innovation is not just a good idea

... Hsp90 is impaired, hidden genetic variation is revealed, resulting in altered genetic signal inputs (black peaks) that are abnormally outputted These altered outputs may lead to an abnormal phenotypic ... This pathway is called the primary processing path­ way [5,6] The mechanism of their production, however, has been largely unclear During spermatogenesis in Drosophila males, antisense piRNAs ... phenotypic variation Transposition is also potentially adaptive by occasionally providing a source of genetic diversity [8] Thus, a trans­ posable element is often defined as a natural, endogenous,...

Ngày tải lên: 09/08/2014, 20:21

... a specific bank network and lacked the "universal" aspect we take for granted today The rapid expansion of Bank of America's program (today's Visa) and the Interbank group's program (MasterCard) ... The inflation of the late 1970s and early 1980s also had an effect Generally, any loan that is extended to a consumer is paid back with dollars that are earned in the future Because of this, both ... to market forces Credit Cards Are No Different The credit cards that seemed to attract the most attention were the bank-issued "universal" cards such as Visa and Mastercard These cards are called...

Ngày tải lên: 15/03/2014, 01:20

... possible is preferred distance in sentences and markables part of speech of the head of the markables the grammatical functions parallelism of grammatical functions the heads match or not where is ... succeeding markable? This is linguistically implausible Pronouns are acting as a kind of local variables A ’he’ at the beginning of a text and a second distant ’he’ at the end of the text hardly tend ... it is related to another markable that is already member of the set) it is verified that it is compatible with all members of the set A markable i is compatible with a coreference set if, for all...

Ngày tải lên: 31/03/2014, 20:20

... only a year, he found that managing a fast-growing business was not his forte He was actually looking forward to being an employee again But after his wife took Imagining the Ideal Life a job ... draws is the chance to start a business that can turn a hobby into a pastime, an avocation into a vocation Robin Knepp spent nine years in the Marine Corps, rising to the rank of captain as a ... Working as a consultant for a large technology consulting company often meant he was in an airplane five nights a week, away from family, away from his home, and away from his life "There was something...

Ngày tải lên: 01/06/2014, 10:25

... significant improvement in clinical indicators of pain and disease activity A first randomized controlled trial in patients with knee OA demonstrated a good safety profile for one intra-articular ... IL-1β early in the disease process Moreover, intra-articular delivery of anakinra (recombinant methionyl human receptor antagonist (r-met HuIL-1ra)) may have beneficial effects on symptoms and structural ... IL-1β is not only involved in the structural damage process of OA but also plays an important role in pain transmission Results from in vitro studies and animal models of OA support the dominant role...

Ngày tải lên: 09/08/2014, 10:21

... non-senescent leaves have already been degraded Given that the current database of Arabidopsis ESTs does not represent senescing tissues, it is perhaps not surprising that an additional 100 new genes, not ... leaf is induced by an array of endogenous factors, such as age and hormonal regulation, as well as by external factors, such as biotic and abiotic stresses It is not known how these signals are ... sequence annotation and classification of genes in the Arabidopsis databases The general picture emerging from this study is that leaf senescence is indeed, like any other developmental process, a very...

Ngày tải lên: 09/08/2014, 20:20

... CVVHD and sepsis-related disseminated intravascular coagulation Two days later, right hand cyanosis was noted and attributed to the presence of a right radial arterial catheter, which was removed ... prior heparin exposure and a low or falling platelet count In addition, effective treatment is available with the anticoagulants argatroban and lepirudin Lastly, a readily available test with a high ... died after cardiac arrest No autopsy was obtained Discussion Thrombocytopenia, a commonly encountered condition in hospitalized patients, is often nothing more than a statistical laboratory variant...

Ngày tải lên: 11/08/2014, 10:22

... Wildtype Codon APOBEC3G Target APOBEC3F Target ATG(G) GAC CAG(G) ATG(G) TTG (A) GAG (A) GGA ATG(G) + + + + + Observed Mutant Codon Mutant Frequency ATA na CAA× ATA* TTA× AAG* AGA ATA 0.7 0.5 0.6 0.1 0.3 ... with accelerated HIV disease progression, and actually appears to have slightly increased antiviral potency based on in vitro infectivity data (cytidine deaminase activity was not directly measured) ... to both APOBEC3G and APOBEC3F that is distinct and separable from cytidine deaminase activity [47-49], although the legitimacy of this capacity is still a topic of debate [50] A therapeutic scheme...

Ngày tải lên: 13/08/2014, 06:20

... patients and carried a higher mortality [13] Nevertheless, the standardized mortality ratio was similar in patients who had AF and in patients who did not have AF, suggesting AF is rather a marker ... K, Lekakis J, McGregor K, Metra M, Morais J, Osterspey A, Zamorano JL, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Hunt SA, Nishimura R, Ornato JP, Page RL, Riegel B: ACC/AHA/ESC ... P, Mazer CD, Barash PG, Hsu PH, Mangano DT: A multicenter risk index for atrial fibrillation after cardiac surgery JAMA 2004, 291:1720-1729 Artucio H, Pereira M: Cardiac arrhythmias in critically...

