mathematics is essential to progress of human

... according to structure of board of directors, the Board of Directors will select a CEO and vice directors Departmets and divisions will assist director Production units are organized into plants ... the dissertation is limited in Traffic construction enterprises under Ministry of Transport (these enterprise mainly focus on 07 corporations) The research purpose in this dissertation is to systematize ... Trang 41.1.2 Roles of operational efficiency evaluatoin in enterprises Operational efficiency evaluation is one of three functions of administrators in enterprises According to Operational efficiency...

Ngày tải lên: 19/07/2014, 09:12

... protein (RecDHis) of P syringae, which is an essential activity of any heli-case motor The RecDHis displayed efficient ATPase activity in the presence of ssDNA Interestingly, RecD also displayed significant ... able to support growth of the cold-sensitive, recD-disrupted strain (CS1) of P syringae at 4C This raises some interesting ques-tions about the contribution of these two enzymatic activities to ... unwinding in vitro, is sufficient for growth of the Antarctic P syringae at low temperature Results Selection of amino acid residues for mutational analysis of P syringae RecD To dissect the biochemical...

Ngày tải lên: 30/03/2014, 04:20

... contributing to inflammation early after cerebral ischemia This adds to the growing body of evidence that IL-1α is a key mediator of the sterile inflammatory response Trang 4Findings Inflammation is recognised ... 4Findings Inflammation is recognised as a major contributor to the worsening of acute brain injury [1] In particular two pro-inflammatory members of the IL-1 family of cytokines, IL-1α and IL-1β, are ... known to be neuroprotective [4] At these times, IL-1β is not present suggesting that IL-1α is the active IL-1 isoform in mediating the early inflammatory period following ischemic brain injury This...

Ngày tải lên: 19/06/2014, 22:20

... Thirdly, the main function of English idioms related to parts of human body is to paraphrase what is going on and what is being said Fourthly, English idioms related to parts of human body are very ... of English GRADUATION THESIS B.A DEGREE IN ENGLISH The Use of English Idioms Related to Parts of Human Body by the Third-Year Students at Faculty of English, Hanoi Open University Supervisor ... the parts of human body appearing in daily communication of English people Through this study, I would like to help learners of English comprehend complicated figurative meanings of English idioms...

Ngày tải lên: 24/06/2016, 21:21

... major sign of OA, but it is now recognized that synovitis, inflammation of synovial membrane, plays a crucial role in early and late stage of OA1,2 Inflammatory mediators involved in synovitis attract ... all of them exist in several isoforms, in mammals The activation of these MAPKs is induced through different pathways, depending on the stimulus and the cell type, resulting in 1Laboratory of ... contributes to the pathogenesis of synovitis in OA Figure 5 Effect of the JNK inhibitor on IL-1β-induced phosphorylation of JNK and ERK1/2 After pretreatment with the JNK inhibitor SP600125...

Ngày tải lên: 04/12/2022, 14:54

... destabilization and persistence of reactivated memories. A persistent fear memory could be a factor for affective disorders For example, the characteristics of post-traumatic disorder (PTSD) is that the ... mechanism by which late Arc expression contribute to memory persistence is refinement of neu-ronal circuit through pruning of dendritic spines We previously have shown that persistence of newly-acquired ... analysis following immunohistochemistry Images of BLA neu-rons (1.00 to 1.50 mm posterior to bregma, 4–6 slices per mouse) were acquired using a confocal microscope (CV1000; YOKOGAWA, Tokyo,...

Ngày tải lên: 04/12/2022, 15:02

... synthesis, and disappears during mitosis The fluctuation of TK1 through the cell cycle is important in providing a balanced supply of dTTP for DNA replication, and is partly due to regulation of TK1 ... the synthesis of dTTP by transfer of a c-phosphate group from a nucleoside triphosphate to the 5¢-hydroxyl group of thymidine, forming dTMP Human TK1 is cytosolic and its activity is absent in ... the time- and storage-dependent differences in behaviour after dilution to 6 lgÆmL)1 indicate that dissociation of the tetramer to the dimer is a slowly progressing process This is supported by...

