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... from 3 to ≥400 base pairs in the juxtamembrane d omain, are found in 20-25% of adult AML cases.1-3 In addition, activating point mutations in the second kinase domain occur in about 7% of adult AML ... resistance to ABT-869, suggesting potential targets for reducing resistance developed in patients receiving FLT3 inhibitors Our findings may indicate a common resistant mechanism in novel therapeutic ... in log-rank test (P D and E by 16h and induced the expression of p21waf1/Cip progressively The increasing expression of cyclin E in MV4-11 cells at 4h, in MOLM-14 cells at 1h and cyclin D in

Ngày tải lên: 11/09/2015, 09:06

... between in vivo and in vitro findings, confirming that not only Th2, but also Th17 cells play an important role in the context of allergic inflammation IL10 producing CD4+ T cells showed a distinct ... Thirty Chinese patients suffering from persistent AR with significant nasal symptoms (e.g., nasal itching, sneezing, nasal obstruction and rhinorrhea) were recruited in the outpatient clinic in the ... treatment were used in the following in vivo and in vitro studies 3.2 In vivo Study mRNA/protein levels of Th17 associated genes and specific cytokines of Th cell subsets were measured in PBMCs from

Ngày tải lên: 23/09/2015, 14:47

... carcinoma[103-a mcarcinoma[103-arker for distinctly fcarcinoma[103-avourcarcinoma[103-able prognosis in brecarcinoma[103-ast ccarcinoma[103-arcinomcarcinoma[103-a pcarcinoma[103-atients carcinoma[103-and ... an in vitro investigation would be conducted to examine the effects of COL-3 and tamoxifen, in single agent or in combination against human breast cancer cell lines, MDA-MB-231 and MCF-7 Finally, ... Scientific Consulting Inc., Lexington, KY, USA) based on nonlinear regression analysis The single-dose intravenous and oral pharmacokinetics of COL-3 was analyzed using model-independent noncompartmental

Ngày tải lên: 09/10/2015, 11:24

... HSAC binding gels The AF% values of the HSAC binding gels in 10 mg L1 nitrophe-nol solutions (individually) for all analytes were > 98% (n = 6) (Fig 4a), demonstrating that the HSAC binding ... environment[6] The DGT device typically consists of a binding layer containing binding agents with a high affinity for the analytes of interest and a diffusion layer, which can effectively control ... the diffusion layer and HSAC as the binding agent (HSAC–DGT) for in situ sampling and measurement of nitrophenols in industrial wastewater was examined The influence of pH and ionic strength on

Ngày tải lên: 13/01/2020, 19:14

... SB) during 10 minutes each Staining was completed with diaminobenzidine (DAB) and slides were counterstained with hematoxylin Induction of tumors in athymic mice Studies involving mice were performed ... streptomycin and 5% heat-inactivated fetal bovine serum The established human breast cancer cell line T-47D was also used in this study (ATCC, Manassas, VA) and was maintained following indications ... combined treatment targeting these two proteins in vivo could result in an improved thera-peutic benefit for breast cancer management, including those tumors not treatable by hormonal therapy In

Ngày tải lên: 14/10/2020, 16:25

... (IHC) staining Cyclin D1 expression in xenograft tumor samples was determined by IHC staining Briefly, 5-μm thick paraffin-embedded tumor sections were deparaffinized in xylene and rehydrated in decreasing ... metformin possesses anticancer activity, which has attracted increasing attention In basic investi-gations, metformin inhibited cell proliferation in several human malignancies including gastric ... signaling pathways was examined by immunoblotting The in vivo anti-tumor effect of metformin was examined using a xenograft mouse model Immunohistochemistry and TUNEL staining were used to determine

Ngày tải lên: 05/11/2020, 07:44

... management in wheat in northwestern India consisting of applying half of the total dose of 120 or 150 kg N ha-1 at planting and remaining half at the crown root initiation stage coinciding with first ... remain in the field as mulch Four to five irrigations were applied at crown root initiation stage, Feekes 5-6, Feekes 7-8, flowering/booting, and grain filling stages (depending upon rainfall ... physiological efficiency INTRODUCTION With decreasing profit margins and increasing awareness regarding non-point source pollution, it is imperative that N management in wheat be further improved

