... Treatment of Cancer Quality-of-Life Questionnaire-Lung Cancer-17 items; EQ-5D: EuroQoL-5 Dimensions; HRQL: Health-related Quality of Life; NSCLC: Non-Small Cell Lung Can-cer; SF-36: Short-Form 36 ... Abstract Background: Existing reports of utility values for metastatic non-small cell lung cancer (NSCLC) vary quite widely and are not all suitable for use in submissions in the UK The aim of this ... 2002, approximately 29,000 people died from lung cancer in England and Wales[1] and it is the most com-mon and the most life-threatening form of cancer in Scot-land [2] Lung cancer is also a major
Ngày tải lên: 18/06/2014, 19:20
... stranded RNAsmall interference RNAnon small cell lung cancer Abstract Lung cancer has emerged as a leading cause of cancer death in the world Non-small cell lung cancer (NSCLC) accounts for 75–80% ... Trang 2Lung cancer is a leading cause of cancer death in Australia and the world [1,2] There are two types of lung cancers, non small cell (NSCLC) and small cell (SCLC) NSCLC accounts for 75–80% ... effects in A549 and SPC-A1 cellsFigure 1 SiRNA-mediated RNAi effects in A549 and SPC-A1 cells (A) dsRNA-mediated inhibition of EGFR gene expression in A549 cells (upper) and SPC-A1 cells (lower)
Ngày tải lên: 14/08/2014, 19:22
Exercise training for people following curative intent treatment for non small cell lung cancer: a randomized controlled trial
... with non-small cell lung cancer: a systematic review.Lung Cancer. 2013;81(1):11 -26. 9 Balduyck B, Hendriks J, Lauwers P, Sardari Nia P, Van Schil P Quality of life evolution after lung cancer ... GK, Adjei AA Small cell lung cancer.Mayo Clin Proc. 2008;83(3):355 -367. 4 Howington JA, Blum MG, Chang AC, Balekian AA, Murthy SC Treatment of stage I and II non-small cell lung cancer: diagnosis ... andWelfarerevealedthatthe5-yearsurvivalofpeoplewith lungcanceris15%.2 Inpeoplediagnosedwithlungcancer, 85%ofcasesarenon-smallcelllungcancer(NSCLC).3 Impor-tantly,forpeoplediagnosedwithearlystageNSCLC,surgical resectionofthetumor,withorwithoutadjuvant
Ngày tải lên: 24/11/2022, 17:57
Immunotherapy for non-small cell lung cancers: Biomarkers for predicting responses and strategies to overcome resistance
... therapy for lung cancer and factors associated with the treatment responses We first review the currently avail-able immune checkpoint blockade therapies for treatment of non-small cell lung cancer ... de Wit M, et al Durvalumab after Chemoradiotherapy in stage III non-small-cell lung Cancer N Engl J Med 2017;377(20):1919 –29. 9 Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, ... Atezolizumab for metastatic non-small cell lung Cancer Clin Cancer Res. 2017;23(16):4534 –9. 12 Sul J, Blumenthal GM, Jiang X, He K, Keegan P, Pazdur R FDA approval summary: Pembrolizumab for the
Ngày tải lên: 03/07/2020, 00:59
Cost effectiveness analysis of afatinib versus pemetrexed-cisplatin for first-line treatment of locally advanced or metastatic EGFR mutation positive non-small-cell lung cancer from the
... Afatinib 85,802 1.69 2.59 1.18 119,048 30% reduction PemCis 69,583 1.58 2.45 0.68 Afatinib 81,724 1.69 2.59 1.18 109,747 40% reduction PemCis 66,534 1.58 2.45 0.68 Afatinib 77,646 1.69 2.59 1.18 100,447 ... real-world setting J Thorac Oncol 2013;8:997 –1003. 21 Nafees B, Stafford M, Gavriel S, Bhalla S, Watkins J Health state utilities for non small cell lung cancer Health Qual Life Outcomes 2008;6:84. ... erlotinib in patients with advanced non-small cell lung cancer who failed previous chemotherapy Lung Cancer 2012;75:82 –8. 15 Rohatgi A WebPlotDigitizer Version 3.9 http://arohatgi.info/ WebPlotDigitizer
Ngày tải lên: 24/07/2020, 02:00
Unfavorable impact of cancer cachexia on activity of daily living and need for inpatient care in elderly patients with advanced non-small-cell lung cancer in Japan: A prospective
