involvement of oxidative stress in alzheimer disease

... online http://arthritis-research.com/content/7/4/R904 Research article Open Access Vol No Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement ... involvement of HIF-1α in the pathogenesis of osteoarthritis Kazuo Yudoh, Hiroshi Nakamura, Kayo Masuko-Hongo, Tomohiro Kato and Kusuki Nishioka Department of Bioregulation, Institute of Medical ... reproduction in any medium, provided the original work is properly cited Abstract Transcription factor hypoxia-inducible factor (HIF)-1 protein accumulates and activates the transcription of genes

Ngày tải lên: 09/08/2014, 06:23

... to induction of the gene in shoots GUS staining pattern of NaCl-treated roots seemed to be more complex GUS staining was indeed sharply reinforced in the terminal Figure 4 Oversensitivity of ... mM NaCl before GUS staining (A) GUS staining pattern in shoots of plantlets (B-C) GUS staining pattern in roots of plantlets shown in A (D-E) Focus on root apices visible in B and C (F-G) Focus ... with different intensity Under control conditions, POP2 was mainly expressed in roots since no GUS staining was visible in shoots (figure 7A) whereas a strong staining was present in roots (figures

Ngày tải lên: 12/08/2014, 03:21

... [28-30] According to the free radical or oxidative stress theory of aging [31], oxidative stress incurs when the cellular antioxidant defense systems fail to counteract ROS bringing them back ... magnitude of dye reduction was expressed as percentage of Resazurin reduction according to this formula: (FI 590 of test agent - FI 590 of negative control)/(FI 590 of 100% reduced of Resazurin - ... agedependent decline in their repairing capacity, increasing their susceptibility to degenerative diseases, cell death and senescence processes In fact, multiple studies showed that the age of tissue

Ngày tải lên: 15/01/2020, 02:05

... autophagy inhibition sensitized choriocarcinoma cell towards oxidative stress Chloroquine, a clinically used lysosomal inhibitor, was also effective in blocking autophagy In the context of choriocarcinoma, ... oxidative stress, implying a protective role of iASPP against oxidative stress through autophagy in choriocarcinoma Conclusions: iASPP regulates growth and the cellular responses towards oxidative stress ... concomitantly hindered autophagy in choriocarcinoma cells Autophagy inhibition per se had no effect on the growth of choriocarcinoma cells but increased the susceptibility of choriocarcinoma cells to oxidative

Ngày tải lên: 17/06/2020, 18:38

... role of oxidative stress We also aimed at evaluating the role of protein kinase C (PKC) in the putative glucose-induced, oxidative stress-mediated impairment of the NO-cGMP signalling in VSMC, since ... signalling, underlining the role of oxidative stress in this phenomenon Our working hypothesis was that high glucose increases in a short-term oxidative stress by a PKC-induced activation of NADPH ... endothelial and in the media layers of the aorta, indicating the occurrence of a PKC-mediated increase of oxidative stress in VSMC, the main component of the media [40] Furthermore, acetylcholine induced

Ngày tải lên: 02/11/2022, 08:46

... the original axon segment maintains the original trajectory The days shown refer to the number of days after day 0 (when imaging began) Scale bar (in l): 24 μm in a-h, 11.6 μm in d (inset) and ... to the number of days after day 0 (when imaging began) Purple arrows in g-i point out a re-growing axon that is also shown in greater detail in Fig 5 Scale bar (in m): 19.5 μm in a-m Trang 6with ... addressed In the present work, we performed a detailed long-term study (of up to 210 days and weekly imaging) focusing on the formation, development and elimination of AxDs with the aim of examining

Ngày tải lên: 04/12/2022, 10:34

... in increasing HIF-1α in the SE offspring Considering the protective effect of HIF-1α , its increase in the brains of SE offspring may be an adaptation to protect against increased oxidative stress ... by increased nitrotyrosine levels, a direct product of oxidative stress, in the brains of SE mothers However, SE mothers and adult SE offspring had quite distinct changes, in markers of brain inflammation ... suggesting cigarette smoke is a direct cause of oxidative stress regardless of the other responses Cotinine levels in P20 offspring in this study are similar to those reported in human infants of