Ngày tải lên: 18/10/2022, 18:54

... that causes a single amino acid sub-stitution (AAS) in a protein sequence is called nsSNP An nsSNP could potentially influence the function of the protein, subse-quently altering the phenotype ... accessible mutations The final output is displayed as a pathogenicity index ranging from 0 to 1 (indexes> 0.5 single pathological mutations) and a confidence index ranging from 0 (low) to 9 (high) ... SNPs&GO collects, in a unique framework, informa-tion derived from protein sequence, protein sequence profile and protein functions RESULTS nsSNPs FOUND BY SIFT PROGRAM Protein sequence with mutational

Ngày tải lên: 02/11/2022, 11:41

... synergistic in combi-nation with teicoplanin, moenomycin, and dalbavancin (Breidenstein et al 2015) It had potent activities against S aureus in rabbit meningitis, murine peritonitis, and thigh infection ... author information is available at the end of the article Trang 2S suis isolates are  resistant to oxytetracycline, erythro-mycin, tylosin tartrate, and clindamycin in Spain (Vela et al 2005) In ... pathological phenomenon in lung and low level of inflammatory cytokines in blood were detected Above all, the in vitro and in vivo bactericidal profiles of NZ2114 indicating it is an ideal candidate

Ngày tải lên: 04/12/2022, 14:54

... of the binding sites of AChE ES: esteratic site AS: anionic substrate binding site ACS: aromatic cation binding site PAS: peripheral anionic binding site NH2N Tacrine Trang 13- Acetylcholinesterase ... Trang 9Treatment methodso Using acetylcholinesterase inhibitor drugs (eg: tacrine, rivastigmine, galantamine and donepezil) o Healthy nutrition o Do exercise Trang 10II In Vitro Model Trang 11Fig ... produced by scopolamine injection Escape latency and traveled distance have improved in groups that received compound 5l plus scopolamine in comparison to scopolamine administered group. All

Ngày tải lên: 26/02/2023, 19:15

... This is only expresses information through words but also performs certainfunctions such as promising, inviting, questing, wishing, etc, in everyday communication Inaddition, in everyday use of language, ... of saying something in the full sense of “say”  Illocutionary act: the act performed in saying something  Perlocutionary act: the act performed by or as a result of saying For instance, in a ... to respond in one way or another, byanswering a question, by agreeing or disagreeing to a proposal, by acknowledging receipt of Trang 4information, and so on, in other words by being an active

Ngày tải lên: 09/04/2013, 08:49

... realize the tance of maintaining and safeguarding marine ecosystems, which are impor-in many ways as impor-indispensable to our well-beimpor-ing as the terrestrialecosystems that we inhabit Daniel Pauly, ... not the kind of picture that interests either wood or the fishing industry Typically, the misleading image theypaint is one of relative abundance in the North Atlantic, one in Holly-xxiv Introduction ... shark-fin soup The finned, bleeding car-casses are thrown back overboard—thousands of them, day in, dayout A few more decades of long-lining will resolve the problem, asextinct sharks cannot be finned

Ngày tải lên: 06/03/2014, 18:21

... study was divided into two phases In Phase 1, using a combination of purposive and representative sampling, a survey instrument was administered in nine schools in three provinces (Western Cape, ... social cohesion within the school context; Carolyn McKinney, in injecting the necessary energy at the point of conception; and Jonathan Jansen, for his unflinching support Processing of the quantitative ... level to ensure healthy learning environments Principals should receive training in managing and leading for diversity Trang 13DET Department of Education and TrainingDoE Department of Education

Ngày tải lên: 16/03/2014, 10:20

... important in explaining the headline inflation in Vietnam during the observed period Goujon (2006) investigates the determinants of inflation in the dollarized economy of Vietnam in the 1990s using ... commodities as leading indicators of inflation between 1958 and 1994, finding that the price of goods performed better than that of gold in predicting inflation Comparing gold and inflation-linked bonds, ... leading indicator of inflation, outperforming CPI and the price of oil in predicting future inflation Tkacz (2007) studies the indicator property of gold prices for inflation by modelling the inflation