... Keywords: Non-small-cell lung cancer, Elderly, Cancer cachexia, Activity of daily living, Length of hospital stay, Medical cost Background The number of elderly people living with advanced lung cancer ... cancer treatments [1] In Japan, 65% of lung cancer morbidity cases and 73% of lung cancer-related deaths were attributed to elderly individuals aged ≥70 years in 2012 [2] Patients with lung cancer, ... activity of daily living and need for inpatient care in elderly patients with advanced non-small-cell lung cancer in Japan: a prospective longitudinal observational study Tateaki Naito1* , Taro
Ngày tải lên: 06/08/2020, 03:21
Development and validation of a predictive model for estimating EGFR mutation probabilities in patients with nonsquamous non-small cell lung cancer in New Zealand
... diagnosed with non-squamous non-small cell lung cancer in northern New Zealand between 1 Feb 2010 and 31 July 2017 A total of 1694 patients were tested forEGFR mutations, of which information on ... New Zealand Full list of author information is available at the end of the article Trang 2Non-small cell lung cancer (NSCLC) comprises about 85% of all lung cancers About 32.3% of NSCLC have ... clinical decision making for patients in whom tissue-based mutation testing is difficult or as a supplement to mutation testing Keywords: Non-small-cell lung carcinoma, Lung Cancer, Epidermal growth
Ngày tải lên: 06/08/2020, 05:46
The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFRmutated and -wildtype non-small cell lung cancer cells
... Followed by Surgery in Non-small Cell Lung Cancer J Thorac Oncol Off Publ Int Assoc Study Lung Cancer 2012;7:1683 –90. 11 Derks S, van Engeland M Epigenetic Disturbances in Colorectal Cancer In: Lübbert ... Precursor Uptake and Decarboxylation Cell Properties Cancer Res 1980;40:3502 –7. 22 Greve G, Schiffmann I, Lübbert M Epigenetic priming of non-small cell lung cancer cell lines to the antiproliferative ... Checkpoint Kinase 1 Expression to Induce Cell Death in Non-Small Cell Lung Cancer Cells PLoS One 2010;5:e14335. 13 Gray JE, Haura E, Chiappori A, Tanvetyanon T, Williams CC, Pinder-Schenck M, et
Ngày tải lên: 22/09/2020, 23:01
The emerging outcome of postoperative radiotherapy for stage IIIA(N2) non-small cell lung cancer patients: Based on the three-dimensional conformal radiotherapy technique and institutional
... in non-small-cell lung cancer Lung Cancer 2013;80:350 –2. 7 Lally BE, Zelterman D, Colasanto JM, Haffty BG, Detterbeck FC, Wilson LD. Postoperative radiotherapy for stage II or III non-small-cell ... radiotherapy for non-small-cell lung cancer: calculations from clinical trials Int J Radiat Oncol Biol Phys 2007;68:1047 –52. 15 Bogart JA, Aronowitz JN Localized non-small cell lung cancer: adjuvant ... resected N2 non-small-cell lung cancer: evidence for subclassification and implications J Clin Oncol 2000;18:2981 –9. 2 Spira A, Ettinger DS Multidisciplinary management of lung cancer N Engl
Ngày tải lên: 29/09/2020, 16:11
Prognostic model for long-term survival of locally advanced non-small-cell lung cancer patients after neoadjuvant radiochemotherapy and resection integrating clinical and histopathologic
... IIIA-N2 non-small-cell lung cancer J Natl Cancer Inst 2007;99:442 –50. 5 Kim AW, Liptay MJ, Bonomi P, Warren WH, Basu S, Farlow EC, et al Neoadjuvant chemoradiation for clinically advanced non-small ... radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small-cell lung cancer: mature results of Southwest Oncology Group Phase II study 8805 J Clin Oncol 1995;13:1880 –92. 2 Albain KS, Swann ... chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomized controlled trial Lancet 2009;374:379 –86. 3 Thomas M, Rübe C, Hoffknecht P, Macha