Ngày tải lên: 04/12/2022, 14:50

... School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China bSchool of Pharmacy, Key Laboratory of Minority Medicine Modernization, Ministry of Education, Ningxia Medical ... the oxidative stress scenario, the indices inter-preting oxidative stress were tracked to further assess the defensive activity of LFP-05S against etiologic oxidative stress The targets of the oxidative ... end-product of lipid peroxidation that accumulates during aging process and oxidative stress and they hence, represent a promising aging marker The LFP-05S feeding reinforced the clearance of lipofuscin

Ngày tải lên: 01/01/2023, 13:38

... long-chain specific acyl-CoA dehydrogenase It was involved in the initial step of mitochondrial beta-oxidation of straight-chain fatty acids and in the maintenance of an internal steady state of lipid ... Processing’ 113 and 75 proteins were involved in translation and folding, sorting and degradation of ‘Genetic Information Processing’ respectively In ‘Metabolism subcategory’, large proportion of ... roles of oxidative stress and antioxidant defensing system in sclerotia formation of Polyporus umbellatus Bing Li1, Xiaofang Tian2, Chunlan Wang1, Xu Zeng1, Yongmei Xing1, Hong Ling1, Wanqiang Yin3,

Ngày tải lên: 19/03/2023, 15:29

... derived from jararhagin disin-tegrin) is essential for binding to the I domain of a2 integrins [24] Similarly, members of the ‘lysine–threo-nine–serine (KTS)–disintegrin’ family contain the consensus ... oxidase-hypoxanthine system (data not shown) These results suggested the involvement of lysine-containing sequences in the acti-vation mechanism Involvement of lysine residues contained within a1CB6 ... group of the tissue inhibitor of metalloproteinases-2 NH2 -ter-minal cysteine has been used to demonstrate the key role of this amino group in the inhibitory effect of tissue inhibitor of metalloproteinases-2

Ngày tải lên: 07/03/2014, 06:20

... EhADH2, indicating the presence of two catalytically independent domains, the N-terminal domain, display-ing ALDH activity, and the C-terminal domain, con-taining an iron-binding domain, which is involved ... bind close to the Fe–S clusters, blocking the access of ROS In this regard, a preliminary docking analysis with coenzymes in the 3D model of EhPFOR suggested that the CoA-binding site was, indeed, ... hand, a set of antioxidant enzymes (including SOD but not Cat) have been iden-tified in the parasite [35,36] Interestingly, in vitro, higher PFOR reactivation was observed in virulent than in nonvirulent

Ngày tải lên: 15/03/2014, 23:20

... observed in human VLCADD [5] In fact, in both mice and humans, clinical symptoms become mainly evident as a consequence of triggers such as fasting, resulting in the accumulation of long-chain acylcarnitines, ... mice Fasting induced a significant increase in both genotypes; however, this was more evident in the VLCAD KO mice (Fig 3A) Interestingly, the MCT diet also induced AOX gene expression in WT mice ... 24 h of fasting, both genotypes showed a signifi-cant increase in the expression of AOX with the MCT diet As shown in Fig 3B, under nonfasting conditions, the expression of CYP4A1 was higher in

Ngày tải lên: 15/03/2014, 23:20

... kinetics of the CoQ-oxidizing module were obtained by titrating with a specific inhibitor of the CoQ-reducing module, malonate (0–3.125 l M ) The kinetics of the CoQ-reducing module were obtained ... CoQ-oxidizing modules Effect of Cd2+on the kinetics of the CoQ-oxidizing module (A) and CoQ-reducing module (B) Effect of Cu 2+ on the kinetics of the CoQ-oxidizing module (C) and CoQ-reducing module ... protein Increasing the amount of added Cu2+ ions to 10 nmolÆmg protein)1 did not further increase the amount of TBARS formed (Fig 6B) Effects of Cd2+and Cu2+ions on the control of fluxes in oxidative

