in silico methods for modeling endocrine disruption

... Residues involved in hydrogen bonds for the non-steroidal agonist BY108346 in Lepidoptera are indicated by a red circle Residues involved in extra pocket formation in Lepidoptera are indicated ... cavities can be explored as a target for allosteric modulators/inhibitors Further, conserved amino acids in hemipteran EcR binding pocket are interesting targets for pharmacophore-based pesticide ... Binding Domain (LBD) is a conserved region responsible for receiving hormonal signalization (Verhaegen et al., 2011) The structural analysis of the ecdysteroid binding site in LBD shows a linkage

Ngày tải lên: 14/01/2020, 14:45

... open access at Springerlink.com Abstract Productivity trend information is valuable in developing policy and for understanding changes in the ‘value for money’ of the care system In this paper, ... adjustment index Input data We used (deflated) expenditure data to calculate our input growth index Specifically, data for 2010 to 2012 for each local authority in England were used Since we are inter-ested ... change in volume of each output weighted by the cost of each service (k) (in this case, k = residential and nursing care for older people) Therefore, in a Laspeyres form, output growth for each

Ngày tải lên: 04/12/2022, 15:06

... (Chapter 2) Modeling and verifying database triggers systems Modeling and verifying context−aware systems (Chapter 3) (Chapter 4) Two types of event−driven systems with precise requirements using ECA ... (Chapter 4) Two types of event−driven systems with precise requirements using ECA structure Modeling and verifying imprecise systems requirements (Chapter 5) Event−driven systems with imprecise requirements ... Aп Luận văn thạc sĩ luận văn cao học luận văn 123docz Trang 12Event−driven systems Graphic user interfaces Rule−based production systems Active objects Context−aware systems Database trigger

Ngày tải lên: 12/07/2023, 13:30

... described before Paraffin sections, hematoxylin and eosin and immunofluorescence staining After fixation in 4% formalin for 24 h, primary tumor tis-sue was processed for paraffin embedding with ... unmasking, microscope slides were placed into boiling 10 mM sodium citrate buffer (pH 6.0) for 60 min, cooled for 30 min, washed with DPBS once for one minute and twice for five minutes Paraffin ... nicotinamide, wnt agonist r-spondin-1 and noggin, a protein involved in bone mor-phogenic protein (BMP) – 4 inhibition, to be essential for organoid formation and maintenance [33, 34] Wnt signaling

Ngày tải lên: 30/05/2020, 21:42

... Galerkin meshless methods including radial point interpolation method (RPIM) and improved moving Kriging (MK) interpolation method Enrichment techniques including the use of step function for crack ... IMPROVED EXTENDED MESHLESS MOVING KRIGING FOR FRACTURE MODELING OF SOLIDS AND FGMs 130 6.1 Introduction to the moving Kriging method 130 Trang 106.1.1 The moving Kriging shape function 131Remark ... load intensities on the mode-I DSIF of a semi-infinite edge crack in an infinite plate under step and blast loadings In the blast case, the dash-dot lines represent the time t and 1 t corresponding

Ngày tải lên: 22/01/2021, 14:09

... Galerkin meshless methods including radial point interpolation method (RPIM) and improved moving Kriging (MK) interpolation method Enrichment techniques including the use of step function for crack ... IMPROVED EXTENDED MESHLESS MOVING KRIGING FOR FRACTURE MODELING OF SOLIDS AND FGMs 130 6.1 Introduction to the moving Kriging method 130 Trang 106.1.1 The moving Kriging shape function 131Remark ... load intensities on the mode-I DSIF of a semi-infinite edge crack in an infinite plate under step and blast loadings In the blast case, the dash-dot lines represent the time t and 1 t corresponding

