hematopoietic stem cell niche bone marrow

... autoimmune hemolytic anemia, and reduced hematopoieticprogenitor cells are seen upon examination of the bone marrow The bone marrowmay become hypoplastic Marrow fibrosis with transfusion-dependent ... determined histocompatibility differences exist between the bonemarrow recipient and the bone marrow donor b) Immunocompetent cells in the donor's marrow that can recognize the foreignhistocompatibility ... GVHD.a) Initiation by donor T cells b) Persistence of circulating alloreactive T cells c) Development of autoreactive T cells d) Development of counterbalancing regulatory cells e) Development of circulating

Ngày tải lên: 10/08/2014, 08:20

... bone marrow transplantation Bone Marrow Transplant 1991;8: 159–170. 2 Bosi A, Vannucchi AM, Grosi A Serum erythropoietin levels in patients undergoing autologous bone marrow transplantation Bone ... in children after bone marrow transplant for hematological malignancies Bone Marrow Transplant 1991;8(suppl 1)2–4. Savdie E Renal complications In: Atkinson K, ed Clinical Bone Marrow Transplantation. ... Immunological reconstruction after allogeneic marrow, autologous marrow or autologous peripheral blood stem cell transplantation In: Atkinson K, ed Clinical Bone Marrow Transplantation Cambridge, England:

Ngày tải lên: 10/08/2014, 08:20

... nephrotoxicity, H/A, lethargy, tremulousness,delirium, seizures, N/V, rash, sore throat, insomnia,bone marrow depression, elevated liver enzymes levelsOintment: 5% (15 g) Adults: 200 mg PO 5 times ... Coccidioidal/cryptococcalinfection: 400 mg load,then 200 mg/d IV 11–20, give 25% of dose Acute systemic candidalinfections: 400 mg load,then 200 mg/d IV Other SE: H/A, nausea, rash, abdominal pain, ... h for 10 dTopical HSV treatment: 1/2 inch ribbon toaffected area 6 times perd Treatment of varicellazoster virus (VZV)infection: Children: 10–20 mg/kgper dose up to 800 mg 4times per d PO Adults:

Ngày tải lên: 10/08/2014, 08:20

... Transfuse: red blood cells Plasma Trang 111 The ABO and Rh blood types of both the patient and the bone marrow donor areimportant consideration, in red cell transfusion of the marrow transplant ... Trang 10I Transfusion TherapyA Table 8.1 outlines marrow donor-recipient red blood cell incompatibility Table 8.1 Marrow Donor-Recipient Red Blood Cell incompatibility Recipient type Donor Type ... Philadelphia: WB Saunders; 1995. Tett S Therapeutic drug monitoring in bone marrow transplant patients In: Atkinson K, ed Clinical Bone Marrow Transplantation: A Reference Textbook Cambridge, United

Ngày tải lên: 10/08/2014, 08:20

... H, Kelly M Stages of bone marrow transplantation: a psychiatric perspective Psychosom Med 1976;38:439–446. 2 Brack G, LaClave L, Blix S The psychological aspects of bone marrow transplant: a ... psychological distress in patients undergoing autologous bone marrow transplantation Oncol Nurs Forum 1992;19:41–48. 4 Artinian B Fostering hope in the bone marrow transplant child, Matern Child Nurs J. ... consequences of bone marrow transplantation in children: a preliminary communication J Psychosoc Oncol 1987;5:73–81. 6 Andrykowski A Psychiatric and psychosocial aspects of bone marrow transplantation

Ngày tải lên: 10/08/2014, 08:20

... human bone marrow stromal cells; hHSC, human hematopoietic stem cell Trang 9Fig 4 Mouse model of peripheral blood hematopoietic stem cell mobilization a, b, c The mouse model of hematopoietic stem ... cultured in Stemline® II Hematopoietic Stem Cell Expansion Medium (Sigma-Aldrich, catalog no S0192) containing 100 ng/mL stem cell factor, thrombopoietin, and G-CSF (all ob-tained from R&D Systems, ... human bone marrow stromal cells and results of the cytotoxicity assays, cytokine arrays, and apoptosis and cell cycle analyses a Mononuclear cells were collected from a healthy donor during bone marrow

Ngày tải lên: 06/08/2020, 05:25

... haematopoietic stem cell (HSC) to generate cellular lineages in the adult liver is an arguing subject currently 4 Definition and classification of stem cells What is a stem cell? A stem cell is a cell ... location of these cells in the liver is unknown at this time The third is a multipotent stem cell in the liver derived from circulating bone marrow (BM) stem cells Since the oval cells and hepatocytes ... Derivation of human EG cells from aborted fetus has also been reported (Shamblott, Axelman et al 1998) The third type of stem cell is the adult stem cells Like ES and EG cells, adult stem cells can self-renew,

