large porous carriers of nanoparticles for drug delivery

... clinical administration because the drug delivery of these agents often requires the use of adjuvants or excipients, which often cause serious side effects For example, Cremophor EL (polyethoxylated ... pharmaceutical drug formula-tion of Taxol® for inducing drug solubility but its clinical usefulness is often hampered by poor water solubility and potential unwanted side effect.15 The nanoparticles ... expected to offer advantages over con-ventional formulations including the ability of drug protec-tion, targeting the drug to the site of acprotec-tion, and reducing the side effects of chemotherapy

Ngày tải lên: 12/12/2017, 10:52

... using ATRA as a proof of principle, that the chick CAM model can be used successfully for drug treatment thereby provid-ing a platform of choice for further evaluation of drug efficiency in neuroblastoma ... explanation for the greater efficiency of tumour formation by SKNAS cells [7] and the rationale for the use of trypsin to enhance tumour formation for IMR32, Kelly and especially BE2C cells Use of trypsin ... chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems Adv Drug Deliv Rev 2007;59(11):1162 –76. 32 Borrill Mather G: The Chick embryo; A new drug delivery model for Neuroblastoma

Ngày tải lên: 24/07/2020, 00:16

... terms of CMC 3.4 Drug delivery The drug delivery application of newly synthesized surfactants was carried out using the well-known anticancer drug cis-platin The drug was encapsulated in PLGA nanoparticles ... of 3.9% and DEE of 72% for PLGA-mPEG NPs loaded with cisplatin [22] The release of drug from cisplatin loaded PLGA-surfactant Nps was studied for 96 h and the results shows the release of drug ... of newly synthesized compounds. Table 8 Drug delivery parameters for cisplatin loaded PLGA-surfactant nanoparticles. Serial No. Nanoparticle formulation Drug encapsulation efficiency (%) Drug

Ngày tải lên: 13/01/2022, 00:27

... heretofore, the present study provides proof of principle for such targeting Conclusion Here, we report the development of a surface engineered magnetic core-shell nanoparticle-based drug delivery ... anti-cancer drug quercetin Further, in this study we described a novel method of drug-loaded nanoparticle delivery to lung cancer using aerosols The optimised proof-of-concept nanoplatform documented ... mechanisms with broad implications for pharmacotherapies, drug de-livery and molecular imaging A targeted drug delivery system requires the design of carriers capable of selectively releasing their

Ngày tải lên: 02/11/2022, 14:24

... efficiency of nanocarrier-mediated drug delivery into the brain Keywords: blood–brain barrier; targeted drug delivery; nanocarriers; transcytosis Trang 21 Introduction Effective delivery of drugs ... linkage to the drug rather than linkage to a drug-containing device However, the use of nanocarriers for drug delivery to the brain may be preferred to prevent degradation of the drug during circulation ... HIRMAb-modified drug conjugates for the same receptor may result in lack in efficacy of the nanoformulation and/or changes in receptor activity, of which the latter may have negative consequences for glucose

Ngày tải lên: 04/12/2022, 16:38

... Polymers: Controlled Delivery of Drugs 122 4.4 Auto-Associative Amphiphilic Polysaccharides as Drug Delivery Systems 124 4.5 Supramolecular Hydrogels: Potential Mode of Drug Delivery 127 4.6 ... 5.10 Hyaluronic Acid for Anticancer Drug and Nucleic Acid Delivery 161 5.11 Chondroitin Sulfate-Based Nanocarriers for Drug/Gene Delivery 164 5.12 Nanoengineering of Vaccines Using Natural ... investigated for drug delivery, for dermal, nasal, pulmonary, parenteral, liposome-modifi ed, implantable delivery devices and for gene delivery (reviewed in Liao et al [ 58 ]) Hyaluronan for tissue

