hematopoietic stem cells transplantation ppt

... mesenchymal stem cells Science 1999, 284:143-147. therapy Circ Res 2008, 102:1319-1330. surrogate in vivo assay system Cells Tissues Organs 2002, 171:90-95. endothelial progenitor cells, and the ... is often required [2] Several types of stem cells have been used for therapeutic neovascularization, including the bone marrow-derived mesenchymal stem cells (MSCs), which have attracted a great ... manufacturer’s instructions Cells in which the nucleus was stained brown were defined as TUNEL-positive and the percentage of apop-totic cells per total number of cells was determined by two

Ngày tải lên: 10/08/2014, 05:21

... Leukemic Stem Cells Three hypotheses have been proposed that lead to the development of leukemic stem cells (LSC/CSC): (A) LSC/CSC might arise from either a hematopoietic stem cell (HSC), hematopoietic ... [9-18] Leukemia Stem Cells/Cancer Stem Cells (LSC/CSC) The cancer stem cell hypothesis postulates that cancer can be initiated, sustained and maintained by a small number of malignant cells that have ... variety of cell types, including hematopoietic and stromal cells of the bone marrow, endothelial cells, epithelial cells, fibroblasts, neuronal cells, and smooth muscle cells [3,53-57] The bone marrow

Ngày tải lên: 12/08/2014, 23:23

... depressive symptoms in par-ents of children undergoing hematopoietic stem cell transplantation （HSCT）before（Time 1［T1］）and one month after transplantation（Time 2［T2］）, and（2）to identify the pre-HSCT ... 1（11） Peripheral blood stem cell 10（44） Umbilical cord blood 9（39） † Calculated for twenty allogeneic patients. GVHD, graft-versus-host disease； HSCT, hematopoietic stem cell transplantation； SD, ... References 1 Copelan EA Hematopoietic stem-cell transplantation New Engl J Med 2006; 354: 1813-26. 2 Horibe K, Tsuchida M, Tsurusawa M, Nakahata T The realities of the medical system for pediatric

Ngày tải lên: 15/01/2020, 06:10

... Blood transplantation for primary immunodeficiency disease Bone hematopoietic stem cell transplantation for inherited metabolic Weisenburger DD Autologous peripheral hematopoietic stem cell transplantation ... J, et al Long-term survival and transplantation of hemopoietic stem cells for immunodeficiencies: report of the P, et al Transplantation of hematopoietic stem cells and long term survival for ... Keywords: Hematopoietic stem cell transplantation B-thalassemia major Fanconi’s anemia Immunodeficiency diseases Inherited metabolic disorders A B S T R A C T Allogeneic hematopoietic stem cell transplantation

Ngày tải lên: 15/01/2020, 06:21

... Trang 1R E V I E W Open AccessBusulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: a meta-analysis Xinying ... a key component of several conditioning regimens used before hematopoietic stem cell transplantation (HSCT) However, the optimum systemic exposure (expressed as the area under the concentration-time ... China Full list of author information is available at the end of the article Trang 2Hematopoietic stem cell transplantation (HSCT) is widely used for the treatment of various malignancies and

Ngày tải lên: 29/05/2020, 18:56

... range during the observation period Cytokines and stem cell transplantation The analysis of the cytokine level in the different types of stem cell transplantation and conditioning regimen occurred ... localized bacterial, viral and fungal infections are known as adverse events after hematopoietic stem cell transplantation representing the major cause for morbidity and mortality Detection and ... events, 61 consecutive pediatric patients with a median age of 7.0 years who underwent hematopoietic stem cell transplantation were enrolled in this single-center retrospective study Interleukin-1

Ngày tải lên: 28/09/2020, 01:35

... centers on hematopoietic stem cells (HSCs), which are essential blood stem cells located in adult bone marrow These cells play a crucial role in regenerating blood and immune system cells Investigations ... system disorders.The different classes of hematopoietic stem cells can be categorized by their potency and structured in a tree [42,45] (see Figure 1-1) At the root of the hierarchy are the Hematopoietic ... types.M Kroiss, Predicting the Lineage Choice of Hematopoietic Stem Cells, Using recurrent neural networks (RNNs) to predict the lineage choice of stem cells reveals key trends in gene expression