Ngày tải lên: 26/01/2021, 08:52

... Galerkin meshless methods including radial point interpolation method (RPIM) and improved moving Kriging (MK) interpolation method Enrichment techniques including the use of step function for crack ... IMPROVED EXTENDED MESHLESS MOVING KRIGING FOR FRACTURE MODELING OF SOLIDS AND FGMs 130 6.1 Introduction to the moving Kriging method 130 Trang 106.1.1 The moving Kriging shape function 131Remark ... load intensities on the mode-I DSIF of a semi-infinite edge crack in an infinite plate under step and blast loadings In the blast case, the dash-dot lines represent the time t and 1 t corresponding

Ngày tải lên: 28/02/2021, 21:37

... Galerkin meshless methods including radial point interpolation method (RPIM) and improved moving Kriging (MK) interpolation method Enrichment techniques including the use of step function for crack ... IMPROVED EXTENDED MESHLESS MOVING KRIGING FOR FRACTURE MODELING OF SOLIDS AND FGMs 130 6.1 Introduction to the moving Kriging method 130 Trang 106.1.1 The moving Kriging shape function 131Remark ... load intensities on the mode-I DSIF of a semi-infinite edge crack in an infinite plate under step and blast loadings In the blast case, the dash-dot lines represent the time t and 1 t corresponding

Ngày tải lên: 17/06/2021, 22:07

... Galerkin meshless methods including radial point interpolation method (RPIM) and improved moving Kriging (MK) interpolation method Enrichment techniques including the use of step function for crack ... IMPROVED EXTENDED MESHLESS MOVING KRIGING FOR FRACTURE MODELING OF SOLIDS AND FGMs 130 6.1 Introduction to the moving Kriging method 130 Trang 106.1.1 The moving Kriging shape function 131Remark ... load intensities on the mode-I DSIF of a semi-infinite edge crack in an infinite plate under step and blast loadings In the blast case, the dash-dot lines represent the time t and 1 t corresponding

Ngày tải lên: 18/06/2021, 09:46

... functions for modeling strong discontinuities like crack in solids using XFEM was developed in [44] The ramp functions were later applied to the crack modeling of for instance general inelastic ... first presented in this thesis Finally, some conclusions and outlooks are extracted in Chapter 7.EXTENDED MESHFREE GALERKIN METHODS FOREnrichment methodsIn terms of fracture modeling using local enriched ... detected early, long before collapse occurs, lots of efforts and money still have to be spent for maintenance Some examples of cracks appearing in engineering structures in Vietnam involve the Song

Ngày tải lên: 08/09/2024, 23:27

... to a singular noun or a verbal infinitive, if possible, and looks it up again Nouns remain in the singular, since the determiner of a noun provides the transla- tion routine with enough information ... The rules for parenthesizing and grouping are stated in the following outline OUTLINE OF THE PARENTHESIZING AND GROUPING ROUTINE The rules listed below are applied in sequence to an initially ... described in greater detail in the following outline OUTLINE OF THE PARSING ROUTINE Shelf 9 is input shelf, Shelf 6 is output shelf, Shelf 1 is for the partial parsings, Shelf 8 is for the complete

Ngày tải lên: 30/03/2014, 17:20

... combinations, as follows: blocking window only, comb filter only, blocking window and comb filter, blocking window and peak envelope, comb filter and peak envelope and, finally, blocking window, ... different processing schemes The naked eye inspection reveals that the processing scheme including combfiltering and artifact blocking window gave the closest result to the original volitional ... important tool in the fields of biomechanics and kinesiology In the time domain, the envelope of the rectified EMG signal is commonly used for several applications including: force estimator

Ngày tải lên: 19/06/2014, 10:20

... Abstract In this paper, we introduce the modified general iterative approximation methods for finding a common fixed point of nonexpansive semigroups which is a unique solution of some variational inequalities ... mapping principle guarantees that Tthas a unique fixed point xtin E It is unclear, in general, what is the behavior of xt as t ® 0, even if T has a fixed point However, in the case of T having ... proved Reich’s results hold in reflexive Banach spaces which have a weakly continuous duality mapping In the last ten years or so, the iterative methods for nonexpansive mappings have recently been

