inflammation coagulation and physiologic dysregulation in patients with cancer

... gold standard for screening and assess-ment of malnutrition in cancer patients exists Among 37 malnutrition screening and assessment methods uti-lized for patients with cancer in clinical practice, ... point in patients of any age with any type of cancer and anticancer therapy were included Studies with a cross-sectional design and those not using MNA-assessed nutritional status for predicting ... mortality/survival, cancer progression, treatment maintenance and (health-related) quality of life and did not predict adverse treatment outcomes and functional status/ decline in patients with cancer For

Ngày tải lên: 03/07/2020, 02:54

... fixed in 10% buffered formalin and embedded in paraffin Three to five micrometer Trang 3thick sections were stained with hematoxylin for 10 minand with eosin for 1 min to establish the diagnosis and ... ZO-1 ap-peared in the submembranous domain of tight junction in epithelia and endothelia [15, 16], binds to actin and the integral tight junction proteins occludin and claudins and junctional ... E Open AccessIncreased systemic zonula occludens 1 associated with inflammation and independent biomarker in patients with hepatocellular carcinoma Amit Kumar Ram1, Biju Pottakat2and Balasubramaniyan

Ngày tải lên: 23/07/2020, 02:45

... content JPL and NS were involved in the interpretation of data, and critical drafting and revising of the manuscript for important intellectual content All authors read and approved the final manuscript. ... (white vs all other), baseline body mass index (BMI), baseline CGI and baseline PANSS Choice of the independent vari-ables was based on clinical relevance and their inclusion in all 6 studies Analysis ... change in PANSS total score at week 6 end point Tolerability end points included adverse event (AE) reports and weight AEs with rates≥5% and with a ≥2% difference between paliperidone ER and risperidone

Ngày tải lên: 11/08/2014, 16:23

... whereas patients in stage 2 did In addition, only the patients in stage 2 experienced improvements in eating and drinking due to HPN Eating and drinking can still be heavily limited in patients ... improvement Applying knowledge General tasks and demands d240 Handling stress and other psychological demands Conversation and use of communication devices and techniques Changing and maintaining body ... position Carrying moving and handling objects Walking and moving Moving around using transportation Self-care Acquisition of necessities Household tasks Caring for household objects and assisting others

Ngày tải lên: 12/08/2014, 01:21

... associa-tion with COPD using a linear mixed effects model Trang 3including disease (COPD or control), smoking, and theinteraction between disease and smoking as fixed effects, and visit number within each ... method since airway inflammation may increase local production of cytokines as well as protein leakage into the airway from the inter-stitium If total protein in the airway is increased due to inflammation, ... immunoassays were useful in identifying potential biomarkers in patients with COPD, and that systemic and sputum biomarkers identified in these patients were associated with clinical variables known

Ngày tải lên: 12/08/2014, 11:21

... clusters in a) the extracellular domain (exons 2-4) and b) the serine/threonine protein kinase domain (exons 9-11) Four mutations occurred in more than one independent patient/family: p.R491W and ... mutation Only in 3 out of the 22 families with HPAH (13.6%, Figure 3) examination of the BMPR2 gene (promoter and coding regions including flanking intronic regions) and the coding regions of ... patients with apparently sporadic disease [1,3-6] and in 58% to 74% of patients with famil-ial PAH [1,4,6,7] In total 298 different mutations in BMPR2 have been identified so far in independent patients

Ngày tải lên: 12/08/2014, 13:22

... LD ↑ in mucosal blood flow NA Epinephrine, norepinephrine in versus norepinephrine 1 ± 0.6 with epinephrine and random order to achieve MAP versus norepinephrine + norepinephrine + dobutamine, ... Comments dopamine infused to achieve increase of 25% in cardiac index 5 versus norepinephrine 0.13 ≈ versus norepinephrine 0.18 HSBF = PCO2gap = norepinephrine or epinephrine in versus epinephrine 0.12 ... the combination of norepinephrine and dobutamine in patients with septic shock on gastric mucosal flow, as assessed using a laser Doppler technique Epinephrine and dobutamine–nor-epinephrine led

Ngày tải lên: 12/08/2014, 20:20

... vasoconstrictor and water-retaining and sodium-retaining systems such as the renin–angiotensin–aldosterone system and the sympathic nervous system, and in the nonosmotic release of arginine vasopressin Persistent ... renin activity, (b) aldosterone, (c) norepinephrine, (d) vasopressin and (e) nitric oxide metabolites (NOx) after treatment with standard medical therapy (SMT) alone (grey shading) shading), with ... fractionated plasma separation, adsorption, and dialysis. Trang 3unit these patients are routinely treated with terlipressin andalbumin, which might have interfered with the haemodynamic measurements

Ngày tải lên: 13/08/2014, 01:20

... transpeptidase, alanine aminotransferase, α2-macroglobulin, haptoglobin, apolipoprotein A1, and total bilirubin) and to identify factors associated with this variability. Results: Serum of 24 patients with ... measurement with the Szasz method (standardized against the original for GGT), and with the standardized method according to the International Federation of Clinical Chemistry (using pyridoxal... ... four without pyridoxal... occurring within the liver Furthermore, and because treatment is now so effective in patients with genotype 2 or 3 infection, the utility of biopsy in

Ngày tải lên: 13/08/2014, 13:20

... biopsy and METAVIR staging and grading performed Of these patients, 453 were from our center [11,14], including 130 patients coinfected with HCV and HIV [14] Eight hundred and seventy (870) patients ... "FibroTest" and "ActiTest" in Medline and in the abstract books of hepatology, gastroenterology, internal medicine and infectious diseases annual meetings Only publications or abstracts concerning ... performed in totally independ-ent cindepend-enters, and two were performed in multiple cindepend-enters, including the non-independent center The AUROCs for the diagnosis of F2F3F4 versus random