Ngày tải lên: 13/08/2014, 21:20

... Ribozymes can target critical sites such as gag [25], tat [26], and U5 [27] C Antisense RNA Antisense RNA is single-stranded RNA bearing complementary nucleotide sequences to a target RNA It pairs ... five patients at 14 days and two of three patients at one year, showing good tissue distribution In addition, there was a transient decrease of greater than 0.5 log mean in rectal tissue-associated ... by an intracellular anti-Rev single-chain antibody Proc Natl Acad Sci USA 1994, 91(11):5075-5079 Marasco WA, Haseltine WA, Chen SY: Design, intracellular expression, and activity of a human anti-human...

Ngày tải lên: 14/08/2014, 19:22

... MPI Ministry of Planning and Investment MUTRAP Multilateral Trade Assistance Project NAPPA National Academy of Politics and Public Administration NGO Non-governmental Organisation ODA Official Development ... what the law is intended to achieve Policymaking and legal drafting have subsequently not been separated and specialised, which has meant the arguments for drafting particular laws are not always ... international treaties such as Asia-Pacific Economic Cooperation, the ASEAN Free Trade Area and the World Trade Organization (WTO), Vietnam agreed to harmonise its commercial laws with international...

Ngày tải lên: 08/08/2015, 19:23

Ngày tải lên: 17/08/2015, 11:16

... its application are completely unrelated to those set forth in the registration cited as a bar to registration of applicant’s mark The Examining Attorney was not persuaded by applicant’s arguments, ... next article mentions that particular vitamins are ingredients in a skin cream for use with skin that has been damaged by wind, sun or shaving Another excerpt notes that a particular company sells ... that these were only a representative sampling from a larger number of such registrations revealed by his search Ser No 75/934,127 Applicant filed a Notice of Appeal with the Trademark Trial and...

Ngày tải lên: 20/12/2013, 23:15

... A. -R Karala and L W Ruddock bacitracin contains at least nine different peptides, of which bacitracin A is the most abundant, and it is mainly used as an antibiotic against infections caused ... thiol–disulfide exchange enzymes, Escherichia coli DsbA and DsbC, as well as the isolated catalytic a domain of PDI Both the PDI a domain and DsbA have a catalytic site, with an associated substrate-binding ... propose that bacitracin should not be regarded as a specific inhibitor of PDI Results Bacitracin does not inhibit the catalysis of disulfide bond formation and isomerization by PDI PDI is a catalyst...

Ngày tải lên: 16/02/2014, 14:20

... stated) and legal disclaimers All of this peripheral information serves as a constant reminder that a game is being played Another barrier to player immersion in the Nokia Game is its reliance on ... with visitor traffic and inquiries, and its owner was forced MelbourneDAC 2003 to replace his home page with a "This is not a game" disclaimer [5] As you can imagine, an audience that is quite ... unfolding of the answers IS the narrative that has me hooked… a meta-narrative" [20] In another editorial "Meta Mystery," Maria Bonasia, a twentysomething Massachusetts-based playwright, discussed "the...

Ngày tải lên: 07/03/2014, 17:20

... F(aa¯ a, aaaa) a ¯ ¯ A( a, a) F (a , aa) a ¯ A( a, a) D (a , aa) a ¯ E (a a, aaa) a ¯ ¯ D (a , aa) a ¯ C(ε, #) A (¯ , a) a ¯ D(ε, ε) F (a , aa) a ¯ A( a, a) D(ε, ε) E(¯ , a) a ¯ D(ε, ε) A (¯ , a) ... A, A , C, D, E, F}, Σ = {a, a, #}, and P consists of the following rules: S(x1 y1 , y2 x2 ) ← D(x1 , x2 ), C(y1 , y2 ) C(ε, #) ← S(aa¯ aa¯ , #¯ a aaa) a a a a D(aa¯ aa¯ , aa¯ aaa) a a ¯ a ... here a rigorous, mathematical proof of this fact not relying on the computer verification Head Grammars A head grammar is a quadruple G = (N, Σ, P, S), where N is a finite set of nonterminals, Σ is...

Ngày tải lên: 16/03/2014, 19:20

... this.Outline I) Introduction A) The average definition for a hero B) What Odysseus is like compared to the definition C) Odysseus isn¹t a hero II) Odysseus is self centered A) He doesn¹t take ... members killed at Cyclops¹ because he was being greedy.III) Odysseus is cold-hearted A) He kills people without giving them a chance 1) Suitors 2) Disloyal maids B) He doesn¹t care about people ... prevent deaths of crew membersIV) Odysseus is disloyal A) He had affairs with other women 1) Calypso 2) Circe B) Wife didn¹t betray him 1) with suitors 2) even though he was thought to be dead V)...

Ngày tải lên: 21/03/2014, 22:48

... for all separable unital C ∗ -algebras A Anderson [An] provided in 1978 the first example of a unital C ∗ -algebra A for which Ext (A) is not a group The C ∗ -algebra A in [An] is generated by the ... example of a C ∗ -algebra A for which Ext (A) is not a group Introduction A random matrix X is a matrix whose entries are real or complex random variables on a probability space (Ω, F, P ) As in [T], ... probability theory (cf [V2], [VDN]): a) A C ∗ -probability space is a pair (B, τ ) consisting of a unital C ∗ -algebra B and a state τ on B b) A family of elements (ai )i∈I in a C ∗ -probability...

Ngày tải lên: 22/03/2014, 20:20