Ngày tải lên: 20/06/2014, 22:20

... Y Liu introduced two iteration schemes by the general iterative method for finding an element of EP φ ∩ F S In 2001, Yamada 10 introduced the following hybrid iterative method for solving the ... hybrid steepest descent method for the variational inequality problem over the intersection of fixed point sets of nonexpansive mappings,” in Inherently Parallel Algorithms in Feasibility and Optimization ... Steepest Descent Methods for Equilibrium Problems and Strict Pseudocontractions in Hilbert Spaces Ming Tian College of Science, Civil Aviation University of China, Tianjin 300300, China Correspondence

Ngày tải lên: 21/06/2014, 05:20

... used in the manufacturing industry for quality engineering purposes In DoE, a design matrix is constructed in a combinatorial fashion that specifies the levels for several different factors for ... screening is to filter, score and rank structures of compounds using in silico methods Virtual screening may be used to select and prioritize compounds for screening in assays, 19 selecting which ... ‘thinking’ approach to conducting innovative research Dr Nilar achieved that by providing abundant ‘space’ for me to tinker with alternative methods to solve problems instead of merely shoving...

Ngày tải lên: 08/09/2015, 22:12

... nonlinear body [27], variational methods can be used for modeling of nonlinear biological soft tissue deformation in the finite deformation regime By defining the modeling problem as an energy minimization ... approach in dealing with nonlinear problem Variational based modeling methods have many applications in soft tissue deformation modeling Realistic and efficient modeling and animation of skin for ... related works in soft tissue modeling 2.1 Non-physical based computational methods The non-physical computational methods for tool-tissue interaction modeling include free-form deformation methods...

Ngày tải lên: 09/09/2015, 11:30

... additional ring (b) one additional ring with smaller Gaussian integration points in each triangle Here (+) are Gauss points for domain integration; (◦) are Gauss points for line integration ... (XFEM) for heterogeneous materials, including porous structures Instead of using the Heaviside enrichment function for the strong discontinuity of the holes’ interfaces, the penalty method is introduced ... cell containing 29 circular inclusions: VCFEM (thickline) and FEM (thin line) 85 4-14 Von Mises stress distribution of the composite unit cell containing 29 circular inclusions:...

Ngày tải lên: 10/09/2015, 15:51

... nite element model (LEVCFEM) for simulating evolving fracture in ductile microstructures containing inclusions, International Journal for Numerical Methods in Engineering, vol 76, pp 19551992, 2009 ... and T Belytschko, Blending in the extended nite element method by discontinuous Garlerkin and assumed strain methods, International Journal for Numerical Methods in Engineering, vol 74, pp 16451669, ... method for modeling phase transformations, International Journal for Numerical Methods in Engineering, vol 54, pp 12091233, 2002 [67] M Stolarska, D Chopp, N Moăs, and T Belytschko, Modelling crack...

Ngày tải lên: 10/09/2015, 15:51

... required for maintaining cell growth rates 166 7.4 Succinate production limits for wild type and the mutants The bold line indicates the limits for wild type strain and the points indicate ... techniques and in silico modeling approaches for characterizing cell culture fermentation and exploring the internal cell metabolism The most relevant statistical methods for examining the experimental ... current research work It involves developing a frame work for modeling and analyzing microbial and mammalian systems using a combined statistical and in silico approach to gain insights about the effect...

Ngày tải lên: 11/09/2015, 21:27

... useful information from data for the purposes of process modeling, control, and monitoring is one of the challenges in chemical industries In this thesis, a new just -in- time learning (JITL) modeling ... competition getting more intense than before, growing demands for improving performance of process still stimulate researchers to develop more efficient and reliable methods for process modeling, control ... approaches for nonlinear process modeling 2.1.1 Standard-learning methods The standard-learning approach includes NARMAX (nonlinear autoregressive moving average models with exogenous inputs),...

Ngày tải lên: 30/09/2015, 05:58