disease as well as work-related Type D personality and mechanisms of disease Type D personality and ... support, and they were Mols and Denollet Health and Quality of Life Outcomes 2010, 8:9 http://www.hqlo.com/content/8/1/9 Page of 10 Table List of criteria for assessing the methodological quality of ... explored the behavioral and biological mechanisms of disease as a Mols and Denollet Health and Quality of Life Outcomes 2010, 8:9 http://www.hqlo.com/content/8/1/9 Table 3: Outcomes of studies: Health...

Ngày tải lên: 18/06/2014, 19:20

... Alzheimer’s disease, and Huntington’s disease 1.2 Objectives of the research The specific objective of the project is to understand the processes of internalization of Ag and TiO2 nanoparticles ... understanding the relationship between the physical and chemical properties of nanomaterials and their potential risk to the environment and human health Where the size, shape, and surface of the ... UNIVERSITY OF AGRICULTURE AND FORESTRY DUONG THI THU HUYEN Topic title: THE UPTAKE MECHANISMS OF AG AND TIO2 NANOPARTICLES TO NERVOUS-SYSTEM CELLS BACHELOR THESIS Major: Environmental Science and Management...

Ngày tải lên: 28/04/2016, 13:47

... composition of 2H and 18O The compositions of the isotopes 2H (D) and 18O were analyzed to obtain δD (‰) and δ18O (‰), respectively, which are defined as the relative deviation of the parts per thousand ... 22-23 of 2003 The amount of precipitation was 30 mm in total Figure shows the precipitation record of the studied event (Fig 2a) and the record of the river flow rate (solid line, Fig 2b) of the ... the discharge of new water and the migration of hazardous elements, which has not been sufficiently analyzed or reported previously As a result of the calculation, and by setting C1 and C2 as mentioned...

Ngày tải lên: 05/09/2013, 09:08