Ngày tải lên: 16/03/2014, 02:20

... overview of involving in main knowledge of chapter two The concepts of sentence stress are identified clearly according to many points of view Some functions of sentence stress are also found in this ... sentence stress while speaking Some of them about 12.5% often use sentence stress in communication, representation, and reading 25% of them rarely use sentence stress in English speaking competence ... aware of the essence of sentence stress to them in their study 46 Question 5: Students’ opinion in producing accurate sentence stress Figure 5: The effectiveness of producing accurate sentence stress

Ngày tải lên: 17/03/2014, 16:12

... malfunction [2,3] Invasive aspergillosis is the most serious form of the disease, involving the invasion of viable tissue and resulting in a mortality rate of 80– 95% [4,5] Circumvention of the host ... fungicidal activity of purified human neutrophils was determined in vitro The kinetics of fungal killing are shown in Fig 5B for a ratio of neutrophils to A fumigatus conidia of : Killing of A fumigatus ... that of sidD in A fumigatus revealed concomitant upregulation of pes1 and diminution of the latter, possibly implying a difference in functionality and bringing into question the classification of

Ngày tải lên: 30/03/2014, 10:20

... Division of Veterinary Medicine, School of Veterinary Science and Medicine, Sutton Bonington Campus, University of Nottingham, Sutton Bonington LE12 5RD, UK Corresponding author: Alexandrina F Mendes, ... damaging effects of hyperglycemia in various cell types [17] Moreover, ROS contribute to the pathogenesis of OA by mediating many of the effects induced by catabolic cytokines, such as IL-1β, in ... reflects that in the plasma, both under normal conditions and in noninflammatory and inflammatory types of arthritis, excluding those associated with infections [12] To our knowledge, no information

Ngày tải lên: 09/08/2014, 14:21

... possess an insulin-like property in vivo [19] Further, there was increasing evidence implicating that RSV alleviated oxidative stress in a variety of hyperglyce-mia-affected tissues, including renal ... indicators of oxidative stress including the contents of superoxide anion, malondialdehyde, and carbonyl protein, and protein expressions of MnSOD and CuZn-SOD were all significantly enhanced in the ... proinflammatory cytokines in the renal tissues of diabetes in vivo It has been shown that hyperglycemia promoted oxi-dative stress in nephritic tissues, eventually leading to renal injury in

Ngày tải lên: 10/08/2014, 05:21

... (ȝM) Kainic Acid (150 ȝM) Figure 6 In vitro and in vivo effect of PETL extract and GABA on the KA-induced oxidative stress KA-induced lipid peroxidation of PC12 cells and brain neuron tissue of ... expression of heat shock protein HSP-70 mRNA, brain-derived neurotrophic factor mRNA, and cyclooxygenase-2 mRNA in rat brain following seizures induced by systemic administration of kainic acid Brain ... injury by scavenging of free radicals Therefore, the aim of this study was to investigate the protective mechanisms of GABA and Pu-erh tea leaf extract on KA-induced injury in neuronal cellsin

Ngày tải lên: 10/08/2014, 10:20

... adhesion is involved in lipid rafts-mediated signal transduction pathways [11] For example, integrin α6β4, a laminin receptor, is incorporated in lipid rafts through palmitoylation at cysteine in the ... the initial activation of Met and EGFR upon cell adhesion does not require the integrin-matrix interaction, it remains possible that the integrin-matrix interaction may contribute to sustained ... 0.2 trypsin inhibitory units/ml aprotinin, and 20 µg/ml leupeptin) The lysates were centrifuged for 10 minutes at 4°C to remove debris, and the protein concentrations were determined using the

Ngày tải lên: 10/08/2014, 10:20

... number of strategies to facilitate the implementation of research findings by using these social influences. One strategy generating considerable interest is the use of opinion leaders. Opinion ... identifying opinion leaders in different professional groups within the United Kingdom (UK) National Health Service using two different instruments, a sociometric instrument [6] and a self-designating ... Mean score of all respondents (SD) Range of scores of all respondents (SD) Total SDOLs Mean score of self- designating opinion leaders (SD) Range of scores of self-designating opinion leaders

Ngày tải lên: 11/08/2014, 05:21