Ngày tải lên: 14/05/2018, 15:13

... model for the drug delivery system The construction of robotic fish-like drug delivery system represents a key challenge for the near future Keywords: Bioinspired Technology; Fish Fin; Drug Delivery ... thrust, and the frequency of the back and forth motion of the fishtail gives the inspiration to optimize the movement of the drug delivery robot The motion optimizations of drug delivery robots could ... source of inspiration for the design of smart materials, robots, and drug delivery system Fish could be example using of body to generate forces during movement, and a characteristic feature of the

Ngày tải lên: 20/03/2024, 14:42

... candidates for drug delivery and disease targeting Until now, many BPMOs-based drug delivery systems have been reported based on the redox conditions for biodegradation.*> Characterization of those formulations, ... types of inorganic porous materials like mesoporous carbon NPs, magnetic colloidal NCs, mesoporous silica-based NPs, mesoporous TiO2 NPs, and others, have been synthesized for fabricating high drug-loading ... increase drug-loading content, drug molecules have been attached to the porous surface of nanocarriers and further ability to stimuli response (Figure 1.3).”Š: ?2 ri: e Figure 1.3 Modern drug delivery

Ngày tải lên: 02/10/2024, 01:12

... con-centration of the drug attached and a known dosage can therefore be delivered and released at the targeted site [16] Another application for the use of NPs is in the field of photonics for diagnostic ... targeted delivery of dox-orubicin significantly increased the efficacy of the anti-cancer drug, thus enabling the effective use of a lower concentration of doxorubicin The targeting ability of the ... penetration of the drug to targeted tissue In addition they enable greater control of the pharmacokinetics and drug body distri-bution [18] There are several ways to utilize the NPs as a drug delivery

Ngày tải lên: 19/03/2023, 15:18

... conjugation of PEG could improve the stability of the micelles, which were designed for systemic delivery of drug and/or gene Trang 55.1.3 Encapsulation of drug molecules Two model drug compounds, ... is a kind of excellent codelivery system for hydrophobic drug and nucleic acid including DNA, RNA For proof of the principle, in vivo gene transfection was performed in the cochlea of guinea ... structure because of the rigid chemical structure of the core-forming segment cholesterol The TEM scans of the micelles also evidenced the formation of the nanoparticles The stability of the micelles

Ngày tải lên: 16/09/2015, 15:54

... stretching of amine The shift and increased intensity of this peak compared with that of PMDS (1240 cm-1) illustrated the formation of a quaternary ammonium salt The 1H-NMR and FTIR spectra of P(MDA-co-CEA) ... C-N stretching of amine The shift and increased intensity of this peak compared with that of PMDA (1240 cm-1) illustrated the formation of a quaternary ammonium salt The degree of grafting (R ... and the proton of the methyl group linked to the hexane and pentane cycles of the pendant chain (signal i) were considered suitable for use in the estimation of R g For the proton of methylene

Ngày tải lên: 16/09/2015, 15:54

... amount of PMDS units in a molar ratio of 1:1 For example, the content of PMDS calculated by 1H-NMR was 80% in weight Thus, 2.5 g of PEGylated PMDS contained 2.0 g of PMDS, i.e 0.007mol of repeated ... the ratio of the actual drug mass encapsulated to the initial drug mass added The loading level was calculated as the ratio of loaded drug mass to the total mass of polymer and loaded drug 3.5 ... PEGylation of PMDS 5.958 g of N-methyldiethanolamine (0.05mol), 0.00125 mol of mPEG (6.25 g, 2.5 g, 1.375 g, 0.8125 g for Mn of 5000, 2000, 1100 and 650 Dalton respectively) and 50.5 g of triethylamine

Ngày tải lên: 16/09/2015, 15:54

... particular, cationic polymers, for delivery of drugs or genes and codelivery of drugs and genes I will also examine some of the difficulties involved with current gene delivery systems using non-viral ... delivering the drug efficiently to the target, modifying the drug for increased efficiency, or finding a novel drug of inherently high efficacy Of the three, devising an efficient means of delivery ... exhibit a number of advantages over other forms of drug carriers because of their core-shell structure, low CMC and targeting ability 2.1.4.1 Core of polymeric micelles as a reservoir for hydrophobic

Ngày tải lên: 16/09/2015, 15:54

... Chapter Review of Microfabricated Microneedles 2.1 Microneedles in Transdermal Drug Delivery Transdermal drug delivery is an alternative method for delivery of DNA/protein based drugs These drugs which ... the implementation of time varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic ... be used for local delivery of other drugs, for example, drugs in anti-restenosis and anti-tumor therapies In transdermal drug delivery, microneedles are designed to painlessly deliver drugs into...