Ngày tải lên: 18/02/2014, 12:20

... the depletion of LIN9 in human cells inhibits proliferation and results in delayed entry into mitosis [9] To address whether this is an isolated function of LIN9 or whether it is medi-ated by ... into mitosis of human cells These results are consistent with the recent identification of LIN54 in an RNA interference (RNAi)-based screen for cell division defects in human cells [19] LIN54 is ... C527) to tyrosine Mutation of the residue equivalent to C525 of Ara-bidopsis TSO1 disrupts flower development and cell division [20] We found that mutation of C525 and C527 abolished the binding of...

Ngày tải lên: 23/03/2014, 04:20

... 2What is “semantics”? Semantics is the study of meaning that is used to understand human expression through language Semantics is perhaps the most difficult part of the grammar of a language to ... cut his hair with the scissorsIn this example, we can notice that there is a tool that helps the Agent to perform the action That is the semantic role of INSTRUMENT He felt sad about cutting his ... anyway (e.g This blouse is too plain) Simple (e.g English is extremely plain subject). With nothing added/ not decorate in anyway (e.g This blouse is too plain) Trang 14Synonymy is the state...

Ngày tải lên: 13/07/2014, 23:26

... tumour-free part of each of the histological pieces and transferred to the laboratory in an ice-cold PSS solution Segments were then cut into rings measuring about 4–5 mm in length for isometric contraction ... epithelium of isolated rings was rubbed using a plastic cylinder introduced in the lumen of the ring Rings were frozen at the end of the experiment for histological examination of actual removal of the ... measurements Use of human tissues was per-formed according to national guidelines, in compliance with the Helsinki Declaration Obtention of freshly isolated and cultured cells For isolated cell-experiments,...

Ngày tải lên: 12/08/2014, 18:20

... triplicate experiments ((c) [top]) Northern analysis of total RNA extracted from protoplasts subjected to the treatments in ((c) [bottom]) The polarity of F-Luc RNA being probed is as indicated Insets ... consistent with the loss of viral RNA synthesis in the Δ SL1 and Δ SL2 mutants of LCV RNA2 (Fig. 5b,c) Together, this indicates that the YSS serves as an RNA synthesis enhancer in the context of ... of LCV RNA2) is expressed It is possible that the accumulated production of (+ )-RNA is needed for the increased translation of a weakly translating message Our results are also reminiscent of...

Ngày tải lên: 08/11/2022, 14:57

... graft-versus-host disease, rheuma-toid arthritis, inflammatory bowel disease and multiple sclerosis1 Recently, many researchers have elucidated the safety and distinct functions related to the therapeutic ... receptors on target cells9 EP receptor is a G-protein coupled receptor (GPCR), and these receptors can be classified into 4 sub-classes EP2 receptor enhances cell proliferation and neovascularisation ... development In tumour-progressing cells, EP2 receptor is highly expressed, while the EP3 receptor expression level is relatively low12,13 This COX-2/PGE2 axis forms an autocrine/paracrine loop,...

Ngày tải lên: 04/12/2022, 15:54

... marker to discriminate the inflammatory response to infection from other types of inflammation Gold standards for the diagnosis of infection do not exist [3]; but procalcitonin is known to be ... specificity of eosinopenia compared with the CRP level in the diagnosis of sepsis on admission to the ICU Eosinopenia can therefore represent a good marker for the diagnosis of sepsis on ICU admission ... the value of eosinopenia in the diagno-sis of sepdiagno-sis in the ICU This is the first report of the reproduc-tion of eosinopenia in acute infecreproduc-tion on ICU admission The aim of the present...

Ngày tải lên: 25/10/2012, 10:35

... the autolysis Therefore, it is premature to draw conclusions regarding the mechanism of the enhancing effects of IST1 on mGFP–calpain 7–Strep autolysis in vitro Both mGFP–calpain 7 and IST1 have ... IST1DMIM1,2suppressed the autolysis This observation might be explained by regarding IST1 as a regulator of the intracellular localization of calpain 7, because IST1 was previously reported to contribute to recruitment ... not shown) Thus, it is not clear why FLAG–IST1 had no enhancing effects on autolysis and FLAG–IST1DMIM1,2inhibited the autoly-sis of mGFP–calpain 7 Other unknown cytosolic fac-tors that physically...

