malignant gliomas treatment using genetically modified neural stem cells

...   1.1   Stem cells   1.1.1   Human pluripotent stem cells   1.1.2   In vitro differentiation potential of human pluripotent and neural stem cells   1.2   ... neuroepithelial-like stem cells for the generation of modified neuronal cultures 59   4.2   Generation of gene-corrected neural stem cells from MJD patient-derived iPS cells 59   4.2.1 ... Introduction 1.1 Stem cells Stem cells have the remarkable potential to differentiate into specialized cells and thereby are key factors for the development of the whole organism All types of stem cells...

Ngày tải lên: 26/11/2015, 09:54

... Section Neural Stem Cells as Progenitor Cells Chapter Systems for ex-vivo Isolation and Culturing of Neural Stem Cells Simona Casarosa, Jacopo Zasso and Luciano Conti Chapter Neural Stem Cell ... Institute Cavalieri-Ottolenghi (NICO) Section Neural Stem Cells as Progenitor Cells Chapter Systems for ex-vivo Isolation and Culturing of Neural Stem Cells Simona Casarosa, Jacopo Zasso and Luciano ... Cell Adhesion Molecules in Neural Stem Cell and Stem CellBased Therapy for Neural Disorders 349 Shan Bian Chapter 13 Neuroinflammation on the Epigenetics of Neural Stem Cells 381 Nando Dulal Das...

Ngày tải lên: 08/03/2014, 19:20

... orders@intechweb.org Neural Stem Cells and Therapy, Edited by Tao Sun p cm ISBN 978-953-307-958-5 Contents Preface IX Part Chapter Characterization of Neural Stem Cells Neural Stem Cells from Mammalian ... Noncoding RNAs in Neural Stem Cell Development 239 Shan Bian and Tao Sun Part Neural Stem Cells and Therapy 257 Chapter 13 Neural Stem/ Progenitor Cell Clones as Models for Neural Development ... (slowly dividing astroglial cells and the bona fide adult neural stem cells) , type C cells (transit-amplifying cells derived from asymmetric division of Type B cells) , type A cells (immature neuroblasts...

Ngày tải lên: 30/03/2014, 23:20

... change a neural stem cell’s fate Under certain conditions, neural stem cells have been induced to differentiate into cells outside the expected neural lineage and conversely, stem cells from nonneural ... Michael R Stark 223 21 Gene Therapy Using Neural Stem Cells Luciano Conti and Elena Cattaneo 233 22 Modeling Brain Pathologies Using Neural Stem Cells Simonetta Sipione and Elena Cattaneo ... “Utilization/Characterization of Neural Stem Cells in vivo,” is a collection of techniques to identify and characterize endogenous stem cells as well as exogenous stem cells after transplantation...

Ngày tải lên: 11/04/2014, 09:58

... cultured Schwann cells Plast Reconstr Surg 2001, 107:485-494 Fong SP, Tsang KS, Chan AB, Lu G, Poon WS, Li K, Baum LW, Ng HK: Trophism of neural progenitor cells to embryonic stem cells: neural induction ... Schwann cells Microsurgery 2002, 22:311-315 Heath CA: Cells for tissue engineering Trends Biotechnol 2000, 18:17-19 Hori J, Ng TF, Shatos M, Klassen H, Streilein JW, Young MJ: Neural progenitor cells ... fiber circumference using the Leica image analysis system (Leica Image Analyzer, Wetzlar, Germany) Blocks of facial muscles and HA-collagen composite scaffolds were fixed with the modified Karnovsky's...

Ngày tải lên: 18/06/2014, 15:20

... of endogenous neural progenitor or stem cells and the transplantation of adult-derived neural progenitor and stem cells [39] Self-renewing multipotent neural progenitor and stem cells have been ... the nervous system Adult-derived neural progenitor and stem cells grafted in the brain promote neuroprotection, by an immunomodulatory mechanism Grafted neural progenitor and stem cells interact ... neuronal cells in the adult brain originate from residual stem cells The existence of stem cells in the adult brain suggests that it has the potential for self-repair and that newborn neuronal cells...

Ngày tải lên: 08/08/2014, 17:20

... breast cancer 22 1.4 Stem cells 1.4.1 Adult stem cells 1.4.1.1 Neural stem cells 1.4.2 Induced pluripotent stem cells 1.5 Stem cell as a vehicle for cancer gene therapy 1.5.1 Stem cell based cancer ... pluripotent stem cell derived -neural stem cell human induced pluripotent stem cell derived -neural stem cell expressing CodA human induced pluripotent stem cell derived -neural stem cell expressing Fcy ... al., 2001) Stem cells as delivery vehicles have been shown to enhance gene delivery efficiency (elaborated in section 3.1) 1.4 Stem cells 1.4.1 Adult stem cells (ASCs) Adult stem cells (ASCs),...