Ngày tải lên: 14/09/2015, 11:17

... control of the rate of polymer degradation can be achieved thereby changing rate of release of the drug Our study focuses on developing controlled releases implants in the form of discs for Paclitaxel ... account for a larger portion of the drug) would serves as a depot for future continuous paclitaxel release Over the duration of the experimental groups, no sign of weight loss or indication of toxicity ... some form of transporter (e.g nanoparticles) maybe needed to carry the free form of the drug deeper into the tissue before releasing it Page 25 Ong Yung Sheng, Benjamin CHAPTER 4: EVALUATION OF...

Ngày tải lên: 05/10/2015, 21:33

... EVALUATION OF TRANSFERRIN-CONJUGATED LIPID SHELL AND POLYMER CORE NANOPARTICLES FOR TARGETED DELIVERY OF DOCETAXEL PHYO WAI MIN (M.B.,B.S (YGN) U.M(1)) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ... synthesize nanoparticles to encapsulate a variety of therapeutic compounds (Feng, 2006) PEGylation, which refers to polyethylene glycol conjugated drugs or drug carriers, is essential for drug delivery ... and formulations of drug delivery system is provided The strategies applied for targeted drug delivery system is also clearly described in this chapter Then, the synthesis and characterization of...

Ngày tải lên: 09/10/2015, 11:18

... injectable delivery, Chapter for oral delivery, Chapter 10 for brain delivery, Chapter 11 for ocular delivery, and Chapter 12 for gene delivery Finally, the fourth section provides an overview of the ... applications of nanoparticles in drug delivery Depending on the route and purpose of drug delivery, the requirements for nanoparticulate systems can vary These aspects are discussed in Chapter for injectable ... size of nanoparticles in perspective, Table compares sizes of various objects Because of the comparable size of the components in the human cells, nanoparticles are of great interest in drug delivery...

Ngày tải lên: 04/06/2014, 15:15

... This extended number of conditions, which led us to the use of a rather limited number of animals per group, Page of 10 (page number not for citation purposes) was necessary for at least two reasons ... anti-inflammatory drug delivery system in an experimental model of antigen-induced arthritis (AIA) in mice Figure Materials and methods Microparticle preparation The microparticles of a mean of and 10 ... arthritis, the articular retention of magnetic microparticles of a mean of and 10 μm in diameter with and without a magnet was compared by means of in vivo imaging For this long-term study, we used...

Ngày tải lên: 09/08/2014, 14:20

... characteristics of the final product The successful formulation of a stable and effective dosage form therefore depends on the careful selection of excipients The use of polymers in the formulation of controlled ... employed to solve the problem of rapid drug release A key consideration in the modification of drug delivery systems is the controlled release of drug at the site of action For example, additives such ... INTRODUCTION delivery of drug In time-controlled delivery, the drug is released in a pre-determined rate while in target-controlled delivery, the drug is delivered to a specific site The delivery...

Ngày tải lên: 13/09/2015, 20:39

... the rate of drug appearance in the blood is determined by the absorption rate of the drug whereas for Class II drugs, the rate of dissolution plays a greater role In the case of Class IV drugs, ... procedure for the 162 analysis of the effects of varying rotational speeds of the classifier wheel Table 21 Results of the Dunn Multiple-Comparisons procedure for the 168 analysis of the effects of ... PARTICLE DEVELOPMENT FOR DRUG DELIVERY LEE CHIN CHIAT B Sc (Pharm) (Hons) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF PHARMACY NATIONAL UNIVERSITY OF SINGAPORE 2004 To...

Ngày tải lên: 17/09/2015, 17:19