Ngày tải lên: 10/05/2022, 14:58

... primitive hematopoietic stem cell compartment through the utilization of a modified Rcas/TVA system We succeeded in transferring a GFP reporter gene into adult hematopoietic stem cells in vivo, ... condition without transplantation. Hematopoietic stem cells (HSCs) are one of the most well-studied adult stem cell populations and have provided many important concepts in the stem cell biology ... of hematopoietic cells (Gr1+ Mac1+ monocytes, B220+ B cells, CD3+ T cells) (Fig. 2E, Fig. S3B) These results implied stable integration of the GFP reporter gene into neonatal hematopoietic stem/progenitor

Ngày tải lên: 19/11/2022, 11:40

... haemopoietic stem cells for immunodeficiencies: report of the European experience 1968– 99 The Lancet 2003;361(9357):553-560 6 Buckley RH Transplantation of hematopoietic stem cells in human ... after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency Blood 2009;113(17):4114-4124 8 Pai S-Y, Logan BR, Griffith LM, et al Transplantation ... Medicine 2014;371(5):434-446 Trang 129 Gennery AR, Slatter MA, Grandin L, et al Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: Entering

Ngày tải lên: 04/12/2022, 15:13

... aging of the hematopoietic system is aging of hematopoietic stem cells (HSCs) While upon aging the number of phenotypic HSCs increases, their regenerative potential as measured in transplantation ... and MPP cells in BM among donor-derived Ly 5.1 + LSK cells in young and old recipient (Ly 5.2 + ) mice. D Frequency of young B cells, T cells and myeloid cells among donor-derived Ly 5.1 + cells ... for early hematopoietic progenitor cells (LSK) cells in OPN / animals (Nilsson et al, 2005) Y?O animals presented with an increase in the frequency of myeloid cells over lymphoid T cells, while

Ngày tải lên: 04/12/2022, 15:58

... investigated its role in the response of hematopoietic stem cells (HSC) to liver fibrosis in mice Methods: Purified (c-kit+/sca1+/lin-) hematopoietic stem cells (HSC) were repeatedly infused into ... therapeutic paradigm for the use of hematopoietic stem cells in this setting It has previously been proposed that injected bone marrow cells differentiate into anti-fibrotic cells of a monocyte/macrophage ... et al Purified hematopoietic stem cells can differentiate into hepatocytes in vivo Nat Med 2000;6:1229-34 11 Sakaida I, Terai S, Yamamoto N, et al Transplantation of bone marrow cells reduces

Ngày tải lên: 26/07/2023, 07:40

... Other types of stem cells Hematopoietic stem cells together with mesenchymal stem cells, the so-called“side population”, and multipo-tent adult progenitor cells (MAPCs), are the stem cells forming ... induced pluripo-tent stem cells are at least, if not more capable than those from adult (stem) cells Mesenchymal stem cells Although adult stem cells are primarily unipotent cells, under certain ... Induced pluripotent stem cells Induced pluripotent stem cells (iPSCs) from somatic cells are revolutionizing the field of stem cells Obtained by reprogramming somatic stem cells of a patient through

Ngày tải lên: 18/06/2014, 16:20

... capacity of cells Cells were scattered in a number of colony distributions 3 days after planted At day 8 ~ 9, the bottle was cov-ered with long-spindle cells Passaged cells (mostly spin-dle cells) ... transplantated cells co-expressed GFP and NeuN The survival transplanted cells in the group SVV was 1.3-fold at 4 days after transplantation and 3.4-fold higher at 14 days after transplantation, ... method of transplantation should be required Meanwhile, there were several limitations in our study: (1) whether SVV change property of stem cells which differentiate into neuronal lineage cells