Ngày tải lên: 13/08/2014, 13:20

... con-trast with some findings involving chronic cervical pain in which the cause was not controlled [7] or involved trauma [12,17,39-41] In a group of 30 patients with chronic neck pain, Revel ... pain should be diagnosed and classified [1] Further-more, large inherent variations in functional propriocep-tive impairment and pain within one group of patients with nontraumatic neck pain ... on pre-investi-gation pain levels, such as pain during the preceding week, worst pain, or pain during specific tasks Position of participant's feet in comfortable position (left) and tandem stance

Ngày tải lên: 13/08/2014, 14:20

... co-mor-bidities found in our patients including history of CAD in 38%, history of CHF in 27%, arterial hypertension in 53% and COPD in 39% and the positive effect of beta-blocker therapy in these different ... mortality in individuals with and without cardiovascular disease [24]. Angiotensin converting enzyme inhibitors (ACEi)/ angiotensin receptor blockers (ARB) and beta-blockers build the mainstay of ... for this conflicting finding in our study is that patients with acute coronary syndrome as well as patients with shock were excluded due to study protocol Patients included in our study had diastolic

Ngày tải lên: 13/08/2014, 21:21

... peopleand anemia patients without renal failure Create equation calculatingestimated erythropoietin levels from a linear correlation betweenerythropoietin and hemoglobin levels in anemia patients without ... conducted this study with twofollowing objectives: 1 To investigate erythropoietin level, serum ferritin and transferrin saturation (TSAT) in patients with end-stage renal disease (ESRD) indicated chronic ... comparing serum EPO levels in CKD patients with estimated serum EPO calculated from the linearregression equation in anemic patients without renal failure and foundthat the EPO response in patients

Ngày tải lên: 10/06/2016, 10:39

... complex was safe and effective in adult and pediatric patients with disseminated candidiasis refractory to standard therapy and in patients intolerant to standard agents.19–21In specific rare ... 30% to 60%.5 In a European surveillance study of candidemia in cancer patients, the overall 30-day mortality was 39%, with increased mortality occurring in older patients, in patients with poorly ... However, echinocandins have not been evaluated as initial therapy for invasive aspergillosis Significant interest has been noted in combina-tion antifungal therapy pairing an echinocandin with either

Ngày tải lên: 10/03/2017, 19:28

... lowering the pain threshold and increasing the likelihood of experiencing resting pain Interestingly, individuals with depressive symptoms had a non-significant association with night pain Greater ... knee pain intensity during daily living in a non-task-specific manner and is associated with functional limitation in patients with knee OA, even after controlling for covariates, including bilateral ... resulting in muscle weakness) Since most patients with knee OA are not physically active [55], and since engaging in ambulatory PA is critical to long-term independent living for patients with

Ngày tải lên: 10/01/2020, 12:37

... expression and cytology levels in peripheral blood mononuclear cells in patients with acute myocardial infarction (AMI), stable angina pectoris (SAP) and controls Methods: 210 patients with AMI, 210 with ... CD314 and CD319 in AMI patients were significantly decreased in comparison with SAP patients and controls respectively, which showed the transduction of activating signal was inhibited in patients ... immune response in different stages of CAD [11, 12] In recent study, we designed this in vitro study to investigate both innate and adaptive immunity in patients with AMI or stable angina pectoris

Ngày tải lên: 15/01/2020, 23:38

... patterns and the impact of known and unknown germline and somatic mutations in patients with MPM from Italy Materials and methods: One-hundred and two MPM patients were enrolled for germline mutation ... lesions, and differences in sequen-cing technology Nineteen TP53 variants were found in 17 of the MPMs examined Silencing of this gene leads to reduction of the p53 protein, contributing in boosting ... 9contributions in clinical data collection and interpretation; MCo, AM, MCS, GPand members of the IMI made substantial contributions in NGS data collection and interpretation; AL and AC collected and interpreted

Ngày tải lên: 17/06/2020, 17:13

... preferences in decision-making [25] They found a more active and demanding attitude in breast cancer patients, which coincides with our findings in this regard Our study, however, investigates ... life and psychological well-being The results point to-ward breast cancer patients needing more information and involvement of the oncologist in SDM and more medical and psychological support initially ... recurrence] and 231 had breast cancer [stage I-III with criteria indicating adjuvant chemotherapy] The type of surgery for breast cancer was mastectomy in 42 patients (18%) and lumpectomy in the remaining

Ngày tải lên: 17/06/2020, 19:34

... life in cancer patients between the patient being fully informed, partially informed, or com-pletely uninformed of their cancer diagnosis This indicates that physicians could inform patients and ... difference in the change in QoL from baseline between totally informed and uninformed of diagnosis in 1593 study patients (SMD 0.12; 95% CI-0.09 to 0.34), and no difference between partly informed and ... diagnosis and totally uninformed of diagnosis in cancer patients Fig 8 Forest plot of Economic difficulty between totally informed of diagnosis and totally uninformed of diagnosis in cancer patients

Ngày tải lên: 06/08/2020, 05:23

... efficacy and influence patient outcomes Cisplatin and carboplatin are alkylating compounds that exert their cytotoxic action by binding to DNA and forming strong inter- and intra-structural cross links, ... [1] Patients with metastatic or recurrent cervical cancer are treated mainly with palliative chemo-therapy In this setting, cisplatin may be combined with either paclitaxel, topotecan, gemcitabine ... chemo-therapy and its overexpression has been associated with resistance in patients with NSCLC, breast cancer and gastric cancer treated with tubulin binding agents [13] The Multiple Drug Resistance 1

Ngày tải lên: 06/08/2020, 06:06