Ngày tải lên: 18/02/2014, 04:20

... cytoplasmic localization characteristic of this kinase (Fig 4D) [28] Comparison of the expression profiles of the human ER and POLDIP3 genes The array of polyA+ RNA isolated from 61 different human ... which is involved in the regeneration of tetrahydrobiopterin, an essential cofactor of several metabolic reactions not directly related to the metabo-lism of pyrimidines [13,14] The Xenopus ER is ... organisms ranging from protists to plants to humans with the exception of fungi, in which this gene has not been isolated so far [1–5] Moreover, it seems to be absent in the sequenced genomes of...

Ngày tải lên: 19/02/2014, 05:20

... gene, which is located on chromosome 1p-36.1–34, and is transmitted in an autosomal reces-sive or a dominant manner The severity of the disease is inversely related to serum levels of alkaline ... the cDNA of TNSALP is denoted as nucleotide +1 instead of the first nucleotide of the cDNA clone originally isolated by Weiss et al [8] TNSALP (1559delT) is unique in that so far, this frameshift ... is not attached by a GPI-anchor, a prediction is that this mutant is no longer embedded into the lipid bilayer via GPI, which helps anchor TNSALP to the plasma membrane, but is secreted out of...

Ngày tải lên: 19/02/2014, 17:20

... corresponding to the N-terminal region of eEF1A, were present; this region is totally deleted in PTI-1.Similar considerations were taken into account to exclude the possibility that P1 corresponded to isoforms ... Trang 1Identification of different isoforms of eEF1A in the nuclear fractionof human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers Barbara Dapas1, ... faster-migrating isoform of eEF1A in cancer cells, the estimation of its pI remains merely indicative.A magnified image of this analysis, performed with a different nuclear extract, is reported in Fig.8B It is...

Ngày tải lên: 21/02/2014, 00:20

... surrounding Ser46 in hsMOK2 conforms to this preference (RDSV) Lastly, because the consensus for Aurora A is reminiscent of that of PKA, we examined the ability of PKA to phosphorylate hsMOK2 protein ... dissociation from lamin A⁄ C at hsMOK2-regulated loci in early mitosis may contribute to the dispersion of lamins A⁄ C into the cytoplasm Materials and methods Plasmid constructs pCMV–hsMOK2, pCMV–laminC(Q294P), ... phosphorylation at this site interferes with the ability of hsMOK2 to bind lamin A⁄ C Results and Discussion hsMOK2 interacts with JNK-associated leucine zipper and JSAP1 To identify partners of hsMOK2...

Ngày tải lên: 07/03/2014, 01:20

... propose a mechanism in which a pro-ton is relocated from the N(1)–C(2)=O locus of the isoalloxazine ring to the imidazole ring of His106, then shuttled to the phosphate ester oxygen atom of the phosphate-leaving ... is thought to be the result of the protonation of anionic reduced flavin on binding of EPSP to give neutral reduced flavin [9], and the associated general acid is thought to be His106 [10] It is ... product dissociation, this internal proton relay system can be reloaded, leading to protonation of His106, such that the enzyme is ready for the next sub-strate turnover In this mechanism, His106...

Ngày tải lên: 07/03/2014, 05:20

... bound to the active site (Fig. 3B). This feature might be related to the mechanism of the enzyme (see Discussion). Discussion Overall structure The structure of SaSTP is very similar to that of MtSTP, ... The phosphate is bound indirectly to the metal ions via water molecules and the Wn–P–O angle (146°) is rea- sonably close to optimal when the roughness of the analysis is taken into account. SaSTP ... three-metal ion structures appears to be binding of another monomer to the active site of STP, which promotes binding of the third metal ion. This interaction may mimic the binding of a product complex, especially...

Ngày tải lên: 07/03/2014, 09:20