Ngày tải lên: 22/05/2014, 08:14

... Keywords: Lead–acid battery; Expanders; Lignins; Phenolic groups in lignin; Metal–lignin compounds 1. Introduction Organic expanders based on lignins exert an influence on the processes of charge and ... battery. In a previous paper of ours, we studied the effect of the functional groups contained in a family of eight lignin products on the performance of SLI batteries when tested according to the DIN-43539-2 ... of carboxyl groups in the lignin. It is low in the samples with phenolic group content up to 1.0% and increases substantially in the samples with higher phenolic content. The increased carboxylic

Ngày tải lên: 05/07/2014, 21:20

... Activation of insulin signaling upon binding of insulin to insulin receptors causes suppression of gluconeogenesis in liver and kidney [14], translocation of glucose transporter-4 (GLUT 4) from inner ... phosphorylase while stimulating glycogen synthase [17] Increased plasma glucose results in increase in plasma insulin while decrease in plasma glucose causes reduction in plasma insulin level as well II ... Individuals in this category can either have predominant insulin resistance with relative insulin deficiency or predominant insulin secretory defect with insulin Trang 223 resistance The etiology of this

Ngày tải lên: 08/09/2015, 18:22

... showing the number of compounds selected using various methods from a) the 110% inhibition bin, b) the 100% inhibition bin and c) the 90% inhibition bin 35 Figure 2.6 Frequency histogram showing ... showing the number of compounds selected using various methods from a) the 100% inhibition bin, b) the 90% inhibition bin and c) the 80% inhibition bin 41 Figure 2.10 Frequency histogram showing ... features of the binding site on the target macromolecule However, pharmacophores have an underlying assumption that the compounds interact with the same binding site and in a similar binding mode.123

Ngày tải lên: 08/09/2015, 22:12

... Trang 1SKIN FLAP SURGERY – NON-INVASIVE IN VIVO METHODOLOGY TO PREDICT SKIN FLAP SHRINKAGE LIM KENG HUI NATIONAL UNIVERSITY OF SINGAPORE 2008 Trang 2SKIN FLAP SURGERY – NON-INVASIVE IN VIVO ... terminal stiffness of skin In addition, this chapter describes an in vivo non-invasive method to predict the direction of the Langer’s line Chapter 6 presents an in vivo non-invasive method using ... would get in a uniform stress field in the test area, and in the absence of force contribution from the deformation (or stretching) of surrounding skin tissues, such as in an in vitro setting Thus,

Ngày tải lên: 11/09/2015, 16:03

... anthraquinones (emodin, aloe-emodin, rhein) in different stages of anti-metastatic processe as compared from both experimental findings as denoted in Pubmed ID and INVDOCK results as denoted in PDB ... sweet-sour taste combinations 50 Figure 4.1 Examples of INVDOCK-generated binding of emodin to kinases involve in metastatic-related signaling pathways The molecule of emodin is represented as ... transcriptase INVDOCK — Inverse docking k-NN — k nearest neighbour LDL — Low density lipoprotein LBD — Ligand binding domain LR — Logistic regression MLMs — Machine learning methods PDB — Protein

Ngày tải lên: 12/09/2015, 08:19

... hai lớp pr1 và pr2. class pr1 { int printing; // public: pr1() { printing = 0; } void set_print(int status) { printing = status; } // }; class pr2 { int printing; // public: ... printing; // public: pr2() { printing = 0; } void set_print(int status) { printing = status; } // }; Chương 2 Lớp , Đ ối tượng và tính đóng gói 23 23 Mỗi đối tượng của ... int passengers; int speed; public: car(int p, int s) { passengers = p; speed = s; } int sp_greater(truck t) ; }; class truck { int weight; int speed; public: truck(int w, int...

Ngày tải lên: 21/08/2012, 15:34