Ngày tải lên: 18/06/2014, 19:20

... mesenchymal stem cells. Symbols (*, †, ‡) indicate significance (at 0.05 level) (by Bonferroni multiple comparison post hoc test). Figure 2 Impact of Adipose-Derived Mesenchymal Stem Cells (ADMSC) Transplantation ... bone marrow-derived MSC is the major source of stem cells in these studies [22,24-27], the therapeutic role of adipose-derived mesenchymal stem cells (ADMSCs) in acute IR injury of the lung has ... Trang 1R E S E A R C H Open AccessAutologous Transplantation of Adipose-Derived Mesenchymal Stem Cells Markedly Reduced Acute Ischemia-Reperfusion Lung Injury in a Rodent

Ngày tải lên: 18/06/2014, 22:20

... neural differentiation of implanted stem cells. Keywords: adipose-derived stem cells, dog, spinal cord injury, transplantation Introduction Central nervous system regeneration is highly limited ... to ASCs because fibroblast cells also behave in this manner Some critics have suggested that even a low fraction of contaminating cells such as hematopoietic stem cells could be the source of ... particularly useful source of mesenchymal stem cells (MSCs) due to ease of harvest, clonogenic potential, and robust proliferative capacity [7] Adipose-derived stem cells (ASCs) can differentiate into

Ngày tải lên: 07/08/2014, 23:22

... pluripotent progenitor/stem cells; their prog-eny includes chondrocytes, tendon cells, haematopoiesis-sup-port stromal cells, adipocytes and osteoblasts [3,4] MSCs, similar to other stem cells, have an ... mesenchymal stem cells (MSCs) Expression levels of ADAM and adhesion molecules during chondrogenic differentiation of mesenchymal stem cells (MSCs) The gene-expression profile of mesenchymal stem cells ... expression of cell-surface proteins on mesenchymal stem cells (MSCs) Modulation of the expression of cell-surface proteins on mesenchymal stem cells (MSCs) (a) and (b) Change in the protein levels

Ngày tải lên: 09/08/2014, 10:20

... hepatic stem cells These include hematopoietic and mesenchymal stem cellsderived from the bone marrow, peripheral blood or umbilical cord blood, and extra-embryonic stem (ES) cells (18) Whether hematopoietic ... liver cells from donor hematopoietic cells (29–34) On the other hand, hematopoietic stem cells did not show the capacity to generate oval cells (35) Also, the overall efficiency by which hematopoietic ... human hematopoietic stem cells transplanted into mice (39), so the overall potential of hematopoietic stem cells in liver-directed cell therapy is quiteuncertain Insights into how human ES cells

Ngày tải lên: 10/08/2014, 18:21

... expanding clinically transplantable stem cells Keywords: Mouse Hematopoietic Stem Cell, Transplantation, Differentiation Background Hematopoietic stem cells (HSCs) are rare cells defined by their unique ... Nakajima K, Kanakura Y: Roles for c-Myc in self-renewal of hematopoietic stem cells J Biol Chem 2004, 279:24986-93 27 Nakano T: Hematopoietic stem cells: generation and manipulation Trends Immunol 2003, ... GFP control cells was not detected When the number of infused cells was raised to × 105 cells, both Sall4A and Sall4B transduced cells repopulated of recipients, whereas GFP transduced cells did

Ngày tải lên: 10/08/2014, 21:23

... with outcome [5] Recently, transplantation of various stem or progenitor cells such as bone marrow (BM)-derived mesenchymal stem cells (MSCs) or endothelial progenitor cells was reported to reduce ... Matthay MA, Martin GS: Stem cells in sepsis and acute lung injury Crit Care Med 2010, 38:2379-2385 Lee JW, Gupta N, Serikov V, Matthay MA: Potential application of mesenchymal stem cells in acute lung ... Mesenchymal stem cells for acute lung injury: preclinical evidence Crit Care Med 2010, 38:S569-573 Mei SH, Haitsma JJ, Dos Santos CC, Deng Y, Lai PF, Slutsky AS, Liles WC, Stewart DJ: Mesenchymal stem cells

Ngày tải lên: 12/08/2014, 13:22