Ngày tải lên: 16/09/2015, 12:10

... life of pediatric patients receiving allogeneic stem cell or bone marrow trans-plantation: results of a longitudinal, multi-center study Bone Marrow Transplant 2006; 38: 119-26. 8 Phipps S, Dunavant ... 1（11） Peripheral blood stem cell 10（44） Umbilical cord blood 9（39） † Calculated for twenty allogeneic patients. GVHD, graft-versus-host disease； HSCT, hematopoietic stem cell transplantation； ... irradiation Blood Cell Therapy-The official journal of APBMT-Vol 2 Issue 3 No 2 2019 Original Article 39 Predictors of parental distress during acute phase of pediatric hematopoietic stem cell transplantation

Ngày tải lên: 15/01/2020, 06:10

... Keywords: Hematopoietic stem cell transplantation B-thalassemia major Fanconi’s anemia Immunodeficiency diseases Inherited metabolic disorders A B S T R A C T Allogeneic hematopoietic stem cell transplantation ... aplastic anemia in children Bone Marrow Transpl adverse events in patients with Fanconi anemia Blood transplantation for primary immunodeficiency disease Bone hematopoietic stem cell transplantation ... peripheral hematopoietic stem cell transplantation restores hematopoietic function following polymorphism as a tool of chimerism detection in allogeneic D, Giardini C, et al Bone marrow transplantation

Ngày tải lên: 15/01/2020, 06:21

... pseudo-autologous bone marrow transplantation Bone Marrow Trans-plant 1996; 18: 1029-34. 12 Fassas A, Anagnostopoulos A, Kazis A, Kapinas K, Sakellari I, Kimiskidis V et al Peripheral blood stem cell transplantation ... Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes Front Immunol 2017; 8: 167. 45 Gu Y, Gong C, Peng X, Wei L, Su C, Qin M, et al Autologous hematopoietic stem cell transplantation ... Supportive care until the recovery of a functioning hematopoietic system  The mobilization of peripheral blood stem cells is typi-cally induced with a hematopoietic stimulating agent such as granulocyte

Ngày tải lên: 16/01/2020, 02:44

... following bone marrow transplantation in relation to busulfan pharmacokinetics Bone Marrow Transplant 1995;16(1):31 –42. 4 Grochow LB Busulfan disposition: the role of therapeutic monitoring in bone marrow ... Busulfan concentration and graft rejection in pediatric patients undergoing hematopoietic stem cell transplantation Bone Marrow Transplant 2002;30(3):167 –73. 3 Slattery JT, Sanders JE, Buckner ... therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children Bone Marrow Transplant 2016;13(4):72 –8. 13 Maheshwari S, Kassim A, Yeh RF,

Ngày tải lên: 29/05/2020, 18:56

... allogeneic hematopoietic stem cell transplant recipients Transpl Infect Dis 2005;7(1):11 –7. 2 Bearman SI Avoiding hepatic veno-occlusive disease: what do we know and where are we going? Bone Marrow ... cytokines including IL-6, TNF-alpha, IL-8 and IL-10 following allogeneic hematopoietic stem cell transplantation Bone Marrow Transplant 2001;28(10):935 –40. 11 Schots R, Kaufman L, Van Riet I, ... Differential effect of conditioning regimens on cytokine responses during allogeneic stem cell transplantation Bone Marrow Transplant 2006;37(7):635 –40. 8 Baker KS, Allen RD, Roths JB, Sidman CL

Ngày tải lên: 28/09/2020, 01:35

... thymic niche is consistently re-seeded from bone marrow-derived donor stem cells leading to on-going thymopoiesis, whereas for unconditioned recipients, initial seeding of the thymic niche at ... haemopoietic stem cells for immunodeficiencies: report of the European experience 1968– 99 The Lancet 2003;361(9357):553-560 6 Buckley RH Transplantation of hematopoietic stem cells in human ... phenotype on the outcome of HLA non-identical, T-cell-depleted bone marrow transplantation: a retrospective European survey from the European group for bone marrow transplantation and the european society