Ngày tải lên: 30/09/2020, 10:52
Clinical effectiveness and clinical toxicity associated with platinum-based doublets in the first-line setting for advanced non-squamous non-small cell lung cancer in Chinese patients: A
... cell lung cancer”, “non-squamous NSCLC”, “adenocarcinoma”, “large-cell lung cancer”, and “squamous NSCLC” After exclusion of pa-tients with a diagnosis of small cell lung cancer or squamous lung ... worsening air pollution associated with industrialization [2,3] Non-small cell lung cancer (NSCLC) accounts for over 80% of lung cancer cases in China [4] Because of the challenges associated ... 9,270 patients with lung cancer After excluding134 patients without tumor histology information, 279 patients with tumor stage less than IIIB, 181 patients with small cell lung cancer, 458 pa-tients
Ngày tải lên: 30/09/2020, 13:15
Expressions of MUC1 and vascular endothelial growth factor mRNA in blood are biomarkers for predicting efficacy of gefitinib treatment in non-small cell lung cancer
... Background Lung cancer is the leading cause of cancer death worldwide and it is responsible for more than million deaths annually [1] Almost 85% lung cancer can be classified as non-small cell lung cancer ... treated with gefitinib and may be promising noninvasive and repeatable markers for predicting efficacy of gefitinib treatment Keywords: Non-small cell lung cancer, Gefitinib, MUC1, Vascular endothelial ... factor mRNA in blood are biomarkers for predicting efficacy of gefitinib treatment in non-small cell lung cancer Jian Li1*, Yi-Ming Hu1, Yong-Jie Du1, Li-Rong Zhu1, Hai Qian2, Yan Wu2 and Wei-Lin
Ngày tải lên: 30/09/2020, 15:05
Randomized phase II study of pemetrexed/cisplatin with or without axitinib for non-squamous non-small-cell lung cancer
... 14:4908 –4914. doi:10.1186/1471-2407-14-290 Cite this article as: Belani et al.: Randomized phase II study of pemetrexed/ cisplatin with or without axitinib for non-squamous non-small-cell lung cancer ... Median relative dose intensity was similar between the three arms for pemetrexed (99%, 99%, and 100%) and for cisplatin (98%, 99%, and 100%) Following combination treatment, 58% of pa-tients in ... Nelson RA, Bogardus A, Grannis FW Jr: Five-year lung cancer survival: which advanced stage nonsmall cell lung cancer patients attain long-term survival? Cancer 2010, 116:1518 –1525. 3 Schiller JH,
Ngày tải lên: 05/11/2020, 00:12
Gene-guided Gefitinib switch maintenance therapy for patients with advanced EGFR mutation-positive Non-small cell lung cancer: An economic analysis
... regimens for advanced non-small-cell lung cancer N Engl J Med 2002, 346(2):92–98 28 Liu B: Comparison of the cost of kinds of second-line drug treatment regimes for Non-small cell lung cancer China ... Cost-effectiveness, Non-small cell lung cancer Background Lung cancer is the most prevalent malignant cancer in adults, with over 1.3 million deaths from the disease per year [1] Non-small cell lung cancer ... supportive care versus placebo plus best supportive care for non-smallcell lung cancer: a randomised, double-blind, phase study Lancet 2009, 374(9699):1432–1440 Zhang L, Ma S, Song X, Han B, Cheng Y,
Ngày tải lên: 05/11/2020, 07:03
Influence of oral glutamine supplementation on survival outcomes of patients treated with concurrent chemoradiotherapy for locally advanced non-small cell lung cancer
... non-small-cell lung cancer: Cancer and Leukemia Group B trial 30407 J Clin Oncol 2011, 29(23):3120 –3125. Trang 1050 El Sharouni SY, Kal HB, Battermann JJ: Accelerated regrowth of non-small-cell ... emission tomography: review and 1999 EORTC recommendations European Organization for Research and Treatment of Cancer (EORTC) PET Study Group Eur J Cancer 1999, 35(13):1773 –1782. 21 Bartlett ... al: Sequential vs concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410 J Natl Cancer Inst 2011, 103(19):1452 –1460. 48 Brade A, Bezjak A, MacRae