Ngày tải lên: 09/09/2015, 18:56

... growth factor Ventricular zone xii Chapter 1: Introduction 1.1 Neural stem cells 1.1.1 A brief history of NSCs The field of neural stem cell (NSC) biology has its humble beginnings in the second ... of NSCs from other neural or non -neural cells, none of the markers can exclusively identify NSCs as many are also found in more committed neural progenitors, differentiated cells or even in other ... alternative to reprograming of terminally committed cells into iPS cells and then deriving NSCs is the direct reprograming of cells into NSCs and neural cells without reverting to a pluripotent state...

Ngày tải lên: 10/09/2015, 09:08

... 1.4.3 Stem cells and cancer 14 1.5 Neural development 16 1.6 Neural stem cells 19 1.6.1 Embryonic neural stem cells 20 1.6.2 Adult neural stem cells ... The stem cell concept 1.3 Symmetrical and asymmetrical division 1.4 Types of stem cells 1.4.1 Embryonic stem cells 1.4.2 Somatic stem cells 1.4.3 Stem ... neural stem cells .24 1.6.3 Neural stem cell applications .26 1.7 Methods to study neural stem cells 28 1.7.1 Identifying neural stem cells in vivo 28 1.7.2 In vitro...

Ngày tải lên: 12/09/2015, 21:26

... embryonic neural stem cells Diabetologia (2006) 49: 1027-1038 J Fu, S S W Tay, E A Ling, S T Dheen Aldose reductase is implicated in high glucose-induced oxidative stress in mouse neural stem cells ... proliferation and cell fate specification of embryonic neural stem cells Society for Neuroscience 35th Annual Meeting, Abstract Number 24.10 (24 Neural Stem Cells in Brain Injury and Disease, Theme A, A10), ... 2005) 2.2 Factors involved in neural tube development The developing neural tube is initially composed of neuroepithelium, a layer of rapidly dividing neural stem cells (NSCs) (Gilbert, 2003)...

Ngày tải lên: 30/09/2015, 06:36

... sequences or images using Discrete Wavelet Transform (DWT) and neural network First of all, DWT extracts some edge features of the original image Then the text regions are obtained using a neural network ... obtained using a neural network The final results are shown in Figure 8(c) Conclusion This paper presents a method for extracting text regions from static images or video sequences using DWT and a neural ... extraction from static image or video sequences is accomplished using the back-propagation (BP) algorithm on a neural network The training of the neural network is based on the features we obtain from...

Ngày tải lên: 05/11/2012, 14:51

... fields In this study, a back-propagation neural network model for estimating of proper strain rate form soil parameter is proposed The back-propagation neural network program adopted in the present ... backpropagation neural network model for predicting proper strain rate involved three phases First, data collection phase involved gathering the data for use in training and testing the neural network ... the training patterns was minimized Experiment were carried out using a number of combinations of input parameters to determine the neural network model that gave the smallest average of the sum...

Ngày tải lên: 22/03/2013, 15:01

... on arsenic removal using iron-based adsorbent In this study, the surface of the rice husk carbon is modified by impregnation with iron Moreover, most researches have been done using pure water ... from water, but using iron alone may be very expensive, limiting its suitability in rural areas of poor countries From the literature survey, there are very few studies on iron -modified rice husk ... kinetics The results, therefore, may not be reflective of the true behavior in the actual treatment system In addition, many researchers have used a linear regression method to estimate the isotherm...

Ngày tải lên: 05/09/2013, 09:38

... the nature and safety of genetically modified food They have been modified substantially for presentation here Q1 What are genetically modified (GM) organisms and GM foods? Genetically modified organisms ... engineering in agriculture BioScience 39: 606–614 Pimentel, D 2000 Genetically modified crops and the agroecosystem: Comments on Genetically modified crops: risks and promise” by Gordon Conway Conservation ... temperatures that normally would kill genetically unmodified seedlings Drought Tolerance/Salinity Tolerance: As the world population grows and more land is utilized for housing instead of food production,...

Ngày tải lên: 25/10/2013, 05:20

... hypoxia and HIF-1a lead to the inhibition of differentiation in cortical neural stem cells, myogenic satellite cells and C2C12 cells by interacting with and stabilizing the Notch ICD domain In contrast, ... results confirm our findings in C6 cells and, moreover, suggest a general correlation of HIF-1a activity with differentiation in malignant glioma cells Discussion Gliomas derived from astrocytes ... 7293 HIF-1a modulates malignant glioma differentiation H Lu et al A C D B Fig Cobalt chloride (CoCl2) and DFO inhibit differentiation induced by forskolin in C6 glioma cells Cells were pretreated...

Ngày tải lên: 18/02/2014, 13:20