Ngày tải lên: 04/12/2022, 15:13

... Targeting leukemic cells in stem cell niches Trang 4ACCEPTED MANUSCRIPTAcute myeloid leukemia and acute lymphoblastic leukemia cells hijack hematopoietic stem cell (HSC) niches in the bone marrow and ... B-cell lymphoma 2; BH3, BCL-2 homology 3; BMDCs, bone marrow-derived cells; BMP, bone morphogenic protein; CAR cell, CXCL12-abundant reticular cell; CBP, CREB-binding protein; c-KIT; stem cell ... [4-6] Since mature blood cells are short-lived, hematopoietic stem cells (HSCs) are required throughout life to replenish progenitor and precursor cells [5, 7] A stem cell niche is a specialized

Ngày tải lên: 26/07/2023, 07:40

... the stem cells and/or attract the endogenous or exogenous stem cells (endogenous from the bone marrow and exogenous by multiple intra-articular injection of the expanded autologous stem cells) ... (265, 266), or introducing new cell sources like debrided waste chondrocytes, Bone Marrow derived Mesenchymal Stem Cells (BM MSCs), or any combination of these cells (29, 214, 215, 267, 268) ... Various authors have suggested the use of BM MSCs for cell-based cartilage repair (51, 61, 214, 215, 269); Bone Marrow-derived Mesenchymal Stem Cells (BM MSCs) have a better proliferation rate than

Ngày tải lên: 10/09/2015, 09:01

... Other Cell-based therapy methods There are some other cell sources used for cartilage repair such as bone marrow derived stem cells (BM MSCs), adipose derived stem cells (ADSCs), periostal cells, ... Autologous chondrocyte implantation ADSC Adipose derived stem cells AMNP Anionic magnetic nanoparticle BM MSC Bone marrow derived stem cells CD Cluster of differentiation CEST Chemical exchange ... such as inadequate cell number, age dependent quality of the chondrocytes and donor site morbidity Recently bone marrow derived mesenchymal stem cells (MSCs) become an alternative cell source for

Ngày tải lên: 10/09/2015, 09:10

... differentiation was induced by high-density pellet cell culture system 2.5×105 cells were centrifuged at 1,100 rpm for 5 minutes The aggregated cells in pellet were incubated with serum-free chondrogenic ... than 98% of cells were negative for hematopoietic markers (CD14, CD31, CD34, and CD45), and endothelial marker (CD31) (figure 3.3) Trang 11Figure 3-3 Flow cytometry analysis of the stem cells surface ... cytoplasm of the labeled cells 3.4.4 Iron content quantification in labeled-MSCs As shown in figure 3.6, mean iron content in labeled cells ranged from 3 to 141 pg per cell The results showed

Ngày tải lên: 10/09/2015, 09:10

... a limited capacity of self-repair Cell based therapy is one promising approach in the treatment of damaged cartilage Bone marrow (BM) derived mesenchymal stem cell (MSC) is a good candidate because ... mosaicplasty, and cell based therapy (autologous chondrocyte implantation, or matrix associated cell implantation)(29) Recently, cell based therapy such as mesenchymal stem cells (MSCs) become ... interactions of the cancer and endothelial cells (219), hepatocyte growth (220) and cell-cell interaction in liver (221, 222), biochemical gradient-guided cellular dynamics (223, 224) and gradient

Ngày tải lên: 10/09/2015, 09:11

... aspirated marrow technology, isolation, culture mesenchymal stem cell (identified as mesenchymal stem cell) 2 Differentiation successful bone marrow mesenchymal stem cell into osteoblast After cell ... differentiation bone marrow mesenchymal stem cell” Objective: 1 Isolation, identification and culture successfully mesenchymal stem cell sample from rabbit bone marrow 2 Differentation mesenchymal stem cell ... developmentally early hematopoietic stem cells and progenitor cell as well as endothelial cells It has been suggested that CD34 negative stem cell may generate hematopoietic stem cell Lee TC (2014)

Ngày tải lên: 08/01/2020, 11:39

... Blood and Marrow Transplantation KEY WORDS CXCR4 ● Chemokine ● Stem cells ● Mobilization ● Hematopoiesis INTRODUCTION Hematopoietic stem/progenitor cells (HSC/HPC) present within the bone marrow ... with bone marrow as a source of hematopoietic cells for allogeneic transplantation IBMTR Histocompatibility and Stem Cell Sources Working Committee and the European Group for Blood and Marrow ... CD34⫹CXCR4⫹and CD34⫹CXCR4⫺cells are shown in (B). Figure 5. Content of hematopoietic progenitor cells within CD34⫹CXCR4⫹and CD34⫹CXCR4⫺cells obtained from steady-state baboon bone marrow The bar graph

Ngày tải lên: 02/11/2022, 10:40