Ngày tải lên: 05/11/2020, 09:26
evidence for efficient phosphorylation of egfr and rapid endocytosis of phosphorylated egfr via the early late endocytic pathway in a gefitinib sensitive non small cell lung cancer cell line
... EGFR signaling required for cell survival and proliferation in non-small cell lung cancer (NSCLC) cell lines We recently provided novel evidence that gefitinib-sensitive PC9 cells show normal endocytosis ... models in vivo [10] and tumor cell lines in vitro [11] A recent in vitro study dem-onstrated that of the 9 non-small cell lung cancer (NSCLC) cell lines examined, the PC9 cell line was most sensitive ... Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line
Ngày tải lên: 02/11/2022, 09:22
lipidomic profiling of lung pleural effusion identifies unique metabotype for egfr mutants in non small cell lung cancer
... negative NSCLC. Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) being the predominant form of the disease, accounting for ~85–90% of all ... Lim2,6 Cytology and histology forms the cornerstone for the diagnosis of non-small cell lung cancer (NSCLC) but obtaining sufficient tumour cells or tissue biopsies for these tests remains a challenge ... deviation 67 ± 14 63 ± 16 69 ± 12 Smoking status Ethnic group Histology Non-small cell lung adenocarcinoma 39 (54.9) Squamous-cell carcinoma 1 (1.4) Lymphoepithelioma-like lung carcinoma 1 (1.4)
Ngày tải lên: 04/12/2022, 15:07
Báo cáo y học: "proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database" docx
... 157,300 deaths from lung cancer [4]. Lung cancer has traditionally been dichotomized into two groups based on the histological features of the tumor: small cell and non-small cell lung cancer. NSCLC ... with non-small cell lung cancer comprise the majority of cases annotated within the database. Other cancers contained in the database include small cell lung cancer, mesothelioma, esophageal cancer, ... North American Association of Central Cancer Registries; NCI: National Cancer Institute; Non-RTK: Non-Receptor Tyrosine Kinase; NSCLC: Non-Small Cell Lung Cancer; OBBR: Office of Biorepositories
Ngày tải lên: 10/08/2014, 09:22
báo cáo khoa học: " Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer" pdf
... levels in normal lung tissues, and nonsmall cell lung cancers Jpn J Cancer Res 1999, 90:1338-43. 11 Tsujii M, Kawano S, DuBois RN: Cyclooxygenase-2 expression in human colon cancer cells increases ... and clinicopathological associations of COX-2 SNP in patients with nonsmall cell lung cancer J Oncol 2009, 139590, Epub 2009 Nov 22. 8 Soslow RA, Dannenberg AJ, Rush D, Woerner BM, Khan KN, Masferrer ... tumors Cancer 2000, 89(12):2637-45. 9 Wolff H, Saukkonen K, Anttila S, Karjalainen A, Vainio H, Ristimaki A: Expression of cyclooxygenase-2 in human lung carcinoma Cancer Research 1998, 58(22):4997-5001.
Ngày tải lên: 10/08/2014, 10:20
báo cáo khoa học: " Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549)" pot
... 25 μg/ml) of DDP on cells (mock A549, A549/miR-NC or A549/miR-451) for 12 h assessed by MTT assay B Effects of μg/ml DDP on cells (mock A549, A549/miR-NC or A549/miR-451) for varied time length ... A549, A549/miR-NC or A549/miR-451 cells B Hoechst staining analysis of apoptosis in mock A549, A549/miR-NC or A549/ miR-451 cells C Analysis of relative caspase-3 activity in mock A549, A549/miR-NC ... 2010, 9:2742-2748 doi:10.1186/1756-9966-30-20 Cite this article as: Bian et al.: Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549) Journal
Ngày tải lên: 10/08/2014, 10:21